Schizophrenia Research-Cognition最新文献

{"title":"Assessment of the German Version of Brief Assessment of Cognition in Schizophrenia (BACS)","authors":"Matin Mortazavi ,&nbsp;Jakob Amon ,&nbsp;Iris Jäger ,&nbsp;Genc Hasanaj ,&nbsp;Zahra Aminifarsani ,&nbsp;Kristin Fischer ,&nbsp;Matthias Gamer ,&nbsp;CDP Working Group ,&nbsp;Alkomiet Hasan ,&nbsp;Richard S.E. Keefe ,&nbsp;Gabriele Sachs ,&nbsp;Peter Falkai ,&nbsp;Daniel Keeser ,&nbsp;Florian Raabe ,&nbsp;Elias Wagner","doi":"10.1016/j.scog.2025.100364","DOIUrl":"10.1016/j.scog.2025.100364","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive impairments are a hallmark of schizophrenia-spectrum disorders (SSD), contributing to poor treatment outcomes and a key treatment target. The Brief Assessment of Cognition in Schizophrenia (BACS) battery is a validated tool designed to evaluate affected core domains in SSD. The present study evaluated psychometric properties of the German version of the BACS in a representative sample of individuals with SSD and healthy control subjects.</div></div><div><h3>Methods</h3><div><em>N</em> = 107 individuals with SSD and <em>n</em> = 175 healthy controls were assessed with the German version of the BACS. Diagnosis was confirmed with the Mini International Neuropsychiatric Interview according to DSM-V. Validity was assessed through pair-wise comparisons between SSD individuals and healthy controls and by using receiver operating characteristic analysis. Internal consistency as a measure of reliability was evaluated using McDonald's Omega and Cronbach's Alpha in addition to factor and principal component analysis.</div></div><div><h3>Results</h3><div>All individuals with SSD exhibited significantly lower z-scores across all BACS subtests and BACS composite scores (Z &lt; -1.5) compared to healthy controls. ROC analysis revealed good diagnostic accuracy with an AUC of 0.83 (95%CI: 0.78,0.88, sensitivity = 0.75, specificity = 0.75). Similar results were observed in sub-cohorts comprising clinically stable SSD patients and those with younger ages (18–35 years old). A unidimensional structure, supported by McDonald's Omega (ω = 0.72) and principal component analysis, confirmed robust internal reliability.</div></div><div><h3>Conclusions</h3><div>The German BACS demonstrates strong validity and internal reliability when assessed in a representative case-control sample. This study provides an extensive normative dataset for individuals with SSD in German-speaking populations, facilitating future research and clinical assessments of cognition.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"41 ","pages":"Article 100364"},"PeriodicalIF":2.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study","authors":"Lei Liu ,&nbsp;Wenyang Han ,&nbsp;Juntao Yu ,&nbsp;Lingna Lou ,&nbsp;Dewen Zhou ,&nbsp;Liang Li ,&nbsp;Peng Xu ,&nbsp;Feng Zou","doi":"10.1016/j.scog.2025.100362","DOIUrl":"10.1016/j.scog.2025.100362","url":null,"abstract":"<div><div>Individuals with schizophrenia (SZ) exhibit deficits in speech perception in noise, which are closely related to their abnormalities in auditory working memory (WM). Auditory WM, especially the non-verbal auditory WM, serves as a bridge between perception, action, and long-term memory, playing a crucial role in integrating sound sequences to facilitate auditory object perception and auditory scene analysis (ASA). Although considerable research has been conducted on auditory sensory memory and visual WM in schizophrenia, studies specifically addressing non-verbal auditory WM remain scarce. Therefore, this study recorded the behavioral performance and event related potentials of 36 SZ and 36 healthy controls (HC) during a modified non-musical tone-sequence delayed matching-to-sample task (DMTS). The results showed that, in the tone-sequence DMTS, SZ had not only lower accuracy but also slower reaction times compared to the HC. More importantly, during the retention period, the memory maintenance of SZ begins to decay rapidly from the mid-stage, manifested by a significantly reduction in the late sustained anterior negativity (SAN2). Meanwhile, the early sustained anterior negativity (SAN1) in patients showed a significant correlation with their general pathological symptoms. The pathological symptoms can be predicted by the SAN1 under load 4 condition. This study provides empirical evidence for the impairment of non-verbal auditory WM maintenance in schizophrenia, which is of significant importance for understanding the auditory dysfunction and ASA difficulties experienced by SZ.