Revista de la Facultad de Ciencias Medicas de Cordoba最新文献_第2页

[ Accumulation of hyaluronic acid in rhinoseptoplasty: intraoperative finding]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.45169

Sebastián Abad-Cuenca, Xavier Eduardo Abad-González

引用次数: 0

[Outcomes of a Transdisciplinary Rehabilitation Program for Patients with Consciousness Disorders (2006-2022, Argentina)]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.42871

Maria Elisa Rivas, Melania Ron, Fernando Martín Salierno, María Soledad Broggi, Lucas Bonamico

{"title":"[Outcomes of a Transdisciplinary Rehabilitation Program for Patients with Consciousness Disorders (2006-2022, Argentina)]","authors":"Maria Elisa Rivas, Melania Ron, Fernando Martín Salierno, María Soledad Broggi, Lucas Bonamico","doi":"10.31053/1853.0605.v82.n1.42871","DOIUrl":"https://doi.org/10.31053/1853.0605.v82.n1.42871","url":null,"abstract":"Introduction: After suffering brain damage with altered consciousness, clinically stable patients are referred to rehabilitation programs. The objective of this study is to describe the results of a transdisciplinary multisensory stimulation program in adults with altered consciousness admitted to a rehabilitation center in Argentina between 2006 and 2022.Methodology: A retrospective case series study was conducted that included 178 patients who completed the multisensory stimulation program. Consciousness was assessed with the Coma Recovery Scale – Revised (CRS-R), functional outcome with the Functional Independence Measure (FIM), and disability with the Disability Rating Scale (DRS).Results: The majority of patients (68%) were men with a diagnosis of unresponsive wakefulness syndrome (RSVS). The median time of injury to admission was 77 days, and the average length of stay was 127 days. The median CRS-R at admission was 6 and 10 at discharge (p = 0.01). The highest percentage (61.8%) of emergence was in traumatic injuries. Patients who emerged showed a significant functional improvement, with a median FIM = 44 and DRS = 11. The stay was significantly shorter in those who emerged (70 vs. 163 days; p = 0.001).Conclusion: These results highlight the benefit of a transdisciplinary multisensory stimulation program to improve diagnostic evaluation and promote recovery of consciousness in patients with severe brain injury.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"6-21"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Real-life study with pharmaceutical cannabidiol in refractory epilepsy]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.45350

Luis Angel Di Giuseppe, Juan Ignacio Appendino, María Del Carmen García, Karina Elena Alvarez, Gabriela Buela, Mariana Andrea Burgos, María Lourdes Posadas-Martínez, Maria Celeste Puga

{"title":"[Real-life study with pharmaceutical cannabidiol in refractory epilepsy]","authors":"Luis Angel Di Giuseppe, Juan Ignacio Appendino, María Del Carmen García, Karina Elena Alvarez, Gabriela Buela, Mariana Andrea Burgos, María Lourdes Posadas-Martínez, Maria Celeste Puga","doi":"10.31053/1853.0605.v82.n1.45350","DOIUrl":"https://doi.org/10.31053/1853.0605.v82.n1.45350","url":null,"abstract":"Pharmaceutical-grade cannabidiol (CBD) is an alternative treatment for patients with drug-resistant epilepsy (DRE). In 2022, the Italian Hospital of Buenos Aires implemented a non-medical change (NMC) of treatment, replacing one commercial pharmaceutical-grade CBD product with another, the latter also being the initial option for new patients.Our objective was to evaluate the clinical outcomes of the commercial product change in this population.Methods: Retrospective cohort of DRE patients who either switched from one commercial pharmaceutical-grade CBD product to another or started treatment with the new product. The clinical response was evaluated by changes in seizure frequency, perception of change with the Patient Global Impression of Change (PGIC) scale, and safety considering discontinuation and/or the presence of adverse effects.Results: Nineteen patients were included, 12 in the change group and 7 in the new start group (7 pediatric and 12 adults). One patient discontinued treatment due to lack of response. Among those who completed follow-up, 8 (44%) reduced seizure frequency, 6 (33%) showed no change, and 4 (22%) increased seizure frequency. According to the PGIC scale, 9 (50%) remained unchanged, 5 (28%) reported barely noticeable changes, and 4 (22%) reported improvement. Adverse events were mild and transient.Conclusion: The new commercial pharmaceutical-grade CBD product is a safe and valid option both for substitution and initial treatment in patients with DRE. During the treatment period, patients perceived stability or improvement according to the PGIC scale.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"110-126"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The implications of Argentina's withdrawal from the world health organization]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.48157

