Epilepsy and Behavior Reports最新文献_第4页

Knowledge, attitudes and practices of psychiatrists in India regarding sudden unexpected death in epilepsy (SUDEP) and seizure-related harm 印度精神科医生对癫痫意外猝死 (SUDEP) 和癫痫发作相关伤害的认识、态度和做法

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100686

Surobhi Chatterjee , Shivangini Singh , Sujita Kumar Kar , Rohit Shankar

{"title":"Knowledge, attitudes and practices of psychiatrists in India regarding sudden unexpected death in epilepsy (SUDEP) and seizure-related harm","authors":"Surobhi Chatterjee , Shivangini Singh , Sujita Kumar Kar , Rohit Shankar","doi":"10.1016/j.ebr.2024.100686","DOIUrl":"10.1016/j.ebr.2024.100686","url":null,"abstract":"<div><p>Sudden unexpected death in Epilepsy (SUDEP) is one of the leading causes of death in people with epilepsy (PWE). Awareness and taking adequate preventive measures are pivotal to reducing SUDEP. Nearly 80% of PWE live in lower-middle-income countries (LMICs) such as India where for many, epilepsy management is by psychiatrists.</p><p>To evaluate the knowledge, attitude and practices of Indian psychiatrists on SUDEP and seizure risk.</p><p>A cross-sectional online survey of 12 Likert response questions using validated themes, was circulated among Indian Psychiatric Society members. Non-discriminatory exponential snowballing technique leading to convenience non-probability sampling was used. The inquiry involved SUDEP-related topics including the need for and importance of counselling. Descriptive statistics and the chi-square test were used for analysis.</p><p>The psychiatrists responding (n = 134) were likely to be males (72.4 %), urban (94 %) and affiliated to academic institutions (76.1 %). Nearly all saw PWE monthly with over half (54 %) seeing more than 10. Nearly two-third (64.17 %) did not counsel PWE regarding SUDEP, due to fear of raising concerns in caregivers/family (33.3 %), patients (38.9 %) or lack of time (35.6 %), though 37 % had lost patients due to SUDEP. Over two-third (66.7 %) agreed risk counselling was important. Barriers included fear of raising concerns, limited time, and training. A strong need for national SUDEP guidelines (89 %) and suitable training (75.4 %) was expressed.</p><p>Though epilepsy care is provided by a considerable number of psychiatrists, there is a poor understanding of SUDEP. Enhancing the awareness and understanding of SUDEP is likely to enhance epilepsy care.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100686"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000431/pdfft?md5=529c6a7359ddc4d4e12ea75f91c13c27&pid=1-s2.0-S2589986424000431-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141630383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interictal psychosis of epilepsy: What is the role of the neurologist? 癫痫发作间期精神病：神经科医生的角色是什么？

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100708

Luis Pintor , Felipe Gutiérrez , Andres M. Kanner

{"title":"Interictal psychosis of epilepsy: What is the role of the neurologist?","authors":"Luis Pintor , Felipe Gutiérrez , Andres M. Kanner","doi":"10.1016/j.ebr.2024.100708","DOIUrl":"10.1016/j.ebr.2024.100708","url":null,"abstract":"<div><p>Psychotic disorders are more frequent in people with epilepsy than the general population. They constitute one of the most serious psychiatric comorbidities which require an immediate psychopharmacologic intervention. Yet, access to psychiatrists is often limited or not available and the neurologists taking care of these patients are called-upon to start treatment with antipsychotic medication. The purpose of this manuscript is to provide clinicians with pragmatic psychopharmacologic strategies to treat interictal psychotic disorders in patients with epilepsy. We review the case of a 45 years-old man with a 35-year history of treatment-resistant focal epilepsy of bitemporal origin who developed a de-novo psychotic episode that began with insomnia, mood lability and agitation and evolved into paranoid delusions, auditory hallucinations and a thought disorder. The patient was diagnosed with an interictal psychotic episode and was treated with aripiprazole which resulted in significant improvement after reaching a 20 mg /day dose and allowed for the patient to be discharged home. In summary, interictal psychotic episodes of epilepsy are relatively frequent in patients with epilepsy and require of an early psychopharmacologic treatment to facilitate their remission or stabilization until mental health professionals can take over their long-term care. Compared to primary psychotic disorders, interictal psychotic episodes respond better and at lower doses of antipsychotic drugs.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"28 ","pages":"Article 100708"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000650/pdfft?md5=e15f480244ed90ea26ee1c7014273010&pid=1-s2.0-S2589986424000650-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aborted sudden cardiac death in a young patient with epilepsy and the Gorlin Goltz syndrome 一名患有癫痫和戈尔林-戈尔茨综合征的年轻患者心跳骤停死亡

