Current Nutraceuticals最新文献

{"title":"The Potential Role of Probiotics in the Management of COVID-19","authors":"Sangeeta Huidrom, M. Beg, Shalu Bawa, Shruti Malhotra","doi":"10.2174/2665978604666230217144343","DOIUrl":"https://doi.org/10.2174/2665978604666230217144343","url":null,"abstract":"\u0000\u0000COVID-19 caused by SARS-CoV-2 is an ongoing global pandemic that causes catastrophic devastation to humankind. COVID-19 virus mainly affects the human respiratory and gastrointestinal systems. Currently, vaccines are available globally and are a game-changer in the fight against COVID-19. However, it has a long way to go to achieve the war against COVID-19 as it will take some more years to completely vaccinate the people, and there are threats and concerns of COVID-19 due to the high mutagenicity rate of the virus. The current methods of treatment involve the use of antiviral drugs and anti-inflammatory drugs but without much success. To date, there is no established prevention or treatment method for this novel virus. The best preventive strategy to combat this disease is to keep the immune system strong. Evidence showed a correlation between gut dysbiosis, COVID-19, and immunomodulation. Since time immemorial, probiotics have improved general health and immunity to various diseases. Probiotics are beneficial bacteria when administered in the right doses conferring a health benefit to the host. Various scientific evidence has proved the therapeutic and protective effects of probiotics against respiratory and gastrointestinal diseases. This review aims to outline the potential role of probiotics in fighting COVID-19 by highlighting the recent evidence on the association between dysbiosis, COVID-19, and probiotics and outlining the antiviral and anti-inflammatory effects of probiotics. This review highlight the association between gut and lung in the gut-lung axis. Furthermore, this review also provides an insight into the indirect evidence of the potential protective role of probiotics in combating COVID-19 or its associated symptoms.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116355667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microscopic Evidence of the Behavior of PH-sensitive Food-grade Polymeric Delivery Systems","authors":"R. Pignatello, Salvatore Rizzo, Giuseppe Cosentino, E. Zingale, A. Bonaccorso, S. Petralia, F. Monforte, Guglielmo G. Condorelli, C. Carbone","doi":"10.2174/2665978604666230201144421","DOIUrl":"https://doi.org/10.2174/2665978604666230201144421","url":null,"abstract":"\u0000\u0000Colon delivery systems are designed for the oral delivery of active compounds in the large intestine. Food-grade copolymers Eudraguard® Biotic (EUGB) and control (EUGC) have been investigated to develop colloidal systems loading natural active ingredients.\u0000\u0000\u0000\u0000In this study, we evaluated the degradation process of these matrices in simulated gastric, intestinal and colonic conditions. Microparticles made of EUGB and EUGC, alone or in combination, were loaded with the model compound resveratrol (RSV). A parallel study was performed on in vitro RSV release and SEM analysis of microparticles kept at different pH values.\u0000\u0000\u0000\u0000All systems ensured a limited gastric release of RSV (below 20%), presenting only small pores on the surface of microparticles treated with simulated gastric fluid. EUGB microparticles showed the maximum release in simulated colon fluid (SCF), showing a complete dissolution of the microparticle matrix. The EUGC-based system allowed a prolonged release of RSV over time, and in SCF, it showed only partial degradation. Using mixed EUGB/EUGC matrices, a prolonged RSV release was observed along the intestinal tract.\u0000\u0000\u0000\u0000Overall, EUGB and EUGC copolymers were able to modulate and localize the release of entrapped cargo in the small intestine and colon. They could have interesting applications in treating bowel diseases synergistically with other therapeutic strategies.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132601181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NMR-based phytochemical profiling of palmyra palm syrup infused with dry ginger, black pepper, and long pepper","authors":"Ravi Shankar Lankalapalli, Ambili Sasikumar Athira, Ramkumar Kiruthika, Nagaraja Ingaladal, K. Krishnakumar, Natakkakath Kaliyathan Raveena, Biju Gopika, Mullan Velandy Reshma","doi":"10.2174/2665978604666230112144757","DOIUrl":"https://doi.org/10.2174/2665978604666230112144757","url":null,"abstract":"\u0000\u0000Trikatu, a vital ingredient in many Indian Ayurvedic drugs, is a consortium of three spices, viz. dry ginger, black pepper, and long pepper, known for its peculiar pungency. To convert Trikatu into a widely acceptable palatable form, we blended these three spices in a decoction form and added them to syrup prepared from palmyra palm neera, which resulted in ‘Trikatu Syrup’ (TS). Recently, we reported in vivo immunomodulatory properties of TS [1].