Polycaprolactone / bioactive glass hybrid scaffolds for bone regeneration

Q1 Materials Science

Biomedical Glasses Pub Date : 2018-11-01 DOI:10.1515/bglass-2018-0010

Cédric Bossard, Henri Granel, Y. Wittrant, É. Jallot, J. Lao, C. Vial, H. Tiainen

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引用次数: 27

Abstract

Abstract Bioactive glasses (BG) bond to bone and stimulate bone regeneration, but they are brittle. Inorganicorganic hybrids appear as promising bone substitutes since they associate the bone mineral forming ability of BG with the toughness of polymers. Hybrids comprised of polycaprolactone (PCL) and SiO2-CaO BG were produced by sol-gel chemistry and processed into porous scaffolds with controlled pore and interconnection sizes. The obtained scaffolds are highly flexible, meaning that PCL effectively introduces toughness. Apatite formation is observed within 24 hours of immersion in simulated body fluid (SBF) and is not limited to the surface as the entire hybrid progressively changes into bone-like minerals. The degradation rate is suitable for bone regeneration with a 13.2% weight loss after 8 weeks of immersion. Primary osteoblasts cultured in scaffolds demonstrate that the samples are not cytotoxic and provide good cell adhesion. The in vivo study confirms the bioactivity, biocompatibility and suitable degradation rate of the hybrid. A physiological bone made of trabeculae and bone marrow regenerates. The structure and kinetic of bone regeneration was similar to the implanted commercial standard based on bovine bone, demonstrating that this new synthetic PCL-BG hybrid could perform as well as animal-derived bone substitutes.

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用于骨再生的聚己内酯/生物活性玻璃复合支架

生物活性玻璃(BG)与骨结合，促进骨再生，但它们是脆性的。无机杂化物似乎是很有前途的骨替代品，因为它们将BG的骨矿物质形成能力与聚合物的韧性联系起来。采用溶胶-凝胶化学法制备了由聚己内酯(PCL)和SiO2-CaO BG组成的杂化物，并将其加工成孔径和互连尺寸可控的多孔支架。所获得的支架具有很高的柔韧性，这意味着PCL有效地引入了韧性。在模拟体液(SBF)浸泡24小时内观察到磷灰石的形成，并且随着整个混合物逐渐转变为骨样矿物质，磷灰石的形成并不局限于表面。降解率适合于骨再生，浸泡8周后重量减轻13.2%。在支架中培养的原代成骨细胞表明样品没有细胞毒性，并且具有良好的细胞粘附性。体内实验证实了该杂交体的生物活性、生物相容性和适宜的降解率。由骨小梁和骨髓组成的生理性骨再生。骨再生的结构和动力学与基于牛骨的植入商业标准相似，表明这种新的合成PCL-BG混合物可以作为动物源性骨替代品。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.