Schizophrenia Research-Cognition最新文献

{"title":"The awareness, characterization, and burden of Cognitive Impairment Associated with Schizophrenia (CIAS) in clinical practice: Results from a nationwide survey in Italy","authors":"Antonio Vita ,&nbsp;Stefano Barlati ,&nbsp;Roberto Cavallaro ,&nbsp;Riccardo Cipelli ,&nbsp;Giulio Corrivetti ,&nbsp;Dario Delmonte ,&nbsp;Eleonora Lusito ,&nbsp;Elisabetta Maia ,&nbsp;Maria Michela Marino ,&nbsp;Giuseppe Nicolò ,&nbsp;Paola Rocca ,&nbsp;Silvana Galderisi","doi":"10.1016/j.scog.2025.100352","DOIUrl":"10.1016/j.scog.2025.100352","url":null,"abstract":"<div><h3>Introduction</h3><div>Cognitive Impairment (CIAS) is a core aspect of schizophrenia and one of the main obstacles to clinical and functional recovery in patients. People with CIAS have difficulties with learning and using information in real world. Despite its well-recognized role, it is not yet a diagnostic criterion in DSM-5 and ICD system. The effective management of CIAS represents a critical unmet need of schizophrenia treatment.</div></div><div><h3>Methods</h3><div>To evaluate the awareness of CIAS in the Italian landscape, we conducted a quantitative survey on psychiatrists highly specialized in schizophrenia, focused on its awareness, assessment, burden, and treatment.</div></div><div><h3>Results</h3><div>Of 152 participants, 139 (91.4 %) consider CIAS assessment important. The terminology most frequently used to describe CIAS is ‘cognitive impairment’. CIAS is assessed, clinically or with formal tools, in approximately 43 % of patients after stabilisation either during follow-up visits (<em>N</em> = 88, 67.7 %) or during hospital stay (<em>N</em> = 57, 43.8 %). 65 % of evaluated patients are considered affected by CIAS. Formal assessment tools (tests, questionnaires, interviews) are used in about 20 % of the centers. The Mini Mental State Examination (MMSE) (<em>N</em> = 75, 72.1 %) and the Wechsler Adult Intelligence Scale (WAIS) (<em>N</em> = 62, 59.6 %) are the most frequently used tools for CIAS evaluation.</div></div><div><h3>Conclusions</h3><div>The clinical characteristics of the patient, structural barriers like the lack of trained personnel or inadequate economic resources, and organizational problems influence the assessment rate. Despite this awareness, greater effort must be made to overcome the barriers, especially economic and organizational ones, which prevent the assessment and treatment of CIAS from becoming established in routine clinical care.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100352"},"PeriodicalIF":2.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenomenology of dissociative symptoms: A comparison between individuals with dissociative disorders and high and low dissociative schizophrenia spectrum disorders","authors":"V.E. de Vries ,&nbsp;R.J.C. Huntjens ,&nbsp;B.E. Sportel ,&nbsp;J.J. Arends ,&nbsp;G.H.M. Pijnenborg","doi":"10.1016/j.scog.2025.100348","DOIUrl":"10.1016/j.scog.2025.100348","url":null,"abstract":"<div><h3>Background</h3><div>The distinction between dissociative disorders (DDs) and schizophrenia spectrum disorders (SSDs) in different categories since DSM-III presumes a clear-cut distinction between both disorders. However, empirical studies did not reveal a clear distinction between the disorders on a symptom level. The aim of the current study was to further examine the overlap and differences in symptoms between DDs and SSDs<strong>.</strong></div></div><div><h3>Methods</h3><div>Levels and types of dissociative and psychotic symptoms were compared between 27 DD patients and 51 SSD patients using MANOVA. For a more fine-grained insight, a subgroup analysis was performed with the DD group and 12 individuals with SSD who report many dissociative experiences (SSD-H). Finally, a discriminant analysis was performed to explore if there are symptoms discriminating between the DD group and both SSD groups.</div></div><div><h3>Results</h3><div>Results showed that the DD group experienced higher levels of each type of dissociative symptoms than the total SSD group. The symptoms self-states alters, discontinuities of time, flashbacks, voices, and depersonalization were found to best discriminate between the groups. These differences did not hold in the subgroup analysis between the DD group and SSD-H group, where only differences on the validity scales rare symptoms, attention seeking and factitious behavior were found.