Schizophrenia Research-Cognition最新文献

{"title":"The aperiodic and periodic activities of EEG dynamically relate with cognitive performance in schizophrenia","authors":"Kexin Zhang ,&nbsp;Yunfei Ji ,&nbsp;Xiaodong Guo ,&nbsp;Tianqi Gao ,&nbsp;Xuemin Zhang ,&nbsp;Xin Yu ,&nbsp;Jing Wang","doi":"10.1016/j.scog.2025.100383","DOIUrl":"10.1016/j.scog.2025.100383","url":null,"abstract":"<div><h3>Background</h3><div>Aperiodic and periodic activities of electrophysiological signals have strong correlation with various neurocognitive factors. In the current study, we aim to investigate the aperiodic exponent and periodic oscillations (alpha and beta band power) and their associations with cognitive performance in schizophrenia (SCZ).</div></div><div><h3>Methods</h3><div>We enrolled 32 SCZ patients and 33 healthy controls (HC) for the study. Cognitive performance was assessed using the total Brief Assessment of Cognition in Schizophrenia (BACS). Before and after the language comprehension tasks (humor, metaphor and irony), the 5-min eyes-closed and eyes-open EEG signals were collected respectively. The aperiodic exponent and periodic power were extracted and obtained according to the division of brain regions. Finally, Pearson correlation was used to examine the relationships between the EEG parameters and behavioral measures.</div></div><div><h3>Results</h3><div>SCZ participants exhibited higher aperiodic exponents and lower periodic oscillations compared to HC. The aperiodic exponent decreased significantly after the tasks in central location (<em>F</em> (56,1) = 8.93, <em>P</em> = 0.004, <em>η</em>² = 0.14) in both groups, while the periodic oscillations had no significant change. The variance of the aperiodic exponent showed significantly negative correlation with <em>Z</em> scores of humor comprehension tasks (<em>r</em> = −0.42, <em>P</em> = 0.027) in SCZ. Besides, the pre-tasks aperiodic exponent in posterior location positively correlated with <em>T</em> scores of attention and speed of information processing (<em>r</em> = 0.35, <em>P</em> = 0.048).</div></div><div><h3>Conclusions</h3><div>Our findings confirmed the higher aperiodic exponent with lower alpha and beta band in SCZ, along with the variability and task-responsiveness of the aperiodic exponent. The findings suggest that aperiodic exponent holds strong cognitive functional implications in SCZ.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100383"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Social knowledge test (SKT) and the Combined stories test (COST) in people with a schizophrenia spectrum disorder","authors":"Amélie M. Achim ,&nbsp;Elisabeth Thibaudeau ,&nbsp;Frédéric Haesebaert ,&nbsp;Audrey Cayouette ,&nbsp;Caroline Cellard","doi":"10.1016/j.scog.2025.100373","DOIUrl":"10.1016/j.scog.2025.100373","url":null,"abstract":"<div><h3>Background</h3><div>People with schizophrenia spectrum disorders (SSD) often present with impaired social cognition. Among the measures available to assess these deficits, the Combined stories test (COST) and the Social knowledge test (SKT), that respectively target theory of mind (ToM) and social knowledge, have shown promising psychometric properties in prior studies. Test-retest reliability was however only examined in the general population, and the acceptability of these tests was not previously examined. This study aimed to further document the psychometric properties of the COST and the SKT and the acceptability of these tests in people with SSD and community controls (CO).</div></div><div><h3>Methods</h3><div>Forty-four (44) participants with SSD and 49 CO were administered the COST and SKT twice, about 4 weeks apart, and were asked to rate the acceptability of the tests on a 0 (Very unpleasant) to 10 (Very pleasant) point scale at both timepoints.</div></div><div><h3>Results</h3><div>In both groups, the results revealed an excellent inter-rater reliability and a good test-retest reliability for both tests, though the control non-social reasoning measure included in the COST showed poorer test-retest reliability in the SSD group. Some practice effects were observed but the ToM score from the COST and the SKT total score showed no evidence of ceiling effects at either timepoints. The average acceptability scores ranged between 7.8/10 and 8.3/10 for the COST and between 6.8/10 and 7.9/10 for the SKT.</div></div><div><h3>Conclusion</h3><div>The SKT and the COST present with good psychometric properties, representing good options for future studies or for use in clinical practice.