Current Nutraceuticals最新文献_第3页

Meet the Editorial Board Member 认识编辑委员会成员

Current Nutraceuticals Pub Date : 2022-05-01 DOI: 10.2174/266597860302221111114741

Ayman M. Mahmoud

引用次数: 0

Evaluation of Antimicrobial Activity of Thymbra spicata L. var. spicata Essential Oil as a Potential Source of Herbal Medicine 作为潜在药材来源的胸腺精油抑菌活性评价

Current Nutraceuticals Pub Date : 2022-03-29 DOI: 10.2174/2665978603666220329235246

A. Şahiner, S. Aksoy, E. A. Yapar, G. Cengi̇z, Ece Halat, M. Ateş

{"title":"Evaluation of Antimicrobial Activity of Thymbra spicata L. var. spicata Essential Oil as a Potential Source of Herbal Medicine","authors":"A. Şahiner, S. Aksoy, E. A. Yapar, G. Cengi̇z, Ece Halat, M. Ateş","doi":"10.2174/2665978603666220329235246","DOIUrl":"https://doi.org/10.2174/2665978603666220329235246","url":null,"abstract":"Since ancient times, humankind has used plants for its flavor, essence and especially for medical purposes in addition to food source. Turkey, due to its geographical location, is home to many varieties of species of medicinal and aromatic plants. Aromatic and medicinal plants produce essential oils in the form of secondary metabolites. These essential oils are being used in food, cosmetic and pharmaceutical industries. Due to the various side effects of synthetic agents, the use of essential oils as antimicrobial agents comes to the fore. The purpose of this study was to determine the essential oil composition of Thymbra spicata L. var. spicata collected from Gaziantep Region of Turkey and to evaluate its antimicrobial efficacy against microorganism species commonly encountered in food, cosmetic and pharmaceutical industries. In this study, the antimicrobial effect of volatile oil obtained from dried leaves of Thymbra spicata L. var. spicata traditionally known as Zahter was investigated. For this purpose, volatile oil was obtained from leaves of the plant by steam vapor distillation method. Antimicrobial efficacy tests were conducted against microorganisms; Staphylococcus aureus, Enterococcus hirae, Enterococcus faecalis, Listeria monocytogenes, Escherichia coli, Klebsiella pneumoniae, Proteus hauseri, Pseudomonas aeruginosa, Salmonella typhimurium and Candida albicans. Result of the experiments showed that the volatile oil obtained from Thymbra spicata L. var. spicata had a cidal effect on selected pathogenic microorganisms even at low concentrations. This study showed that the high carvacrol content of the T. spicata L. var. spicata grown in the Gaziantep region of Turkey is a promising source of antimicrobial raw materials in the pharmaceutical, cosmetic and food industries.","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125052887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutraceutical Potentials of Azanza garckeana (Snot Apple): A Review 甘露甘露的营养保健潜力综述

Current Nutraceuticals Pub Date : 2022-03-21 DOI: 10.2174/2665978603666220321122409

Abiola Fatimah Adenowo, Fausat Titilola Salisu, M. Akinsanya, M. Kazeem

{"title":"Nutraceutical Potentials of Azanza garckeana (Snot Apple): A Review","authors":"Abiola Fatimah Adenowo, Fausat Titilola Salisu, M. Akinsanya, M. Kazeem","doi":"10.2174/2665978603666220321122409","DOIUrl":"https://doi.org/10.2174/2665978603666220321122409","url":null,"abstract":"\u0000\u0000Nutraceuticals are products derived from natural sources and are used as therapeutic agents for the management of various health disorders. Several nutraceuticals have been produced from fruits, including wild edible fruits. Azanza garckeana is an example of wild edible fruit which belongs to the Malvaceae family. It is a semi-deciduous flowering plant which grows in savanna-wooded grasslands and open forests. It can be found in tropical Eastern Africa, Southern Africa and some countries of Western Africa. All parts of the plant are useful for medical and economic purpose. There are various traditional claims on the application of various parts of the plant in the management and treatment of diabetes, infertility, aches and pains, hemorrhage, liver and cardiac diseases, amongst others.\u0000\u0000\u0000\u0000This article presents a review of the plant Azanza garckeana regarding its botanical description, its traditional relevance economically and medically, and its established nutritional as well as pharmacological relevance based on reported in vitro and in vivo experimental investigations.\u0000\u0000\u0000\u0000Experimental reports on the nutritional and pharmacological potentials of Azanza garckeana are sparse. Therefore, there is a need for extensive research to further establish the plant as a potential candidate of a pharmacological or nutraceutical agent for the management of oxidative stress related diseases and other human health disorders.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115986632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of natural plant products against Hemagglutinin-esterase (HE) of human coronavirus 天然植物产物抗人冠状病毒血凝素酯酶(HE)的作用

