Schizophrenia Research-Cognition最新文献

{"title":"Exploring the relationships between Early Childhood Adversity, Social Cognition, and Aggression in a South African Study of People Living with Schizophrenia","authors":"K. van der Walt ,&nbsp;O. Wootton ,&nbsp;J. Rokicki ,&nbsp;A. Vaskinn ,&nbsp;D. Jonker ,&nbsp;M. Campbell ,&nbsp;E. Susser ,&nbsp;U.K. Haukvik ,&nbsp;R.C. Gur ,&nbsp;D.J. Stein ,&nbsp;C. Friestad","doi":"10.1016/j.scog.2025.100382","DOIUrl":"10.1016/j.scog.2025.100382","url":null,"abstract":"<div><div>People living with schizophrenia (PLS) are at increased risk of being both victims and perpetrators of violence. Recent research suggests that social cognitive impairments may contribute to heightened aggression in schizophrenia. Childhood trauma, a well-established risk factor for both schizophrenia and aggression, is also linked to more severe cognitive deficits in PLS. Few studies have explored the relationships between childhood trauma, social cognition, and aggression in large sample sizes, particularly in low- and middle-income settings, where varying socioeconomic factors and exposure to violence may influence these associations. In this study, a subsample of participants (PLS = 585; controls = 882) from the <em>Genomics of Schizophrenia in the South African Xhosa People</em> study completed The Childhood Trauma Questionnaire (CTQ), Penn Emotion Identification Test (ER), Life History of Aggression Questionnaire (LHA), and Structured Diagnostic Interview for DSM-IV Axis I Disorders. Group differences in CTQ, ER, LHA, and selected demographic and clinical factors were assessed using <em>t</em>-tests and chi-square tests. Multivariable linear regressions were employed to test for associations among CTQ, ER, and LHA. We found that PLS had significantly higher childhood trauma and lifetime aggression scores and poorer emotion recognition performance than controls. Higher childhood trauma was associated with higher lifetime aggression and worse emotion recognition performance. However, emotion recognition performance was not associated with lifetime aggression. In this setting, childhood trauma predicts lifetime aggression and poorer emotion recognition, but there is no evidence that emotion recognition ability is related to aggression.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100382"},"PeriodicalIF":3.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring theory of mind abilities in Lebanese chronic patients with schizophrenia: A cross-sectional study","authors":"Marie Ghosn ,&nbsp;Chadia Haddad ,&nbsp;Jean-Marc Rabil ,&nbsp;Georges Haddad","doi":"10.1016/j.scog.2025.100385","DOIUrl":"10.1016/j.scog.2025.100385","url":null,"abstract":"<div><h3>Introduction</h3><div>In recent decades, social cognition has become a central focus in schizophrenia research. Multiple previous studies reported impairments in multiple social cognitive domains. One particular domain of social cognition affected in schizophrenia is “Theory of Mind (TOM). The objective of this study was to examine the heterogeneity of ToM impairments within the schizophrenia population and compare TOM performance between individuals diagnosed with schizophrenia and a matched healthy control group.</div></div><div><h3>Methods</h3><div>a cross-sectional study was conducted between June 2024 and September 2024 at the Psychiatric Hospital of the Cross (HPC) in Lebanon that explored TOM abilities in 146, chronic Lebanese schizophrenia inpatients and 50 healthy controls, using the Arabic translation of the “TOM-15,” a False Belief Task.</div></div><div><h3>Results</h3><div>A significant difference between schizophrenia patients and healthy controls was found, with the patient group scoring poorer on both first-order, and second-order false belief and in the comprehension control task of the TOM-15. Furthermore, among the patient population, impairments in second-order false belief were more pronounced than first-order. Performance on the BACS scale for neuro-cognition showed moderate associations with performance on the TOM-15. Multivariable analysis revealed a negative association between depression and second-order tasks as well as females outperforming males in TOM-15, especially in the second-order task.</div></div><div><h3>Conclusion</h3><div>The results revealed significant TOM impairments in patients with schizophrenia as compared to healthy controls, with greater difficulties observed in second-order false belief tasks.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100385"},"PeriodicalIF":3.