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"41 ","pages":"Article 100362"},"PeriodicalIF":2.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective cognition in schizophrenia and bipolar disorder: Complaints with SSTICS & SACCS","authors":"Emmanuel Stip ,&nbsp;Fadwa Al Mugaddam ,&nbsp;Karim Abdel Aziz ,&nbsp;Syed Fahad Javaid ,&nbsp;Javaid Nauman ,&nbsp;Iffat ElBarazi ,&nbsp;Stéphane Potvin ,&nbsp;Valérie Tourjman ,&nbsp;Naomi White","doi":"10.1016/j.scog.2025.100354","DOIUrl":"10.1016/j.scog.2025.100354","url":null,"abstract":"","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"41 ","pages":"Article 100354"},"PeriodicalIF":2.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domain-specific associations between social cognition and aggression in schizophrenia spectrum disorders","authors":"Sarah A. Berretta ,&nbsp;Lindsay D. Oliver ,&nbsp;Courtland S. Hyatt ,&nbsp;Ricardo E. Carrión ,&nbsp;Katrin Hänsel ,&nbsp;Aristotle Voineskos ,&nbsp;Robert W. Buchanan ,&nbsp;Anil K. Malhotra ,&nbsp;Sunny X. Tang","doi":"10.1016/j.scog.2025.100361","DOIUrl":"10.1016/j.scog.2025.100361","url":null,"abstract":"<div><div>Aggression in schizophrenia spectrum disorders (SSD) is rare but elevated relative to the general population. Existing studies have not identified reliable personal predictors of aggression in SSD. In line with social information processing models suggesting that difficulties interpreting social cues and others' intentions may lead to aggression, we evaluated whether social cognitive domains or global social cognition could be modifiable risk factors in SSD.</div><div>We examined aggression and social cognition in 59 participants with SSD and 43 healthy volunteers (HV). Self-reported aggression was measured via the Reactive-Proactive Aggression Questionnaire (RPAQ). Social cognition was assessed using five tasks measuring emotion processing, theory of mind, and social perception. Group differences were analyzed using Mann-Whitney-Wilcoxon tests. Multiple regressions examined effects of social cognition on aggression, controlling for demographic and clinical covariates. Supplemental mediation analyses tested whether impairments in emotion processing, theory of mind, or overall social cognition explained the relationship between SSD diagnosis and increased aggression.</div><div>Reported aggression was higher in the SSD group, and social cognitive abilities were impaired across domains (<em>p</em> &lt; .001). Better emotion processing (β = −0.35, <em>p</em> = .03) and theory of mind (β = −0.32, <em>p</em> = .03) predicted lower aggression in SSD, even when accounting for demographic and neurocognitive variables. Exploratory models adjusting for overall psychiatric symptom severity showed that theory of mind remained significant, while emotion processing attenuated. However, social cognition did not mediate the relationship between diagnosis and aggression. Future studies should examine other social processing factors, such as attributional bias.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"41 ","pages":"Article 100361"},"PeriodicalIF":2.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain functional connectivity associated with cognitive deficits in younger patients at first episode of schizophrenia","authors":"Na Liu ,&nbsp;Lihua Xu ,&nbsp;Xiaofeng Guan ,&nbsp;Ansi Qi ,&nbsp;Fei Liu ,&nbsp;Chengqing Yang ,&nbsp;Xiangyun Long ,&nbsp;Junjuan Zhu ,&nbsp;Nan Huang ,&nbsp;Jie Zhang ,&nbsp;Yi Xu ,&nbsp;Jing Chen ,&nbsp;Huan Huang ,&nbsp;Jijun Wang ,&nbsp;Zheng Lu","doi":"10.1016/j.scog.2025.100359","DOIUrl":"10.1016/j.scog.2025.100359","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive deficits are a core feature of schizophrenia and are influenced by the age at onset of psychosis. Both preclinical and early-onset schizophrenia patients exhibit abnormalities in the frontal cortex, parahippocampus, precuneus, and hippocampus—regions that are closely associated with cognitive deficits. This study examines whether cognitive-related functional connectivity (FC) within these regions differs in first-episode schizophrenia (FES) patients with varying ages of onset.