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100667

Guilherme Salazar Serrano , Alexandre Dias de Oliveira , Ramsés Miotto , Katia Lin , Guilherme Loureiro Fialho

{"title":"Aborted sudden cardiac death in a young patient with epilepsy and the Gorlin Goltz syndrome","authors":"Guilherme Salazar Serrano , Alexandre Dias de Oliveira , Ramsés Miotto , Katia Lin , Guilherme Loureiro Fialho","doi":"10.1016/j.ebr.2024.100667","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100667","url":null,"abstract":"<div><p>Epilepsy is one of the most common chronical neurological conditions affecting over 50 million people worldwide. In addition to the stigma and discrimination, individuals with epilepsy suffer from a nearly three-fold increased risk of premature death compared to the general population. Although these premature deaths occur due to multiple causes, sudden unexpected death in epilepsy (SUDEP) still challenges neurologists and clinicians dealing with individuals with epilepsy. Recently, an increased interest in cardiac outcomes related to acute seizures and chronic epilepsy resulted in the groundbreaking development of the “epileptic heart” concept, and sudden <em>cardiac</em> death in individuals with epilepsy, which is 4.5 times as frequent as SUDEP according to some observational data, has gained more attention. As we gather information and learn about possible comorbidities and consequences of seizures and/or chronic epilepsy, we present a clinical case of a young patient with an unusual association of epilepsy, the Gorlin Goltz syndrome, and a cardiac fibroma with Wolf-Parkinson-White (WPW), who had multiple aborted cardiac arrests. Diagnostic challenges and multiple possible causes of sudden cardiac death in this single patient report are discussed.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"26 ","pages":"Article 100667"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000248/pdfft?md5=2acd1c3760f52981b0ff9ab2a189333b&pid=1-s2.0-S2589986424000248-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140644446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The epileptic heart: Cardiac comorbidities and complications of epilepsy. Atrial and ventricular structure and function by echocardiography in individuals with epilepsy – From clinical implications to individualized assessment 癫痫患者的心脏：心脏合并症和癫痫并发症。通过超声心动图检查癫痫患者的心房和心室结构与功能--从临床意义到个体化评估

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100668

Guilherme Loureiro Fialho , Ramsés Miotto , Márcia Tatsch Cavagnollo , Hiago Murilo Melo , Peter Wolf , Roger Walz , Katia Lin

{"title":"The epileptic heart: Cardiac comorbidities and complications of epilepsy. Atrial and ventricular structure and function by echocardiography in individuals with epilepsy – From clinical implications to individualized assessment","authors":"Guilherme Loureiro Fialho , Ramsés Miotto , Márcia Tatsch Cavagnollo , Hiago Murilo Melo , Peter Wolf , Roger Walz , Katia Lin","doi":"10.1016/j.ebr.2024.100668","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100668","url":null,"abstract":"<div><p>Epilepsy is an increasing global neurological health issue. Recently,epidemiological and mechanistic studies have raised concern about cardiac involvement in individuals with epilepsy. This has resulted in the “epileptic heart” concept. Epidemiological data linking epilepsy to cardiovascular disease indicate an increased risk for ventricular and atrial arrhythmias, myocardial infarction, heart failure, and sudden death among individuals with epilepsy. Pathways of this interaction comprise increased prevalence of traditional cardiac risk factors, genetic abnormalities, altered brain circuitry with autonomic imbalance, and antiseizure medications with enzyme-inducing and ionic channel-blocking proprieties. Pathophysiological findings in the atria and ventricles of patients with epilepsy are discussed. Echocardiographic findings and future applications of this tool are reviewed. A risk stratification model and future studies on cardiac risk assessment in individuals with epilepsy are proposed.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"26 ","pages":"Article 100668"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258998642400025X/pdfft?md5=6457a39b268f00e36775d92a33969ac0&pid=1-s2.0-S258998642400025X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adult-onset status epilepticus in patients with COQ8A coenzyme Q10 deficiency: A case series COQ8A 辅酶 Q10 缺乏症患者的成人癫痫状态：病例系列