</div></div><div><h3>Conclusion</h3><div>It can be stated that none of the dissociative and psychotic symptoms is specific to DDs or SSDs. Therefore it is advisable to be cautious with classifying based on the presence of (certain) symptoms. A transdiagnostic approach towards assessment and treatment, regardless of classification, is indicated.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100348"},"PeriodicalIF":2.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of early visual processing, social cognition, and functional outcomes in schizophrenia spectrum disorders","authors":"Akke Ganse-Dumrath ,&nbsp;Anya Chohan ,&nbsp;Steven Samuel ,&nbsp;Paul Bretherton ,&nbsp;Corinna Haenschel ,&nbsp;Anne-Kathrin Fett","doi":"10.1016/j.scog.2025.100351","DOIUrl":"10.1016/j.scog.2025.100351","url":null,"abstract":"<div><div>Non-affective psychotic disorders are marked by cognitive and sensory processing abnormalities, including in early visual processing and social cognition. Understanding the relationships between these deficits and their impact on daily-life functional outcomes may help to improve outcomes in affected individuals. This systematic review and meta-analysis aimed to summarise the existing evidence on the relationships between early visual processing, social cognition, and functional outcomes, and to assess the evidence regarding the mediating role of social cognition in the association between early visual processing and functional outcomes in individuals with schizophrenia spectrum disorders. A comprehensive search across five databases identified 364 potentially eligible studies, with eight articles meeting all inclusion criteria. Meta-analytic techniques were employed to synthesise effect sizes and assess a meta-mediation model. Three random-effects meta-analyses revealed significant associations between all three domains of interest. Social cognition partially mediated the relationship between early visual processing and functional outcomes. The direct effect of early visual processing on functional outcomes remained significant, albeit with a reduced effect size. The findings suggest that interventions targeting both early visual processing and social cognition concurrently may improve functional outcomes more effectively than focusing on either domain alone.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100351"},"PeriodicalIF":2.3,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in cognitive performance among young adults with first-episode schizophrenia in China","authors":"NingJing Sang ,&nbsp;YiMin Fan ,&nbsp;HaiYing Chen ,&nbsp;HuiRu Cui ,&nbsp;YanYan Wei ,&nbsp;XiaoChen Tang ,&nbsp;LiHua Xu ,&nbsp;Yi Mei ,&nbsp;JiJun Wang ,&nbsp;TianHong Zhang","doi":"10.1016/j.scog.2025.100353","DOIUrl":"10.1016/j.scog.2025.100353","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with schizophrenia exhibit distinctive patterns of cognitive impairments, which pose difficulties in patients' everyday functionality and reduce patients' quality of life. Previous research suggests that many demographic variables, such as gender and age, influence the cognitive performance profiles of schizophrenia patients; however, the gender differences in neurocognitive dysfunction among first-episode schizophrenia (FES) patients remain less clear.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, we compared the cognitive performance of FES patients to that of healthy controls (HC), with a specific focus on gender differences within the Chinese population aged under 35 years. Cognitive performance was assessed using the raw scores from the MATRICS Consensus Cognitive Battery (MCCB).</div></div><div><h3>Results</h3><div>FES patients show lower overall cognitive impairment across all MCCB domains compared to HCs. Significant sex effects were observed: females outperformed males in aspects of speed of processing and verbal learning in FES, while males outperformed females in parts of working memory and reasoning and problem solving among HC patients. In both FES and HC groups, females exceeded males in visual learning. Moreover, employing a three-way multivariate analysis of variance (MANOVA) displayed interaction effects between gender and clinical diagnosis in areas of speed of processing and verbal learning.</div></div><div><h3>Conclusions</h3><div>This suggests that schizophrenia and biological sex may jointly influence performance in these domains, emphasizing the need for early intervention and gender-sensitive approaches to address cognitive deficits in schizophrenia.