\u0000\u0000\u0000\u0000The immunomodulatory effects of spices are attributed largely to the presence of certain phytochemicals. The importance of phytochemicals in spices as immunomodulatory agents necessitate a thorough investigation of these bioactives in formulations comprising spices. In the present study, we have focused on understanding the retention of spice and syrup-based phytochemicals in the formulated product that assists in product standardization of TS.\u0000\u0000\u0000\u0000NMR serves as a highly reliable tool for explicit structural confirmation of phytochemicals when compared to HPLC or mass spectrometry tools. NMR spectra of a phytochemical, whether in pure form or when the phytochemical is a part of the mixture, enable qualitative and quantitative studies with a mixture of phytochemicals in organic extracts of food matrices. Hence, the NMR spectral comparison of compounds isolated from the organic extracts of TS is described here.\u0000\u0000\u0000\u0000Fractionation of TS using Diaion® HP-20 resulted in the partitioning of compounds based on their polarity. Purification of the acetone fraction by column chromatography aided in the efficient isolation of compound 1 (pellitorine), compound 2 (piperine), compounds 3-5 (trienamides), and compound 6 (pipataline). Acetonitrile fraction yielded compound 7 (uridine) and compound 8 (3-O-methyl-myo-inositol), which were neither reported in the three spices nor palmyra palm. A qualitative display of the acetone fraction of TS with its phytochemicals 1-6 served as a fingerprint of TS.\u0000\u0000\u0000\u0000In summary, TS, a palatable spice-based nutraceutical in palmyra palm syrup with immunomodulatory potential 1, was thoroughly investigated for the phytochemical composition of its organic fractions. The process of fractionating TS using Diaion® HP-20, subsequent flash purification, and column chromatography facilitated the isolation of prominent phytochemicals. We report the utility of NMR as a reliable and efficient tool for fingerprinting phytochemicals in formulations, nutraceuticals, etc., which assists in ascertaining their authenticity.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115018211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic Formulation Development and Local Application with Focus on Local Buccal, Nasal and Pulmonary Application","authors":"Karola Lima-Engelmann, Marc Schneider","doi":"10.2174/2665978604666221122112434","DOIUrl":"https://doi.org/10.2174/2665978604666221122112434","url":null,"abstract":"\u0000\u0000These days, probiotics are commonly used in functional foods or as dietary supplements. But its positive effect goes far beyond the digestive tract. Local effects of probiotics are currently being studied intensively. The local effect of probiotics in the oral cavity and in the nose has already been examined in some clinical studies. A local pulmonary effect is also of particular interest. In this case, however, studies were only carried out on animals but already elucidated its potential. Various solid and liquid dosage forms are suitable as vehicles for local application. An improved formulation of probiotic products based on pharmaceutical formulation development might bring many different advantages for the effectiveness and duration of action, but also the stability of the probiotic products. Possibilities for the development of suitable probiotic formulations using different methods are presented and explained in more detail. The aim of this review paper is to provide an\u0000overview of the current state of clinical research of local application of probiotics and to present the benefits and opportunities of probiotic formulation development.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116664484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prebiotics as Adjunctive Therapy in Diabetes: A Review\u0000Prebiotics in Diabetes","authors":"Akash Kumar, B. Prajapati, Jhilam Pramanik","doi":"10.2174/2665978603666220818085437","DOIUrl":"https://doi.org/10.2174/2665978603666220818085437","url":null,"abstract":"\u0000\u0000Prebiotic compounds are used by the host microbiome and confer health benefits to the host. Food intake affects the composition of the gut microbiome. The number and composition of gut flora have been linked to metabolic diseases. Diabetes is a chronic condition that alters blood sugar levels. The main form of energy for the body is blood glucose, which is produced from the food. Nutritional interventions can be used to manage blood sugar levels. There are different types of compounds that can be used as prebiotics such as; Inulin-type fructans, Trans-galactooligosaccharides, Lactulose, Isomaltooligosaccharide, Lactosucrose, Xylooligosaccharides, Soybean oligosaccharide, and Glucooligosaccharides. Research evidence suggests that prebiotic consumption supports or improves the gut microbiome, inhibits reactive oxygen species production (ROS), reduces serum glutamic pyruvic transaminase (SGPT) levels, reduces oxidative stress, inhibits NF-κB activation process, reduces inflammation, improves dysfunction, improves insulin resistance, decreases malondialdehyde levels in serum, improves glucose tolerance, decreases intestinal permeability, inhibits α-glucosidase and improves glycemic control. This review focuses on the potential of prebiotic use as adjuvant therapy in diabetes.