Epilepsy and Behavior Reports最新文献_第4页

Early antiseizure response to cenobamate (200 mg/day) in focal drug-resistant epilepsy: a retrospective single-center analysis 局灶性耐药癫痫患者早期使用cenobamate （200mg /天）抗癫痫反应：一项回顾性单中心分析

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-11-26 DOI: 10.1016/j.ebr.2025.100839

Ewa Czapińska-Ciepiela, Agnieszka Kondak, Monika Kowalczyk, Piotr Czapiński

{"title":"Early antiseizure response to cenobamate (200 mg/day) in focal drug-resistant epilepsy: a retrospective single-center analysis","authors":"Ewa Czapińska-Ciepiela, Agnieszka Kondak, Monika Kowalczyk, Piotr Czapiński","doi":"10.1016/j.ebr.2025.100839","DOIUrl":"10.1016/j.ebr.2025.100839","url":null,"abstract":"<div><div>Clinical studies have shown cenobamate (CNB) is effective for treating drug-resistant focal epilepsy. This study examines Polish patients with epilepsy, assessing the efficacy and safety of CNB at 200 mg/day and factors influencing early therapeutic response. A retrospective observational study involved 100 patients with drug-resistant focal epilepsy, treated in a private Polish epilepsy outpatient clinic from March 2022 to March 2025. The primary goal was to evaluate response to CNB 200 mg/day, using seizure reduction thresholds (50 %, 75 %, 100 %), and to identify determinants such as demographic data, disease duration and etiology, intellectual disability, baseline seizure frequency, previous antiseizure medications (ASMs) and medication combinations. Adverse reactions and changes in concomitant ASMs were also evaluated. Of the 100 patients, 95 continued CNB therapy. Most had multi-drug resistance. After three months at 200 mg/day, ≥50 % seizure reduction was seen in 63 %, ≥75 % in 36 %, and 100 % in 18 %. Age, sex, epilepsy etiology or duration, intellectual disability, prior seizure count, previous ASMs, and medication combinations did not affect CNB’s efficacy. Most tolerated CNB well, with adverse effects including dizziness and balance disorders (49 %), somnolence (38 %), diplopia (17 %), weakness (10 %), and concentration or memory issues (10 %). Lacosamide use increased adverse effects, which mostly resolved after dose reduction. Other adjusted drugs were lamotrigine, topiramate, and oxcarbazepine. CNB at 200 mg/day was highly effective and generally well-tolerated, especially with reduced doses of other ASMs. Efficacy was independent of epilepsy severity or treatment factors, suggesting CNB’s promise in multi-drug-resistant patients.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100839"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autosomal dominant Kufs disease in a Georgian adult woman: A case report 常染色体显性库夫斯病在格鲁吉亚成年妇女：1例报告

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-07-10 DOI: 10.1016/j.ebr.2025.100805

Nikoloz Papiashvili , Sopio Gagua , Nana Gonjilashvili , Natela Okujava , Aleksandre Tsereteli

引用次数: 0

The role of genetic testing in evaluating surgical outcomes for pediatric focal cortical dysplasia associated with NPRL3 variant 基因检测在评估小儿局灶性皮质发育不良与NPRL3变异相关的手术结果中的作用

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-07-16 DOI: 10.1016/j.ebr.2025.100808

Bei Li , Liang Liu , Jianyun Su , Shanshan Jia , Zhijing Wang , Xia Li , Siyu Zhao

{"title":"The role of genetic testing in evaluating surgical outcomes for pediatric focal cortical dysplasia associated with NPRL3 variant","authors":"Bei Li , Liang Liu , Jianyun Su , Shanshan Jia , Zhijing Wang , Xia Li , Siyu Zhao","doi":"10.1016/j.ebr.2025.100808","DOIUrl":"10.1016/j.ebr.2025.100808","url":null,"abstract":"<div><div>This case report describes a 5-year-and-10-month-old female patient who developed sleep-related hypermotor epilepsy, at the age of 2, exhibiting various forms of seizures since the age of 2. Initially, the seizures were controlled for one year with multiple anti-seizure medications; however, symptoms recurred when the patient was 3 years and 5 months old, leading to an increased seizure frequency and a poor response to combined drug therapy. Long-term video-EEG revealed discharges originating from the frontal lobe, while MRI and PET-CT scans indicated FCD in the left frontal region. The patient underwent left frontal epileptogenic focus resection at the age of 6, with pathological findings confirming FCD type 1b. Whole-exome sequencing of blood and brain tissue samples revealed NPRL3 gene variants. Although she remained seizure-free for one year post-surgery, the patient experienced a relapse, with follow-up EEG revealing multifocal discharges. These findings indicate that variants in the NPRL3 gene contribute to focal cortical dysplasia (FCD) and are frequently associated with drug-resistant epilepsy. For FCD 1b patients with NPRL3 gene variants, the risks and benefits of surgery should be carefully evaluated. This report explores the role of NPRL3 gene variants in FCD1b and their impact on surgical treatment, emphasizing the importance of comprehensive preoperative assessment and individualized therapeutic strategies.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100808"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special issue on advancing physical activity and exercise research in epilepsy and seizure disorders 关于在癫痫和发作性疾病中推进身体活动和运动研究的特刊