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100353"},"PeriodicalIF":2.3,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study on the association between executive functions and social disabilities in people with a psychotic disorder","authors":"B.C. van Aken ,&nbsp;R. Rietveld ,&nbsp;A.I. Wierdsma ,&nbsp;Y. Voskes ,&nbsp;G.H.M. Pijnenborg ,&nbsp;J. van Weeghel ,&nbsp;C.L. Mulder","doi":"10.1016/j.scog.2025.100349","DOIUrl":"10.1016/j.scog.2025.100349","url":null,"abstract":"<div><h3>Background</h3><div>Social recovery (SR) in people with psychotic disorders involves taking on social roles and completing daily tasks. Functional recovery (FR), particularly executive functions, is critical for these roles. Psychotic disorder patients often experience severe cognitive impairments, especially in executive functions. This study investigates the relationship between functional and social recovery in individuals with psychotic disorders and examines the effect of employment status on this association.</div></div><div><h3>Method</h3><div>This cross-sectional study involved people with a psychotic disorder. SR was measured using the WHO-DAS, divided into Daily Functioning (DF) and Social Functioning (SF) scales. FR was measured using the BRIEF-A and the TOL. Employment status was categorized into Non-active, Otherwise Active, and Active. The Likelihood-ratio Test (LRT) was used for model selection.</div></div><div><h3>Results</h3><div>Data from 251 participants (mean age 41.5) showed that the BRIEF-A affected both DF and SF, while the TOL only affected DF. Only being Otherwise Active influenced DF. Employment status had no influence on SF. Being Otherwise Active positively influenced perceived disabilities in Daily Functioning.</div></div><div><h3>Conclusion</h3><div>Measuring executive functions using both performance-based and self-report measures is important. Both measures are associated differently with perceived disabilities in daily and social functioning. Being a volunteer or looking for a job positively influences perceived disabilities in Daily Functioning.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100349"},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social cognitive training among individuals with schizophrenia: Identifying responders to treatment","authors":"Anja Vaskinn ,&nbsp;André Løvgren ,&nbsp;Ole A. Andreassen ,&nbsp;Kjetil Sundet","doi":"10.1016/j.scog.2025.100350","DOIUrl":"10.1016/j.scog.2025.100350","url":null,"abstract":"<div><div>In this follow-up study of a previous randomized controlled trial of targeted facial affect recognition training among individuals with schizophrenia, reliable change indices (RCIs) were employed to identify responders to treatment. The original study found improved theory of mind at 3-month follow-up. The current study included 15 participants who received the intervention and who completed all three assessment points in the original study. Six of them had RCIs over the cutoff (≥+1.64), indicating that they had a clinically meaningful and statistically reliable improvement in ToM. The responders had significantly higher psychotic symptom level at baseline, but no other group differences between responders and nonresponders were identified. The study found no support for suggested moderators of treatment effect of social cognitive training (sex, education). As no consistently replicated barriers to treatment gains have been identified, we suggest that social cognitive training, where available, should be offered to interested clients.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100350"},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study","authors":"Aishwarya Raje ,&nbsp;Abhijit R. Rozatkar ,&nbsp;Urvakhsh Meherwan Mehta ,&nbsp;Ritu Shrivastava ,&nbsp;Ameya Bondre ,&nbsp;Manaal Amir Ahmad ,&nbsp;Anshika Malviya ,&nbsp;Yogendra Sen ,&nbsp;Deepak Tugnawat ,&nbsp;Anant Bhan ,&nbsp;Tamonud Modak ,&nbsp;Nabagata Das ,&nbsp;Srilakshmi Nagendra ,&nbsp;Erlend Lane ,&nbsp;Juan Castillo ,&nbsp;John A. Naslund ,&nbsp;John Torous ,&nbsp;Soumya Choudhary","doi":"10.1016/j.scog.2025.100347","DOIUrl":"10.1016/j.scog.2025.100347","url":null,"abstract":"<div><h3>Introduction</h3><div>Cognitive deficits represent a core symptom of schizophrenia and a principal contributor to illness disability, yet evaluating cognition in routine clinical settings is often not feasible as cognitive assessments take longer than a standard doctor's visit. Using smartphones to assess cognition in schizophrenia offers the advantages of convenience in that patients can complete assessments outside of the clinic, temporality in that longitudinal trends can be identified, and contextuality in that cognitive scores can be interpreted with other measures captured by the phone (e.g. sleep). The current study aims to design a battery of cognitive assessments corresponding to the MATRICs Consensus Battery of Cognition (MCCB), in partnership with people living with schizophrenia.