Schizophrenia Research-Cognition最新文献

{"title":"The altered volume of striatum: A neuroimaging marker of treatment in first-episode and drug-naïve schizophrenia","authors":"Gao-Xia Wei ,&nbsp;Haoran Shen ,&nbsp;Li-Kun Ge ,&nbsp;Bo Cao ,&nbsp;Roja Manohar ,&nbsp;Xiangyang Zhang","doi":"10.1016/j.scog.2024.100308","DOIUrl":"https://doi.org/10.1016/j.scog.2024.100308","url":null,"abstract":"<div><p>Although schizophrenia patients exhibit structural abnormalities in the striatum, it remains largely unknown for the role of the striatum subregions in the treatment response of antipsychotic drugs. The purpose of this study was to investigate the associations between the striatal subregions and improved clinical symptoms in first-episode drug-naïve (FEDN) schizophrenia. Forty-two FEDN schizophrenia patients and 29 healthy controls (HCs) were recruited. At baseline, the Positive and Negative Syndrome Scale (PANSS) was used to assess the clinical symptoms of patients, MRI scanner was used to obtain anatomical images of patients and HCs. After 12-week stable doses of risperidone treatment, clinical symptoms were obtained in 38 patients and anatomical images in 26 patients. After 12 weeks of treatment, the left nucleus accumbens volume decreased, whereas the left pallidum volume increased in schizophrenia patients. The decreased left nucleus accumbens volume was positively correlated with cognitive factor improvement measured by PANSS. Intriguingly, greater left nucleus accumbens volume at baseline predicted greater cognitive improvements. Furthermore, the responders who had &gt;50 % improvement in cognitive symptoms exhibited significantly greater baseline left nucleus accumbens volume compared to non-responders. The left striatum volume at baseline and after treatment predicted the cognitive improvements in FEDN schizophrenia, which could be a potential biomarker for the development of precision medicine approaches targeting cognitive function.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100308"},"PeriodicalIF":2.8,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221500132400009X/pdfft?md5=3db7db2504f4a598c689ad17e67a8aa6&pid=1-s2.0-S221500132400009X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140113786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identity recognition from faces and bodies in schizophrenia spectrum disorders","authors":"Madisen T. Russell ,&nbsp;Michal Hajdúk ,&nbsp;Cassi R. Springfield ,&nbsp;Hans S. Klein ,&nbsp;Emily L. Bass ,&nbsp;Vijay A. Mittal ,&nbsp;Trevor F. Williams ,&nbsp;Alice J. O’Toole ,&nbsp;Amy E. Pinkham","doi":"10.1016/j.scog.2024.100307","DOIUrl":"https://doi.org/10.1016/j.scog.2024.100307","url":null,"abstract":"<div><p>Deficits in facial identity recognition and its association with poor social functioning are well documented in schizophrenia, but none of these studies have assessed the role of the body in these processes. Recent research in healthy populations shows that the body is also an important source of information in identity recognition, and the current study aimed to thoroughly examine identity recognition from both faces and bodies in schizophrenia. Sixty-five individuals with schizophrenia and forty-nine healthy controls completed three conditions of an identity matching task in which they attempted to match unidentified persons in unedited photos of faces and bodies, edited photos showing faces only, or edited photos showing bodies only. Results revealed global deficits in identity recognition in individuals with schizophrenia (η_p² = 0.068), but both groups showed better recognition from bodies alone as compared to faces alone (η_p² = 0.573), suggesting that the ability to extract useful information from bodies when identifying persons may remain partially preserved in schizophrenia. Further research is necessary to understand the relationship between face/body processing, identity recognition, and functional outcomes in individuals with schizophrenia-spectrum disorders.