Physiologically beneficial actions of Alliin in health and disease.

Daniel Ortuño-Sahagún, Daniel U. Torres-Reyes, Alma Marina Sánchez Sánchez, Lucrecia Carrera-Quintanar
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Abstract

Garlic has been considered to have medicinal properties in different cultures since ancient times. Vegetables of the allium genus are a natural source of sulfur-containing organic compounds. These compounds have recently been investigated for their positive health effects, such as antioxidant and anti-inflammatory, as well as cardioprotective and anticarcinogenic properties. In this review we focus on one of the main components of garlic; alliin or S-allyl-L-cysteine sulfoxide, which is a non-protein amino acid that exhibits a broad spectrum of beneficial effects on physiology, both at the cellular and whole organism levels. Methods: We conducted a systematic literature search of the MEDLINE (PubMed) database. Search terms used for alliin were: “S-allylcysteine sulfoxide” OR “L-alliin” OR “ACSO”, all of them combined into a separated search term individually as follows: AND “antioxidant”; AND “cardioprotective”; AND “anti-inflammatory”; AND “antimicrobial”; AND “disease”, and; AND “neuroprotective”. Here, we review and integrate the existing experimental evidence on the effects of alliin, mainly on its antioxidant and anti-inflammatory effects, as well as its cardioprotective action, and its role as an adjuvant for the treatment of different diseases, such as: infectious diseases, inflammatory diseases, metabolic diseases and cancer. Finally, we propose alliin as a possible neuroprotective agent, through the combination of its antioxidant and anti-inflammatory effects, and its ability to reduce markers of metabolic inflammation in obesity.
大蒜素对健康和疾病的生理有益作用。
自古以来,大蒜就被认为在不同的文化中具有药用价值。葱属蔬菜是含硫有机化合物的天然来源。最近对这些化合物的积极健康作用进行了研究,如抗氧化和抗炎,以及保护心脏和抗癌特性。在这篇综述中,我们将重点介绍大蒜的主要成分之一;alliin或s -烯丙基- l-半胱氨酸亚砜,这是一种非蛋白质氨基酸,在细胞和整个生物体水平上都表现出广泛的有益生理作用。方法:对MEDLINE (PubMed)数据库进行系统的文献检索。有关蒜氨酸的检索词为:" s -丙氨酸半胱氨酸亚砜"或" l -蒜氨酸"或" ACSO ",所有这些词分别组合为一个单独的检索词如下:及"抗氧化剂";和“护心”;和“消炎”;和“抗菌”;和“疾病”,和;和“神经”。本文就蒜素的抗氧化、抗炎作用、心脏保护作用以及作为辅助治疗感染性疾病、炎症性疾病、代谢性疾病和癌症等不同疾病的实验证据进行综述和整合。最后,我们提出大蒜素作为一种可能的神经保护剂,通过其抗氧化和抗炎作用的结合,以及其减少肥胖代谢炎症标志物的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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