Revista de la Facultad de Ciencias Medicas de Cordoba最新文献

[Monoclonal Antibodies in Allergic Diseases: Development, Pharmacology, and Clinical Applications]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.44413

Selene Pury, Ricardo José Saranz, María José Irastorza, Laura Veronica Sasia, Pilar Visconti, Graciela Alegre, Natalia Andrea Lozano, Yanina Viviana Berardi, Alejandro Lozano

{"title":"[Monoclonal Antibodies in Allergic Diseases: Development, Pharmacology, and Clinical Applications]","authors":"Selene Pury, Ricardo José Saranz, María José Irastorza, Laura Veronica Sasia, Pilar Visconti, Graciela Alegre, Natalia Andrea Lozano, Yanina Viviana Berardi, Alejandro Lozano","doi":"10.31053/1853.0605.v81.n4.44413","DOIUrl":"10.31053/1853.0605.v81.n4.44413","url":null,"abstract":"The understanding of immunological processes associated with allergic diseases and advancements in antibody bioengineering has driven the development of specific biological therapies. Monoclonal antibodies, selectively targeting cytokines involved in the pathogenesis of allergic processes or their receptors, have emerged as a promising tool in treating various conditions, including asthma, allergic rhinitis, urticaria, and severe atopic dermatitis. Since the approval of the first anti-CD3 mouse monoclonal antibody in 1986, remarkable progress has been achieved, marked by the development of chimeric, 'humanized,' and 'fully human' antibodies. The 'humanization' of monoclonal antibodies has played a crucial role in reducing the risk of immunogenicity and minimizing adverse effects, thereby notably enhancing the safety and efficacy of these therapeutic interventions.\u0000\u0000The aim of this article is to address the characterization, development, pharmacokinetics, pharmacodynamics, and clinical utility of monoclonal antibodies, with a primary focus on allergic diseases.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"804-823"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of symptomatic endobronchial hamartoma by bronchoscopy.

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.44412

María Emilia Cano, Felipe Pagnoncelli Fachin, José Carlos Felicetti

引用次数: 0

Laparoscopic Hepaticojejunostomy. Initial experience in 21 consecutive cases.

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.44694

Christian Janikow, Maisa AlIkhwan, Mohammed Nasser, Ahmed Bayazeed, Esraa Alshahrani

{"title":"Laparoscopic Hepaticojejunostomy. Initial experience in 21 consecutive cases.","authors":"Christian Janikow, Maisa AlIkhwan, Mohammed Nasser, Ahmed Bayazeed, Esraa Alshahrani","doi":"10.31053/1853.0605.v81.n4.44694","DOIUrl":"10.31053/1853.0605.v81.n4.44694","url":null,"abstract":"Introduction: laparoscopic hepaticojejunostomy is a complex procedure indicated for different pathologies. Still, the laparoscopic approach is not the gold standard, but it is well known for its benefits regarding post operative recovery. We present our experience in 21 consecutive cases of laparoscopic hepaticojejunostomy done at King Fahad General Hospital in Jeddah.Methods: 21 consecutives laparoscopic hepaticojejunostomies were done from January 2022 to December 2023. Gender: 10 male and 11 female, average age 46 years. The most common indication is due to multiple common bile duct stones.Results: average surgical time: 180 minutes, average blood loss: 168 ml. According to Clavien-Dindo´s classification, we recorded one complication type: 3A. Average discharge days were 5.5; no mortality was reported.Conclusion: We believe that the success of laparoscopic hepaticojejunostomy is related to excellent knowledge of the biliary system and an experienced surgeon in advanced laparoscopic procedures.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"793-803"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Brain metastases in a patient with antecedent of cardiac myxoma: a case report and review of literature]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.44662

Raymundo Solís-Gómez, Natalia Dávalos Cabral, Gerardo Arrieta Limón, Brandon Alberto Hurtado Presa, Andrea Salgado Alvear, Laura Michelle Reyes Martínez, Fabiola Eunice Serrano Arias