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wide Range Achievement Test word reading subtest score as an indicator of premorbid intellectual disability in serious mental illness","authors":"Susan R. McGurk ,&nbsp;Renata Botello ,&nbsp;Daniel Fulford ,&nbsp;Kim T. Mueser","doi":"10.1016/j.scog.2025.100381","DOIUrl":"10.1016/j.scog.2025.100381","url":null,"abstract":"<div><h3>Objective</h3><div>Performance on reading tests is often used as an indicator of premorbid intellectual disability in individuals with serious mental illness (SMI), but independent evidence validating their use is lacking. This study evaluated the accuracy of the Wide Range Achievement Test Word Reading Subtest in predicting history of intellectual disability in people with SMI.</div></div><div><h3>Methods</h3><div>Participants were 105 people with SMI (62.8 % schizophrenia) with either a confirmed history of intellectual disability based on medical record review (Confirmed ID; <em>n</em> = 18) or no such history (No ID; <em>n</em> = 87). Participants were administered the WRAT-III Reading Subtest, the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery, and three other cognitive tests. A receiver operator characteristics (ROC) curve was fit to identify the optimal cutoff score on the WRAT for correctly classifying the Confirmed ID and No ID groups. <em>t</em>-tests and effect sizes were used to compare the two groups on the WRAT and cognitive tests.</div></div><div><h3>Results</h3><div>The ROC curve indicated that a cutoff score of 70 or below on the WRAT correctly identified 88.9 % of individuals with Confirmed ID (sensitivity) and incorrectly identified 5.6 % of individuals with No ID (Specificity) (<em>p</em> &lt; .001). Performance on the cognitive battery was worse in the Confirmed ID group than No ID group, but the effect size for the WRAT was higher than any of the cognitive tests.</div></div><div><h3>Conclusions</h3><div>A WRAT Word Reading Subtest score of ≤70 is a strong indicator of premorbid intellectual disability in people with SMI.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100381"},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and administration of the flexible adapted cognitive test battery for schizophrenia (FACTS)","authors":"Bing Cai ,&nbsp;William S. Stone ,&nbsp;Xinyi Ouyang ,&nbsp;Fei Deng ,&nbsp;Hanhui Chen ,&nbsp;Min Qian ,&nbsp;Margaux M. Grivel ,&nbsp;Matcheri S. Keshavan ,&nbsp;Ezra S. Susser ,&nbsp;Lawrence H. Yang ,&nbsp;Michael R. Phillips","doi":"10.1016/j.scog.2025.100377","DOIUrl":"10.1016/j.scog.2025.100377","url":null,"abstract":"<div><h3>Background</h3><div>Age and educational eligibility criteria for administration of the most widely used cognitive battery for schizophrenia typically exclude 20 % of individuals with schizophrenia in high-income countries and 25–50 % in middle- and low-income countries.</div></div><div><h3>Methods</h3><div>We developed the Flexible Adapted Cognitive Test battery for Schizophrenia (FACTS) that can be administered to <em>all</em> individuals with schizophrenia, regardless of age or education. To evaluate the utility and validity of the nine tests in the FACTS, two process measures are assessed during the administration of each test: ‘test comprehension’ and ‘test completion’ (successful or unsuccessful). The FACTS was administered to 495 community-dwelling individuals with schizophrenia and 308 healthy controls, including 473 (58.9 %) older or undereducated individuals typically excluded from studies of cognition in schizophrenia. Inter-rater reliability of the test comprehension and completion measures was assessed.</div></div><div><h3>Findings</h3><div>Older, undereducated participants successfully completed 82 % (3499/4257) of the administered tests. The mean weighted Kappa value for the nine test comprehension measures was 0.90 (range: 0.82–0.96), and the mean unweighted Kappa for the 20 test and subtest completion measures was 0.94 (range: 0.85–1.00).</div></div><div><h3>Interpretation</h3><div>Cognitive functioning is a core symptom cluster of schizophrenia, so the comprehensive assessment of cognitive functioning must become a standard part of the assessment of <em>all</em> individuals with schizophrenia, regardless of age or education. The development of the FACTS, which can be successfully administered to most older, undereducated individuals with schizophrenia, provides a model for doing this.</div></div><div><h3>Funding</h3><div>This study was supported by National Institute of Mental Health grants MH108385-R01 and MH127631-R01.