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125206682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiologically beneficial actions of Alliin in health and disease.","authors":"Daniel Ortuño-Sahagún, Daniel U. Torres-Reyes, Alma Marina Sánchez Sánchez, Lucrecia Carrera-Quintanar","doi":"10.2174/2665978603666220815112034","DOIUrl":"https://doi.org/10.2174/2665978603666220815112034","url":null,"abstract":"\u0000\u0000Garlic has been considered to have medicinal properties in different cultures since ancient times. Vegetables of the allium genus are a natural source of sulfur-containing organic compounds. These compounds have recently been investigated for their positive health effects, such as antioxidant and anti-inflammatory, as well as cardioprotective and anticarcinogenic properties.\u0000\u0000\u0000\u0000In this review we focus on one of the main components of garlic; alliin or S-allyl-L-cysteine sulfoxide, which is a non-protein amino acid that exhibits a broad spectrum of beneficial effects on physiology, both at the cellular and whole organism levels.\u0000\u0000\u0000\u0000Methods: We conducted a systematic literature search of the MEDLINE (PubMed) database. Search terms used for alliin were: “S-allylcysteine sulfoxide” OR “L-alliin” OR “ACSO”, all of them combined into a separated search term individually as follows: AND “antioxidant”; AND “cardioprotective”; AND “anti-inflammatory”; AND “antimicrobial”; AND “disease”, and; AND “neuroprotective”.\u0000\u0000\u0000\u0000Here, we review and integrate the existing experimental evidence on the effects of alliin, mainly on its antioxidant and anti-inflammatory effects, as well as its cardioprotective action, and its role as an adjuvant for the treatment of different diseases, such as: infectious diseases, inflammatory diseases, metabolic diseases and cancer.\u0000\u0000\u0000\u0000Finally, we propose alliin as a possible neuroprotective agent, through the combination of its antioxidant and anti-inflammatory effects, and its ability to reduce markers of metabolic inflammation in obesity.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116580754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cocos Nucifera- A Nutraceutical with Multiple Therapeutic Potentials","authors":"Smriti Ojha, Saurabh Gupta, Disha Sharma, Akhalesh Kumar, Sudhanshu Mishra","doi":"10.2174/2665978603666220628104537","DOIUrl":"https://doi.org/10.2174/2665978603666220628104537","url":null,"abstract":"\u0000\u0000Cocos Nucifera (L.) is a tree and offers multiple advantages for the food industry, health industry, and employment Coconut water is the world's most resourceful natural commodity, with considerable scientific data supporting its function in health and medical applications in terms of hydration maintenance. It has been shown to have anti-inflammatory, hepatoprotective, antipyretic, wound curing, antihypertensive, antithrombotic, hypoglycaemic, hypolipidaemic, diuretic, antioxidant, and renal regeneration properties. Many research detailing its nutritional and therapeutic qualities have emerged in reputable scientific journals during the last few decades. A glance at the traditional Ayurvedic writings provides information about the therapeutic benefits of Coconut that is consistent with current scientific results.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132791503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent updates on the pharmacological potential of plant-based rutin","authors":"Akanksha Pandey, Ramesh Kumar, A. Mishra, A. Pandey, A. Pandey","doi":"10.2174/2665978603666220614151613","DOIUrl":"https://doi.org/10.2174/2665978603666220614151613","url":null,"abstract":"\u0000\u0000Flavonoids have been found to be beneficial in the treatment of several diseases owing to their intense biological activity, bioavailability and safety aspects. Rutin, an important polyphenolic flavonoid, is consumed on a daily basis in the diet. Rutin, also known as vitamin P and quercetin-3-O- rutinoside, is a nontoxic and non-oxidizable molecule. It is present in vegetables, food items and beverages.\u0000\u0000\u0000\u0000The present review is aimed at providing a comprehensive overview on the medicinal attributes, metabolism, biological and pharmacological activities, and mechanisms of action of rutin. Limitations and future prospects on rutin related research are also described.