Eduardo Cuestas

引用次数: 0

Long-term Titanium mesh cage implant failure after total en bloc spondylectomy due to spinal chondrosarcoma: case report and literature review

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.44999

María Belén Ginetti, Pablo Oyhamburu, Martín Bosio, Fernando Di Tullio

{"title":"Long-term Titanium mesh cage implant failure after total en bloc spondylectomy due to spinal chondrosarcoma: case report and literature review","authors":"María Belén Ginetti, Pablo Oyhamburu, Martín Bosio, Fernando Di Tullio","doi":"10.31053/1853.0605.v82.n1.44999","DOIUrl":"10.31053/1853.0605.v82.n1.44999","url":null,"abstract":"Objective: To report an unusual titanium mesh cage failure after ten years of follow-up.Clinical case: A 40-year-old woman diagnosed with low-grade spinal chondrosarcoma underwent a total en-bloc spondylenctomy (TES) surgery. This technique required a wide resection, anterior reconstruction with a titanium mesh cage (TMC), and posterior stabilization. For several years a favorable clinical outcome was achieved. After 10 years of follow-up, the patient developed acute non-traumatic low back pain without neurological repercussions. The images confirmed a rupture of the titanium cage. After ruling out tumor recurrence, the patient went through spinal instrumentation revision.Conclusion: Isolated TMC rupture is a rare event scarcely reported in the literature. There is a strong recommendation to instrument two levels proximal and distal to the bone defect in 360° reconstructions after a TES. Stability had likely been lost over the years due to the slow resorption of the bone graft. We consider necessary studies with a higher casuistry and level of evidence to analyze the contributing factors for the event of TMC rupture.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"154-164"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Liberation of mechanical ventilation in tracheostomized pediatric patients during their stay in the intensive care unit]

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.45243

Julia Inés Simonassi, María Tatiana Canzobre, Victoria Eleonora Lopez Fiorito, Cinthia Giselle Perez, Solana Pellegrini

{"title":"[Liberation of mechanical ventilation in tracheostomized pediatric patients during their stay in the intensive care unit]","authors":"Julia Inés Simonassi, María Tatiana Canzobre, Victoria Eleonora Lopez Fiorito, Cinthia Giselle Perez, Solana Pellegrini","doi":"10.31053/1853.0605.v82.n1.45243","DOIUrl":"https://doi.org/10.31053/1853.0605.v82.n1.45243","url":null,"abstract":"Introduction: Tracheostomy in pediatric intensive care has a prevalence between 5% and 10% of patients on mechanical ventilation.Objective: The objective of this study was to determine the duration and outcome of the weaning process from mechanical ventilation (MV) and the behavior according to the reason for the tracheostomy.Methodology: Data from 59 patients under 18 years of age who received MV and underwent tracheostomy between January 2018 and March 2023 at the Juan P. Garrahan National Pediatric Hospital, Argentina, were retrospectively examined. Demographic variables, reasons for admission to the unit, days on MV, tracheostomy characteristics, and the weaning process from MV were recorded.Results: The main reasons for tracheostomy were airway disorders (50.8%) and prolonged MV (30.5%). Notable variability was observed in the duration and success of the weaning process among different groups of patients. Patients with airway disorders showed a faster weaning (median: 1.5 days) and higher success in this process, while those with prolonged MV and neurological disorders experienced longer processes (medians: 25.5 and 28 days, respectively) and more patients required partial or total mechanical ventilation at the end of this process. The presence of diaphragmatic dysfunction was more common in those who took longer to wean.Conclusion: The weaning from MV is a complex process, and the reason for the tracheostomy influences its progression.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"78-94"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term Titanium mesh cage implant failure after total en bloc spondylectomy due to spinal chondrosarcoma