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100377"},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The aperiodic and periodic activities of EEG dynamically relate with cognitive performance in schizophrenia","authors":"Kexin Zhang ,&nbsp;Yunfei Ji ,&nbsp;Xiaodong Guo ,&nbsp;Tianqi Gao ,&nbsp;Xuemin Zhang ,&nbsp;Xin Yu ,&nbsp;Jing Wang","doi":"10.1016/j.scog.2025.100383","DOIUrl":"10.1016/j.scog.2025.100383","url":null,"abstract":"<div><h3>Background</h3><div>Aperiodic and periodic activities of electrophysiological signals have strong correlation with various neurocognitive factors. In the current study, we aim to investigate the aperiodic exponent and periodic oscillations (alpha and beta band power) and their associations with cognitive performance in schizophrenia (SCZ).</div></div><div><h3>Methods</h3><div>We enrolled 32 SCZ patients and 33 healthy controls (HC) for the study. Cognitive performance was assessed using the total Brief Assessment of Cognition in Schizophrenia (BACS). Before and after the language comprehension tasks (humor, metaphor and irony), the 5-min eyes-closed and eyes-open EEG signals were collected respectively. The aperiodic exponent and periodic power were extracted and obtained according to the division of brain regions. Finally, Pearson correlation was used to examine the relationships between the EEG parameters and behavioral measures.</div></div><div><h3>Results</h3><div>SCZ participants exhibited higher aperiodic exponents and lower periodic oscillations compared to HC. The aperiodic exponent decreased significantly after the tasks in central location (<em>F</em> (56,1) = 8.93, <em>P</em> = 0.004, <em>η</em>² = 0.14) in both groups, while the periodic oscillations had no significant change. The variance of the aperiodic exponent showed significantly negative correlation with <em>Z</em> scores of humor comprehension tasks (<em>r</em> = −0.42, <em>P</em> = 0.027) in SCZ. Besides, the pre-tasks aperiodic exponent in posterior location positively correlated with <em>T</em> scores of attention and speed of information processing (<em>r</em> = 0.35, <em>P</em> = 0.048).</div></div><div><h3>Conclusions</h3><div>Our findings confirmed the higher aperiodic exponent with lower alpha and beta band in SCZ, along with the variability and task-responsiveness of the aperiodic exponent. The findings suggest that aperiodic exponent holds strong cognitive functional implications in SCZ.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100383"},"PeriodicalIF":3.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theory-of-mind improvement in schizophrenia after integrative cognitive remediation: which patients benefit more?","authors":"Agurne Sampedro ,&nbsp;Javier Peña ,&nbsp;Pedro Sánchez ,&nbsp;Naroa Ibarretxe-Bilbao ,&nbsp;Nagore Iriarte-Yoller ,&nbsp;Cristóbal Pavón ,&nbsp;Natalia Ojeda","doi":"10.1016/j.scog.2025.100380","DOIUrl":"10.1016/j.scog.2025.100380","url":null,"abstract":"<div><div>Social cognition, and specifically theory of mind, is considered a key factor in predicting functional outcomes and quality of life in schizophrenia. Although cognitive remediation is an effective intervention for improving theory of mind, little is known about the factors that moderate this improvement. Therefore, the aim of this study is to identify moderators of theory-of-mind improvement in schizophrenia after integrative cognitive remediation (REHACOP). Data from two randomized controlled trials were used in this secondary analysis. The sample included 182 patients (experimental group = 94; active control group = 88) from the Mental Health Network in Álava (Spain). A comprehensive assessment of clinical symptoms, neurocognition, theory of mind, and functional outcome at baseline and follow-up was carried out. Hierarchical regression analyses were used to identify moderators of theory-of-mind improvement. Regardless of the patients' initial profiles, the REHACOP was effective in improving theory of mind (<em>F</em> = 27.00, <em>p</em> &lt; .001). Regression analyses, however, revealed that baseline neurocognition (<em>β</em> = −0.223, <em>t</em> = −2.075, <em>p</em> = .039), baseline theory of mind (<em>β</em> = −0.325, <em>t</em> = −3.100, <em>p</em> = .002), and baseline positive symptoms (<em>β</em> = −0.243, <em>t</em> = −2.296, <em>p</em> = .023) played a moderating role in the improvement of theory of mind after the REHACOP. Results showed that those participants with lower baseline neurocognition and theory-of-mind scores and less positive symptoms obtained greater theory-of-mind benefits. Determining the factors that account for the different patterns of improvement after cognitive remediation could be helpful in the implementation of personalized cognitive remediation plans and for the appropriate use of healthcare resources.