Current Nutraceuticals最新文献

{"title":"The antimitotic Podophyllotoxin and its derivatives- recent synthetic advances","authors":"S. Riaz, K. Khan, G. Chotana, A. Faisal, R. Saleem","doi":"10.2174/2665978602666211102103152","DOIUrl":"https://doi.org/10.2174/2665978602666211102103152","url":null,"abstract":"\u0000\u0000The substantial antimitotic potential of podophyllotoxin and its derivatives has attracted both synthetic and medicinal chemists to expand the chemical space for the subsequent biological evaluation of these compounds. The interest ranges from total synthesis, hemi-synthesis, one-pot synthetic approaches and structure-activity relationship studies. In the first segment of the review, we present recent development in the synthesis of podophyllotoxin and also describe its mode of action. The second section covers the synthesis and the structure-activity relationships of podophyllotoxin derivatives, along with the discussion of important structural features required by the molecule for displaying antimitotic activity. The last part describes the synthesis and biological evaluation of potent 4-aza podophyllotoxin derivatives. This review is of interest to chemists who study natural and synthetic compounds for drug discovery.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114998267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction, Encapsulation and Potential Health Benefits of Plant Phenolic Compounds","authors":"Q. Vuong","doi":"10.2174/266597860204211203091845","DOIUrl":"https://doi.org/10.2174/266597860204211203091845","url":null,"abstract":"Polyphenols derived from plants have diverse structures and properties and have received increasing interest. Polyphenols are secondary metabolites, which can exhibit defensive mechanisms against diseases and pathogens. In food, they may contribute to bitterness, astringency, colour, flavour, odour and may inhibit lipid oxidation and microbial growth [1]. They also possess antioxidant activities and therapeutic properties; thus, they can also be potentially used in cosmetic and pharmaceutical products [2]. Polyphenols are rich in plant materials, such as Tuckeroo (Cupaniopsis anacardioides), Australian Maroon Bush (Scaevola spinescens R. Br.), lemon myrtle (Backhousia citriodora), and Salacia chinensis L. Tuckeroo, Australian Maroon Bush, and lemon myrtle, which are native to Australia. In contrast, Salacia chinensis L. grows widely in the forests of Asian countries, such as Vietnam, China, India, and Sri Lanka. These plant materials have been traditionally used as herbal medicine for various diseases, revealing that polyphenols derived from these materials are potential therapeutic agents. Therefore, it is important to effectively extract, encapsulate and further test the properties of the extracts prepared from these materials.","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125842173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising Conditions for Encapsulation of Salacia chinensis Root Extract enriched with Phenolic Compounds","authors":"Thanh V. Ngo, C. Scarlett, M. Bowyer, Rebecca McCullum, Q. Vuong","doi":"10.2174/2665978602666210805094012","DOIUrl":"https://doi.org/10.2174/2665978602666210805094012","url":null,"abstract":"\u0000\u0000S. chinensis extract contains bioactive compounds, which exhibit high antioxidant activities. However, for commercial uses, it is necessary to encapsulate the extract to protect it from degradation.\u0000\u0000\u0000\u0000This study aimed to optimise spray-drying conditions and then compare with freeze-drying to identify the most suitable conditions for encapsulation of Salacia chinensis L. root extract. \u0000\u0000\u0000\u0000Three factors of spray-drying encapsulation, including maltodextrin concentration, inlet temperature and feed rate, have been tested for the impacts on the physical and phytochemical properties of S. chinensis root extract. Based on the optimal conditions, the spray-drying was then compared with freeze-drying.\u0000\u0000\u0000\u0000The results showed that maltodextrin concentration, inlet temperature and feed rate had significant impacts on recovery yield, phenolics, mangiferin and antioxidant activity of the spray-dried extract. The optimal spray-drying encapsulation conditions were maltodextrin concentration of 20 %, inlet temperature of 130ºC and feed rate of 9 mL/min. Under these optimal conditions, the encapsulated extract had comparable solubility, total phenolics, mangiferin, and antioxidant activity, lower bulk density, moisture content, and water activity as compared to encapsulated extract made using the freeze-drying technique. These optimal spray-drying conditions are recommended to encapsulate the extract of S. chinensis root.\u0000\u0000\u0000\u0000Spray-drying was found to be more effective for encapsulation of S. chinensis root extract than freeze-drying. Therefore, spray-drying is recommended for further applications.