Schizophrenia Research-Cognition最新文献

{"title":"A remote and avatar-based approach for social cognitive impairments in psychotic disorders: A Canadian adaptation of RC2S","authors":"Elisabeth Thibaudeau,&nbsp;Elodie Peyroux,&nbsp;Nicolas Franck,&nbsp;Zelda Prost,&nbsp;Martin Lepage","doi":"10.1016/j.scog.2026.100462","DOIUrl":"10.1016/j.scog.2026.100462","url":null,"abstract":"<div><h3>Background</h3><div>Social cognition is a core impairment in psychotic disorders and is strongly associated with functional outcomes. Although social cognitive training is effective, challenges remain regarding skill generalization and accessibility. This study aimed to develop culturally adapted French- and English-Canadian versions of RC2S and to assess the feasibility and acceptability of remote delivery.</div></div><div><h3>Methods</h3><div>Fourteen individuals with a psychotic disorder were assessed at baseline, offered 24 twice-weekly RC2S sessions with a therapist over 12 weeks, and reassessed post-intervention. Motivation and therapeutic alliance were assessed through intra-session questionnaires. RC2S uses a personalized approach targeting social cognition and combines pen-and-paper exercises with digital relational simulations using avatars to promote skill transfer. Feasibility and acceptability were examined descriptively and paired-samples <em>t</em>-tests assessed exploratory pre–post changes.</div></div><div><h3>Results</h3><div>All participants who initiated RC2S met the predefined completion criterion (≥50% of sessions), and all completed at least 75% of planned sessions (mean = 20.9). Acceptability was high for cultural adaptation, ease of use, and remote interaction (all&gt;4.1/5), although ratings were lower for the RC2S interface (mean = 3.75/5). Motivation and therapeutic alliance remained high throughout the intervention (MUSIC&gt;5.1;WAI &gt; 4.3). Therapist support, perceived benefits, and remote accessibility were key facilitators. The largest exploratory pre–post changes occurred in therapist-administered goal attainment and functional impact measures. Findings from independently administered measures were more mixed, although a large change was observed for theory of mind.</div></div><div><h3>Conclusions</h3><div>Findings support the feasibility and acceptability of remotely delivered, culturally adapted RC2S. Exploratory outcomes were mixed, requiring confirmation in a randomized trial with independent, blinded outcome assessment.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"46 ","pages":"Article 100462"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of sex on cognition in psychosis","authors":"Bodyl A. Brand,&nbsp;Robert A. McCutcheon","doi":"10.1016/j.scog.2026.100453","DOIUrl":"10.1016/j.scog.2026.100453","url":null,"abstract":"","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"46 ","pages":"Article 100453"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148995331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early clinical insight in first-episode psychosis","authors":"Ilias I. Vlachos","doi":"10.1016/j.scog.2026.100447","DOIUrl":"10.1016/j.scog.2026.100447","url":null,"abstract":"","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"45 ","pages":"Article 100447"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148167235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From thought to language: Comparing schizophrenia spectrum disorders and Wernicke’s aphasia with machine learning and LLMs","authors":"Perry van der Zande,&nbsp;Andreas van Cranenburgh,&nbsp;Frank Tsiwah","doi":"10.1016/j.scog.2026.100443","DOIUrl":"10.1016/j.scog.2026.100443","url":null,"abstract":"<div><div>Schizophrenia spectrum disorders (SSD) and Wernicke’s aphasia (WA) both disrupt meaningful speech, yet they arise from fundamentally different disturbances in thought and language. SSD is defined by formal thought disorder, in which disorganized thinking is inferred from abnormalities in speech, whereas WA reflects a primary breakdown of language implementation following focal brain damage. We investigated whether quantitative markers of lexical–semantic, syntactic structure, and semantic coherence in spontaneous speech can distinguish SSD, WA, and healthy controls.</div><div>Using Natural Language Processing techniques, we extracted syntactic, lexical and local semantic similarity features from spontaneous speech transcripts and used them in supervised machine learning models to classify diagnostic groups. In parallel, an instruction-tuned large language model (LLM) was used in a zero-shot setting to assign transcripts to diagnostic categories and to track the severity of language disturbance.</div><div>Our results showed a distinct linguistic pattern, particularly in syntactic and local semantic organization for WA, indicating a paradigmatic language disorder. By contrast, the same features were less effective in distinguishing SSD from matched controls, in line with the view that SSD reflects a more diffuse disturbance of thought that only partially manifests in surface language. Zero-shot LLM classifications approached the performance of supervised models for WA-related contrasts and were sensitive to graded language disturbance. At the same time, strong task and dataset effects underscored the need for carefully controlled speech elicitation. Together, these findings highlight both the promise and the limitations of automated language analysis for clinical diagnostics and for understanding speech and thought abnormalities.