{"title":"Dynamical vs. genetic disease: what do complex rhythms reveal about pathophysiology?","authors":"L. Glass","doi":"10.1109/IEMBS.2001.1020503","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1020503","url":null,"abstract":"Human disease is often associated with complex dynamical features. This observation suggests various directions for research including collecting data over long times, developing mathematical models for diseases and studying the effects of parameter changes in the models, developing biological models that display complex rhythms mimicking the disease, and developing therapies.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123828733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E.M. Ventouras, C. Papageorgiou, N. Uzunoglu, G.N. Christodoulou
{"title":"Tikhonov regularization using a minimum-product criterion: Application to brain electrical tomography","authors":"E.M. Ventouras, C. Papageorgiou, N. Uzunoglu, G.N. Christodoulou","doi":"10.1109/IEMBS.2001.1019008","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019008","url":null,"abstract":"Tikhonov regularization is applied to the inversion of EEG potentials. The discrete model of the inversion problem results from an analytic technique providing information about extended intracranial distributions, with separate current source and sink positions. A three-layered concentric sphere model is used for representing head geometry. The selected regularization parameter is the minimizer of the product of the norm of the Tikhonov regularized solution and the norm of the corresponding residual. The simulations performed indicate that this regularization parameter selection method is more robust than the empirical composite residual and smoothing operator (CRESO) approach, in cases where only gaussian measurement noise exists in the discrete inverse model equation. Therefore the minimum product criterion can be used in real evoked potentials' data inversions, for the creation of brain electrical activity tomographic images, when the amount of noise present in the measured data is unknown.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123929256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of inter-electrode distance on EMG","authors":"A. Melaku, Dinesh Kumar, A. Bradley","doi":"10.1109/IEMBS.2001.1020377","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1020377","url":null,"abstract":"This paper reports experimental research undertaken to study the effect of variation of inter-electrode distance on the electromyogram (EMG). The experiments were conducted on ten healthy subjects and they performed isometric contraction of their biceps of the right arm at 20, 50 and 80% of their maximal voluntary contraction (MVC). EMG was recorded using surface electrodes with the distance between the two active electrodes being 18 and 36mm. It has been observed that at low levels of muscle contraction there was no significant variation due to the change in the distance between the electrodes while at 50 and 80% of MVC there was a significant change in the amplitude of the EMG. Using time-frequency analysis of EMG, the study demonstrates a variation of the spectral content of the EMG with change in the IED. The study also has shown that there is a variation of the EMG with muscle contraction but that the comparison should be done if the distance between the electrodes has been kept constant.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123383621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Carlsson, E. Soderqvist, L. Brodin, G. Kallner, J. Hultman, H. Elmqvist, S. Saha
{"title":"Initial experience with a thin single segment pressure and conductance catheter for measurement of left ventricular volume","authors":"C. Carlsson, E. Soderqvist, L. Brodin, G. Kallner, J. Hultman, H. Elmqvist, S. Saha","doi":"10.1109/IEMBS.2001.1018858","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1018858","url":null,"abstract":"A thin and soft multifunctional catheter was evaluated for the simultaneous real time monitoring of left ventricular volume and pressure with special consideration to side effects such as interference with normal cardiac electrophysiology. In four pigs, pressure and volume were simultaneously recorded by using the thin single segment pressure and conductance catheter. Measurements were done under varied cardiac conditions: at baseline, during preload reduction and afterload increase. Volumes were calibrated with intracardiac ultrasound measurements. During preload reduction the pressure and volume decreased as expected. A cautious afterload increase resulted in a corresponding pressure and volume increase, the maximum of the pressure curve changed from early to late. Both SV and EDV increased. The very few arrhythmias were mainly caused by surgical interference. The present study demonstrates that our thin single segment conductance catheter for the simultaneous measurement of LV volume and pressure has a performance that warrants further development with the goal of making the method available for human use. In particular, the catheter did not cause any arrhythmias.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"58 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123389464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An AFM-based study of porcine OBP film for artifical olfaction","authors":"Q. Cai, M. Pan, Guang Li, Yuquan Chen","doi":"10.1109/IEMBS.2001.1019569","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019569","url":null,"abstract":"The odorant binding protein (OBP) plays an important role in olfactory signal transmission. This paper studies the potential application of OBP on bionic artificial nose. Above all, OBP is immobilized in solid phase. So two kinds of OBP film were prepared. Firstly, OBP is covalently immobilized on the silicon wafer using DITC as a crosslinker. Secondly, polypyrrole film was fabricated on the ITO glass by the electrochemical polymerization. The topograph of these films was measured using an Atomic Force Micrograph (AFM). In order to evaluate the affinity of OBP and its antibody, the AFM probe was coated with the anti-OBP using the covalent method. The force-distance curve, acquired by the AFM instrument, was analyzed to reveal the characteristics of thin film and the binding property between OBP and antibody.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123609511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Kao, Len-Jon Hwang, Yui-Han Lin, Tzong-Huei Lin, C. Hsiao