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131041499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Detailed Review on Herbal Treatments for Treatment of PCOS- Polycystic ovary syndrome (PCOS)","authors":"A. Wal, P. Wal, Nikita Saraswat, Simran Wadhwa","doi":"10.2174/2665978602666210805092103","DOIUrl":"https://doi.org/10.2174/2665978602666210805092103","url":null,"abstract":"\u0000\u0000The review gives a brief about PCOS and the symptoms related to the disease. Around 2.2 to 26% cases of PCOS are present globally. The disorder generally occurs in the reproductive age group women. The review has a mention of few herbs which can be used to correct the diseased condition. The various herbs have positive effect on the diseased condition and can be used to cure symptoms like hypothyroidism, hyperplasia, obesity, diabetes, Menorrhagia, sleep disturbances, cardiovascular problems, hyperlipidemia, hirsutism, infertility, irregular menstrual cycle, etc. The search engines used are PubMed, various review articles, etc.\u0000\u0000\u0000\u0000\u0000The method involved in the review includes various medicinal herbs that have seen to affect women having various gynecological disorders like Poly Cystic Ovarian Syndrome, Uterine Fibroids, and Endometriosis. \u0000\u0000\u0000\u0000\u0000The herbs included in the review include Bauhinia variegata useful in hormone imbalance, Phyllanthus emblica, Terminalia bellirica, Terminalia chebula, and Commiphora wightii are used to regulate the hormones, Cinnamon cassia acts as an anti-oxidant, Tribulus terrestris improves reproductive dysfunction, Hypericum perforatum regulates depression, Commiphora myrrha prevents menorrhagia, Nigella sativa controls cholesterol, Saraca asoca has estrogenic action, Asparagus racemosus promotes folliculogenesis, Tinospora cordifolia regulates menstrual flow, Ocimum sanctum as an anti-oxidant. \u0000\u0000\u0000\u0000The plants taken had positive effect on women with PCOS without causing any side-effects. The natural herbs used for the treatment of PCOS did not have any side effects and treated the diseased condition naturally. The review is to understand the natural plants available for the treatment of the disease naturally. The herbs can be used individually or can be used in combination.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114626537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized, Placebo-controlled, Triple-blind Study to Determine the Effect of Farlong Ginseng Plus® NotoGinseng Extract on Cholesterol and Blood Pressure","authors":"M. Evans, E. Lewis, David C. Crowley, A. Zeng, Jing Struve, N. Guthrie","doi":"10.2174/2665978602666210714131146","DOIUrl":"https://doi.org/10.2174/2665978602666210714131146","url":null,"abstract":"\u0000\u0000This randomized, placebo-controlled, triple-blind study examined the efficacy of 12 weeks of Farlong NotoGinseng™ (FNG) supplementation on LDL-C and blood pressure (BP) in otherwise healthy participants (n=95) with normal to mild hypertension and hypercholesterolemia.\u0000\u0000\u0000\u0000Lipid profile, BP, and endothelial vasodilation parameters were assessed at baseline and weeks 4, 8 and 12. Safety was assessed at screening and end of the study. The Therapeutic Lifestyle Change (TLC) diet was followed during a 4-week run-in and throughout.\u0000\u0000\u0000\u0000Participants on FNG had a 4.33% reduction in LDL-C at week 8 (p=0.045) and a 1.80% improvement in HDL-C at week 12. Those on placebo had a non-significant 1.37% HDL-C reduction at both weeks 8 and 12. The FNG group showed a 0.94% reduction in systolic (SBP) and a 0.16% reduction in diastolic BP (DBP) at week 12. The placebo group also had 0.5% and 1.24% increases in SBP and DBP, respectively. A total of 17.5% of participants supplemented with FNG had improvements in all three CVD risk factors (LDL-C, HDL-C and SBP) compared to 5.0% of those on placebo (p=0.040). A greater proportion of participants with borderline high baseline LDL-C had reductions in their CVD risk factors (p=0.037) with FNG. However, participants in the placebo group with similar LDL-C characteristics did not have improvements in either their BP or lipid profile. \u0000\u0000\u0000\u0000FNG was well-tolerated and may have a positive influence on reducing CVD risk by improving BP and lipid profile. Left unaddressed, those with CVD risk factors may progress to a more hypertensive and hypercholesterolemic state.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132360201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of antioxidant activity and analysis of phenolic compounds of some Asteraceae plants by HPLC: A comparison between Methanol and Ethanol extracts","authors":"Donia Anvari, R. Jamei","doi":"10.2174/2665978602666210713143401","DOIUrl":"https://doi.org/10.2174/2665978602666210713143401","url":null,"abstract":"\u0000\u0000Medicinal and healing plants have been used in treating human diseases for centuries because of their therapeutic effects. They may assist in curing common ailments such as a multitude of skin problems, various disorders from muscle spasms to cuts and wounds. They can be used to relieve symptoms of different illnesses from a cold to some forms of arthritis or some allergies as well. The Asteraceae plant is a strong source of antimicrobial and antioxidant agents and this paper focuses on its specifications.