</div></div><div><h3>Methods</h3><div>FES patients (ages 18–45, <em>n</em> = 24) and matched healthy controls (HC, <em>n</em> = 29) were divided into younger and older subgroups based on the median age of 25 years: FES_young, FES_older, HC_young, and HC_older. All participants completed the MATRICS Consensus Cognitive Battery (MCCB) and underwent resting-state functional magnetic resonance imaging. FC within regions of interest (ROIs) was analyzed using the CONN toolbox.</div></div><div><h3>Results</h3><div>Significant cognitive differences were observed between the four groups (H = 13.447, <em>p</em> = 0.004, Rank ε² = 0.259). The most prominent differences were found between the FES_young and HC_young groups (Holm-adjusted <em>p</em> = 0.012). Cognitive deficits in FES patients were significantly associated with reduced FC between the right precuneus (A31_R) and right parahippocampal gyrus (TI_R) (rho = 0.549, <em>p</em> = 0.010, Fisher's z = 0.616). FES_young showed significantly lower FC between A31_R and TI_R compared to HC_young (Holm-adjusted <em>p</em> = 0.001).</div></div><div><h3>Conclusion</h3><div>Earlier onset schizophrenia is associated with more severe cognitive deficits and specific impairments in brain functional connectivity. These findings highlight the importance of considering age of onset when assessing cognitive and neural dysfunction in schizophrenia.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"41 ","pages":"Article 100359"},"PeriodicalIF":2.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive predictors and genetic moderators of employment outcomes in people with schizophrenia","authors":"Rachael Keir Blackman ,&nbsp;Dwight Dickinson ,&nbsp;Michael D. Gregory ,&nbsp;Bhaskar S. Kolachana ,&nbsp;Daniel P. Eisenberg ,&nbsp;Karen F. Berman","doi":"10.1016/j.scog.2025.100356","DOIUrl":"10.1016/j.scog.2025.100356","url":null,"abstract":"<div><div>Although some individuals with schizophrenia are able to maintain gainful employment, many are not. To better understand this differential real-life outcome, we tested general and specific cognitive measures as predictors of future employment and genetic moderators of these relationships. One hundred and twenty-four patients with schizophrenia spectrum illness (31.5 % female, mean age 32.5 ± 10.5 years) participated in a research study at the National Institute of Mental Health Intramural Research Program's Clinical Center and were later recontacted regarding outcomes (average time to recontact = 8.6 ± 4.0 years). At the initial visit, patients completed a comprehensive battery of neuropsychological tests and provided blood samples for genotyping. Cognitive scores at the initial visit were tested as predictors of future employment status (employed vs. unemployed) at follow-up using logistic regressions, and polygenic risk scores for schizophrenia were tested as moderators. At follow-up, 45.2 % of individuals were employed. General cognitive ability indexes (“<em>g</em>” and IQ) and verbal memory were predictive of subsequent employment status. Additionally, polygenic risk for schizophrenia moderated the effect of working memory cognitive scores on the prediction of future employment. The results suggest that certain broad indexes of cognitive dysfunction may be particularly salient in targeting interventions to address real-world functioning in schizophrenia. These data also suggest that further investigation into the genetic underpinnings of real-life outcomes in this illness is warranted.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100356"},"PeriodicalIF":2.