{"title":"[Brain metastases in a patient with antecedent of cardiac myxoma: a case report and review of literature]","authors":"Raymundo Solís-Gómez, Natalia Dávalos Cabral, Gerardo Arrieta Limón, Brandon Alberto Hurtado Presa, Andrea Salgado Alvear, Laura Michelle Reyes Martínez, Fabiola Eunice Serrano Arias","doi":"10.31053/1853.0605.v81.n4.44662","DOIUrl":"10.31053/1853.0605.v81.n4.44662","url":null,"abstract":"Introduction: Cardiac myxomas are the most common benign neoplasms of the heart, mainly located in the left atrium. The preferred treatment is the resection of the myxoma. This method not only prevents complications but also has a low recurrence rate. Brain metastases usually occur when tumor fragments embolize and implant at the destination place.Case presentation: We report the case of a patient with multiple brain metastases, found during follow-up, after the presentation of stroke. This case stands out because the embolization causing the brain metastasis might have occurred either during the ischemic stroke or when the cardiac myxoma was being removed. In our case, the patient was evaluated during follow-up with brain magnetic resonance imaging, finding multiple metastatic lesions. To determine the type of lesion, a biopsy was performed and the histological diagnosis, which was indicative of metastatic tissue of left atrial myxoma.Conclusion: Patients with cardioembolism should undergo a complete diagnostic protocol to distinguish the cause of embolization, whether it is a blood clot or a tumor embolus. The treatment of choice is the resection of the myxoma, which cures the primary neurological symptoms and prevents neurological complications. However, it is essential to maintain active surveillance for a longer time for the detection and appropriate treatment of brain metastases.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"783-792"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Adherence factors to the gluten-free diet in people with celiac disease in Paraguay]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.43220

Raúl Emilio Real Delor, María Elena Aguilera

{"title":"[Adherence factors to the gluten-free diet in people with celiac disease in Paraguay]","authors":"Raúl Emilio Real Delor, María Elena Aguilera","doi":"10.31053/1853.0605.v81.n4.43220","DOIUrl":"10.31053/1853.0605.v81.n4.43220","url":null,"abstract":"Introduction: The adherence to a gluten-free diet in people with celiac disease is a constant challenge for them and their family environment. Not everyone is able to adapt to the new eating style and may develop maladaptive behaviors. The objective was to evaluate the factors of adherence to the gluten-free diet in people with celiac disease in Paraguay in 2023.Methodology: We perform an observational, cross-sectional design in adolescent and adult subjects with celiac disease. A telematic questionnaire containing demographic and clinical data was applied. The adherence to the diet was evaluated with the Leffler questionnaire, eating attitudes and behaviors with the CD-FAB instrument, and family support with the family APGAR test. Descriptive and analytical statistics were applied with SPSS Statistics 25™ software. The research respected ethical aspects.Results: The final sample consisted of 292 people. The median age was 33 years and predominated the female sex (85.3%). Good adherence to the gluten-free diet was detected in 151 (51.7%) people and good adaptation to it in 164 (56.2%). In 141 cases (48.3%) it was stated that they had family support. The analysis showed that prolonged time since diagnosis and having family support were significantly associated with adherence to the gluten-free diet (p <0.05).Conclusions: In people with celiac disease, adherence to the gluten-free diet was related to a prolonged time since diagnosis and receiving family support. It is recommended to investigate the causes of maladaptive behaviors to the gluten-free diet.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"655-669"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Unveiling Hormonal Secrets]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.44304

Andrés Felipe García Ramos, Claudia Monsalve Arango, Jose Fernando Botero Arango, Natalia Aristizabal Henao, Nathalia Buitrago Gómez, William Fernando Cabarcas Lopez

