Biomedical Glasses最新文献_第3页

Anti-biofilm activity of two novel, borate based, bioactive glass wound dressings 两种新型硼酸盐基生物活性玻璃伤口敷料的抗生物膜活性

Biomedical Glasses Pub Date : 2019-01-01 DOI: 10.1515/bglass-2019-0006

Steven B. Jung, T. Day, T. Boone, Brenton Buziak, A. Omar

引用次数: 20

The influence of gadolinium on the thermal properties of bioactive glasses 钆对生物活性玻璃热性能的影响

Biomedical Glasses Pub Date : 2019-01-01 DOI: 10.1515/bglass-2019-0016

R. Borges, Natália Del Rey Menezes, J. Marchi

引用次数: 7

Atomic-scale clustering inhibits the bioactivity of fluoridated phosphate glasses 原子尺度的聚类抑制氟化磷酸盐玻璃的生物活性

Biomedical Glasses Pub Date : 2019-01-01 DOI: 10.1515/bglass-2019-0007

Adja B. R. Touré, E. Mele, J. K. Christie

引用次数: 6

Effects of ZnO addition on thermal properties, degradation and biocompatibility of P45Mg24Ca16Na(15−x)Znx glasses ZnO对P45Mg24Ca16Na（15−x）Znx玻璃热性能、降解和生物相容性的影响

Biomedical Glasses Pub Date : 2019-01-01 DOI: 10.1515/bglass-2019-0005

Yunqi Wang, Chenkai Zhu, A. Parsons, C. Rudd, I. Ahmed, N. Sharmin

{"title":"Effects of ZnO addition on thermal properties, degradation and biocompatibility of P45Mg24Ca16Na(15−x)Znx glasses","authors":"Yunqi Wang, Chenkai Zhu, A. Parsons, C. Rudd, I. Ahmed, N. Sharmin","doi":"10.1515/bglass-2019-0005","DOIUrl":"https://doi.org/10.1515/bglass-2019-0005","url":null,"abstract":"Abstract Four phosphate-based glass formulations in the system P45Mg24Ca16Na(15−x)Znx, referred to as P45Znx (x = 0, 5, 10 and 15 mol%), were prepared using a melt quenching process. The effect of ZnO addition on density, molar volume, thermal properties and degradation rates were studied. An increase in the glass transition, crystallisation, melting and liquidus temperatures were seen when replacing Na2O with ZnO. The molar volume of the bulk glasses was seen to decrease with increasing ZnO content. The dissolution rate of the zinc-free glass was 2.48 × 10−8 kg m−2 s−1 and addition of 5 mol% ZnO resulted in a reduction of the dissolution rate to 1.68 × 10−8 kg m−2 s−1. However, further addition of ZnO from 5 mol% to 15 mol% increased the dissolution rate of the glass system. The glasses were deliberately crystallised and XRD studies identified the Z n2P2O7 phase for glass code P45Zn5, and Zn(PO3)2 phase for P45Zn10 and P45Zn15 glasses. Cyto-compatibility studies were conducted using MG63 cells for 14 days. An overall increase in the metabolic activity and DNA concentration of cells was seen from day 1 to day 14 for all glass formulations investigated. However, increasing ZnO content from 0 to 15 mol% seemed to have a negative effect on the cellular activity. Interestingly, a remarkably higher ALP activity was seen at day 14 for glass codes P45Zn5 and P45Zn10 in comparison with the TCP control and the P45Zn0 glass.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2019-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42376361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Surface Properties and Reactivity of Phosphate-based Glasses by Inverse Gas Chromatography and Dynamic Vapour Sorption 反相气相色谱法和动态气相吸附法研究磷酸盐玻璃的表面性质和反应性

