生物活性玻璃聚己内酯纤维膜及其对牙髓干细胞的体外反应

Q1 Materials Science

Biomedical Glasses Pub Date : 2018-12-01 DOI:10.1515/bglass-2018-0011

S. Labbaf, A. B. Houreh, M. Rahimi, Hungkit Ting, J.R. Jones, M. Nasr-Esfahani

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引用次数: 6

摘要

摘要本研究报道了溶胶-凝胶衍生的生物活性玻璃（BG）/聚己内酯（PCL）复合纤维膜的制备和体外生物学评价，该膜是骨再生应用的潜在候选者。通过将玻璃颗粒引入静电纺丝工艺制备了非织造复合毡。添加玻璃提高了纤维的均匀性。评估了膜在模拟体液中的磷灰石形成能力，并表明羟基磷灰石在SBF中在21天内形成并完全覆盖了膜的表面。在细胞培养中，粘附的牙髓干细胞在PCL/BG纤维膜上增殖并产生矿化基质。

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Bioactive glass-polycaprolactone fiber membrane and response of dental pulp stem cells in vitro

Abstract The study reports the fabrication and in vitro biological evaluation of a sol-gel derived bioactive glass (BG) / polycaprolactone (PCL) composite fiber membrane, as a potential candidate for bone regeneration applications. The non woven composite mats were prepared by introducing the glass particles into the electrospinning process. Adding the glass improved the homogeneity of the fibers. The apatite forming ability of the membranes in simulated body fluid were evaluated and showed that hydroxyapatite had formed within 21 days in SBF and completely covered the surface of the membrane. In cell culture, dental pulp stem cells adhered proliferated and produced mineralized matrix on the PCL/BG fiber membrane.

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.