\u0000\u0000\u0000\u0000This study aimed to investigate the antioxidant potential and radical scavenging of different solvents (Methanol and Ethanol) of five species, i.e., Artemisia absinthium L., Arctium lappa L., Centaurea cyanus L., Silybum marianum L., and Echinops ritro L., belonging to the Asteraceae family.\u0000\u0000\u0000\u0000Methanol and ethanol extracts of the above plants were prepared. The obtained sections were evaluated for total phenolic content (TPC), total flavonoid content (TFC), total antioxidant capacity (TAC), chain-breaking activity (CBA), thiobarbituric acid (TBA), and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. Also, Ferric reducing antioxidant power (FRAP), Nitric oxide (NO) radical scavenging, Hydrogen peroxide (H2O2) radical scavenging, and Superoxide (O2-) radical inhibition assay were measured. Phenolic compounds were determined and measured by high-performance liquid chromatography (HPLC) as well.\u0000\u0000\u0000\u0000The collected and analyzed data showed that the highest values for the TPC, TFC, TBA, and DPPH were related to methanol extract of A. lappa L. Moreover, the maximum values for the CBA, H2O2, and O2- were observed in the Ethanol extract of E. ritro L., while methanol extract of E. ritro L. showed the highest amount of FRAP and NO. Eventually, the highest value for TAC was related to A. absintium L., and it was also realized that methanol compared to ethanol solvent was more successful in the extraction procedure.\u0000\u0000\u0000\u0000These findings suggest that A. lappa L. and E. ritro L. extracts can be considered excellent natural antioxidant agents. The type of solvent can affect the extraction of phenolic compounds. Sinapic acid, as the highest level of phenolic acid, was found in S. marianum L.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126063891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological evaluation of polar extract of Chrozophora tinctoria for effective treatment of cancer; in vitro qualitative and quantitative analysis","authors":"S. Khan, Faisal Rashid, H. S. Shah, J. Iqbal","doi":"10.2174/2665978602666210713141734","DOIUrl":"https://doi.org/10.2174/2665978602666210713141734","url":null,"abstract":"\u0000\u0000Worldwide, cancer claims a significant public health problem and is another leading cause of death after ischemic heart diseases. Currently, the nutraceuticals and their biologically active phytoconstituents have received the greatest attention for the prevention and treatment of cancer due to origin authenticity, natural compatibility, and least toxicity.\u0000\u0000\u0000\u0000The aerial part of the C. tinctoria was extracted with methanol and then fractionated with liquid-liquid extraction by utilizing water, butanol, ethyl acetate, chloroform, and n-hexane. In addition to total phenolic, the flavonoid contents were also determined. Phytochemical analysis was performed, and maximum phenolic and flavonoid contents were obtained in chloroform and ethyl acetate fractions. \u0000\u0000\u0000\u0000The obtained fractions were assessed for potential anticancer agents by utilizing HeLa and MCF–7 cells. The most active fractions from initial anticancer screening were further investigated microscopically to determine apoptosis, production of reactive oxygen species (ROS) as well as cell cycle arrest (flow cytometry). Interestingly, the maximum cytotoxic activity in cancer cells was observed by ethyl acetate and chloroform fraction.\u0000\u0000\u0000\u0000It is concluded that ethyl acetate and chloroform fractions showed the most promising anticancer activity and would be a new treatment option for the most common cancer in females.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133236932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Glucose Lowering Effect by an Extract from Aronia (Aronia melanocarpa) – a pilot intervention study","authors":"Kirsten Berger, Johanna Josefine Ostberg-Potthoff, T. Bakuradze, P. Winterhalter, E. Richling","doi":"10.2174/2665978602666210709103232","DOIUrl":"https://doi.org/10.2174/2665978602666210709103232","url":null,"abstract":"\u0000\u0000The polyphenols from red fruits exhibit protective effects against degenerative diseases, including diabetes mellitus type 2, cardiovascular disease, etc. \u0000\u0000\u0000\u0000In this small pilot intervention study with only ten volunteers, we investigated the influence of phenolic extracts prepared from an Aronia juice and a red grape juice concentrate on peripheral glucose, blood glucose, and insulin after the intake of a drink containing these extracts plus maltodextrin and water.