{"title":"Computer analysis of the electrocardiograms from ECG paper recordings","authors":"T. Kao, Len-Jon Hwang, Yui-Han Lin, Tzong-Huei Lin, C. Hsiao","doi":"10.1109/IEMBS.2001.1019511","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019511","url":null,"abstract":"The volume of electrocardiograms (ECG's) recorded in hospital is increasing. Although modern electrocardiographs have digital output, most of ECG's are still recorded on plain papers. Recently, exchanging patients' clinical information between healthcare facilities has become very important. It will be very helpful, if plane paper type of ECG could be converted to digital form. In general, the background of ECG paper charts can be divided into three types: uniform background, background with colored grid and background with black grid. In this study, we developed a morphological method to retrieve ECG data on paper charts using optical scanner and computer. The results show that our method can erase the background noise and acquire the digital ECG signal from ECG paper charts correctly. Conversion of ECG by optical scanner is of practical use when attempting ECG data exchange between healthcare providers.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121201296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Bertrand, J. Bardet, M. Dabonneville, A. Mouzat, P. Vaslin
{"title":"Automatic determination of the different control mechanisms in upright position by a wavelet method","authors":"P. Bertrand, J. Bardet, M. Dabonneville, A. Mouzat, P. Vaslin","doi":"10.1109/IEMBS.2001.1020398","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1020398","url":null,"abstract":"A recent model to analyze the center of pressure trajectories is based on fractional Brownian motion. By doing so, one notes that standing still is described by different mechanisms following the frequency. Previous studies exhibit the existence of a control mechanism which stabilizes the upright position at a large enough time scale (from 0.3 s to 1.2 s depending on the method and on the authors) or equivalently at low frequencies. The different mechanisms are separated by a critical time scale or equivalently a critical frequency. This critical frequency is fundamental to understand the control mechanism of upright position: only physiological phenomenon at frequencies larger than this critical frequency could contribute to the task of maintaining equilibrium. A new statistical method is introduced based on recent progress in signal processing: the wavelet analysis. The algorithm is entirely automatic. Seventeen healthy young subjects were studied under quiet-standing conditions, the mean value of critical frequency is 1.8 Hz corresponding to a mean critical time scale 0.68 s. The algorithm is entirely automatic.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114341118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scalar fuzzy logic a new mathematic model for approximate reasoning","authors":"M. Mlynski, W. Ameling","doi":"10.1109/IEMBS.2001.1019683","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019683","url":null,"abstract":"Atrial and ventricular tachycardia are typically treated with Implantable Cardioverter Defibrillators (ICDs). Current dual-chamber ICDs have over 200 parameters, which have to be set all properly to ensure an accurate ICD programming. Since this is a time-consuming procedure, an expert-system to calculate a complete set of ICD parameters based on the given clinical patient-data was developed, where the expert knowledge was acquired and implemented into a knowledge base in cooperation with cardiologist physicians.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"34 10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116276194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dynamics of excitation in rings and annuli","authors":"L. Glass, Y. Nagai, K. Hall","doi":"10.1109/IEMBS.2001.1018845","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1018845","url":null,"abstract":"Excitable media, such as the Belousov-Zhabotinsky reaction or the heart support reentrant waves of excitation. The dynamics of this excitation depends on the properties of the medium, the geometry of the medium and perturbations to the system. Here we discuss the dynamics in ring and annular geometries as well as the effects of single and periodic stimulation of the dynamics.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121480609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low noise amplification for optical detector arrays [microbes detection]","authors":"A. Duncan, L. Powers","doi":"10.1109/IEMBS.2001.1017440","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1017440","url":null,"abstract":"Detection of low intensity light pulses is accomplished using a three stage amplifier design. A highly sensitive input stage provides a large gain and buffers the sensor from the following stages. An integration stage averages the input signal and holds the output value during data collection. Low impedance output drive capability and noise immunity are provided by a third stage. The combination of these three stages produces a system capable of detecting photocurrent signals in the range of 10-100 nA.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"187 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121524417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}