{"title":"[Unveiling Hormonal Secrets]","authors":"Andrés Felipe García Ramos, Claudia Monsalve Arango, Jose Fernando Botero Arango, Natalia Aristizabal Henao, Nathalia Buitrago Gómez, William Fernando Cabarcas Lopez","doi":"10.31053/1853.0605.v81.n4.44304","DOIUrl":"10.31053/1853.0605.v81.n4.44304","url":null,"abstract":"Background: Thyroid dysfunction during pregnancy negatively impacts both the woman and her offspring, with the early gestational period being critical for potential repercussions. Establishing pre-conception and during-conception care strategies is crucial for favorable pregnancy outcomes.Objective: This review aims to compile the most recent scientific evidence to guide diagnostic and therapeutic approaches based on clinical cases, including a description of thyroid physiology during pregnancy and strategies for identifying high-risk patients for treatment.Method: This bibliographic review combined DeCS and MeSH terms from the PICOT question, spanning the period from 2015 to 2022 across 5 databases. Articles in both English and Spanish were included if they addressed the PICOT question and contributed to the explanation of two case reports.Results: A total of 1452 articles were collected, which, following an initial elimination of duplicates and subsequent blind review based on inclusion and exclusion criteria by two reviewers, resulted in 32 articles included in this review.Conclusions: Overt hypothyroidism is associated with adverse maternal-fetal outcomes, and its treatment improves these complications. However, in borderline conditions such as subclinical hypothyroidism, isolated hypothyroxinemia, and thyroid autoimmune conditions, uncertainty about the treatment's impact persists due to a scarcity of controlled trials. Emphasizing the importance of all physicians being familiar with this condition during gestation.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"824-841"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Blood pressure patterns in pressurometry and their ralationship with cardiovascular events in follow-up] 测血压前的血压模式及其与后续心血管事件的关系。

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n3.44619

Damian Jesus Malano, Joaquin Perea, Luis Guillermo García Chamorro, Francisco Goldaracena, Andres Mazuquin, Sofía Corzo, German Denner, Mario Racki, Ezequiel Zaidel, Alvaro Sosa Liprandi

{"title":"[Blood pressure patterns in pressurometry and their ralationship with cardiovascular events in follow-up]","authors":"Damian Jesus Malano, Joaquin Perea, Luis Guillermo García Chamorro, Francisco Goldaracena, Andres Mazuquin, Sofía Corzo, German Denner, Mario Racki, Ezequiel Zaidel, Alvaro Sosa Liprandi","doi":"10.31053/1853.0605.v81.n3.44619","DOIUrl":"10.31053/1853.0605.v81.n3.44619","url":null,"abstract":"Introducción: Nuestro objetivo fue determinar en una cohorte de pacientes de un hospital de la ciudad de Buenos Aires, cómo fue la distribución de ritmo circadiano y el impacto según el tipo de comportamiento circadiano en la tasa de eventos cardiovasculares en el seguimiento. Material y métodos: Estudio de cohorte retrospectiva que incluyó pacientes adultos que se realizaron una presurometría ambulatoria en un hospital de la ciudad de Buenos Aires, incorporados a un registro propio entre marzo de 2017 y julio de 2020, con seguimiento de hasta 36 meses de la presurometría índice.Resultados: De 522 sujetos, se incluyeron 494 en el análisis final. El 48% eran de sexo masculino y la edad promedio fue de 58,9 años. El 62% (n = 308) presentó hipertensión arterial nocturna. El patrón dipper invertido fue el grupo que presentó más eventos cardiovasculares en el seguimiento (6% n: 24). Además, en el tiempo libre de evento globales, se evidencio menos tasas de supervivencia para el grupo con patrón dipper invertido (Log Rank test p: 0.0033).Conclusión: En una cohorte contemporánea y de la ciudad de Buenos Aires, el grupo patrón dipper invertido se asoció con la aparición de desenlaces cardiovasculares. En base a estos hallazgos, se deben implementar medidas para incrementar su diagnóstico en nuestro medio.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"705-718"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Melatonin reverses oxidative damage in the submandibular gland of rats treated with Cyclophosphamide

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.46931

引用次数: 0

[Impact of educational intervention in a population with type 2 diabetes mellitus]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.44579