\u0000\u0000\u0000\u0000Maltodextrin in water served as control; additionally, phenolic extracts from Aronia or grape juice were added. Blood samples were taken before ingestion of the bolus drink and 30, 60, 90, 120, 180, 240, and 360 min after. Additionally, continuously the peripheral glucose was measured using a commercially available sensor system.\u0000\u0000\u0000\u0000In all ten volunteers, the intake of Aronia extract (100 mg) reduced both the peripheral glucose and the blood glucose levels significantly (p ≤ 0.05) in comparison to the control. Blood insulin levels were not affected. Whereas the intake of red grape extract (120 mg) did not reduce the glucose levels but increased the insulin levels significantly.\u0000\u0000\u0000\u0000Our pilot study showed that even low amounts of a phenolic Aronia extract could lower glucose absorption. Thus, due to the blood glucose-lowering effects of Aronia phenolics in healthy volunteers, these preliminary results warrant further investigation in the frame of a follow-up study with a larger number of volunteers.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116018584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the phytochemical profiles, antioxidant and cytotoxic activities of crude extracts from fresh and dried Tuckeroo (Cupaniopsis anacardioides) fruits","authors":"N. Pham, Q. Vuong, J. Sakoff, M. Bowyer, C. Scarlett","doi":"10.2174/2665978602666210709110427","DOIUrl":"https://doi.org/10.2174/2665978602666210709110427","url":null,"abstract":"\u0000\u0000Tuckeroo (Cupaniopsis anacardioides) is one of eleven species that belongs to the Sapindaceae family, which is native to Australia.\u0000\u0000\u0000\u0000This study aimed to investigate the phytochemicals, antioxidant capacity, and cytotoxic activity in vitro of Tuckeroo extracts prepared from fresh or dried whole fruits, or just their skin, using acetone (50%) or methanol (50%).\u0000\u0000\u0000\u0000Spectrophotometric analysis was conducted to determine total phenolic content and antioxidant properties, and HPLC analysis was applied to further identified major compounds within the extracts. Cytotoxic activities of the extracts were also tested on ten cancer cell lines including HT29 (colon); U87, SJ-G2 (glioblastoma); MCF-7 (Breast); A2780 (ovarian); H460 (lung); A431 (skin); Du145 (prostate); BE2-C (neuroblastoma); MIA PaCa-2 (pancreas); and one non-tumour derived normal breast cell line (MCF10A).\u0000\u0000\u0000\u0000The results showed that the type of samples or solvents used significantly affected the levels of phenolic compounds, antioxidant capacity and cytotoxicity of the extracts. The extract prepared from the fresh skin of the Tuckeroo fruits had the highest level of phenolics, individual major bioactive compounds, antioxidant and cytotoxic properties.\u0000\u0000\u0000\u0000Fresh Tuckeroo fruit skin is a rich source of phytochemicals, which are potentially potent biologically active agents for application in the health industries. More studies are recommended to further isolate, identify and assess the anti-cancer potential from extract prepared from Tuckeroo fruit skin.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128814809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen Peroxide and Quercetin Induced Changes on Cell Viability, Apoptosis and Oxidative Stress in HepG2 Cells","authors":"A. Yılmaz, Gökhan Biçim, K. Toprak, Betul Karademir Yilmaz, I. Milisav, A. Yalçın","doi":"10.2174/2665978601999200807160528","DOIUrl":"https://doi.org/10.2174/2665978601999200807160528","url":null,"abstract":"\u0000\u0000Different cellular responses influence the progress of cancer. In\u0000this study, the effects of hydrogen peroxide and quercetin induced changes on cell\u0000viability, apoptosis, and oxidative stress in human hepatocellular carcinoma (HepG2)\u0000cells were investigated.\u0000\u0000\u0000\u0000The effects of hydrogen peroxide and quercetin on cell viability, cell cycle\u0000phases, and oxidative stress related cellular changes were investigated. Cell viability was\u0000assessed by WST-1 assay. Apoptosis rate, cell cycle phase changes, and oxidative stress\u0000were measured by flow cytometry. Protein expressions of p21, p27, p53, NF-Kβ-p50,\u0000and proteasome activity were determined by Western blot and fluorometry, respectively.\u0000\u0000\u0000\u0000 Hydrogen peroxide and quercetin treatment resulted in decreased cell viability\u0000and increased apoptosis in HepG2 cells. Proteasome activity was increased by hydrogen\u0000peroxide but decreased by quercetin treatment.\u0000\u0000\u0000\u0000 Both agents resulted in decreased p53 protein expression and increased cell\u0000death by different mechanisms regarding proteostasis and cell cycle phases.\u0000","PeriodicalId":367098,"journal":{"name":"Current Nutraceuticals","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126603506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}