Pablo José Astesana, Paula Beatriz Alba, Carla Andrea Gobbi, Eduardo Horacio Albiero, Marcelo Augusto Yorio
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The average age, weight and BMI were 62.54 years, 69.60 kg and 27.13 in the St group vs 58.58 years, 65.70 kg and 26.83 in the control group (p= 0.0001, p= 0.01, p=ns respectively). Lumbar, femoral neck and total hip BMD were statistically higher in patients who received St than in controls (-0.87 vs -1.74 p=0.00, - 1.15 vs 1.56 p= 0.00 and - 0.33 vs - 0.75 p= 0.01). Regarding the time of St treatment, a significant difference was found only in relation to BMD and lumbar spine between the groups of 6 to 12 months and those that received between 12 and 36 months. No relationship was found between BMD and the different types of St received.</p><p><strong>Conclusion: </strong>Treatment with St could improve BMD in hypercholesterolemic postmenopausal women who takes these drugs.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"719-733"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina]\",\"authors\":\"Pablo José Astesana, Paula Beatriz Alba, Carla Andrea Gobbi, Eduardo Horacio Albiero, Marcelo Augusto Yorio\",\"doi\":\"10.31053/1853.0605.v81.n4.44652\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>New evidence has emerged on pleiotropic properties of Statins (St), that would be potentially beneficial in the treatment of osteoporosis (OP)</p><p><p>Our objective was to study the effect of St on bone mineral density (BMD) in postmenopausal women.</p><p><strong>Methods: </strong>This is a cross-sectional, analytical study, that analyze postmenopausal women with hypercholesterolemia who received treatment with St for at least 6 months, and as a control group (CG), postmenopausal women who did not receive St assisted in two rheumatology services in the city of Córdoba from August 2014 to September 2018.</p><p><strong>Results: </strong>202 postmenopausal women received St and 203 constituted the CG. The average age, weight and BMI were 62.54 years, 69.60 kg and 27.13 in the St group vs 58.58 years, 65.70 kg and 26.83 in the control group (p= 0.0001, p= 0.01, p=ns respectively). Lumbar, femoral neck and total hip BMD were statistically higher in patients who received St than in controls (-0.87 vs -1.74 p=0.00, - 1.15 vs 1.56 p= 0.00 and - 0.33 vs - 0.75 p= 0.01). Regarding the time of St treatment, a significant difference was found only in relation to BMD and lumbar spine between the groups of 6 to 12 months and those that received between 12 and 36 months. 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引用次数: 0
摘要
有新的证据表明他汀类药物（ES）在治疗骨质疏松症（OJ）方面具有潜在的多养特性。我们的目标是研究ES对绝经后妇女骨密度（MOD）的影响。方法:研究分析,研究了绝经后妇女,截面与高胆固醇治疗的是至少6个月,而对照组(GC)绝经后妇女没有得到协助这两个服务科尔多瓦市风湿病学2014年8月以来,截至2018年9月。结果：202名绝经后妇女服用他汀类药物（ES）， 203名妇女服用GC。ES组的平均年龄、体重和BMI分别为62.54岁、69.60公斤和27.13岁，对照组的平均年龄、体重和BMI分别为58.58岁、65.70公斤和26.83岁（p= 0.0001、p= 0.01、p=ns）。与对照组相比，接受ES的患者腰椎、股颈和全髋关节MOD的统计数据更高（- 0.87 vs - 1.74 p= 0.00, - 1.15 vs 1.56 p= 0.00, - 0.33 vs - 0.75 p= 0.01）。在ES治疗时间方面，6 - 12个月组与12 - 36个月组仅在MO和腰椎方面存在显著差异。没有发现MOD与所接收的不同类型的ES之间的关系。结论：ES治疗可能有利于改善绝经后高胆固醇妇女服用这些药物的MOD。
[Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina]
New evidence has emerged on pleiotropic properties of Statins (St), that would be potentially beneficial in the treatment of osteoporosis (OP)
Our objective was to study the effect of St on bone mineral density (BMD) in postmenopausal women.
Methods: This is a cross-sectional, analytical study, that analyze postmenopausal women with hypercholesterolemia who received treatment with St for at least 6 months, and as a control group (CG), postmenopausal women who did not receive St assisted in two rheumatology services in the city of Córdoba from August 2014 to September 2018.
Results: 202 postmenopausal women received St and 203 constituted the CG. The average age, weight and BMI were 62.54 years, 69.60 kg and 27.13 in the St group vs 58.58 years, 65.70 kg and 26.83 in the control group (p= 0.0001, p= 0.01, p=ns respectively). Lumbar, femoral neck and total hip BMD were statistically higher in patients who received St than in controls (-0.87 vs -1.74 p=0.00, - 1.15 vs 1.56 p= 0.00 and - 0.33 vs - 0.75 p= 0.01). Regarding the time of St treatment, a significant difference was found only in relation to BMD and lumbar spine between the groups of 6 to 12 months and those that received between 12 and 36 months. No relationship was found between BMD and the different types of St received.
Conclusion: Treatment with St could improve BMD in hypercholesterolemic postmenopausal women who takes these drugs.
期刊介绍：
The Journal of the Faculty of Medical Sciences is a scientific publication of the Secretariat of Science and Technology of the Faculty of Medical Sciences of the National University of Cordoba. Its objective is to disseminate and promote research work related to Medical and Biological Sciences. It publishes scientific works of national and international professionals on different topics related to health sciences from the field of medicine, nursing, kinesiology, diagnostic imaging, phonoaudiology, nutrition, public health, chemical sciences, dentistry and related.
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