Revista de la Facultad de Ciencias Medicas de Cordoba最新文献

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Strangulated femoral hernia leading to lower extremity necrotizing soft tissue infection. 绞窄性股疝导致下肢坏死性软组织感染。
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-06-26 DOI: 10.31053/1853.0605.v82.n2.45345
Ellie Zhang, Hayes Fountain, Timothy Trestrail, Joshua Kronenfeld, Carolina Jimenez, Robert Cubas
{"title":"Strangulated femoral hernia leading to lower extremity necrotizing soft tissue infection.","authors":"Ellie Zhang, Hayes Fountain, Timothy Trestrail, Joshua Kronenfeld, Carolina Jimenez, Robert Cubas","doi":"10.31053/1853.0605.v82.n2.45345","DOIUrl":"10.31053/1853.0605.v82.n2.45345","url":null,"abstract":"<p><p>This article presents a rare case of a necrotizing soft tissue infection secondary to a strangulated and perforated femoral hernia. The patient had presented several days after the onset of symptoms and was in septic shock due to spillage of intestinal contents into the thigh. Urgent operative management was undertaken to obtain source control and debride the significant necrotic tissue that was present. Additionally, small bowel resection via a midline laparotomy was required as the bowel was necrotic on intraoperative evaluation. Specific management challenges included the closure of hernia defect in an infected field and the complex wound care regimen necessitated by the extent of tissue necrosis. Prompt surgical intervention, in the setting of a necrotizing soft tissue infection, is imperative to achieving a favorable outcome.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 2","pages":"409-418"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical fitness in wheelchair users with spinal cord injury, level of mobility and community participation: an observational cross-sectional study 脊髓损伤轮椅使用者的身体健康、活动水平和社区参与:一项观察性横断面研究
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-06-26 DOI: 10.31053/1853.0605.v82.n2.45763
Vanina Anahí Pisano, Emiliano Liotino, Belén Rubinich, Micaela Balvidares, Camila Vitale, Rocío Zanazzi, Rafael Balbarrey, Jennifer Bentos
{"title":"Physical fitness in wheelchair users with spinal cord injury, level of mobility and community participation: \u0000an observational cross-sectional study","authors":"Vanina Anahí Pisano, Emiliano Liotino, Belén Rubinich, Micaela Balvidares, Camila Vitale, Rocío Zanazzi, Rafael Balbarrey, Jennifer Bentos","doi":"10.31053/1853.0605.v82.n2.45763","DOIUrl":"10.31053/1853.0605.v82.n2.45763","url":null,"abstract":"<p><strong>Introduction: </strong>Physical fitness is often low in people with spinal cord injury. It is related to functionality, participation, and wheelchair mobility. We have found discrepancies about what happens to physical fitness after rehabilitation discharge.</p><p><strong>Objective: </strong>To describe the physical fitness of wheelchair users with spinal cord injury attending a rehabilitation institute. Secondary objective: to describe the level of mobility and community participation.</p><p><strong>Methodology: </strong>Observational, cross-sectional study. Subjects living in the community were included. The main variable was the level of physical fitness according to the 6-minute manual propulsion test. Secondary variables such as community mobility (SCIM III and WST-Q) and participation perception (RNLI) were considered.</p><p><strong>Results: </strong>Sixteen subjects were included. The level of physical fitness was low in 87.5% of them. Regarding community mobility, 56% moved independently over distances greater than 100 meters. As for the perception of participation, 62.5% had mild to moderate restrictions.</p><p><strong>Conclusion: </strong>Physical fitness, community mobility, and participation in subjects with spinal cord injury were described. The majority of the sample has low physical fitness, requires some degree of assistance in community mobility, and has mild to moderate participation restrictions.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 2","pages":"343-361"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Forgotten Document: History, Memory, and Truth of the Hospital Nacional de Clínicas 被遗忘的文件:国立医院的历史、记忆和真相Clínicas