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100373"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feature binding and detachment in psychosis: A virtual reality study","authors":"A.J. (Ante) Schlesselmann ,&nbsp;G.H.M. (Marieke) Pijnenborg ,&nbsp;S.A. (Saskia) Nijman ,&nbsp;W. (Wim) Veling ,&nbsp;R.J.C. (Rafaele) Huntjens","doi":"10.1016/j.scog.2025.100376","DOIUrl":"10.1016/j.scog.2025.100376","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia spectrum disorders (SSDs) significantly impact daily functioning, particularly through cognitive deficits like memory impairment. Traditionally attributed to neurobiological factors, recent evidence highlights the role of psychological processes like detachment, which may disrupt episodic memory encoding and retrieval by impairing feature binding. This study used a virtual reality (VR) paradigm to explore whether state detachment in SSDs is linked to impaired feature binding for adverse stimuli.</div></div><div><h3>Methods</h3><div>Twenty-five SSD patients from Dutch mental health centers and 25 individuals from the general population participated. Using an immersive VR paradigm, participants navigated a virtual shopping mall, interacted with 3D avatars, and identified their emotional facial expressions. Three memory tests followed: avatar identity recognition (basic memory), binding emotional expressions to avatars, and binding avatar identity to the encounter's temporal order. State detachment was measured using the Clinician-Administered Dissociative States Scale (CADSS).</div></div><div><h3>Results</h3><div>The SSD and comparison group did not display significant performance differences in any of the three feature binding tasks. However, across groups, results indicated that higher state detachment levels corresponded with worsened identity-emotion binding specifically for angry faces.</div></div><div><h3>Conclusion</h3><div>The present study provides tentative empirical support for the role of detachment in feature binding deficits for angry faces both in the patient and comparison group. Future studies should further explore the impact of psychological mechanisms like detachment on memory dysfunction, particularly regarding aversive stimuli.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100376"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and acceptability of combining cognitive remediation and tDCS in long-term psychiatric clinical care","authors":"Anika Poppe ,&nbsp;Leonie Bais ,&nbsp;Daniëlle van Duin ,&nbsp;Branislava Ćurčić-Blake ,&nbsp;Gerdina Hendrika Maria Pijnenborg ,&nbsp;Lisette van der Meer","doi":"10.1016/j.scog.2025.100358","DOIUrl":"10.1016/j.scog.2025.100358","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>Cognitive impairments are commonly experienced by individuals with severe mental illness (SMI) and are associated with problems in everyday life. This pragmatic, randomized, controlled, pilot trial explored the acceptability, feasibility, and preliminary effects of cognitive remediation (CR) combined with transcranial direct current stimulation (tDCS) for cognitive and everyday functioning in individuals with SMI in long-term psychiatric clinical care. We hypothesized that combining CR and tDCS is feasible and acceptable to individuals with SMI.</div></div><div><h3>Study design</h3><div>Twenty-four individuals with SMI were randomized to either CR + active tDCS (<em>n</em> = 13) or CR + sham tDCS (<em>n</em> = 11) over 32 sessions (16 weeks). Acceptability was evaluated in semi-structured interviews. Cognitive and everyday functioning were evaluated at baseline, post-16 week waiting period, post-intervention, and 6-months post-intervention.</div></div><div><h3>Study results</h3><div>Overall, participants were positive about the training. Over 60 % of participants successfully finished at least 20 sessions, meeting the predefined criteria for feasibility. CR appeared to yield subjective improvements to participants, significant improvements in cognitive tests post-intervention and at follow-up and improved self-reported negative symptoms at follow-up. Observer-rated everyday functioning and cognition, and subjective cognitive complaints did not change following CR.</div></div><div><h3>Conclusions</h3><div>This study concludes that CR is an acceptable and feasible intervention for individuals with SMI in long-term psychiatric clinical care. The addition of tDCS requires further investigation to ascertain its potential benefits.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100358"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between cognitive reserve (education), social cognition and negative symptoms","authors":"Sebastián Lema Spinelli ,&nbsp;Juan Francisco Rodríguez-Testal ,&nbsp;Álvaro Cabana ,&nbsp;Sandra Romano ,&nbsp;Leonel Gómez-Sena","doi":"10.1016/j.scog.2025.100379","DOIUrl":"10.1016/j.scog.2025.100379","url":null,"abstract":"<div><h3>Background</h3><div>Negative symptoms (NS) are a core feature of schizophrenia spectrum disorders, yet their relationship with cognitive reserve (defined by educational attainment) and social cognition remains underexplored. This study examined whether education predicts NS and whether this relationship is mediated by social cognition, specifically emotional or inferential theory of mind Reading the Mind in the Eyes Test (RMET) vs. the Hinting Test.