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100380"},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between cognitive reserve (education), social cognition and negative symptoms","authors":"Sebastián Lema Spinelli ,&nbsp;Juan Francisco Rodríguez-Testal ,&nbsp;Álvaro Cabana ,&nbsp;Sandra Romano ,&nbsp;Leonel Gómez-Sena","doi":"10.1016/j.scog.2025.100379","DOIUrl":"10.1016/j.scog.2025.100379","url":null,"abstract":"<div><h3>Background</h3><div>Negative symptoms (NS) are a core feature of schizophrenia spectrum disorders, yet their relationship with cognitive reserve (defined by educational attainment) and social cognition remains underexplored. This study examined whether education predicts NS and whether this relationship is mediated by social cognition, specifically emotional or inferential theory of mind Reading the Mind in the Eyes Test (RMET) vs. the Hinting Test.</div></div><div><h3>Methods</h3><div>A mediation model and multiple regression analysis were conducted within an ex-post-facto, cross-sectional design. The sample included 144 participants: 69 diagnosed with schizophrenia spectrum disorders and 75 healthy controls. Women comprised 52.8 % of the sample, with a mean age of 42.67 years (<em>SD</em> = 15.88). The average years of formal education were 8.37 (<em>SD</em> = 2.77) in the patient group and 8.62 (<em>SD</em> = 3.66) in the control group.</div></div><div><h3>Results</h3><div>The mediation model explained 67.57 % of the variance in NS, with age as a covariate. RMET showed a significant indirect effect (<em>d</em> = −0.22) in predicting NS, while HT did not (<em>d</em> = −0.12). In the patient group, multiple regression analysis explained 69.2 % of the variance, with education emerging as a significant predictor of NS.</div></div><div><h3>Conclusions</h3><div>Education, as an indicator of cognitive reserve, significantly predicts NS. This relationship is mediated by social cognition, with differential effects depending on the specific type of social cognition, either within the patient group or across the entire sample. These findings highlight the importance of cognitive reserve and social cognition in understanding and potentially mitigating NS in schizophrenia.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100379"},"PeriodicalIF":2.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired effort allocation in schizophrenia","authors":"Elodie Blouzard ,&nbsp;Fabien Cignetti ,&nbsp;Florent Meyniel ,&nbsp;Arnaud Pouchon ,&nbsp;Mircea Polosan ,&nbsp;Julien Bastin ,&nbsp;Clément Dondé","doi":"10.1016/j.scog.2025.100378","DOIUrl":"10.1016/j.scog.2025.100378","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>Effort allocation is a crucial component of amotivation in schizophrenia. This study investigates the hypothesis that schizophrenia is associated with impairments in dynamic cost/benefit decision-making processes.</div></div><div><h3>Study design</h3><div>We employed a modified version of the effort allocation task developed by Meyniel et al. (2013). Participants were asked to allocate effort during 30-s intervals to maximize their gains. We examined the effects of task difficulty and incentive levels on participants' effort allocation on a trial-by-trial basis.</div></div><div><h3>Study results</h3><div>Individuals with schizophrenia (<em>N</em> = 25) showed decreased capacity to adapt dynamically to task parameters, as compared to healthy controls (N = 25). (1) Both populations increased the duration of each effort based on difficulty. Only healthy controls decreased rest duration based on incentive. The magnitude of these adaptations was significantly decreased in people with schizophrenia (difficulty: d = 1.25, incentive: d = 0.91). (2) Both groups decreased effort re-initiations with increasing difficulty with significant differences in the magnitude of adaptation between groups. (3) Participants with schizophrenia spent less time exerting effort above the required threshold, resulting in lower overall gains compared to healthy controls (η² = 0.17).</div></div><div><h3>Conclusions</h3><div>Individuals with schizophrenia exhibit a selective impairment in effort-cost decision-making. This deficit may contribute to maladaptive behavior patterns characterized by suboptimal effort allocation and reduced goal-direct activities.