Anti-biofilm activity of two novel, borate based, bioactive glass wound dressings

Q1 Materials Science
Steven B. Jung, T. Day, T. Boone, Brenton Buziak, A. Omar
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引用次数: 20

Abstract

Abstract Bioactive glass was first developed in the late 1960’s as a compound that would facilitate bone re-growth. In more recent years, this technology has been used to promote wound healing through its ability to stimulate soft tissue growth, angiogenesis, reduce inflammation, and prevent infection. Chronically infected wounds, which result from biofilm formation, affect millions of patients in the Unites States each year and cost billions of dollars to treat. The present studies demonstrate exposure of pre-formed biofilms to bioactive glass, under simulated body conditions, resulted in significant reduction in bacterial load. Additionally, specific therapeutically active metal ions such as copper and zinc were added to a borate bioactive glass formulation through a process of ion doping and found to further enhance the anti-biofilm activity. Based on the present findings, the antibiofilm agents released by borate bioactive glasses may prove effective to eradicate the biofilm infections that prevent healing in patients with chronic wounds.
两种新型硼酸盐基生物活性玻璃伤口敷料的抗生物膜活性
摘要生物活性玻璃最早是在20世纪60年代末开发出来的,它是一种促进骨骼再生的化合物。近年来,这项技术通过刺激软组织生长、血管生成、减少炎症和预防感染的能力,被用于促进伤口愈合。由生物膜形成引起的慢性感染伤口每年影响美国数百万患者,治疗费用高达数十亿美元。目前的研究表明,在模拟身体条件下,将预先形成的生物膜暴露于生物活性玻璃中,可显著降低细菌负荷。此外,通过离子掺杂过程将特定的治疗活性金属离子如铜和锌添加到硼酸盐生物活性玻璃制剂中,并发现其可进一步增强抗生物膜活性。基于目前的研究结果,硼酸盐生物活性玻璃释放的抗生物膜剂可能被证明可以有效根除阻止慢性伤口患者愈合的生物膜感染。
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来源期刊
Biomedical Glasses
Biomedical Glasses Materials Science-Surfaces, Coatings and Films
自引率
0.00%
发文量
0
审稿时长
17 weeks
期刊介绍: Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.
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