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-06-26 DOI: 10.31053/1853.0605.v82.n2.48798
Norma Acerbi Cremades
{"title":"The Forgotten Document: History, Memory, and Truth of the Hospital Nacional de Clínicas","authors":"Norma Acerbi Cremades","doi":"10.31053/1853.0605.v82.n2.48798","DOIUrl":"10.31053/1853.0605.v82.n2.48798","url":null,"abstract":"<p><p>The article presents a necessary historical rectification regarding the authorship of the design and construction of the Hospital Nacional de Clínicas, inaugurated in Córdoba in 1913. Based on documentary and epistolary analysis, it becomes evident that the true author of the project was Engineer Rafael Aranda, who drafted the plans in 1882, inspired by the Hospital of Lugo (Italy), rather than Architect Francesco Tamburini, to whom the work has been mistakenly attributed in various circles. The article highlights the patrimonial implications of this omission, documents the roles of key academic and political figures in the hospital’s inception, and underscores the importance of safeguarding historical memory through reliable primary sources.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 2","pages":"442-445"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Abdominal pain and inconclusive ultrasound: a CT scan may not always be the best next step] 腹痛和超声波不确定。
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.44691
Julio César Moreno-Alfonso, Sara Hernández Martín, Lidia Ayuso González, Alberto Perez Martínez
{"title":"[Abdominal pain and inconclusive ultrasound: a CT scan may not always be the best next step]","authors":"Julio César Moreno-Alfonso, Sara Hernández Martín, Lidia Ayuso González, Alberto Perez Martínez","doi":"10.31053/1853.0605.v82.n1.44691","DOIUrl":"10.31053/1853.0605.v82.n1.44691","url":null,"abstract":"<p><p>A 4-year-old male presented to the emergency department with fever, mucous diarrhea, abdominal pain, and vomiting for 36 hours. On abdominal palpation, he had generalized pain without rebound and increased hydroaereal sounds. The blood count showed leukocytosis and elevated C-reactive protein, and an ultrasound revealed intestinal loops with abundant content, increased peristalsis, and a normal appendix. Due to the suspicion of invasive gastroenteritis, he was admitted for observation. Due to the persistence of symptoms, a new ultrasound was performed which showed pelvic free fluid but did not identify the appendix. An abdominal radiography was previously performed, which showed an image compatible with appendicolith. With the suspicion of appendicitis, surgery was indicated, and an appendicular peritonitis was identified. The patient recovered well and was discharged seven days later. Diagnosing appendicitis in children can be a complex process. The most sensitive diagnostic tests are ultrasound and tomography. Abdominal radiography, however, is a widely available test with low radiation and has a positive predictive value of 90% for appendicitis (detecting appendicolith or periappendicular 'air silence'). In ambiguous cases, an abdominal X-ray could avoid invasive tests that require sedation or high doses of radiation.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"206-214"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of ultrasound in critically ill patients with heart failure] 超声在心力衰竭危重患者中的作用。
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.45185
Julieta Lozita, Juan Pablo Leopoldo Ricarte Bratti, Judith Mailen Vicentin, Nadia Elizabeth Pinto