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100378"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness and management of cognitive impairment associated with schizophrenia in psychiatrists and patients: Results from a cross-sectional survey","authors":"Tomiki Sumiyoshi ,&nbsp;Satoru Ikezawa ,&nbsp;Kaori Inaba ,&nbsp;Tatsuro Marumoto ,&nbsp;Ichiro Kusumi ,&nbsp;Kazuyuki Nakagome","doi":"10.1016/j.scog.2025.100375","DOIUrl":"10.1016/j.scog.2025.100375","url":null,"abstract":"<div><div>This study evaluated awareness, management, and the burden of cognitive impairment associated with schizophrenia (CIAS) in Japan. A non-interventional, cross-sectional study was conducted online between April and December 2023, involving 149 psychiatrists and 852 patients. Psychiatrists prioritized controlling positive symptoms in the acute phase of the illness, while improving social functioning was the top priority for the maintenance/stable phase. Management of CIAS was regarded as most important for the reintegration of patients into society. Psychiatrists reported higher occurrence of CIAS among inpatients than outpatients. While 72 % of psychiatrists assessed CIAS, only 15 % used the Brief Assessment of Cognition in Schizophrenia. Further, 58 % of them reported that ≤40 % of their patients received interventions for CIAS. Sixty-eight percent of patients reported current or previous experiences of CIAS. The most common CIAS-related burdens were “unable to perform tasks I could do before or they take longer” (65 %) and “unable to maintain concentration” (64 %). In patients not currently experiencing CIAS (<em>n</em> = 496), these burdens were reported by 52 % and 50 %, respectively. Although CIAS was generally recognized by psychiatrists, the use of appropriate assessment tools and interventions was not common. While many patients reported CIAS-related burdens, a substantial proportion of them were unaware of CIAS. These observations indicate that the greater awareness of CIAS may facilitate its management in clinical practice, thus enhancing the ability of patients to reintegrate into society.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100375"},"PeriodicalIF":2.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feature binding and detachment in psychosis: A virtual reality study","authors":"A.J. (Ante) Schlesselmann ,&nbsp;G.H.M. (Marieke) Pijnenborg ,&nbsp;S.A. (Saskia) Nijman ,&nbsp;W. (Wim) Veling ,&nbsp;R.J.C. (Rafaele) Huntjens","doi":"10.1016/j.scog.2025.100376","DOIUrl":"10.1016/j.scog.2025.100376","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia spectrum disorders (SSDs) significantly impact daily functioning, particularly through cognitive deficits like memory impairment. Traditionally attributed to neurobiological factors, recent evidence highlights the role of psychological processes like detachment, which may disrupt episodic memory encoding and retrieval by impairing feature binding. This study used a virtual reality (VR) paradigm to explore whether state detachment in SSDs is linked to impaired feature binding for adverse stimuli.</div></div><div><h3>Methods</h3><div>Twenty-five SSD patients from Dutch mental health centers and 25 individuals from the general population participated. Using an immersive VR paradigm, participants navigated a virtual shopping mall, interacted with 3D avatars, and identified their emotional facial expressions. Three memory tests followed: avatar identity recognition (basic memory), binding emotional expressions to avatars, and binding avatar identity to the encounter's temporal order. State detachment was measured using the Clinician-Administered Dissociative States Scale (CADSS).</div></div><div><h3>Results</h3><div>The SSD and comparison group did not display significant performance differences in any of the three feature binding tasks. However, across groups, results indicated that higher state detachment levels corresponded with worsened identity-emotion binding specifically for angry faces.</div></div><div><h3>Conclusion</h3><div>The present study provides tentative empirical support for the role of detachment in feature binding deficits for angry faces both in the patient and comparison group. Future studies should further explore the impact of psychological mechanisms like detachment on memory dysfunction, particularly regarding aversive stimuli.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100376"},"PeriodicalIF":2.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}