</div></div><div><h3>Methodology</h3><div>Focus group discussions (FGDs) and interviews were conducted with people diagnosed with schizophrenia across three sites (Boston, Bhopal, and Bangalore) to help design, refine, and assess the proposed smartphone battery of cognitive tests on the mindLAMP app. Interviews were conducted between December 2023 and March 2024. Inductive thematic analysis was used to analyze data.</div></div><div><h3>Results</h3><div>Participants found the app and its proposed cognitive assessments to be acceptable, helpful, and easy to use. They particularly found the gamified nature of the cognitive tests to be appealing and engaging. However, they also proposed ways to further increase engagement by including more information about each cognitive test, more visual instructions, and more information about scoring. Across all sites, there were many similarities in themes.</div></div><div><h3>Discussion &amp; conclusion</h3><div>People living with schizophrenia, from different sites in the US and India, appear interested in using smartphone apps to track their cognition. Thematic analysis reinforces the importance of feedback and data sharing, although this presents a challenge, given the novel nature of smartphone-based cognitive measures that have not yet been standardized or validated.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100347"},"PeriodicalIF":2.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143242305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective cognition in schizophrenia and bipolar disorder: Investigation of group differences and associations with objective cognition and clinical characteristics using a novel measure of subjective cognition","authors":"Kristoffer Grimstad ,&nbsp;Håkon Sørensen ,&nbsp;Anja Vaskinn ,&nbsp;Christine Mohn ,&nbsp;Stine Holmstul Olsen ,&nbsp;Ole A. Andreassen ,&nbsp;Trine Vik Lagerberg ,&nbsp;Ingrid Melle ,&nbsp;Merete Glenne Øie ,&nbsp;Torill Ueland ,&nbsp;Beathe Haatveit","doi":"10.1016/j.scog.2025.100345","DOIUrl":"10.1016/j.scog.2025.100345","url":null,"abstract":"<div><div>Cognitive dysfunction is a well-documented feature of schizophrenia (SZ) and bipolar (BD) disorder. The person's subjective experience of cognitive difficulties is less investigated. Here we investigated subjective cognition in SZ and BD compared to healthy controls (HC).</div><div>Subjective and objective cognition were assessed in 91 SZ participants, 55 BD participants and 55 HC, applying a novel measure of subjective cognition, the self-assessed cognitive complaints scale (SACCS) and a clinically relevant neuropsychological test battery. The psychometric properties of SACCS were investigated. The relationship between subjective and objective cognition, and subjective cognition and clinical variables were explored in SZ and BD.</div><div>The SACCS showed adequate psychometric properties. Clinical groups reported significantly more cognitive complaints than HCs, without differences between SZ and BD. There were no significant associations between subjective and objective cognitive measures. There was a small trend association between subjective cognition and insight in SZ participants, and moderate sized associations between subjective cognition and general psychopathology and functioning in BD participants.</div><div>Although SZ participants are more cognitively impaired than BD participants, the two groups report similar levels of subjective cognitive complaints, with no association between subjective and objective cognition. Our results suggest that the expression of subjective cognition is associated with different clinical factors in SZ and BD.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100345"},"PeriodicalIF":2.