Glass ionomer bone cements based on magnesium-containing bioactive glasses

Q1 Materials Science

Biomedical Glasses Pub Date : 2019-02-01 DOI:10.1515/bglass-2019-0001

R. Wetzel, L. Hupa, D. Brauer

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引用次数: 1

Abstract

Abstract Glass ionomer cements (GIC) are used in restorative dentistry and their properties (low heat during setting, adhesion to mineralised tissue and surgical metals) make them of great interest for bone applications.However, dental GIC are based on aluminium-containing glasses, and the resulting release of aluminium ions from the cements needs to be avoided for applications as bone cements. Replacing aluminium ions in glasses for use in glass ionomer cements is challenging, as aluminium ions play a critical role in the required glass degradation by acid attack as well as in GIC mechanical stability. Magnesium ions have been used as an alternative for aluminium in the glass component, but so far no systematic study has looked into the actual role of magnesium ions. The aim of the present study is therefore the systematic comparison of the effect of magnesium ions compared to calcium ions in GIC glasses. It is shown that by partially substituting MgO for CaO in simple SiO2-CaO-CaF2 glasses, ion release from the glass and, subsequently, GIC setting behaviour can be adjusted. Magnesium ions act as typical network modifiers here but owing to their larger field strength compared to calcium ions reduce ion release from the glasses significantly. By choosing an optimum ratio of magnesium and calcium ions in the glass, GIC setting and subsequently compressive strength can be controlled.

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基于含镁生物活性玻璃的玻璃离子骨水泥

摘要玻璃离聚物水泥（GIC）用于修复性牙科，其特性（固化过程中的低热、与矿化组织和外科金属的粘附性）使其在骨应用中备受关注。然而，牙科GIC是基于含铝玻璃的，因此在用作骨水泥时需要避免铝离子从水泥中释放。取代玻璃中的铝离子用于玻璃离聚物水泥具有挑战性，因为铝离子在酸侵蚀所需的玻璃降解以及GIC机械稳定性中发挥着关键作用。镁离子已被用作玻璃部件中铝的替代品，但到目前为止，还没有系统研究镁离子的实际作用。因此，本研究的目的是系统比较镁离子与钙离子在GIC玻璃中的作用。结果表明，在简单的SiO2-CaO-CaF2玻璃中，通过部分用MgO代替CaO，可以调节玻璃中的离子释放，随后调节GIC的凝固行为。镁离子在这里起着典型的网络改性剂的作用，但由于其与钙离子相比具有更大的场强，因此显著减少了离子从玻璃中的释放。通过选择玻璃中镁离子和钙离子的最佳比例，可以控制GIC的设置和随后的抗压强度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.