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a brief online multi-index assessment for predicting increased psychotic-like experiences in the community: A perceptual, cognitive and affective approach.","authors":"Caroline Cullen ,&nbsp;Keith Gaynor ,&nbsp;Klaus Kessler","doi":"10.1016/j.scog.2025.100357","DOIUrl":"10.1016/j.scog.2025.100357","url":null,"abstract":"<div><div>Research has shown that impairments in perception, reasoning, and social cognition are evident across the psychosis continuum and are implicated in the transition from subclinical symptoms to clinical psychosis. In this pilot feasibility study, a brief computerised assessment of visual perception, reasoning, social cognition and emotion dysregulation was administered to 157 adults in the community alongside self-report measures of psychotic-like experiences. The feasibility, reliability, and the predictive validity of the assessment tool were examined. The assessment procedure was feasible, evidenced through high completion rates. However, reliability estimates were suboptimal for online assessment measures. Self-reported visual perception and state emotion dysregulation predicted psychotic-like experiences explaining 53% of the variance when controlling for age. This study provides preliminary evidence that state difficulties with emotion regulation and self-reported visual perception abnormalities can predict increased psychotic-like experiences in the community. Future adaptations could address technological issues encountered with assessment tasks and ensure measures are psychometrically robust when administered online. Brief online assessments hold potential for research of both cognition and affect along the psychosis continuum although caution must be exercised with the chosen methodology.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100357"},"PeriodicalIF":2.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cariprazine on attention and quality of life in patients with predominant negative symptoms of schizophrenia: A post-hoc analysis","authors":"Oloruntoba J. Oluboka ,&nbsp;Andrea Bardell ,&nbsp;Howard C. Margolese ,&nbsp;Philip G. Tibbo ,&nbsp;Lisa Buchy ,&nbsp;Christine Di Cresce ,&nbsp;Jun Yu ,&nbsp;Roger S. McIntyre","doi":"10.1016/j.scog.2025.100355","DOIUrl":"10.1016/j.scog.2025.100355","url":null,"abstract":"<div><h3>Background</h3><div>Cariprazine, a potent dopamine D₃-preferring D₃/D₂ receptor partial agonist, has demonstrated benefits on negative symptoms among patients with schizophrenia. Secondary endpoint and post-hoc analyses have also suggested a benefit of cariprazine on quality of life (QoL) and attention.</div></div><div><h3>Methods</h3><div>Data for this <em>post-hoc</em> analysis were pooled from two 6-week, placebo-controlled phase 3 trials evaluating cariprazine among patients with acute exacerbations of schizophrenia. One study included an aripiprazole active-control arm for assay sensitivity.</div><div>Two populations were analyzed: pooled intention-to-treat (ITT) population (<em>N</em> = 1043), and the pooled subgroup with predominant negative symptoms (PNS, <em>n</em> = 215), as defined by the Positive and Negative Syndrome Scale (PANSS) subscale and item cut-off criteria at baseline. Analyses of interest were: Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4) total score; Cognitive Drug Research (CDR) power of attention (PoA), and continuity of attention (CoA).</div></div><div><h3>Results</h3><div>Among study completers, cariprazine and aripiprazole were associated with significant SQLS-R4 improvements in the ITT and PNS populations. Differences in CDR-PoA scores were significant for cariprazine vs. placebo in the ITT and PNS populations, but not for aripiprazole in the ITT or PNS analyses. Differences in CDR-CoA scores were significant for cariprazine vs. placebo in the ITT and PNS analyses; and was significant for aripiprazole vs. placebo in the PNS analysis, but not in the ITT analysis.</div></div><div><h3>Conclusions</h3><div>This post-hoc analysis suggests that cariprazine may be associated with beneficial effects on measures of attention and QoL among patients with schizophrenia, and these effects could be more pronounced among individuals with PNS.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100355"},"PeriodicalIF":2.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The awareness, characterization, and burden of Cognitive Impairment Associated with Schizophrenia (CIAS) in clinical practice: Results from a nationwide survey in Italy","authors":"Antonio Vita ,&nbsp;Stefano Barlati ,&nbsp;Roberto Cavallaro ,&nbsp;Riccardo Cipelli ,&nbsp;Giulio Corrivetti ,&nbsp;Dario Delmonte ,&nbsp;Eleonora Lusito ,&nbsp;Elisabetta Maia ,&nbsp;Maria Michela Marino ,&nbsp;Giuseppe Nicolò ,&nbsp;Paola Rocca ,&nbsp;Silvana Galderisi","doi":"10.1016/j.scog.2025.100352","DOIUrl":"10.1016/j.scog.2025.100352","url":null,"abstract":"<div><h3>Introduction</h3><div>Cognitive Impairment (CIAS) is a core aspect of schizophrenia and one of the main obstacles to clinical and functional recovery in patients. People with CIAS have difficulties with learning and using information in real world. Despite its well-recognized role, it is not yet a diagnostic criterion in DSM-5 and ICD system. The effective management of CIAS represents a critical unmet need of schizophrenia treatment.