Investigating the effect of Copper Addition on SiO2-ZnO-CaO-SrO-P2O5 Glass Polyalkenoate Cements: Physical, Mechanical and Biological Behavior

Q1 Materials Science

Biomedical Glasses Pub Date : 2019-02-01 DOI:10.1515/bglass-2019-0002

S. Mokhtari, A. Wren

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引用次数: 12

Abstract

Abstract The physical, mechanical, and biological behaviour of copper containing glass polyalkenotare cements were investigated, where copper (Cu2+) was incorporated into a SiO2-ZnO-CaO-SrO-P2O5 based glass system. Three GPCs were formulated for this study, a Control and two Cu-GPCs with 6 (Cu-1) and 12 (Cu-2) Mol.% of CuO substituted for the SiO2 in the glass. Rheological evaluation of GPCs determined that the addition of the Cu decreases the working and setting times in the cements. The mechanical properties of the cements were evaluated after 1 - 21 days incubation in DI water. The compressive strength of the cements were found to range between 21-36 MPa, with Cu-1 having the highest compressive strength. Biaxial flexural strength and Shear Bond Strength of the GPCs were found to increase with respect to time and were higher for the Cu-GPCs at 14 MPa and 2.1 MPa respectively. Bioactivity testing was conducted using Simulated Body Fluid (SBF) which revealed CaP precipitants on each of the GPCs surfaces. The effect o f Cu addition to the GPCs greatly enhanced the antibacterial inhibition zone (IZ) when tested in E.coli (3mm), S.aureus (24mm) and S.epidermidis (22mm). Cytocompatibility testing revealed more favorable MC3T3 osteoblast cell viability when compared to the Control GPC.

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铜添加对SiO2-ZnO-CaO-SrO-P2O5玻璃聚烯酸盐水泥的物理、力学和生物行为影响的研究

摘要:本文研究了含铜玻璃聚烯酮水泥的物理、机械和生物行为，其中铜(Cu2+)加入到SiO2-ZnO-CaO-SrO-P2O5基玻璃体系中。本研究配制了三种GPCs，一种对照，两种Cu-GPCs，分别以6 (Cu-1)和12 (Cu-2)摩尔%的CuO取代玻璃中的SiO2。GPCs的流变学评价表明，Cu的加入减少了水泥的工作时间和凝结时间。在去离子水中培养1 ~ 21天后，评价水泥的力学性能。水泥的抗压强度在21 ~ 36 MPa之间，其中Cu-1的抗压强度最高。GPCs的双轴抗折强度和剪切强度随时间增加而增加，其中Cu-GPCs在14 MPa和2.1 MPa时最高。利用模拟体液(SBF)进行生物活性测试，在每个GPCs表面显示CaP沉淀。对大肠杆菌(3mm)、金黄色葡萄球菌(24mm)和表皮葡萄球菌(22mm)的抑菌带(IZ)进行了实验，结果表明Cu对GPCs的抑菌带(IZ)明显增强。细胞相容性测试显示，与对照GPC相比，MC3T3成骨细胞活力更有利。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.