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100307"},"PeriodicalIF":2.8,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215001324000088/pdfft?md5=a0778242a047837b81670f43259fc1a4&pid=1-s2.0-S2215001324000088-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using virtual reality to improve verbal episodic memory in schizophrenia: A proof-of-concept trial","authors":"Bryce J.M. Bogie ,&nbsp;Chelsea Noël ,&nbsp;Feng Gu ,&nbsp;Sébastien Nadeau ,&nbsp;Cecelia Shvetz ,&nbsp;Hassan Khan ,&nbsp;Marie-Christine Rivard ,&nbsp;Stéphane Bouchard ,&nbsp;Martin Lepage ,&nbsp;Synthia Guimond","doi":"10.1016/j.scog.2024.100305","DOIUrl":"https://doi.org/10.1016/j.scog.2024.100305","url":null,"abstract":"<div><h3>Background</h3><p>Schizophrenia is associated with impairments in verbal episodic memory. Strategy for Semantic Association Memory (SESAME) training represents a promising cognitive remediation program to improve verbal episodic memory. Virtual reality (VR) may be a novel tool to increase the ecological validity and transfer of learned skills of traditional cognitive remediation programs. The present proof-of-concept study aimed to assess the feasibility, acceptability, and preliminary efficacy of a VR-based cognitive remediation module inspired by SESAME principles to improve the use of verbal episodic memory strategies in schizophrenia.</p></div><div><h3>Methods</h3><p>Thirty individuals with schizophrenia/schizoaffective disorder completed this study. Participants were randomized to either a VR-based verbal episodic memory training condition inspired by SESAME principles (intervention group) or an active control condition (control group). In the training condition, a coach taught semantic encoding strategies (active rehearsal and semantic clustering) to help participants remember restaurant orders in VR. In the active control condition, participants completed visuospatial puzzles in VR. Attrition rate, participant experience ratings, and cybersickness questionnaires were used to assess feasibility and acceptability. Trial 1 of the Hopkins Verbal Learning Test – Revised was administered pre- and post-intervention to assess preliminary efficacy.</p></div><div><h3>Results</h3><p>Feasibility was demonstrated by a low attrition rate (5.88 %), and acceptability was demonstrated by limited cybersickness and high levels of enjoyment. Although the increase in the number of semantic clusters used following the module did not reach conventional levels of statistical significance in the intervention group, it demonstrated a notable trend with a medium effect size (<em>t</em> = 1.48, <em>p</em> = 0.15, <em>d</em> = 0.54), in contrast to the control group where it remained stable (<em>t</em> = 0.36, <em>p</em> = 0.72, <em>d</em> = 0.13). These findings were similar for the semantic clustering ratio in the intervention (<em>t</em> = 1.61, <em>p</em> = 0.12, <em>d</em> = 0.59) and control (<em>t</em> = 0.36, <em>p</em> = 0.72, <em>d</em> = 0.13) groups. There was no significant change in the number of recalled words in either group following VR immersion.</p></div><div><h3>Discussion</h3><p>This VR intervention was feasible, acceptable, and may be useful for improving the use of semantic encoding strategies. These findings support the use of more ecological approaches for the treatment of cognitive impairments in schizophrenia, such as VR-based cognitive remediation.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100305"},"PeriodicalIF":2.8,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215001324000064/pdfft?md5=46bb3243972af3d0359d1eb580f2c628&pid=1-s2.0-S2215001324000064-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of hemispheric asymmetry in executive control of attention in schizophrenia with atypical antipsychotic treatment: Potential benefits of olanzapine","authors":"Yong Zhao ,&nbsp;Yifan Li ,&nbsp;Jing Du ,&nbsp;Chuanlong Fang ,&nbsp;Wansheng Li ,&nbsp;Mengyu Lv ,&nbsp;Yue Wu ,&nbsp;Kai Wang ,&nbsp;Tingting Wu ,&nbsp;Yanghua Tian ,&nbsp;Juanjuan Zhang","doi":"10.1016/j.scog.2024.100306","DOIUrl":"https://doi.org/10.1016/j.scog.2024.100306","url":null,"abstract":"<div><p>Deficits in executive control of attention have been reported in schizophrenia patients, but can be ameliorated by treatment of atypical antipsychotics along with the symptoms. However, it remains unclear whether this effect is related to a modulation of hemispheric asymmetry in executive control by the medicine. In this behavioral study, we employed a lateralized version of the attention network test to examine the hemispheric asymmetry of executive control in schizophrenia patients before and after olanzapine