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"45 ","pages":"Article 100443"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive profiles in older adults with psychotic disorders: Results from routine clinical assessments","authors":"Imane Nait Abbou ,&nbsp;Camille Maheu-Savard ,&nbsp;Francisca Chalifoux ,&nbsp;Jessika Roy-Desruisseaux ,&nbsp;Jean-François Trudel ,&nbsp;Jean-Robert Maltais","doi":"10.1016/j.scog.2026.100420","DOIUrl":"10.1016/j.scog.2026.100420","url":null,"abstract":"<div><h3>Objectives</h3><div>Cognitive impairment is common in older adults with psychotic disorders; however, few studies have examined their performance on widely used cognitive screening tools. This study aimed to characterize the cognitive profile of this population using four commonly administered instruments: the Mini-Mental State Examination (MMSE), the Modified Mini-Mental State (3MS), the Montreal Cognitive Assessment (MoCA), and the Frontal Assessment Battery (FAB).</div></div><div><h3>Methods</h3><div>In this descriptive cross-sectional study, 77 adults aged ≥60 years with a diagnosed psychotic disorder underwent cognitive assessment using the MMSE, 3MS, MoCA, and FAB. Demographic and clinical data were also collected, including psychiatric symptom severity (Positive and Negative Syndrome Scale; PANSS), functional status (Specific Level of Functioning Scale; SLOF), and education level.</div></div><div><h3>Results</h3><div>Median scores were 28/30 (MMSE), 92/100 (3MS), 22/30 (MoCA), and 15/18 (FAB). Cognitive deficits were most prominent in delayed recall, verbal fluency, inhibitory control, abstraction, and visuospatial function. Principal component analysis revealed strong positive correlations among cognitive performance, educational attainment, and functional capacity. PANSS total and negative symptom scores were negatively correlated with MMSE, 3MS, and FAB scores. No distinct cognitive subgroups were identified, suggesting a relatively homogeneous cognitive profile across the sample.</div></div><div><h3>Conclusions</h3><div>Older adults with psychotic disorders exhibit consistent impairments across specific cognitive domains. Familiarity with these patterns may help clinicians distinguish typical cognitive changes in this population from atypical profiles that warrant further investigation, including referral to geriatric psychiatry or memory clinics.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"44 ","pages":"Article 100420"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speech under stress: Affective and cognitive reactivity in schizophrenia and their functional correlates","authors":"Kyle S. Minor ,&nbsp;Madisen T. Russell ,&nbsp;Evan J. Myers ,&nbsp;Audrey T. Satchivi ,&nbsp;Maya E. Brown-Hughston ,&nbsp;Erica L. Whiting ,&nbsp;Deborah Daluga ,&nbsp;Rachel C. Marks ,&nbsp;Michaela M. Di Palmo ,&nbsp;Basma O. Aly","doi":"10.1016/j.scog.2026.100423","DOIUrl":"10.1016/j.scog.2026.100423","url":null,"abstract":"<div><div>Disorganized speech is a core diagnostic criterion of schizophrenia, yet mechanisms driving its variability remain unclear. Building on evidence from schizotypy and first-episode psychosis literature, we examined whether affective and cognitive systems influence speech disorganization in schizophrenia. Thirty-five individuals with schizophrenia (n = 35) and 37 healthy controls completed a validated speech paradigm across three conditions: neutral, affective, and cognitive load. Trained raters assessed disorganized speech using the Communication Disturbances Index (CDI). Reactivity was quantified using standardized residual change scores. The schizophrenia group exhibited significantly greater disorganized speech across all conditions (<em>d</em> = 0.58–0.89). Of note, affective reactivity emerged only when using regression-based analyses controlling for neutral condition disorganization, not with repeated-measures ANOVA—revealing important methodological considerations for detecting subtle stress-vulnerability patterns. Despite well-documented cognitive deficits in schizophrenia, cognitive reactivity was not observed. Both affective and cognitive reactivity showed medium inverse correlations with neurocognitive functioning (<em>r</em> = −0.36 to −0.41), but lower correlations with social or role functioning, contrasting with findings in earlier illness stages. These results demonstrate that disorganized speech in schizophrenia is contextually sensitive, with reactivity patterns linked to cognitive impairment. Furthermore, it builds upon prior evidence in schizotypy and first-episode psychosis groups, establishing associations across the psychosis-spectrum. Future research should explore how reactivity patterns evolve across illness stages to inform tailored interventions targeting emotion regulation and cognitive remediation based on individual reactivity profiles.