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.44961

Ezequiel Martinez, Matias Pereira Duarte, Gonzalo Kido, Gaston Camino-Willhuber, Julio Bassani, Marcelo Gruenberg, Matias Petracchi

{"title":"Long-term Titanium mesh cage implant failure after total en bloc spondylectomy due to spinal chondrosarcoma","authors":"Ezequiel Martinez, Matias Pereira Duarte, Gonzalo Kido, Gaston Camino-Willhuber, Julio Bassani, Marcelo Gruenberg, Matias Petracchi","doi":"10.31053/1853.0605.v82.n1.44961","DOIUrl":"https://doi.org/10.31053/1853.0605.v82.n1.44961","url":null,"abstract":"Objective: To report an unusual titanium mesh cage failure after ten years of follow-up.Clinical case: A 40-year-old woman diagnosed with low-grade spinal chondrosarcoma underwent a total en-bloc spondylenctomy (TES) surgery. This technique required a wide resection, anterior reconstruction with a titanium mesh cage (TMC), and posterior stabilization. For several years a favorable clinical outcome was achieved. After 10 years of follow-up, the patient developed acute non-traumatic low back pain without neurological repercussions. The images confirmed a rupture of the titanium cage. After ruling out tumor recurrence, the patient went through spinal instrumentation revision.Conclusion: Isolated TMC rupture is a rare event scarcely reported in the literature. There is a strong recommendation to instrument two levels proximal and distal to the bone defect in 360° reconstructions after a TES. Stability had likely been lost over the years due to the slow resorption of the bone graft. We consider necessary studies with a higher casuistry and level of evidence to analyze the contributing factors for the event of TMC rupture.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"140-153"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Monoclonal Antibodies in Allergic Diseases: Development, Pharmacology, and Clinical Applications] 单克隆抗体在过敏症中的应用：发展、药理学和临床应用。

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.44413

Selene Pury, Ricardo José Saranz, María José Irastorza, Laura Veronica Sasia, Pilar Visconti, Graciela Alegre, Natalia Andrea Lozano, Yanina Viviana Berardi, Alejandro Lozano

{"title":"[Monoclonal Antibodies in Allergic Diseases: Development, Pharmacology, and Clinical Applications]","authors":"Selene Pury, Ricardo José Saranz, María José Irastorza, Laura Veronica Sasia, Pilar Visconti, Graciela Alegre, Natalia Andrea Lozano, Yanina Viviana Berardi, Alejandro Lozano","doi":"10.31053/1853.0605.v81.n4.44413","DOIUrl":"10.31053/1853.0605.v81.n4.44413","url":null,"abstract":"The understanding of immunological processes associated with allergic diseases and advancements in antibody bioengineering has driven the development of specific biological therapies. Monoclonal antibodies, selectively targeting cytokines involved in the pathogenesis of allergic processes or their receptors, have emerged as a promising tool in treating various conditions, including asthma, allergic rhinitis, urticaria, and severe atopic dermatitis. Since the approval of the first anti-CD3 mouse monoclonal antibody in 1986, remarkable progress has been achieved, marked by the development of chimeric, 'humanized,' and 'fully human' antibodies. The 'humanization' of monoclonal antibodies has played a crucial role in reducing the risk of immunogenicity and minimizing adverse effects, thereby notably enhancing the safety and efficacy of these therapeutic interventions.\u0000\u0000The aim of this article is to address the characterization, development, pharmacokinetics, pharmacodynamics, and clinical utility of monoclonal antibodies, with a primary focus on allergic diseases.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"804-823"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparoscopic Hepaticojejunostomy. Initial experience in 21 consecutive cases. 腹腔镜Hepaticojejunostomy。连续21例的初步经验。