</div></div><div><h3>Methods</h3><div>A mediation model and multiple regression analysis were conducted within an ex-post-facto, cross-sectional design. The sample included 144 participants: 69 diagnosed with schizophrenia spectrum disorders and 75 healthy controls. Women comprised 52.8 % of the sample, with a mean age of 42.67 years (<em>SD</em> = 15.88). The average years of formal education were 8.37 (<em>SD</em> = 2.77) in the patient group and 8.62 (<em>SD</em> = 3.66) in the control group.</div></div><div><h3>Results</h3><div>The mediation model explained 67.57 % of the variance in NS, with age as a covariate. RMET showed a significant indirect effect (<em>d</em> = −0.22) in predicting NS, while HT did not (<em>d</em> = −0.12). In the patient group, multiple regression analysis explained 69.2 % of the variance, with education emerging as a significant predictor of NS.</div></div><div><h3>Conclusions</h3><div>Education, as an indicator of cognitive reserve, significantly predicts NS. This relationship is mediated by social cognition, with differential effects depending on the specific type of social cognition, either within the patient group or across the entire sample. These findings highlight the importance of cognitive reserve and social cognition in understanding and potentially mitigating NS in schizophrenia.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100379"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness and management of cognitive impairment associated with schizophrenia in psychiatrists and patients: Results from a cross-sectional survey","authors":"Tomiki Sumiyoshi ,&nbsp;Satoru Ikezawa ,&nbsp;Kaori Inaba ,&nbsp;Tatsuro Marumoto ,&nbsp;Ichiro Kusumi ,&nbsp;Kazuyuki Nakagome","doi":"10.1016/j.scog.2025.100375","DOIUrl":"10.1016/j.scog.2025.100375","url":null,"abstract":"<div><div>This study evaluated awareness, management, and the burden of cognitive impairment associated with schizophrenia (CIAS) in Japan. A non-interventional, cross-sectional study was conducted online between April and December 2023, involving 149 psychiatrists and 852 patients. Psychiatrists prioritized controlling positive symptoms in the acute phase of the illness, while improving social functioning was the top priority for the maintenance/stable phase. Management of CIAS was regarded as most important for the reintegration of patients into society. Psychiatrists reported higher occurrence of CIAS among inpatients than outpatients. While 72 % of psychiatrists assessed CIAS, only 15 % used the Brief Assessment of Cognition in Schizophrenia. Further, 58 % of them reported that ≤40 % of their patients received interventions for CIAS. Sixty-eight percent of patients reported current or previous experiences of CIAS. The most common CIAS-related burdens were “unable to perform tasks I could do before or they take longer” (65 %) and “unable to maintain concentration” (64 %). In patients not currently experiencing CIAS (<em>n</em> = 496), these burdens were reported by 52 % and 50 %, respectively. Although CIAS was generally recognized by psychiatrists, the use of appropriate assessment tools and interventions was not common. While many patients reported CIAS-related burdens, a substantial proportion of them were unaware of CIAS. These observations indicate that the greater awareness of CIAS may facilitate its management in clinical practice, thus enhancing the ability of patients to reintegrate into society.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100375"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom severity and cognitive performance in patients with substance induced psychotic disorder and schizophrenia: a cross-sectional comparative study","authors":"Kaloyan Stoychev ,&nbsp;Ivanka Veleva ,&nbsp;Eleonora Mineva-Dimitrova ,&nbsp;Petranka Chumpalova ,&nbsp;Emiliya Dimitrova","doi":"10.1016/j.scog.2025.100388","DOIUrl":"10.1016/j.scog.2025.100388","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>psychotic disorders induced by substances like marijuana, amphetamines and methamphetamines (SIPDs) are a growing mental health problem, yet the question do they represent a separate psychotic class independent from schizophrenia (SZ) still stands. Studies comparing clinical and cognitive performance of SIPD and SZ patients have produced inconsistent results.