\u0000\u0000\u0000\u0000Various search engines and databases were used for literature search with keyword combinations including rutin, antioxidant, pharmacological efficacy, bioavailability, clinical studies and molecular targets.\u0000\u0000\u0000\u0000A wide range of in vitro and in vivo studies on rutin suggested its potential biological and pharmacological effects, including antioxidant, anti-inflammatory, antidiabetic, anti-hyperlipidemic, renoprotective, hepatoprotective, cardioprotective, and anticancer activities. Rutin exhibited the drug action by modulating various signaling pathways including PI3K/AKT pathway, β-catenin signaling, JAK-STAT signaling, and apoptotic pathways.\u0000\u0000\u0000\u0000The available data suggest the potential therapeutic utility of rutin against a diverse number of disorders, mainly derived from its antioxidant activity and the modulation of signaling pathways. Further, it helps in minimizing the side effects of the therapy for the treatment of several chronic diseases. Thus promising activities of rutin make it a potent drug candidate.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121193107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Short Review On Efficacy Of Derivatives Of Curcumin","authors":"Rege, Sameera A, Varshneya Megha A, Momin, Shamim A","doi":"10.2174/2665978603666220610161741","DOIUrl":"https://doi.org/10.2174/2665978603666220610161741","url":null,"abstract":"\u0000\u0000Curcumin with medicinal value should possess good bioavailability and stability. Unfortunately, the bioavailability of curcumin is less and its stability depends on the medium. After intake of curcumin, it undergoes metabolism to form metabolites, which are bioactive and show better bioavailability than curcumin. Hence, the disadvantages of curcumin can be overcome by the formation of its synthetic derivative. In this review paper, the derivatives of curcumin namely tetrahydrocurcumin, hexahydrocurcumin, octahydrocurcumin, deketene curcumin and dimethoxycurcumin are discussed. The diketo group, diene moiety and ortho-methoxy phenolic groups present in curcumin influence its properties. Curcumin undergoes degradation in alkaline and non-polar mediums, mainly because of its property to exhibit keto-enol tautomerism, which is further enhanced due to the presence of diene moiety and ortho-methoxy phenolic groups. If the keto-enol tautomerism is inhibited by its derivatization, then its stability is improved. This is especially true in the case of hexahydrocurcumin, octahydrocurcumin and deketene curcumin which do not possess an active methylene group. Although tetrahydrocurcumin undergoes keto-enol tautomerism, the degradation of enol tautomer is prevented due to the absence of diene moiety. The activities of curcumin are medium dependent whereas the activities of hydrogenated derivatives of curcumin and deketene curcumin are medium independent. Dimethoxycurcumin exhibits keto-enol tautomerism and can undergo degradation in alkaline and non-polar mediums at a faster rate than curcumin. The reason is that the strong activating hydroxyl groups in curcumin are replaced by a stronger activating methoxy groups in dimethoxycurcumin. On the other hand, in acidic and polar mediums, the rate of beneficial activities of dimethoxycurcumin is more than curcumin. Also, the bioavailability of the above-mentioned derivatives of curcumin is more than curcumin.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128345694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Polyphenolic Nutraceuticals in the Management of Glioblastoma Multiforme.","authors":"S. Raysing, A. Gorle","doi":"10.2174/2665978603666220525161010","DOIUrl":"https://doi.org/10.2174/2665978603666220525161010","url":null,"abstract":"\u0000\u0000Glioblastoma Multiforme (GBM) is a malignant central nervous system tumor. GBM is produced by aggressive proliferation of cells and invasion of normal brain tissue. The current conventional therapies for GBM include surgery, chemotherapy, and radiation therapies which are challenging and produce adverse effects. Thus, polyphenolic nutraceuticals are effective natural compounds for preventing and treating GBM due to their chemoprotective activity. Polyphenols are bioactive, non-nutrient plant chemicals structurally sub-divided into 5 groups; among these groups, phenolics and flavonoids are widely studied as they have lesser side effects and the more significant potential to pass the Blood-Brain Barrier (BBB). These polyphenolic nutraceuticals have the potential to advance current GBM treatment options. This review throws light on the anti-cancer efficacy of major polyphenol classes (Phenolic acid, Flavonoids, Stilbenes, Lignans) and discusses their prospective mechanisms of action in GBM.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133928386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}