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.44694

Christian Janikow, Maisa AlIkhwan, Mohammed Nasser, Ahmed Bayazeed, Esraa Alshahrani

{"title":"Laparoscopic Hepaticojejunostomy. Initial experience in 21 consecutive cases.","authors":"Christian Janikow, Maisa AlIkhwan, Mohammed Nasser, Ahmed Bayazeed, Esraa Alshahrani","doi":"10.31053/1853.0605.v81.n4.44694","DOIUrl":"10.31053/1853.0605.v81.n4.44694","url":null,"abstract":"Introduction: laparoscopic hepaticojejunostomy is a complex procedure indicated for different pathologies. Still, the laparoscopic approach is not the gold standard, but it is well known for its benefits regarding post operative recovery. We present our experience in 21 consecutive cases of laparoscopic hepaticojejunostomy done at King Fahad General Hospital in Jeddah.Methods: 21 consecutives laparoscopic hepaticojejunostomies were done from January 2022 to December 2023. Gender: 10 male and 11 female, average age 46 years. The most common indication is due to multiple common bile duct stones.Results: average surgical time: 180 minutes, average blood loss: 168 ml. According to Clavien-Dindo´s classification, we recorded one complication type: 3A. Average discharge days were 5.5; no mortality was reported.Conclusion: We believe that the success of laparoscopic hepaticojejunostomy is related to excellent knowledge of the biliary system and an experienced surgeon in advanced laparoscopic procedures.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"793-803"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain metastases in a patient with antecedent of cardiac myxoma: a case report and review of literature 有心脏混血儿病史的患者的脑转移

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-12-13 DOI: 10.31053/1853.0605.v81.n4.44662

Raymundo Solís-Gómez, Natalia Dávalos Cabral, Gerardo Arrieta Limón, Brandon Alberto Hurtado Presa, Andrea Salgado Alvear, Laura Michelle Reyes Martínez, Fabiola Eunice Serrano Arias

{"title":"Brain metastases in a patient with antecedent of cardiac myxoma: a case report and review of literature","authors":"Raymundo Solís-Gómez, Natalia Dávalos Cabral, Gerardo Arrieta Limón, Brandon Alberto Hurtado Presa, Andrea Salgado Alvear, Laura Michelle Reyes Martínez, Fabiola Eunice Serrano Arias","doi":"10.31053/1853.0605.v81.n4.44662","DOIUrl":"10.31053/1853.0605.v81.n4.44662","url":null,"abstract":"Introduction: Cardiac myxomas are the most common benign neoplasms of the heart, mainly located in the left atrium. The preferred treatment is the resection of the myxoma. This method not only prevents complications but also has a low recurrence rate. Brain metastases usually occur when tumor fragments embolize and implant at the destination place.Case presentation: We report the case of a patient with multiple brain metastases, found during follow-up, after the presentation of stroke. This case stands out because the embolization causing the brain metastasis might have occurred either during the ischemic stroke or when the cardiac myxoma was being removed. In our case, the patient was evaluated during follow-up with brain magnetic resonance imaging, finding multiple metastatic lesions. To determine the type of lesion, a biopsy was performed and the histological diagnosis, which was indicative of metastatic tissue of left atrial myxoma.Conclusion: Patients with cardioembolism should undergo a complete diagnostic protocol to distinguish the cause of embolization, whether it is a blood clot or a tumor embolus. The treatment of choice is the resection of the myxoma, which cures the primary neurological symptoms and prevents neurological complications. However, it is essential to maintain active surveillance for a longer time for the detection and appropriate treatment of brain metastases.","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"81 4","pages":"783-792"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0