</div></div><div><h3>Study design</h3><div>we performed a cross-sectional analysis of 62 subjects divided into two statistically matched groups (<em>n</em> = 31 each) with SZ and SIPD respectively. We compared the clinical severity of their symptoms as measured by the positive and negative PANSS scores. We then applied the following neurocognitive battery – 10 Words Memory Test of Luria for verbal learning and verbal memory; Digit Symbol Substitution Test (DSST) and Benton Visual Retention Test for processing speed and visual memory; Trail Making Test Part A &amp; B for attention and cognitive flexibility (along with DSST); Logical Memory Test (LMT) for episodic memory and thinking disorders; Verbal Fluency Test (VFT) for semantic memory and language. We referenced the performance results of the two groups to the normative values of each of the tests.</div></div><div><h3>Study results</h3><div>SZ subjects had significantly higher positive and negative PANSS scores and greater impairment in all cognitive domains except semantic memory and language (VFT). Compared to the normative values of all tests both SZ and SIPD patients performed poorer.</div></div><div><h3>Conclusions</h3><div>Our data support the assumption that the two conditions share a common underlying neurobiological vulnerability that is more pronounced quantitatively in schizophrenia.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100388"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A cross-sectional study on the association between executive functions and social disabilities in people with a psychotic disorder” [Schizophr. Res. Cogn. Volume 40 (2025), article number: 100349]","authors":"B.C. van Aken ,&nbsp;R. Rietveld ,&nbsp;A.I. Wierdsma ,&nbsp;Y. Voskes ,&nbsp;G.H.M. Pijnenborg ,&nbsp;J. van Weeghel ,&nbsp;C.L. Mulder","doi":"10.1016/j.scog.2025.100360","DOIUrl":"10.1016/j.scog.2025.100360","url":null,"abstract":"","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"41 ","pages":"Article 100360"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensionality of hallucination-like experiences: A factor structure refinement of the Launay-Slade Hallucination Scale","authors":"H. Honcamp ,&nbsp;L.K. Goller ,&nbsp;M. Amorim ,&nbsp;S.X. Duggirala ,&nbsp;J.F. Johnson ,&nbsp;M. Schwartze ,&nbsp;A.P. Pinheiro ,&nbsp;S.A. Kotz","doi":"10.1016/j.scog.2025.100368","DOIUrl":"10.1016/j.scog.2025.100368","url":null,"abstract":"<div><h3>Background</h3><div>Previous research on the multidimensionality of hallucination-like experiences (HLEs) across the psychosis continuum highlights methodological disparities, emphasizing the need for a cautious interpretation of findings and transparent reporting of parameters used in the analysis.</div></div><div><h3>Methods</h3><div>This study aimed to refine the factorial structure of the 16-item Launay-Slade Hallucination Scale (LSHS), enhance methodological clarity, and improve the robustness of LSHS factor solutions. To this end, an Exploratory Factor Analysis (EFA) was performed on a heterogeneous sample (<em>N</em> = 278) with specified parameters (e.g., estimation procedure) that remain true to data characteristics and assumptions underlying EFA.</div></div><div><h3>Results</h3><div>The results revealed a four-factor structure including “Multisensory HLEs”, “Auditory daydreaming”, “Vivid thoughts and inner speech”, and “Personified HLEs”. Our investigation introduces a new factor specific to the perceived presence of another person or another voice. This aligns with theories on self-monitoring difficulties associated with an external attribution bias as hallucination proneness (HP) increases across the continuum.</div></div><div><h3>Conclusion</h3><div>The current results provide an opportunity for investigating neurophysiological and neurobehavioral correlates of HP considering highly differentiated individual profiles of HLEs. Future studies should focus on validating the robustness of the four-factor structure derived from this research across diverse samples of the general population (e.g., different age groups and cultural backgrounds). Specified composite scores underlying HLEs could be of additive value when assessing emerging clinical risk on the psychosis continuum.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"41 ","pages":"Article 100368"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective cognition in schizophrenia and bipolar disorder: Complaints with SSTICS & SACCS","authors":"Emmanuel Stip ,&nbsp;Fadwa Al Mugaddam ,&nbsp;Karim Abdel Aziz ,&nbsp;Syed Fahad Javaid ,&nbsp;Javaid Nauman ,&nbsp;Iffat ElBarazi ,&nbsp;Stéphane Potvin ,&nbsp;Valérie Tourjman ,&nbsp;Naomi White","doi":"10.1016/j.scog.2025.100354","DOIUrl":"10.1016/j.scog.2025.100354","url":null,"abstract":"","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"41 ","pages":"Article 100354"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}