Yaliana Tafurt Cardona, Rober Andrés Ramón Collazos, Camilo Alexander Murillo Cumber, Juan Pablo Ortiz Tique, Paul Mendoza Perez, Edison Peralta-Pineda

{"title":"[Impact of educational intervention in a population with type 2 diabetes mellitus]","authors":"Yaliana Tafurt Cardona, Rober Andrés Ramón Collazos, Camilo Alexander Murillo Cumber, Juan Pablo Ortiz Tique, Paul Mendoza Perez, Edison Peralta-Pineda","doi":"10.31053/1853.0605.v81.n4.44579","DOIUrl":"10.31053/1853.0605.v81.n4.44579","url":null,"abstract":"Introduction: The complications associated with the chronic pathophysiological process of type 2 diabetes mellitus (T2DM) have a significant impact on the affected population. The Diabetes Knowledge Questionnaire (DKQ-24) determines the level of knowledge about diabetes, providing health professionals with information to carry out useful educational interventions and prevent both acute and chronic complications of the diseaseObjective: To assess the long-term effect of implementing a hospital-based therapeutic diabetes education model (self-care and knowledge) on patients with type 2 diabetes mellitus (T2DM) in a population from southern Colombia.Materials and methods: Longitudinal study, prospective type, conducted on 60 hospitalized T2DM patients. The DKQ-24 was used for pre-assessment, and after 90 days, it was administered again, along with the collection of biometric variables. The intervention consisted of 5 sessions of therapeutic diabetes education in hospital settings.Results: The average results according to the DKQ-2 questionnaire pre-intervention (10.13±3.28) and post-intervention (20.13±2.77) showed significant differences (p<0.000). The biometric profile indicated significant differences (p<0.000) during pre and post-intervention, except for systolic blood pressure (p=0.275). The Cronbach's alpha for the DKQ 24 had an adequate value of 0.86. The intraclass correlation coefficient (ICC) for average measures was 0.860, considered \"good\" (p<0.000).Conclusions: The diabetes educational intervention demonstrated significant changes in basic knowledge levels regarding the disease, glycemic control, and complication prevention, improving the patient's biometric profile and highlighting its importance.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"752-767"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pseudoaneurysm of the hepatic artery as a cause of liver re-transplantation] 肝动脉假性动脉瘤是导致肝脏再次移植的原因之一。

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.43452

Rodrigo Antonio Gasque, José Gabriel Cervantes, Magalí Chahdi Beltrame, Marcelo Enrique Lenz Virreira, Emilio Gastón Quiñonez, Francisco Juan Mattera

{"title":"[Pseudoaneurysm of the hepatic artery as a cause of liver re-transplantation]","authors":"Rodrigo Antonio Gasque, José Gabriel Cervantes, Magalí Chahdi Beltrame, Marcelo Enrique Lenz Virreira, Emilio Gastón Quiñonez, Francisco Juan Mattera","doi":"10.31053/1853.0605.v81.n4.43452","DOIUrl":"10.31053/1853.0605.v81.n4.43452","url":null,"abstract":"A 69-year-old man underwent liver transplantation with a deceased donor for cirrhosis secondary to steatohepatitis. The arterial anastomosis was performed between the celiac trunk of the donor and the hepatic artery of the recipient. In the second postoperative month, he developed abdominal pain and abnormal liver function tests. MRI angiography and subsequent digital angiography confirmed a 50 x 60 mm hepatic artery pseudoaneurysm (PAH) with dilation of the bile duct and bilomas in both hepatic lobes. Endovascular treatment could not be performed due to the absence of contrast passage to the intrahepatic branches during angiography. A surgical ligation and resection of the PAH that compromised both hepatic arteries was chosen. The primary anastomosis was not viable because it was not possible to identify a viable proximal end or ostium. Given the ischemic compromise of the bile duct, an exception route for re-transplantation was requested from INCUCAI, thus entering the waiting list and accessing a new graft 30 days later. His subsequent evolution was favorable. Now he's asymptomatic under follow-up after 9 years of the liver re-transplantation.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"842-851"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0