Biomedical Glasses Pub Date : 2018-12-01 DOI: 10.1515/bglass-2018-0012

Shiva Naseri, William C. Lepry, M. S. Mohammadi, K. Waters, S. Nazhat

{"title":"Surface Properties and Reactivity of Phosphate-based Glasses by Inverse Gas Chromatography and Dynamic Vapour Sorption","authors":"Shiva Naseri, William C. Lepry, M. S. Mohammadi, K. Waters, S. Nazhat","doi":"10.1515/bglass-2018-0012","DOIUrl":"https://doi.org/10.1515/bglass-2018-0012","url":null,"abstract":"Abstract The chemical durability of phosphate-based glasses (PGs) in an aqueous environment is crucial in determining their dissolution properties and their ultimate performance in vivo. In this study, inverse gas chromatography (IGC) and dynamic vapour sorption (DVS)were used to investigate the short-term aqueous interactions of PG particles doped with SiO2 and TiO2 (50P2O5-40CaO-xSiO2- (10-x)TiO2, where x=7, 5, 3, and 0 mol%). IGC was used to evaluate the solubility parameter and surface energy of PGs. A good correlation between the polar parts of the solubility parameter and surface energy with glass transition temperature (Tg) and dissolution rates was demonstrated. DVS was applied to monitor the sorption characteristics of the PG particles. An increase in silica content resulted in greater vapour sorption and mass change. Nuclear magnetic resonance spectroscopy data of the PGs post exposure to vapour demonstrated that increased SiO2 content disrupted the glass network and formed protonated phosphate species. Fourier transform infrared spectroscopy verified the presence of non-reacted water molecules in the PGs depending on SiO2 content. Moreover, there was a good correlation between the values measured through IGC and DVS, demonstrating the ability of both techniques in predicting the dissolution properties of PGs as consequence of alterations in their chemistry.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2018-0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48246457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Bioactive glass-polycaprolactone fiber membrane and response of dental pulp stem cells in vitro 生物活性玻璃聚己内酯纤维膜及其对牙髓干细胞的体外反应

Biomedical Glasses Pub Date : 2018-12-01 DOI: 10.1515/bglass-2018-0011

S. Labbaf, A. B. Houreh, M. Rahimi, Hungkit Ting, J.R. Jones, M. Nasr-Esfahani

引用次数: 6

Polycaprolactone / bioactive glass hybrid scaffolds for bone regeneration 用于骨再生的聚己内酯/生物活性玻璃复合支架

Biomedical Glasses Pub Date : 2018-11-01 DOI: 10.1515/bglass-2018-0010

Cédric Bossard, Henri Granel, Y. Wittrant, É. Jallot, J. Lao, C. Vial, H. Tiainen

{"title":"Polycaprolactone / bioactive glass hybrid scaffolds for bone regeneration","authors":"Cédric Bossard, Henri Granel, Y. Wittrant, É. Jallot, J. Lao, C. Vial, H. Tiainen","doi":"10.1515/bglass-2018-0010","DOIUrl":"https://doi.org/10.1515/bglass-2018-0010","url":null,"abstract":"Abstract Bioactive glasses (BG) bond to bone and stimulate bone regeneration, but they are brittle. Inorganicorganic hybrids appear as promising bone substitutes since they associate the bone mineral forming ability of BG with the toughness of polymers. Hybrids comprised of polycaprolactone (PCL) and SiO2-CaO BG were produced by sol-gel chemistry and processed into porous scaffolds with controlled pore and interconnection sizes. The obtained scaffolds are highly flexible, meaning that PCL effectively introduces toughness. Apatite formation is observed within 24 hours of immersion in simulated body fluid (SBF) and is not limited to the surface as the entire hybrid progressively changes into bone-like minerals. The degradation rate is suitable for bone regeneration with a 13.2% weight loss after 8 weeks of immersion. Primary osteoblasts cultured in scaffolds demonstrate that the samples are not cytotoxic and provide good cell adhesion. The in vivo study confirms the bioactivity, biocompatibility and suitable degradation rate of the hybrid. A physiological bone made of trabeculae and bone marrow regenerates. The structure and kinetic of bone regeneration was similar to the implanted commercial standard based on bovine bone, demonstrating that this new synthetic PCL-BG hybrid could perform as well as animal-derived bone substitutes.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2018-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43249741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

The Anti-biofilm Activity of Nanometric Zinc doped Bioactive Glass against Putative Periodontal Pathogens: An in vitro Study 纳米锌掺杂生物活性玻璃抗牙周病病原菌生物膜活性的体外研究

