[Monoclonal Antibodies in Allergic Diseases: Development, Pharmacology, and Clinical Applications]

Q3 Medicine
Selene Pury, Ricardo José Saranz, María José Irastorza, Laura Veronica Sasia, Pilar Visconti, Graciela Alegre, Natalia Andrea Lozano, Yanina Viviana Berardi, Alejandro Lozano
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引用次数: 0

Abstract

The understanding of immunological processes associated with allergic diseases and advancements in antibody bioengineering has driven the development of specific biological therapies. Monoclonal antibodies, selectively targeting cytokines involved in the pathogenesis of allergic processes or their receptors, have emerged as a promising tool in treating various conditions, including asthma, allergic rhinitis, urticaria, and severe atopic dermatitis. Since the approval of the first anti-CD3 mouse monoclonal antibody in 1986, remarkable progress has been achieved, marked by the development of chimeric, 'humanized,' and 'fully human' antibodies. The 'humanization' of monoclonal antibodies has played a crucial role in reducing the risk of immunogenicity and minimizing adverse effects, thereby notably enhancing the safety and efficacy of these therapeutic interventions. The aim of this article is to address the characterization, development, pharmacokinetics, pharmacodynamics, and clinical utility of monoclonal antibodies, with a primary focus on allergic diseases.

单克隆抗体在过敏症中的应用:发展、药理学和临床应用。
对与过敏性疾病相关的免疫过程和抗体生物工程的理解的进步导致了特定生物疗法的发展。单克隆抗体选择性地靶向参与过敏过程发病机制的细胞因子或其受体,已成为治疗各种疾病的一种有前途的工具,如哮喘、过敏性鼻炎、荨麻疹和严重的特应性皮炎。起源自通过第一个反物质monoclonal anti-CD3 murino在1986年,已出现一段漫长的征程,为特点的空想,因分子结构的抗体免疫球蛋白是类似于人类humanizados”和人类到底所谓“完全相同”。单克隆抗体的“人性化”大大降低了免疫原性的风险和不良反应的发生率,显著提高了这些疗法的安全性和有效性。本文旨在探讨单克隆抗体的表征、发展、药代动力学、药代动力学和临床效用,主要集中在过敏性疾病中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
60
审稿时长
20 weeks
期刊介绍: The Journal of the Faculty of Medical Sciences is a scientific publication of the Secretariat of Science and Technology of the Faculty of Medical Sciences of the National University of Cordoba. Its objective is to disseminate and promote research work related to Medical and Biological Sciences. It publishes scientific works of national and international professionals on different topics related to health sciences from the field of medicine, nursing, kinesiology, diagnostic imaging, phonoaudiology, nutrition, public health, chemical sciences, dentistry and related.
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