treatment, compared to matched healthy controls. Executive control was measured as a conflict effect, indexed as the response time (RT) difference between incongruent versus congruent flanker conditions, and was compared between stimuli presented in the left and the right visual field (i.e., processed by right versus left hemisphere of the brain). Results showed that pre-treatment schizophrenia patients revealed a right hemisphere superiority in conflict effect (i.e., a smaller effect in the right hemisphere than in the left hemisphere), driven by the incongruent condition. Olanzapine treatment reduced this right hemisphere superiority by improving the efficiency of the left hemisphere in the incongruent condition. These results suggested that olanzapine treatment may improve the efficiency of executive control in the left hemisphere in schizophrenia patients.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100306"},"PeriodicalIF":2.8,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215001324000076/pdfft?md5=6d1288b55e8a6db482e758adf9cbb0ed&pid=1-s2.0-S2215001324000076-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the HHEX polymorphism and delayed memory in first-episode schizophrenic patients","authors":"Zhen Hua Zhu ,&nbsp;Xu Yuan Yin ,&nbsp;Yuan Cai ,&nbsp;Ning Ning Jia,&nbsp;Pei Jie Wang,&nbsp;Qi Qi,&nbsp;Wen Long Hou,&nbsp;Li Juan Man,&nbsp;Li Hui","doi":"10.1016/j.scog.2024.100304","DOIUrl":"https://doi.org/10.1016/j.scog.2024.100304","url":null,"abstract":"<div><p>The hematopoietically-expressed homeobox gene (<em>HHEX</em>) played a critical role in regulating the immune system that the abnormality of which was involved in the psychopathology and cognitive deficits of psychiatric disorders. The aim of this study was to investigate the effect of <em>HHEX</em> rs1111875 polymorphism on the susceptibility and cognitive deficits of first-episode schizophrenic patients (FSP). We assessed cognitive function in 239 first-episode patients meeting DSM-IV for schizophrenia, and 368 healthy controls using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The <em>HHEX</em> rs1111875 polymorphism was genotyped. Our results showed that the allelic and genotypic frequencies of <em>HHEX</em> rs1111875 polymorphism didn't differ between FSP and healthy controls (both <em>p</em> &gt; 0.05) after adjusting for sex and age. Cognitive test scores in FSP were significantly lower than those in healthy controls on all scales (all <em>p</em> &lt; 0.001) except for the visuospatial/constructional score (<em>p</em> &gt; 0.05) after adjusting for covariates. There was a significant genotype (<em>p</em> &lt; 0.05) rather than genotype × diagnosis (<em>p</em> &gt; 0.05) effect on the delayed memory score after adjusting for covariates. The <em>HHEX</em> rs1111875 polymorphism was significantly associated with the delayed memory score in FSP (<em>p</em> &lt; 0.05), but not in healthy controls (<em>p</em> &gt; 0.05) after adjusting for covariates. Our findings supported that the <em>HHEX</em> rs1111875 polymorphism did not contribute to the susceptibility to FSP. However, this polymorphism might influence the delayed memory in FSP. Moreover, FSP had poorer cognitive function than healthy controls except for the visuospatial/constructional domain.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100304"},"PeriodicalIF":2.8,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215001324000052/pdfft?md5=b564fe8ebdeb78249546fe3e59641d9e&pid=1-s2.0-S2215001324000052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139992564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: “Associative learning and facial expression recognition in schizophrenic patients: Effects of social presence” and “Does cannabis affect cognitive functioning in patients with schizophrenia?”","authors":"Mehmet Hamdi Örüm","doi":"10.1016/j.scog.2024.100303","DOIUrl":"https://doi.org/10.1016/j.scog.2024.100303","url":null,"abstract":"","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100303"},"PeriodicalIF":2.8,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215001324000040/pdfft?md5=8c508213df5f70de6ad5ce7d7b1e21bd&pid=1-s2.0-S2215001324000040-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Face and emotion recognition in individuals diagnosed with schizophrenia, ultra-high risk for psychosis, unaffected