{"title":"[Role of ultrasound in critically ill patients with heart failure]","authors":"Julieta Lozita, Juan Pablo Leopoldo Ricarte Bratti, Judith Mailen Vicentin, Nadia Elizabeth Pinto","doi":"10.31053/1853.0605.v82.n1.45185","DOIUrl":"10.31053/1853.0605.v82.n1.45185","url":null,"abstract":"<p><p>Heart failure (HF) is a clinical syndrome with symptoms and/or signs caused by structural and/or functional cardiac abnormalities. After discharge, patients with acute heart failure (AHF) face a significant risk of rehospitalization and mortality. Detection of residual congestion is crucial to reduce readmissions, improve prognosis, and decrease mortality. Echocardiography provides critical information about the severity of left ventricular dysfunction, elevated filling pressures, valvular dysfunction, and estimation of pulmonary artery systolic pressure. The VExUS approach integrates ultrasound evaluation of the inferior vena cava, hepatic veins, portal vein, and renal veins, providing valuable information about systemic congestion. Lung ultrasound detects pulmonary congestion, facilitating early intervention to prevent progression and hospitalizations. Ultrasound evaluation of the internal jugular vein and femoral vein complements the evaluation of venous congestion. Distension of the internal jugular vein during the Valsalva maneuver or the relationship between the diameter of the internal jugular vein and the femoral vein can predict adverse outcomes in patients with HF. In conclusion, a comprehensive ultrasound approach is crucial in the management of patients with critically ill heart failure. Multiparameter ultrasound evaluation provides vital information, guiding appropriate therapeutic interventions and avoiding potentially harmful measures.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"188-205"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study] [成人心肾综合征患者保留射血分数的贫血和心力衰竭:一项横断面研究]
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.44359
Maria Teresa Politi, Gustavo Javier Daquarti, Damián Néstor Spagnuolo, Raúl Ferreyra, Mirta Diez, Guillermo Bortman
{"title":"[Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study]","authors":"Maria Teresa Politi, Gustavo Javier Daquarti, Damián Néstor Spagnuolo, Raúl Ferreyra, Mirta Diez, Guillermo Bortman","doi":"10.31053/1853.0605.v82.n1.44359","DOIUrl":"10.31053/1853.0605.v82.n1.44359","url":null,"abstract":"<p><strong>Introduction: </strong>Patients hospitalized for heart failure with preserved ejection fraction (HFpEF) have a higher prevalence of anemia than those hospitalized for heart failure with reduced ejection fraction (HFpEF). However, it is unknown if this relationship is maintained in patients with chronic kidney disease, forming cardiorenal syndrome type IV.</p><p><strong>Methods: </strong>Cross-sectional, multicenter study of patients with chronic kidney disease hospitalized for heart failure. The primary outcome was the difference in hemoglobin concentration. The secondary outcome was the difference in the prevalence of anemia.</p><p><strong>Results: </strong>229 patients were enrolled. Hemoglobin concentration was lower in patients with HFpEF compared to patients with HFrEF (11.1±1.8 g/dl vs 12.3±2.0 g/dl; p < 0.0001). . Presenting HFpEF was associated with a lower hemoglobin concentration (β1 = -0.90 g/dl; p = 0.001), after including the use of iron supplements, moderate to severe deterioration of glomerular filtration rate, sex and age. The prevalence of anemia was higher in patients with HFpEF compared to those with HFrEF (72.3% vs 59.8%; p = 0.0462). Belonging to the HFpEF group was not associated with anemia (OR = 1.77; p = 0.078), after including the same covariates. Exploratory, belonging to the HFpEF group was associated with moderate to severe anemia, after including the same covariates.</p><p><strong>Conclusion: </strong>In patients with type IV cardiorenal syndrome, hemoglobin concentration is lower in patients hospitalized with HFpEF, possibly playing a role in the destabilization of these patients.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"22-40"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Dermatofibrosarcoma protuberans treated with Mohs surgery] 【莫氏手术治疗隆突性皮肤纤维肉瘤】
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.45363
Lía Salomé Abeledo, Carla Barbini, Gerardo Russier, Corina Busso
