Biomedical Glasses最新文献

Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering 三维打印聚己内酯/多组分生物活性玻璃支架在骨组织工程中的潜在应用

Biomedical Glasses Pub Date : 2020-01-01 DOI: 10.1515/bglass-2020-0006

A. Fathi, F. Kermani, A. Behnamghader, S. Banijamali, M. Mozafari, F. Baino, S. Kargozar

{"title":"Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering","authors":"A. Fathi, F. Kermani, A. Behnamghader, S. Banijamali, M. Mozafari, F. Baino, S. Kargozar","doi":"10.1515/bglass-2020-0006","DOIUrl":"https://doi.org/10.1515/bglass-2020-0006","url":null,"abstract":"Abstract Over the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3. The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"57 - 69"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42328303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Injectable bioactive glass-based pastes for potential use in bone tissue repair 可注射生物活性玻璃基糊剂在骨组织修复中的潜在用途

Biomedical Glasses Pub Date : 2020-01-01 DOI: 10.1515/bglass-2020-0003

D. Tulyaganov, A. Akbarov, N. Ziyadullaeva, Bekhzod Khabilov, F. Baino

引用次数: 4

Bibliometric profiles of top 50 most cited articles on bioactive glass 生物活性玻璃50篇最受引用文章的文献计量概况

Biomedical Glasses Pub Date : 2020-01-01 DOI: 10.1515/bglass-2020-0007

M. Sujon, S. Noor, M. A. Zabidi, K. Shariff, M. Alam

{"title":"Bibliometric profiles of top 50 most cited articles on bioactive glass","authors":"M. Sujon, S. Noor, M. A. Zabidi, K. Shariff, M. Alam","doi":"10.1515/bglass-2020-0007","DOIUrl":"https://doi.org/10.1515/bglass-2020-0007","url":null,"abstract":"Abstract Citation analysis of a certain publication acknowledges its impact on the scientific community. This study conducted a multivariate analysis of the top 50 most cited articles published on the field of Bioactive Glass. A systemic search was performed using the “All database” section of the Web of Science to retrieve the top 50 most cited original publications. The selected articles were then manually cross-matched with Elsevier Scopus and Google Scholar Database. Parameters such as article title, authorship, institution, country of publication, year, citation count, citation density, current citation index, and journal name were retrieved from Web of Science. Different ranges of citation numbers were retrieved for these publications in which 197-913 are from Web of Science, 209-962 are from Elsevier Scopus, and 269-1225 are from Google Scholar. A total of 153 authors contributed to this marked list, where Professor L.L. Hench contributed the highest number of articles (n=21). Imperial College London published the highest number of articles (n=21). In summary, this study provides a good scientometric picture of bioactive glass related publications, which illustrate the trend of biomaterials development over the years and suggests future scopes to the scientific community.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"70 - 84"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49078806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel borosilicate bioactive scaffolds with persistent luminescence 新型持续发光的硼硅酸盐生物活性支架

Biomedical Glasses Pub Date : 2020-01-01 DOI: 10.1515/bglass-2020-0001

P. R. D. Cerro, Henri Teittinen, I. Norrbo, M. Lastusaari, J. Massera, L. Petit

引用次数: 2

Yttrium doped phosphate-based glasses: structural and degradation analyses 掺钇磷酸盐基玻璃:结构和降解分析

Biomedical Glasses Pub Date : 2020-01-01 DOI: 10.1515/bglass-2020-0004

A. Arafat, Sabrin A. Samad, J. Titman, A. Lewis, E. Barney, I. Ahmed

{"title":"Yttrium doped phosphate-based glasses: structural and degradation analyses","authors":"A. Arafat, Sabrin A. Samad, J. Titman, A. Lewis, E. Barney, I. Ahmed","doi":"10.1515/bglass-2020-0004","DOIUrl":"https://doi.org/10.1515/bglass-2020-0004","url":null,"abstract":"Abstract This study investigates the role of yttrium in phosphate-based glasses in the system 45(P2O5)–25(CaO)– (30-x)(Na2O)–x(Y2O3) (0≤x≤5) prepared via melt quenching and focuses on their structural characterisation and degradation properties. The structural analyses were performed using a combination of solid-state nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). 31P NMR analysis showed that depolymerisation of the phosphate network occurred which increased with Y2O3 content as metaphosphate units (Q2) decreased with subsequent increase in pyrophosphate species (Q1). The NMR results correlated well with structural changes observed via FTIR and XPS analyses. XRD analysis of crystallised glass samples revealed the presence of calcium pyrophosphate (Ca2P2O7) and sodium metaphosphate (NaPO3) phases for all the glass formulations explored. Yttrium-containing phases were found for the formulations containing 3 and 5 mol% Y2O3. Degradation analyses performed in Phosphate buffer saline (PBS) and Milli-Q water revealed significantly reduced rates with addition of Y2O3 content. This decrease was attributed to the formation of Y-O-P bonds where the octahedral structure of yttrium (YO6) cross-linked phosphate chains, subsequently leading to an increase in chemical durability of the glasses. The ion release studies also showed good correlation with the degradation profiles.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"34 - 49"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45238827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Modelling the elastic mechanical properties of bioactive glass-derived scaffolds 生物活性玻璃衍生支架的弹性力学性能建模