siblings, and healthy controls in a sample from Turkey","authors":"Meylin Sağdıç ,&nbsp;Busra Izgi ,&nbsp;Hale Yapici Eser ,&nbsp;Mete Ercis ,&nbsp;Alp Üçok ,&nbsp;Kemal Kuşçu","doi":"10.1016/j.scog.2024.100301","DOIUrl":"https://doi.org/10.1016/j.scog.2024.100301","url":null,"abstract":"<div><p>Face and emotion recognition are crucial components of social cognition. We aimed to compare them in patients diagnosed with schizophrenia (SCZ), ultra-high risk for psychosis (UHR), unaffected siblings of schizophrenia patients (SIB), and healthy controls (HC). Methods: One hundred sixty-six participants (45 SCZ, 14 UHR, 45 SIB, and 62 HC) were interviewed with the Structured Clinical Interview for DSM-5 (SCID-5). Positive and Negative syndrome scale (PANSS), PennCNB Facial Memory (CPF), and Emotion Recognition Task (ER40) were applied. Results: In CPF, SCZ performed significantly lower than SIB and HC. SIB was also significantly lower than HC for total correct responses. The sample size of the UHR group was small, and the statistical comparisons did not reach a significance, however, a trend towards decreased performance between the SCZ and SIB was found. In ER40, SCZ performed significantly lower than HC and SIB in all domains, except for the insignificant findings for angry ER between SIB and SCZ. SIB also performed significantly lower than HC for angry, negative, and total ER. UHR was similar to SCZ for happy and sad ER and performed significantly lower than HC for happy ER. The effect of SCZ diagnosis on the efficiency of CPF and ER40 was significant when corrected for age and education. For SCZ, PANSS also significantly affected the CPF and ER40. Conclusion: Our findings suggest varying levels of face and emotion recognition deficits in individuals with SCZ, UHR, and SIB. Face and emotion recognition deficits are promising schizophrenia endophenotypes related to social cognition.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100301"},"PeriodicalIF":2.8,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215001324000027/pdfft?md5=d37998e11d62fbeeed315aef9dd08ef0&pid=1-s2.0-S2215001324000027-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Montreal Cognitive Assessment (MoCA) as a screening tool for cognitive impairment in early stages of psychosis","authors":"Sebastian Corral ,&nbsp;Pablo A. Gaspar ,&nbsp;Rolando I. Castillo-Passi ,&nbsp;Rocío Mayol Troncoso ,&nbsp;Adrian P. Mundt ,&nbsp;Yuriy Ignatyev ,&nbsp;Rodrigo R. Nieto ,&nbsp;Alicia Figueroa-Muñoz","doi":"10.1016/j.scog.2024.100302","DOIUrl":"https://doi.org/10.1016/j.scog.2024.100302","url":null,"abstract":"<div><h3>Background</h3><p>Cognitive alterations have been reported in early stages of psychosis including people with First Episode Psychosis (FEP), Clinical High-Risk Mental State (CHR), and Psychotic-Like Experience (PLE). This study aimed to compare the cognitive function in early stages of psychosis using the Montreal Cognitive Assessment (MoCA), a low-cost and brief assessment tool of cognitive functions.</p></div><div><h3>Methods</h3><p>A total of 154 individuals, including 35 with FEP, 38 CHR, 44 PLE, and 37 healthy controls (HC), were evaluated with the MoCA in Santiago, Chile. We calculated the mean total score of the MoCA and the standard deviation of the mean. Groups were assessed for a trend to lower scores in a pre-determined sequence (HC &gt; PLE &gt; CHR &gt; FEP) using the Jonckheere-Terpstra test (T_JT).</p></div><div><h3>Results</h3><p>The mean total MoCA scores were 24.8 ± 3.3 in FEP, 26.4 ± 2.4 in CHR, 26.4 ± 2.3 in PLE, and 27.2 ± 1.8 in HC. The analyses revealed a significant trend (<em>p</em> &lt; 0.05) toward lower MoCA individual domain scores and MoCA total scores in the following order: HC &gt; PLE &gt; CHR &gt; FEP. The mean total scores of all groups were above the cut-off for cognitive impairment (22 points).</p></div><div><h3>Conclusions</h3><p>The MoCA describes lower scores in cognition across early stages of psychosis and may be a useful low-cost assessment instrument in early intervention centers of poorly resourced settings.