Biomedical Glasses Pub Date : 2018-11-01 DOI: 10.1515/bglass-2018-0009

N. Esfahanizadeh, M. Nourani, A. Bahador, N. Akhondi, M. Montazeri

{"title":"The Anti-biofilm Activity of Nanometric Zinc doped Bioactive Glass against Putative Periodontal Pathogens: An in vitro Study","authors":"N. Esfahanizadeh, M. Nourani, A. Bahador, N. Akhondi, M. Montazeri","doi":"10.1515/bglass-2018-0009","DOIUrl":"https://doi.org/10.1515/bglass-2018-0009","url":null,"abstract":"Abstract Colonization of periodontal pathogens on the surgical sites is one of the primary reasons for the failure of regenerative periodontal therapies. Bioactive glasses (BGs) owing to their favorable structural and antimicrobial properties have been proposed as promising materials for the reconstruction of periodontal and peri-implant bone defects. This study aimed to investigate the antibiofilm activity of zinc-doped BG (Zn/BG) compared with 45S5 Bioglass® (BG®) on putative periodontal pathogens. In this in vitro experimental study, the nano BG doped with 5-mol% zinc and BG® were synthesized by sol-gel method. Mono-species biofilms of Aggregatibacter actinomycetemcomitans (A. a), Porphyromonas gingivalis (P. g), and Prevotella intermedia (P. i)were prepared separately in a well-containing microplate. After 48 hours of exposure to generated materials at 37°C, the anti-biofilm potential of the samples was studied by measuring the optical density (OD) at 570nm wavelengths with a microplate reader. Two-way ANOVA then analyzed the results. Both Zn/BG and BG® significantly reduced the biofilm formation ability of all examined strains after 48 hours of incubation (P=0.0001). Moreover, the anti-biofilm activity of Zn/BG was significantly stronger than BG® (P=0.0001), which resulted in the formation of a weak biofilm (OD<1) compared with a moderately adhered biofilm observed with BG® (1<OD<2). Zn/BG showed a significant inhibitory effect on the biofilm formation of all examined periodontal pathogens. Given the enhanced regenerative and anti-biofilm properties of this novel biomaterial, further investigations are required for its implementation in clinical situations.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2018-0009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46101839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Bioactive glass combined with zein as composite material for the application in bone tissue engineering 生物活性玻璃与玉米醇溶蛋白复合材料在骨组织工程中的应用

Biomedical Glasses Pub Date : 2018-07-01 DOI: 10.1515/bglass-2018-0007

J. Hum, Shiva Naseri, A. Boccaccini

引用次数: 8

Effects of Fe2O3 addition and annealing on the mechanical and dissolution properties of MgO-and CaO-containing phosphate glass fibres for bio-applications Fe2O3添加和退火对生物用含MgO和CaO磷酸盐玻璃纤维力学性能和溶解性能的影响

Biomedical Glasses Pub Date : 2018-07-01 DOI: 10.1515/bglass-2018-0006

Chao Tan, I. Ahmed, A. Parsons, Chenkai Zhu, F. Betanzos, C. Rudd, Xiaoling Liu

{"title":"Effects of Fe2O3 addition and annealing on the mechanical and dissolution properties of MgO-and CaO-containing phosphate glass fibres for bio-applications","authors":"Chao Tan, I. Ahmed, A. Parsons, Chenkai Zhu, F. Betanzos, C. Rudd, Xiaoling Liu","doi":"10.1515/bglass-2018-0006","DOIUrl":"https://doi.org/10.1515/bglass-2018-0006","url":null,"abstract":"Abstract This paper investigated the preparation of phosphate glass fibres (PGFs) in the following systems: i) 45P2O5-5B2O3-5Na2O-(29-x)CaO-16MgO-(x)Fe2O3 and ii) 45P2O5-5B2O3-5Na2O-24CaO-(21-x)MgO-(x)Fe2O3 (where x = 5, 8 and 11 mol%) for biomedical applications. Continuous fibres of 23 ± 1 μm diameter were prepared via a meltdraw spinning process. Compositions with higher Fe2O3 content and higher MgO/CaO ratio required higher melting temperature and longer heating time to achieve glass melts for fibre pulling. The effects of Fe2O3 addition and annealing treatment on mechanical properties and degradation behaviours were also investigated. Adding Fe2O3 was found to increase the tensile strength from 523 ± 63 (Ca-Fe5) to 680 ± 75 MPa (Ca-Fe11), improve the tensile modulus from72 ± 4 (Ca-Fe5) to 78 ± 3 GPa (Ca-Fe11) and decrease the degradation rate from 4.0 (Mg-Fe5) to 1.9 × 10−6 kg m−2 s−1 (Mg-Fe11). The annealing process reduced the fibre tensile strength by 46% (Ca-Fe5), increased the modulus by 19.6%(Ca-Fe8) and decreased the degradation rate by 89.5% (Mg-Fe11) in comparison to the corresponding as drawn fibres. Additionally, the annealing process also impeded the formation of precipitate shells and revealed coexistence of the precipitation and the pitting corrosion as fibre degradation behaviours.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2018-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46658663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10