Biomedical Glasses Pub Date : 2020-01-01 DOI: 10.1515/bglass-2020-0005

F. Baino, E. Fiume

引用次数: 3

Tantalum doped SiO2-CaO-P2O5 based bioactive glasses: Investigation of in vitro bioactivity and antibacterial activities 钽掺杂SiO2-CaO-P2O5基生物活性玻璃的体外生物活性和抗菌活性研究

Biomedical Glasses Pub Date : 2020-01-01 DOI: 10.1515/bglass-2020-0002

Zakaria Tabia, Sihame Akhtach, K. Mabrouk, Meriame Bricha, K. Nouneh, A. Ballamurugan

{"title":"Tantalum doped SiO2-CaO-P2O5 based bioactive glasses: Investigation of in vitro bioactivity and antibacterial activities","authors":"Zakaria Tabia, Sihame Akhtach, K. Mabrouk, Meriame Bricha, K. Nouneh, A. Ballamurugan","doi":"10.1515/bglass-2020-0002","DOIUrl":"https://doi.org/10.1515/bglass-2020-0002","url":null,"abstract":"Abstract Multifunctionality can be achieved for bioactive glasses by endowing them with multiple other properties along with bioactivity. One way to address this topic is by doping these glasses with therapeutic metallic ions. In this work, we put under investigation a series of bioactive glasses doped with tantalum. We aim to study the effect of tantalum, on the structure, bioactivity and antibacterial property of a ternary bioactive glass composition based on SiO2-CaO-P2O5. Fourier Transformed Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD) and Electron Scanning Microscopy (SEM) were used to assess the structural and morphological properties of these glasses and monitor their changes after in vitro acellular bioactivity test. Antibacterial activity was tested against gram positive and negative bacteria. Characterization results confirmed the presence of calcium carbonate crystallites along with the amorphous silica matrix. The assessment of bioactivity in SBF indicated that all compositions showed a fast bioactive response after only six hours of immersion period. However, analytical characterization revealed that tantalum introduced a slight latency in hydroxyapatite deposition at higher concentrations (0.8-1 %mol). Antibacterial test showed that tantalum ions had an inhibition effect on the growth of E. coli and S. aureus. This effect was more pronounced in compositions where mol% of tantalum is superior to 0.4%. These results proved that tantalum could be used, in intermediate proportions, as a promising multifunctional dopant element in bioactive glasses for bone regeneration applications.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"10 - 22"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45183983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Investigating the effect of Copper Addition on SiO2-ZnO-CaO-SrO-P2O5 Glass Polyalkenoate Cements: Physical, Mechanical and Biological Behavior 铜添加对SiO2-ZnO-CaO-SrO-P2O5玻璃聚烯酸盐水泥的物理、力学和生物行为影响的研究

Biomedical Glasses Pub Date : 2019-02-01 DOI: 10.1515/bglass-2019-0002

S. Mokhtari, A. Wren

{"title":"Investigating the effect of Copper Addition on SiO2-ZnO-CaO-SrO-P2O5 Glass Polyalkenoate Cements: Physical, Mechanical and Biological Behavior","authors":"S. Mokhtari, A. Wren","doi":"10.1515/bglass-2019-0002","DOIUrl":"https://doi.org/10.1515/bglass-2019-0002","url":null,"abstract":"Abstract The physical, mechanical, and biological behaviour of copper containing glass polyalkenotare cements were investigated, where copper (Cu2+) was incorporated into a SiO2-ZnO-CaO-SrO-P2O5 based glass system. Three GPCs were formulated for this study, a Control and two Cu-GPCs with 6 (Cu-1) and 12 (Cu-2) Mol.% of CuO substituted for the SiO2 in the glass. Rheological evaluation of GPCs determined that the addition of the Cu decreases the working and setting times in the cements. The mechanical properties of the cements were evaluated after 1 - 21 days incubation in DI water. The compressive strength of the cements were found to range between 21-36 MPa, with Cu-1 having the highest compressive strength. Biaxial flexural strength and Shear Bond Strength of the GPCs were found to increase with respect to time and were higher for the Cu-GPCs at 14 MPa and 2.1 MPa respectively. Bioactivity testing was conducted using Simulated Body Fluid (SBF) which revealed CaP precipitants on each of the GPCs surfaces. The effect o f Cu addition to the GPCs greatly enhanced the antibacterial inhibition zone (IZ) when tested in E.coli (3mm), S.aureus (24mm) and S.epidermidis (22mm). Cytocompatibility testing revealed more favorable MC3T3 osteoblast cell viability when compared to the Control GPC.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"5 1","pages":"13 - 33"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2019-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48077552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Glass ionomer bone cements based on magnesium-containing bioactive glasses 基于含镁生物活性玻璃的玻璃离子骨水泥