{"title":"[Dermatofibrosarcoma protuberans treated with Mohs surgery]","authors":"Lía Salomé Abeledo, Carla Barbini, Gerardo Russier, Corina Busso","doi":"10.31053/1853.0605.v82.n1.45363","DOIUrl":"10.31053/1853.0605.v82.n1.45363","url":null,"abstract":"<p><strong>Objetives: </strong>Dermatofibrosarcoma protuberans is a sarcomatous neoplasm with low incidence. It exhibits slow growth; however, it has the capacity to involve deep tissues. Clinically, it can mimic benign lesions, presenting as thickened or atrophic plaques that slowly transform into protruding lesions. The treatment of choice is surgical excision, with Mohs micrographic surgery standing out for its advantages.</p><p><strong>Clinical case: </strong>A 40-year-old male patient with dermatofibrosarcoma protuberans on the back underwent excision using the Mohs technique, with no tumor recurrence after two years of follow-up. Conclusion: It is important to highlight that the Mohs technique offers advantages over conventional methods, allowing for tissue optimization, ensuring clear margins, and achieving a low recurrence rate</p><p><strong>Conclusion: </strong>It is important to highlight that the Mohs technique offers advantages over conventional methods, allowing for tissue optimization, ensuring clear margins, and achieving a low recurrence rate</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"165-175"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ophthalmoplegia as a Rare Initial Presentation of Cryptococcal Meningitis: A Case Report and Literature Review 双核间眼移植物作为隐球菌性脑膜炎的罕见初始表现。
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.44952
Raymundo Solís-Gómez, Itzel A Hernández-Dehesa, Aztlani Adan-Ruiz, Adrián F Sánchez-Cruz, Eduardo Argüelles-González
{"title":"Ophthalmoplegia as a Rare Initial Presentation of Cryptococcal Meningitis: A Case Report and Literature Review","authors":"Raymundo Solís-Gómez, Itzel A Hernández-Dehesa, Aztlani Adan-Ruiz, Adrián F Sánchez-Cruz, Eduardo Argüelles-González","doi":"10.31053/1853.0605.v82.n1.44952","DOIUrl":"10.31053/1853.0605.v82.n1.44952","url":null,"abstract":"<p><strong>Introduction: </strong>Cryptococcal meningitis (CM) frequently associates immunocompromised patients, specifically in HIV infection, and it has high mortality. Neuro-ophthalmic manifestations are rare in patients with CM, especially internuclear ophthalmoplegia (INO) or wall-eyed bilateral internuclear ophthalmoplegia (WEBINO), most of them the result of secondary vasculitis.</p><p><strong>Case report: </strong>A 53-year-old woman with chronic hepatic failure, had sudden drowsiness, diplopia, fever, and internuclear ophthalmoplegia. MRI showed generalized leptomeningeal enhancement plus infratentorial nodular enhancement type in the midbrain and left cerebellar hemisphere. An India ink test was positive for Cryptococcus neoformans.</p><p><strong>Conclusion: </strong>Cryptococcal meningitis causes a wide spectrum of neurological manifestations, but neuro-ophthalmological signs are infrequent. Physicians should consider that these meningitis events are capable of generating symptoms due to intra-axial involvement of the Central Nervous System (CNS) due to vasculitis.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"176-187"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Residual hypoxemia during titration with self-adjusting CPAP at home in patients without prior adaptation] [未适应的患者在家中自行调节CPAP滴定时残留低氧血症]
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.44671
Julieta Franzoy, Magali Blanco, Glenda Ernst, Maria Belen Ginetti, Marcella Perri, Eduardo Borsini