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"44 ","pages":"Article 100423"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on Ziermans, Hajdúk, Pinkham, et al.'s “Call to Action on Social Cognition Measures in Clinical Research”","authors":"Francesca Happé","doi":"10.1016/j.scog.2025.100405","DOIUrl":"10.1016/j.scog.2025.100405","url":null,"abstract":"","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"43 ","pages":"Article 100405"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on Ziermans T. et al. “Call to Action on Social Cognition Measures”","authors":"Ruben C. Gur ,&nbsp;Raquel E. Gur","doi":"10.1016/j.scog.2025.100413","DOIUrl":"10.1016/j.scog.2025.100413","url":null,"abstract":"","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"44 ","pages":"Article 100413"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosis-proneness is associated with reduced cognitive error-monitoring during instrumental learning","authors":"Wanchen Zhao ,&nbsp;Samuel D. McDougle ,&nbsp;Tyrone D. Cannon","doi":"10.1016/j.scog.2025.100408","DOIUrl":"10.1016/j.scog.2025.100408","url":null,"abstract":"<div><h3>Background</h3><div>People higher in psychosis-proneness tend to resist belief revision despite contradictory evidence, potentially due to impaired error-monitoring. Post-error slowing (PES), one measure of error-monitoring, is linked to working memory (WM) recruitment. With limited WM capacity, psychosis-proneness could impair belief updating through poor error-monitoring during instrumental learning.</div></div><div><h3>Methods</h3><div>153 participants from Prolific were included in final analyses. To investigate how error-monitoring may explain impaired belief updating among those with psychosis-proneness, we implemented a Visuomotor Reinforcement Learning Task with varying WM loads, Interpretation Inflexibility Task, and Multidimensional Schizotypy Scale – Brief.</div></div><div><h3>Results</h3><div>Participants with higher positive schizotypy showed less PES at lower loads on the visuomotor instrumental learning task. WM capacity was associated positively with PES but negatively with positive schizotypy. Notably, it is only among participants higher in positive schizotypy that reduced PES associated with more severe belief inflexibility</div></div><div><h3>Conclusions</h3><div>These results suggest that impaired top-down error monitoring in psychosis-proneness may stem from WM limitations, leading to greater reliance on slower RL-based learning. This cognitive profile might prevent efficient belief adjustment and error correction, connecting executive function deficits in psychosis-proneness to performance monitoring and cognitive inflexibility.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"43 ","pages":"Article 100408"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does neurocognition predict personal recovery over time in psychotic disorder patients?","authors":"R. Rietveld ,&nbsp;A.M. Kamperman ,&nbsp;B.C. van Aken ,&nbsp;G.H.M. Pijnenborg ,&nbsp;C.L. Mulder","doi":"10.1016/j.scog.2026.100425","DOIUrl":"10.1016/j.scog.2026.100425","url":null,"abstract":"<div><h3>Background</h3><div>Personal recovery has been recognized as an important goal in patients with psychotic disorders. It is defined as a deeply personal, unique process of living a satisfying life even with the limitations caused by the illness. Neurocognitive impairments are a core feature of psychotic disorders and proven to be a key determinant of functional outcomes, such as daily- and social functioning, work and independent living. However, the relationship with personal recovery remains unclear. Few studies investigated the relationship, and the findings remains inconclusive. This study explores the relationship between neurocognition and personal recovery, both cross-sectionally and over a year time.</div></div><div><h3>Method</h3><div>Data from baseline and T1 (one year later) was used from the UP's cohort; this is a longitudinal observational study (<em>n</em> = 366) of schizophrenia spectrum disorder patients. Personal recovery was assessed using the ReQOL and the Individual Recovery Outcomes Counter (I.ROC). Neurocognition was assessed using the BACS (composite score and subdomains). Linear mixed models were used to analyze the association between neurocognition and personal recovery over time.</div></div><div><h3>Results</h3><div>Global neurocognition and neurocognitive domains (verbal memory, working memory, motor speed, verbal fluency, attention and executive function) were not associated with personal recovery at baseline and after a one-year period. The models controlling for age and sex explained only a small proportion of the variance, adding the PANSS-R significantly improved the explained variance. Additional analyses showed robust finding across different personal recovery measures using the I.ROC. Personal recovery improved with 6.9% between baseline and one year later: the ReQOL improved from 57.6% to 64.5%, the I.ROC improved from 43.9% to 50.8%.</div></div><div><h3>Conclusion</h3><div>Neurocognition did not predict personal recovery in this study. Patients with and without neurocognitive impairments showed similar levels of personal recovery at baseline and over a one-year time. This finding suggests that personal recovery can be accomplished in the presence of neurocognitive impairments and highlights the importance of addressing both domains independently. Psychotic symptoms are a stronger predictor of personal recovery than neurocognitive impairments. Future research is needed to investigate possible indirect relationships through metacognition.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"44 ","pages":"Article 100425"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}