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100302"},"PeriodicalIF":2.8,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215001324000039/pdfft?md5=587b5439eb1eff38cb600473207ca4c7&pid=1-s2.0-S2215001324000039-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139653021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between anemia and its correlates and cognitive function in Chinese patients with chronic schizophrenia: A large cross-sectional study","authors":"Yang Jiang ,&nbsp;Yi Cai ,&nbsp;Yaoyao Lu ,&nbsp;Guanghui Wu ,&nbsp;Xiang-Yang Zhang","doi":"10.1016/j.scog.2024.100300","DOIUrl":"https://doi.org/10.1016/j.scog.2024.100300","url":null,"abstract":"<div><h3>Background</h3><p>Although both anemia and schizophrenia (SCZ) can cause cognitive decline, it is unclear whether anemia worsens cognitive decline in patients with SCZ. The primary objective of this study was to investigate the prevalence of anemia and the relationship between anemia, SCZ symptom severity, and cognitive function in patients with SCZ.</p></div><div><h3>Methods</h3><p>We obtained demographic and clinical data from 1690 inpatients with SCZ. All psychiatric symptoms and cognitive functioning were assessed by the Positive and Negative Syndrome Scale (PANSS), the Mini-Mental State Examination (MMSE), and the Repeated Battery for the Assessment of Neuropsychological Status (RBANS). Hemoglobin (HGB) values as well as red blood cell (RBC) counts were collected by routine blood tests.</p></div><div><h3>Results</h3><p>The proportion of anemia in patients with SCZ was 26.36 % (383/1453). Compared to SCZ patients without anemia, SCZ patients with anemia were older, had a lower bodyweight, a smaller waist circumference and lower apolipoprotein B levels, but longer QT intervals. Further logistic regression analysis revealed that anemia was associated with age, gender, and weight. In addition, there was no difference in cognitive function between SCZ patients with and without anemia.</p></div><div><h3>Conclusion</h3><p>Our findings suggest a high proportion of anemia in patients with chronic SCZ in the Han Chinese population. Several demographic and clinical variables are associated with anemia in SCZ patients.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100300"},"PeriodicalIF":2.8,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215001324000015/pdfft?md5=6d3386b437b972b7a0075de28ca6d8d5&pid=1-s2.0-S2215001324000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does cannabis affect cognitive functioning in patients with schizophrenia?","authors":"Hajar Rachid ,&nbsp;Zineb Saif ,&nbsp;Salma Raoui ,&nbsp;Zineb Serhier ,&nbsp;Mohamed Agoub","doi":"10.1016/j.scog.2023.100299","DOIUrl":"https://doi.org/10.1016/j.scog.2023.100299","url":null,"abstract":"<div><h3>Introduction</h3><p>Cannabis use impairs cognitive performance in healthy subjects; several studies have shown improved cognitive outcomes in schizophrenic patients using cannabis. The aim of this study was to evaluate the effects of cannabis use on cognitive function in Moroccan patients with schizophrenia who were cannabis users.</p></div><div><h3>Method</h3><p>Two groups were recruited in a Moroccan University Psychiatric Centre. Fifty patients diagnosed with schizophrenia according to the DSM-V who were cannabis users (SZ CANN +) and forty-nine patients diagnosed with schizophrenia according to DSM-V who do not use cannabis (SZ CANN-). Cognitive functioning was assessed using the CogState neuropsychological battery.</p></div><div><h3>Results</h3><p>The results of the study suggest that SZ CANN- patients performed better in the test of psychomotor function, attention and verbal memory. While SZ CANN+ patients performed better in the test of working memory, visual memory and emotional recognition. We found no relationship between SZ CANN+ patients and SZ CANN- patients concerning executive function.</p></div><div><h3>Conclusions</h3><p>Our results suggest that cannabis use may have different effects on neurocognitive functioning. It is associated with disorders of psychomotor function, attention and verbal memory. So, it is associated with an improvement in working memory, visual memory and emotion recognition.</p></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"36 ","pages":"Article 100299"},"PeriodicalIF":2.8,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215001323000227/pdfft?md5=a01c48f832d65f3124deb88aab6d911f&pid=1-s2.0-S2215001323000227-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139033679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}