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100716

Panagiota-Eleni Tsalouchidou , Clara Juenemann , Wiebke Hahn , Felix Zahnert , Leona Möller , Lukas Hakel , André Kemmling , Katja Menzler , Ole J. Simon , Lars Timmermann , Susanne Knake , Felix Bernhard

{"title":"Adult-onset status epilepticus in patients with COQ8A coenzyme Q10 deficiency: A case series","authors":"Panagiota-Eleni Tsalouchidou , Clara Juenemann , Wiebke Hahn , Felix Zahnert , Leona Möller , Lukas Hakel , André Kemmling , Katja Menzler , Ole J. Simon , Lars Timmermann , Susanne Knake , Felix Bernhard","doi":"10.1016/j.ebr.2024.100716","DOIUrl":"10.1016/j.ebr.2024.100716","url":null,"abstract":"<div><div>This case series describes the clinical features, diagnostic challenges, treatment approaches, and outcomes of three adult patients with COQ8A-related CoQ10 deficiency presenting with focal status epilepticus, who were effectively treated at the Department of Neurology, Philipps University Marburg, Marburg, Germany. The patients, all from consanguineous families with the first two being siblings, presented with a late onset of the disease, characterized by progressive cerebellar ataxia and epilepsy, with clinical deterioration and focal status epilepticus occurring in adulthood. The first patient exhibited myoclonic status, while the second and third patients presented with bilateral tonic-clonic seizures followed by focal status epilepticus manifesting with cortical blindness. Despite differing semiologies, all patients displayed similar EEG findings with continuous or nearly continuous occipital sharp waves and spikes. MRI findings revealed focal changes in the Diffusion-Weighted Imaging (DWI) and Fluid Attenuated Inversion Recovery (FLAIR) sequences. Significant clinical improvement was observed following treatment with high doses of CoQ10, with the diffusion restriction abnormalities being reversible after therapy. In conclusion, consistent with existing literature, we observed a characteristic EEG pattern that can help identify the disease and facilitate early diagnosis and treatment. The diffusion restriction abnormalities on MRI were reversible after therapy, and high doses of CoQ10 proved beneficial even in cases of status epilepticus.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"28 ","pages":"Article 100716"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of ictal apnea refines the clinical spectrum of ATRX syndrome 检测发作性呼吸暂停可完善 ATRX 综合征的临床范围

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100717

Galal Banat , Friedrich G. Woermann , Rami Abou Jamra , Christian G. Bien , Christian Brandt

引用次数: 0

Epileptologists’ attitudes toward physical exercise and sports for persons with epilepsy in China 癫痫专家对中国癫痫患者体育锻炼和运动的态度

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100685

Weihao Liao , Lu Lu , Weixi Xiong , Jie Mu , Dong Zhou

{"title":"Epileptologists’ attitudes toward physical exercise and sports for persons with epilepsy in China","authors":"Weihao Liao , Lu Lu , Weixi Xiong , Jie Mu , Dong Zhou","doi":"10.1016/j.ebr.2024.100685","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100685","url":null,"abstract":"<div><p>We undertook a survey among epileptologists in China to explore their attitudes toward physical exercise and sports for persons with epilepsy (PWEs). A total of 288 epileptologists participated. Most recognized the potential benefits of physical exercise and sports for PWEs, including improved cognitive function (74.6 %), alleviation of mental disorders (73.2 %), and enhanced quality of life (83.8 %). Epileptologists overwhelmingly agreed on the importance of discussing and encouraging physical exercise and sports for PWEs (97.4 % and 95.2 %, respectively). Before engagement in physical exercise and sports, most epileptologists considered that the duration of seizure-free status could be shorter if the seizures were typically focal, non-motor, or without impaired awareness (p < 0.05). There was consensus (99.1 %) on the need to grade the risk of related activities. Opinions were divided regarding the use of health certificates for restricting PWEs (favored by 63.2 %). The majority (93.9 %) called for an expert consensus or clinical guidelines in China. In conclusion, epileptologists in China generally demonstrate a positive attitude toward physical exercise and sports for PWEs. Both benefits and risks of these activities have generally been acknowledged. It is recommended to prioritize activities with lower risks and higher benefits. However, the recommendations for PWEs with a lower likelihood of recurrence and less risky seizure types can be more liberal. Urgent development of normative guidance from governmental and professional bodies is warranted.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100685"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258998642400042X/pdfft?md5=c4c2ac1ebf5ebb311c3662e7d4a46d71&pid=1-s2.0-S258998642400042X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional neurological disorder, physical activity and exercise: What we know and what we can learn from comorbid disorders 功能性神经紊乱、体力活动和锻炼：我们从并发症中学到的知识和经验

