天然植物产物抗人冠状病毒血凝素酯酶(HE)的作用

Current Nutraceuticals Pub Date : 2022-02-23 DOI:10.2174/2665978603666220223093343

Mantasha Idrisi, M. Shahid, Falaq Naz, Y. Siddique

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引用次数: 0

摘要

新冠肺炎疫情已在全球蔓延，造成了巨大的经济社会损失。由于缺乏有效的药物，其控制已成为一项艰巨的任务。本研究通过分子对接的方法，研究了部分天然植物产物对人冠状病毒血凝素酯酶的影响。采用HEX 8.0.0软件对部分天然植物产物进行抗人冠状病毒血凝素酯酶(HE)的分子对接研究。结合自由能范围为-298.14 ~ -161，以姜黄素最高。结果表明，天然植物产物可以作为抗病毒药物，并有可能作为天然治疗剂。

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Role of natural plant products against Hemagglutinin-esterase (HE) of human coronavirus

COVID-19 has spread worldwide and become a great cause of economic and social loss. Due to the non-availability of effective medicine/drug, its control has become a difficult task. In the present study, the effect of some selected natural plant products was studied on the Hemagglutinin-esterase of the human coronavirus by performing molecular docking. Molecular docking study for some selected natural plant products against Hemagglutinin-esterase (HE) human coronavirus was performed using HEX 8.0.0 software. The free energy of binding ranges from -298.14 to -161, curcumin being the highest. The results suggest that the natural plant products could act as possible anti-viral agents and maybe used as possible natural therapeutic agents.

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Current Nutraceuticals

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