</div></div><div><h3>Methods</h3><div>To evaluate the awareness of CIAS in the Italian landscape, we conducted a quantitative survey on psychiatrists highly specialized in schizophrenia, focused on its awareness, assessment, burden, and treatment.</div></div><div><h3>Results</h3><div>Of 152 participants, 139 (91.4 %) consider CIAS assessment important. The terminology most frequently used to describe CIAS is ‘cognitive impairment’. CIAS is assessed, clinically or with formal tools, in approximately 43 % of patients after stabilisation either during follow-up visits (<em>N</em> = 88, 67.7 %) or during hospital stay (<em>N</em> = 57, 43.8 %). 65 % of evaluated patients are considered affected by CIAS. Formal assessment tools (tests, questionnaires, interviews) are used in about 20 % of the centers. The Mini Mental State Examination (MMSE) (<em>N</em> = 75, 72.1 %) and the Wechsler Adult Intelligence Scale (WAIS) (<em>N</em> = 62, 59.6 %) are the most frequently used tools for CIAS evaluation.</div></div><div><h3>Conclusions</h3><div>The clinical characteristics of the patient, structural barriers like the lack of trained personnel or inadequate economic resources, and organizational problems influence the assessment rate. Despite this awareness, greater effort must be made to overcome the barriers, especially economic and organizational ones, which prevent the assessment and treatment of CIAS from becoming established in routine clinical care.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100352"},"PeriodicalIF":2.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenomenology of dissociative symptoms: A comparison between individuals with dissociative disorders and high and low dissociative schizophrenia spectrum disorders","authors":"V.E. de Vries ,&nbsp;R.J.C. Huntjens ,&nbsp;B.E. Sportel ,&nbsp;J.J. Arends ,&nbsp;G.H.M. Pijnenborg","doi":"10.1016/j.scog.2025.100348","DOIUrl":"10.1016/j.scog.2025.100348","url":null,"abstract":"<div><h3>Background</h3><div>The distinction between dissociative disorders (DDs) and schizophrenia spectrum disorders (SSDs) in different categories since DSM-III presumes a clear-cut distinction between both disorders. However, empirical studies did not reveal a clear distinction between the disorders on a symptom level. The aim of the current study was to further examine the overlap and differences in symptoms between DDs and SSDs<strong>.</strong></div></div><div><h3>Methods</h3><div>Levels and types of dissociative and psychotic symptoms were compared between 27 DD patients and 51 SSD patients using MANOVA. For a more fine-grained insight, a subgroup analysis was performed with the DD group and 12 individuals with SSD who report many dissociative experiences (SSD-H). Finally, a discriminant analysis was performed to explore if there are symptoms discriminating between the DD group and both SSD groups.</div></div><div><h3>Results</h3><div>Results showed that the DD group experienced higher levels of each type of dissociative symptoms than the total SSD group. The symptoms self-states alters, discontinuities of time, flashbacks, voices, and depersonalization were found to best discriminate between the groups. These differences did not hold in the subgroup analysis between the DD group and SSD-H group, where only differences on the validity scales rare symptoms, attention seeking and factitious behavior were found.</div></div><div><h3>Conclusion</h3><div>It can be stated that none of the dissociative and psychotic symptoms is specific to DDs or SSDs. Therefore it is advisable to be cautious with classifying based on the presence of (certain) symptoms. A transdiagnostic approach towards assessment and treatment, regardless of classification, is indicated.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100348"},"PeriodicalIF":2.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}