Current Nutraceuticals Pub Date : 2022-02-23 DOI: 10.2174/2665978603666220223093343

Mantasha Idrisi, M. Shahid, Falaq Naz, Y. Siddique

引用次数: 0

Physico-Chemical Characterization Of Edible Gums Obtained From Anogeissus Latifolia And Abelmoschus Esculentus: Promising Food Additive For Novel Drug Delivery 可食性树胶的理化特性研究:新型药物输送食品添加剂

Current Nutraceuticals Pub Date : 2022-02-01 DOI: 10.2174/2665978603666220201122908

R. Tiwari, Ritesh Solanki, V. Rastogi

{"title":"Physico-Chemical Characterization Of Edible Gums Obtained From Anogeissus Latifolia And Abelmoschus Esculentus: Promising Food Additive For Novel Drug Delivery","authors":"R. Tiwari, Ritesh Solanki, V. Rastogi","doi":"10.2174/2665978603666220201122908","DOIUrl":"https://doi.org/10.2174/2665978603666220201122908","url":null,"abstract":"\u0000\u0000Background: In challenging assignments for advancing practices of characterization of the fluid-dried gum extracted from the fresh fruit of the Okra Gum (Abelmoschus Esculentus) and refined Gum Ghatti (Anogeissus Latifolia) vine is defined in this paper\u0000\u0000\u0000\u0000Introduction: It outlines a systematic study of the physico-chemical properties of gums in response to a European Union request for a thorough review of the quality of gums as food additives.\u0000\u0000\u0000\u0000Method : Ash percent, acid insoluble ash percent, cold water soluble percent, pH, acidity (as HCl) percent by mass, viscosity, elemental and heavy metals analysis and FT-IR are the parameters tested following traditional procedures and current analytical instruments. The aim of this study was to determine the key functional characteristics of commercially important natural gums. These included flow, solubility, and angle of repose, as well as bulk and true density.\u0000\u0000\u0000\u0000Result: The angle of repose of okra gum was found to be very high (45.66 °), which means that Okra Gum has more adhesive properties than 38.13 ° Gum Ghatti. . Okra powder was shown to be sparingly soluble in water and insoluble in acetone, ethanol, and chloroform. Gum Ghatti was shown to be slightly soluble in water, practically insoluble in ethanol, acetone and Chloroform. The compressibility index and repose angle of Okra gum are 32.96 percent and 38.13, respectively\u0000\u0000\u0000\u0000Conclusion: The results of this study established the basic characteristics of gums and demonstrated their potential applications in the fields of novel drug delivery, cosmetics, and other pharmaceutical industries.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123925525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meet the Editorial Board Member 认识编辑委员会成员

Current Nutraceuticals Pub Date : 2022-02-01 DOI: 10.2174/266597860301220406124010

Rahman Shah Z. Saleem

引用次数: 0

Efficient transport and biotransformation of dipeptide-like tyrosine/phenylalanine-conjugated phenolic amide esters in THP-1 cells and PBMCs: A potential means for transporting compounds inside monocytes/macrophages THP-1细胞和pbmc中二肽样酪氨酸/苯丙氨酸偶联酚酰胺酯的有效运输和生物转化:单核/巨噬细胞内转运化合物的潜在手段

Current Nutraceuticals Pub Date : 2021-12-24 DOI: 10.2174/2665978603666211224121836