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive impairments in first-episode psychosis patients with attenuated niacin response","authors":"MingLiang Ju ,&nbsp;Bin Long ,&nbsp;YanYan Wei ,&nbsp;XiaoChen Tang ,&nbsp;LiHua Xu ,&nbsp;RanPiao Gan ,&nbsp;HuiRu Cui ,&nbsp;YingYing Tang ,&nbsp;ZhengHui Yi ,&nbsp;HaiChun Liu ,&nbsp;ZiXuan Wang ,&nbsp;Tao Chen ,&nbsp;Jin Gao ,&nbsp;Qiang Hu ,&nbsp;LingYun Zeng ,&nbsp;ChunBo Li ,&nbsp;JiJun Wang ,&nbsp;HuanZhong Liu ,&nbsp;TianHong Zhang","doi":"10.1016/j.scog.2025.100346","DOIUrl":"10.1016/j.scog.2025.100346","url":null,"abstract":"<div><h3>Background</h3><div>Psychosis is a complex brain disorder with diverse biological subtypes influenced by various pathogenic mechanisms, which can affect treatment efficacy. The ANR(Attenuated Niacin Response) subtype is characterized by pronounced negative symptoms and functional impairments, suggesting a distinct clinical profile. However, research on the cognitive characteristics associated with the ANR subtype in drug-naïve first-episode psychosis(FEP) patients remains limited.</div></div><div><h3>Methods</h3><div>This observational study involved 54 FEP patients and 52 healthy controls(HC). Clinical psychopathology was assessed using the Positive and Negative Syndrome Scale(PANSS), while cognitive performance was evaluated through the Chinese version of the MATRICS Consensus Cognitive Battery(MCCB). Additionally, niacin response was measured using aqueous methylnicotinate patches, with responses quantified to classify participants into ANR or normal niacin response (NNR) groups.</div></div><div><h3>Results</h3><div>Among the FEP patients, 25.9 % were classified as having ANR, significantly higher than the 7.7 % in the HC group (<em>χ</em>^<em>2</em> = 6.247, <em>p</em> = 0.012). The ANR group exhibited more severe negative symptoms and higher total PANSS scores compared to the NNR group, with significant differences in cognitive performance on the Trail Making test and the Brief Visuospatial Memory Test-Revised. Correlation analyses revealed a significant positive relationship between overall symptom severity and niacin response, as well as between cognitive performance and niacin response, particularly for the Trail Making and Symbol coding tests.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that the ANR subtype in first-episode psychosis is linked to more severe negative symptoms and cognitive impairments. Targeted assessments and interventions for patients with ANR may improve treatment outcomes and enhance understanding of cognitive dysfunction in psychotic disorders.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100346"},"PeriodicalIF":2.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered theta band and theta/beta ratio in mismatch negativity associate with treatment effect in schizophrenia with auditory hallucinations","authors":"Qian Guo ,&nbsp;Zexin Zhao ,&nbsp;Wenzheng Wang ,&nbsp;Xiaonan Hu ,&nbsp;Hao Hu ,&nbsp;Yao Hu ,&nbsp;Lihua Xu ,&nbsp;Xu Liu ,&nbsp;Xiaohua Liu ,&nbsp;Guanjun Li ,&nbsp;Zhongying Shi ,&nbsp;Jijun Wang","doi":"10.1016/j.scog.2025.100344","DOIUrl":"10.1016/j.scog.2025.100344","url":null,"abstract":"<div><div>Evidence suggests that attenuated mismatch negative (MMN) waves have a close link to auditory verbal hallucinations (AVH) and their clinical outcomes, especially impaired neural oscillations such as θ, β representing attentional control. In current study, thirty patients with schizophrenia and AVH (SZ) and twenty-nine healthy controls (HC) underwent multi-feature MMN paradigm measurements including frequency and duration deviant stimuli (fMMN and dMMN). Clinical symptoms and MMN paradigm were followed up among SZ group after 8-week treatment. Results demonstrated that hallucinating patients exhibited attenuated dMMN amplitudes across Fz (p = 0.010), F1 (p = 0.020) and F2 (p = 0.014) electrodes, which were trendily recovered after treatment. Meanwhile, θ band and TBR at frontal fMMN and right temporal dMMN were significantly reduced in SZs. After treatment, SZs showed reduced scores of Hoffman's Auditory Hallucinations Rating Scale (AHRS), with a remarkable recovery in right temporal TBR of dMMN (p = 0.042) and a trending change in frontal TBR of fMMN (p = 0.090). The β band was decreased in dMMN (p = 0.035) by time. Additionally, P3 scores of Positive and Negative Syndrome Scale (PANSS) were negatively correlated with θ band of fMMN at baseline. Baseline scores of AHRS negatively predicted changes of dMMN amplitude after treatment, and changes of β band in left temporal dMMN predicted the reduction in scores of PANSS negative scale. These findings supported that deficits in θ oscillation and TBR during auditory attention process were crucial to clinical progression of schizophrenia with AVH.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100344"},"PeriodicalIF":2.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}