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100682

Kelly A. Boylan , Barbara A. Dworetzky , Gaston Baslet , Ginger Polich , M. Angela O’Neal , Claus Reinsberger

{"title":"Functional neurological disorder, physical activity and exercise: What we know and what we can learn from comorbid disorders","authors":"Kelly A. Boylan , Barbara A. Dworetzky , Gaston Baslet , Ginger Polich , M. Angela O’Neal , Claus Reinsberger","doi":"10.1016/j.ebr.2024.100682","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100682","url":null,"abstract":"<div><p>Functional neurological disorder (FND) is a common neurologic disorder associated with many comorbid symptoms including fatigue, pain, headache, and orthostasis. These concurrent symptoms lead patients to accumulate multiple diagnoses comorbid with FND, including fibromyalgia, chronic fatigue syndrome, postural orthostatic tachycardia syndrome, persistent post-concussive symptoms, and chronic pain. The role of physical activity and exercise has not been evaluated in FND populations, though has been studied in certain comorbid conditions. In this traditional narrative literature review, we highlight some existing literature on physical activity in FND, then look to comorbid disorders to highlight the therapeutic potential of physical activity. We then consider abnormalities in the autonomic nervous system (ANS) as a potential pathophysiological explanation for symptoms in FND and comorbid disorders and postulate how physical activity and exercise may provide benefit via autonomic regulation.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100682"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258998642400039X/pdfft?md5=971a069ebd403ba309bad894e5ac50d8&pid=1-s2.0-S258998642400039X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of exercise on sleep in patients with epilepsy: A systematic review 运动对癫痫患者睡眠的影响：系统回顾

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100675

Christina Mueller , Ashley Thomas , Amy W. Amara , Jennifer DeWolfe , S. Justin Thomas

{"title":"Effects of exercise on sleep in patients with epilepsy: A systematic review","authors":"Christina Mueller , Ashley Thomas , Amy W. Amara , Jennifer DeWolfe , S. Justin Thomas","doi":"10.1016/j.ebr.2024.100675","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100675","url":null,"abstract":"<div><p>Exercise interventions in epilepsy have been shown to improve seizure frequency, physical capacity, quality of life, mood, and cognitive functioning. However, the effectiveness of exercise in improving sleep in epilepsy is less clear. The purpose of this report is to identify the published literature regarding exercise interventions in people with epilepsy to determine 1) what proportion of published clinical trials assess sleep as an outcome, and 2) what benefits of exercise interventions on sleep have been observed. We searched the PubMed, PsycINFO, and SCOPUS electronic databases using the search terms “epilepsy AND [exercise OR physical activity]” and identified 23 articles reporting on 18 unique clinical trials. Nine studies were conducted in adults, five in children, and four in adults and children with active seizures, controlled seizures, or both. Exercise modalities included aerobic exercise, strength training, walking, and yoga, among others, and some also included educational and motivational components. Exercise effects on sleep were tested in four studies, two of which only included indirect measures of sleep- and rest-related fatigue, with mixed results. Of the two reports assessing sleep directly, one reported marginal non-significant improvements in subjective sleep quality and no improvements in objective sleep quality in children after twelve weeks of walking, and the other reported no benefits in subjective sleep quality after twelve weeks of combined aerobic, strength, and flexibility training in adults. Given the health benefits of sleep and detrimental effects of sleep deprivation in epilepsy, epilepsy researchers need to assess the effects of exercise interventions on sleep.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"26 ","pages":"Article 100675"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000327/pdfft?md5=11b633771c5492cba4f5978ab14274d8&pid=1-s2.0-S2589986424000327-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and tolerance of the ketogenic diet in patients with Zellweger Syndrome 泽尔维格综合征患者生酮饮食的安全性和耐受性

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100655

Borst Stephanie , Ciliberto Michael , Thati Ganganna Sreenath

引用次数: 0