Jae B. Park

{"title":"Efficient transport and biotransformation of dipeptide-like tyrosine/phenylalanine-conjugated phenolic amide esters in THP-1 cells and PBMCs: A potential means for transporting compounds inside monocytes/macrophages","authors":"Jae B. Park","doi":"10.2174/2665978603666211224121836","DOIUrl":"https://doi.org/10.2174/2665978603666211224121836","url":null,"abstract":"\u0000\u0000Recent studies suggest that dipeptide-like tyrosine/phenylalanine-conjugated phenolic amide compounds may contain several biological activities including anti-inflammatory activity. However, there is currently no information about their transport and biotransformation in monocytes/macrophages involved in inflammation process. \u0000\u0000\u0000\u0000The objective of this study was to investigate cell transport and biotransformation of the phenolic amides and esters in monocyte/macrophage-like cells. \u0000\u0000\u0000\u0000Cell transport and biotransformation of the phenolic amides and esters (N-coumaroylphenylalanine, N-caffeoylphenylalanine, N-feruloylphenylalanine, N-coumaroyltyrosine, N-caffeoyltyrosine, N-feruloyltyrosine and their O-methyl esters) were investigated in THP-1 cells and PBMCs using HPLC, cellular and kinetics methods\u0000\u0000\u0000\u0000In THP-1 cells, the phenolic amides were not transported significantly, but their O-methyl esters were transported significantly (P < 0.02). Also, the transport of the esters was found to be sodium-independent and pH-dependent. Among the tested esters, N-feruloylphenylalanine-O-methyl ester showed the highest uptake (Km of 25 µM), and the uptake was inhibited by PepT1/2 substrate and blocker (GlySar and enalapril) in THP-1 cells. Particularly, enalapril competitively inhibited the uptake with Ki of 560 µM. The data also showed that N-feruloylphenylalanine-O-methyl ester and N-feruloyltyrosine-O-methyl ester could be biotransformed into parent phenolic amides in THP-1 cells. Similarly, the ester compounds were also found to be transported and biotransformed in PBMCs.\u0000\u0000\u0000\u0000The data suggest that dipeptide-like tyrosine/phenylalanine-conjugated phenolic amide esters may be transported and biotransformed in THP-1 cells and PBMCs.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134488519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Nigella Sativa (Black seeds) Supplementation on Plasma Lipid Profile in Human Subjects – A review 补充黑籽对人体血脂的影响综述

Current Nutraceuticals Pub Date : 2021-12-02 DOI: 10.2174/2665978602666211202102631

N. Maideen

{"title":"Effects of Nigella Sativa (Black seeds) Supplementation on Plasma Lipid Profile in Human Subjects – A review","authors":"N. Maideen","doi":"10.2174/2665978602666211202102631","DOIUrl":"https://doi.org/10.2174/2665978602666211202102631","url":null,"abstract":"\u0000\u0000Dyslipidemia is the major risk factor for atherosclerotic cardiovascular disease (ASCVD), cerebrovascular disease and peripheral artery disease (PAD). It is characterized by higher plasma concentrations of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c), apolipoprotein B (apoB), very low density lipoprotein-cholesterol (VLDL-c), triglycerides (TGs) and low levels of high density lipoprotein-cholesterol (HDL-c). Herbal medicines are preferred by many across the globe particularly to manage chronic conditions such as dyslipidemia, hypertension, type 2 diabetes, cancer, and plenty of others. Nigella sativa (Black seeds or Black cumin seeds) is a miracle herb employed within the management of many sicknesses for centuries. Hence, this review focuses on the ameliorative effects of N. sativa on the plasma lipid concentrations of human subjects. Numerous randomized controlled clinical trials (RCTs) and different clinical studies demonstrated that N. sativa possess potential anti-dyslipidemic activity. The patients with dyslipidemia may well be benefited by using N. sativa along with healthy lifestyle changes and statin and other antihyperlipidemic medications as adjuvant therapy if needed.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125246659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-infective and Antineoplastic properties of Green Tea Catechins: Examining the Therapeutic Risk-Benefit ratio 绿茶儿茶素的抗感染和抗肿瘤特性:检查治疗风险-效益比