{"title":"[Residual hypoxemia during titration with self-adjusting CPAP at home in patients without prior adaptation]","authors":"Julieta Franzoy, Magali Blanco, Glenda Ernst, Maria Belen Ginetti, Marcella Perri, Eduardo Borsini","doi":"10.31053/1853.0605.v82.n1.44671","DOIUrl":"10.31053/1853.0605.v82.n1.44671","url":null,"abstract":"<p><strong>Introduction: </strong>Self-adjusting titration (APAP) at home is accepted to define therapeutic pressure (CPAPT). The APAP device report may be insufficient to ensure adequate therapeutic response in all patients. There is no consensus on the use of oximetry during APAP titration.</p><p><strong>Objective: </strong>To evaluate the prevalence and magnitude of residual hypoxemia (RH) in titration with APAP not monitored at home and to identify related variables.</p><p><strong>Materials and methods: </strong>Retrospective study based on APAP titrations with coupled oximetry, arterial blood gases and spirometry test. A T90 > 10% of the night was considered significant RH. Predictors of HR were identified by logistic regression (RL).</p><p><strong>Results: </strong>116 cases were included. 41% in the group with RH. These were older (66.7 vs. 59.6 years, p: 0.02), lower absolute FEV1 (2.17 vs. 2.57 liters, p: 0.06), lower absolute FVC (2.9 vs. 3.3 liters, p: 0.02) and lower basal PO2 (77.3 vs. 84.2 mmHg, p: 0.04). The titration period reached 3.6 ± 1 nights, average adherence of 374 ± 88.4 minutes/night; CPAPT (cm H2O): 9.4 ± 1.8, AHIr; 3.1 ± 3.2 ev/h and leaks (liters/min): 19.7 ± 11.2. Multiple logistic regression identified age > 66 years as a predictor of RH (OR 3.32, 95% CI 1.43 - 7.69, p: 0.005) and FEV1 < 1.76 liters (OR 3.29 – IC95% 1.27 – 8.53, p: 0.0139).</p><p><strong>Conclusions: </strong>Incompletely corrected nocturnal oximetry was observed in a significant proportion of patients with APAP. Age over 66 years and absolute FEV1 < 1.76 liters were correlated with residual hypoxemia.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"61-77"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hypoglycemia in a patient with pleural solitary fibrous tumor and response to pasireotide] [一例胸膜孤立性纤维性肿瘤患者的低血糖及对pasireotide的反应]
Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2025-03-31 DOI: 10.31053/1853.0605.v82.n1.44424
Elizabeth Karen Videla, Pablo Ferrada, Jorge Miller, Eduardo Torres, Analía Álvarez, Javier Herrera, Bertha De la Torre
{"title":"[Hypoglycemia in a patient with pleural solitary fibrous tumor and response to pasireotide]","authors":"Elizabeth Karen Videla, Pablo Ferrada, Jorge Miller, Eduardo Torres, Analía Álvarez, Javier Herrera, Bertha De la Torre","doi":"10.31053/1853.0605.v82.n1.44424","DOIUrl":"10.31053/1853.0605.v82.n1.44424","url":null,"abstract":"<p><strong>Introduction: </strong>hypoglycemia is a common and multifactorial clinical condition. A rare cause is that associated with non-islet cell tumors.</p><p><strong>Objective: </strong>to report our experience on the management of severe hypoglycemia in a patient with solitary pleural fibrous tumor and his response to pasireotide.</p><p><strong>Clinical case: </strong>63-year-old patient with a history of glomerulonephritis, hypothyroidism, arterial hypertension and a one-year diagnosis of solitary pleural fibrous tumor. Referred to endocrinology due to hypoglycemia for 6 months. Acromegaloid features were confirmed. Laboratory: Hct 36%, Hb 11.9 g/dl, GB 3570/mm3 (Eo 2%, Ba2%, Bac 4%, NS 36%, Li 30%, Mo 14% metamyelocytes 1%, myelocytes 11%), platelets 120,000 /mm3, ESR 10 mm, CRP 9 mg/L, TP 114%, TTPK 25 sec, blood glucose 57 mg/dL, renal function, hepatogram and lipid profile without particularities. IGF-1 84 ng/ml (VR 57 - 188), C-peptide 0.10 ng/ml (VR 1.10 - 4.40), somatotropin 0.98 ng/ml (VR up to 2.5) and basal insulin 0.4 uU/ml (VR 2.6 - 24) . IFG-2 measurement is not available in Argentina. A chest CT showed a pleural tumor measuring 13 cm. Without possibilities of surgical resection and without response to chemotherapy. Treatment was started with infusion of 25% dextrose, dexamethasone, pasireotide with good response. The patient died due to an infectious complication.</p><p><strong>Conclusion: </strong>pasireotide could be a therapeutic alternative in cases that are not candidates for surgery or refractory to other medical treatment.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"127-139"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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