Biomedical Glasses Pub Date : 2019-02-01 DOI: 10.1515/bglass-2019-0001

R. Wetzel, L. Hupa, D. Brauer

{"title":"Glass ionomer bone cements based on magnesium-containing bioactive glasses","authors":"R. Wetzel, L. Hupa, D. Brauer","doi":"10.1515/bglass-2019-0001","DOIUrl":"https://doi.org/10.1515/bglass-2019-0001","url":null,"abstract":"Abstract Glass ionomer cements (GIC) are used in restorative dentistry and their properties (low heat during setting, adhesion to mineralised tissue and surgical metals) make them of great interest for bone applications.However, dental GIC are based on aluminium-containing glasses, and the resulting release of aluminium ions from the cements needs to be avoided for applications as bone cements. Replacing aluminium ions in glasses for use in glass ionomer cements is challenging, as aluminium ions play a critical role in the required glass degradation by acid attack as well as in GIC mechanical stability. Magnesium ions have been used as an alternative for aluminium in the glass component, but so far no systematic study has looked into the actual role of magnesium ions. The aim of the present study is therefore the systematic comparison of the effect of magnesium ions compared to calcium ions in GIC glasses. It is shown that by partially substituting MgO for CaO in simple SiO2-CaO-CaF2 glasses, ion release from the glass and, subsequently, GIC setting behaviour can be adjusted. Magnesium ions act as typical network modifiers here but owing to their larger field strength compared to calcium ions reduce ion release from the glasses significantly. By choosing an optimum ratio of magnesium and calcium ions in the glass, GIC setting and subsequently compressive strength can be controlled.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"5 1","pages":"1 - 12"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2019-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45899372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fabrication of 3D microchannels for tissue engineering in photosensitive glass using NIR femtosecond laser radiation 近红外飞秒激光在光敏玻璃中制备用于组织工程的三维微通道

Biomedical Glasses Pub Date : 2019-02-01 DOI: 10.1515/bglass-2019-0003

Ulrike Brokmann, T. Milde, E. Rädlein, K. Liefeith

{"title":"Fabrication of 3D microchannels for tissue engineering in photosensitive glass using NIR femtosecond laser radiation","authors":"Ulrike Brokmann, T. Milde, E. Rädlein, K. Liefeith","doi":"10.1515/bglass-2019-0003","DOIUrl":"https://doi.org/10.1515/bglass-2019-0003","url":null,"abstract":"Abstract The biocompatibility of photosensitive glasses allows various biomedical applications; one is the field of tissue engineering and more precisely microengineered tissue-on-a-chip platforms to study the tissue microenvironment and disease modelling. Three dimensional architectures of adapted components are required for modern materials. A photosensitive lithiumalumosilicate glass FS21 was investigated regarding the interaction with a Ti:Sapphire laser systemto build three dimensional buried channels inside the glass. Femtosecond laser radiation with a wavelength of 800 nm and pulse duration of 140 fs was used to modify the glass structure. Subsurface channel geometries were achieved by a subsequent thermal treatment and were formed into capillaries using wet chemical etching of the exposed and crystallised channels. Contrary to ultraviolet (UV) exposure, spectral optical investigations showed that fs laser exposure caused various radiation induced defects in the base glass coupled with the generation of photoelectrons for the photochemical modification of silver ions. We observed an outgassing of different species coming from raw materials of the original glass batch during the glass crystallisation process. Etch rate ratios differ between 1:25 and 1:45 and are dependent on: stoichiometric deviation between surface and bulk, crystal size and distribution and exchange of the etching agent in narrow capillaries.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"5 1","pages":"34 - 45"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2019-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46167053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11