Current Nutraceuticals Pub Date : 2021-11-24 DOI: 10.2174/2665978602666211124093814

Luciene De Paula Mendes, Sharif Beyah, E. Hefti

{"title":"Anti-infective and Antineoplastic properties of Green Tea Catechins: Examining the Therapeutic Risk-Benefit ratio","authors":"Luciene De Paula Mendes, Sharif Beyah, E. Hefti","doi":"10.2174/2665978602666211124093814","DOIUrl":"https://doi.org/10.2174/2665978602666211124093814","url":null,"abstract":"\u0000\u0000Background: Green tea is a commonly used dietary supplement and food product. Green tea contains many polyphenolic compounds known as green tea catechins (GTCs). There are numerous reports exploring the potential benefit of using green tea catechins as chemotherapeutic agents to treat neoplastic disorders and infectious processes. The prevalence of cancer diagnoses, bacterial infections, and viral diseases that include SARS-CoV-2 have led to increased interest in GTCs as a therapeutic option in patients suffering from these conditions. \u0000\u0000Objective: This concise review explores the evidence related to the therapeutic use of GTCs to treat neoplastic disorders as well as bacterial and viral infections. \u0000\u0000Methods: PubMed, NIH, OVID online databases were utilized to retrieve relevant scientific literature that address GTCs role in treating cancer and infectious disease. \u0000\u0000Results: While there are preliminary data indicating potentially adventitious properties of GTCs, there is a paucity of large prospective clinical trial data to support the use of GTCs in a therapeutic capacity to treat these disease processes. There are documented instances of GTCs interacting with medications indicated to treat neoplastic diseases. \u0000\u0000Conclusions: Currently, it appears the therapeutic benefit of using GTCs is outweighed by the potential risks. \u0000\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125350656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical methods for the quantification of selenium species in biological matrix: Where are we? 生物基质中硒的定量分析方法:进展如何?

Current Nutraceuticals Pub Date : 2021-11-17 DOI: 10.2174/2665978602666211117154655

Rama Alhasan, C. Perrin-Sarrado, C. Jacob, C. Gaucher

{"title":"Analytical methods for the quantification of selenium species in biological matrix: Where are we?","authors":"Rama Alhasan, C. Perrin-Sarrado, C. Jacob, C. Gaucher","doi":"10.2174/2665978602666211117154655","DOIUrl":"https://doi.org/10.2174/2665978602666211117154655","url":null,"abstract":"\u0000\u0000Over the years, scientific investigations have proven the importance of selenium as an essential element for mammals, emphasizing its activity against many diseases and even its prophylactic effects. It is also established now that a malconsumption of selenium can be harmful. Therefore, the nature and the concentration of selenium and its derivatives found in the diet, the body, and even in the environment, for example, in the soil, should be determined carefully.\u0000\u0000\u0000\u0000\u0000 In this review, analytical methods for speciation and determination of selenium concentrations in biological samples are summarized.\u0000\u0000\u0000\u0000\u0000Methods ranging from routine to cutting-edge are explored, focusing on their analytical characteristics, such as specificity for discrete selenium species, sensitivity, accuracy, reproducibility, and skills required.\u0000\u0000\u0000\u0000\u0000There are already numerous studies regarding the analysis of selenium species. Beyond the method employed for actual measurements, we propose to review the preanalytic steps for sample handling in biological matrices, which directly affect results that will be more accurate with careful pretreatment. Furthermore, to reach better outcomes in terms of the identification of selenium species, different combinations of techniques might be the answer. We highlight here the last and the cutting-edge methods to identify and quantify selenium such as, high-performance liquid chromatography combined to inductively coupled plasma mass spectrometry (HPLC-ICP-MS), hydride generation atomic absorption spectrometry (HG-AAS), hydride-generation combined to atomic fluorescence spectrometry (HG-AFS), or to inductively coupled plasma optical emission spectrometry (HG-ICP-OES). This review emphasizes the importance of such investigations and the need to achieve reliable, safe, and effective quantification and methods of determination.\u0000\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128180675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1