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-09-10 DOI: 10.1016/j.ebr.2025.100827

Jane B. Allendorfer

引用次数: 0

Emptying the fridge syndrome: a case of nocturnal food craving associated with peak perampanel concentration 清空冰箱综合症：夜间食物渴望与perampanel浓度峰值相关的案例

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-08-10 DOI: 10.1016/j.ebr.2025.100821

Paola Vassallo , Josemir W. Sander

引用次数: 0

Case report: Surgical disconnection for medically refractory epilepsy in ARID1B-related Coffin-Siris syndrome 病例报告：arid1b相关的Coffin-Siris综合征难治性癫痫的手术断开

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-08-27 DOI: 10.1016/j.ebr.2025.100825

Xiao-Lai Ye , Cui-Jing Wang , Min-Zhi Yin , Ru-En Yao , Ying Zhou , Fo-Yang Fan , Qin-Chuan Liang

引用次数: 0

Prolonged psychiatric symptoms revealed as nonconvulsive status epilepticus in ring chromosome 20 syndrome 20环染色体综合征的长期精神症状表现为非惊厥性癫痫持续状态

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-10-19 DOI: 10.1016/j.ebr.2025.100834

Mihoko Kawai , Kento Nakamura , Ryosuke Aratake , Mayuko Ota , Koutaro Sakurai , Kousuke Kanemoto

{"title":"Prolonged psychiatric symptoms revealed as nonconvulsive status epilepticus in ring chromosome 20 syndrome","authors":"Mihoko Kawai , Kento Nakamura , Ryosuke Aratake , Mayuko Ota , Koutaro Sakurai , Kousuke Kanemoto","doi":"10.1016/j.ebr.2025.100834","DOIUrl":"10.1016/j.ebr.2025.100834","url":null,"abstract":"<div><div>Ring chromosome 20 (r[20]) syndrome is a rare epilepsy-associated chromosomal disorder often accompanied by intellectual disability and psychiatric symptoms. It lacks distinctive physical features and typically exhibits normal brain imaging; therefore, its diagnosis is frequently delayed, especially when clinicians are unfamiliar with it. Nonconvulsive status epilepticus (NCSE), a hallmark of this syndrome, can be overlooked even by epilepsy specialists, who interpret it as a psychiatric symptom, particularly in patients with limited expressive capacity. A 42-year-old woman with a long-standing history of drug-resistant epilepsy and behavioral symptoms was ultimately diagnosed with r(20) syndrome. She developed tonic seizures and fear episodes at age 6 and was diagnosed with epilepsy. After age 11, drug-resistant NCSE emerged and was not clearly identified as status epilepticus; it was considered to involve impaired awareness seizures and psychiatric symptoms. At age 41, perampanel (PER) was initiated, triggering aggressive behavior and new backward-falling episodes, further complicating her clinical presentation. Video electroencephalogram (EEG) confirmed NCSE, and chromosomal analysis identified r(20). After PER discontinuation, aggression and backward-falling episodes resolved. Lacosamide was introduced, reducing the frequency of NCSE from several daily episodes to 2–3 per week. This case underscores the diagnostic challenges of r(20) syndrome and the risk of misdiagnosing NCSE as a psychiatric illness. Additionally, PER may exacerbate psychiatric symptoms in r(20) cases with intellectual disability. Precise seizure classification and confirmation by ictal EEG, along with integrated neuropsychiatric care, are essential for accurate diagnosis and effective management.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100834"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory sensory phenomena as the main seizure type in a child with low-grade glioma: a case report 以嗅觉感觉现象为主要癫痫类型的儿童低级别胶质瘤：1例报告

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-09-27 DOI: 10.1016/j.ebr.2025.100830

Takato Akiba, Shinpei Abe, Junya Fujimura, Hiromichi Shoji

{"title":"Olfactory sensory phenomena as the main seizure type in a child with low-grade glioma: a case report","authors":"Takato Akiba, Shinpei Abe, Junya Fujimura, Hiromichi Shoji","doi":"10.1016/j.ebr.2025.100830","DOIUrl":"10.1016/j.ebr.2025.100830","url":null,"abstract":"<div><div>Olfactory sensory phenomena (OSP) are a rare and often underrecognized descriptor of seizures without observable clinical manifestations, particularly in children. We report a case involving a 7-year and 9-month-old boy who experienced OSP as the sole seizure manifestation for nearly a year, resulting in a delayed diagnosis. Symptoms were initially misattributed to gastroesophageal reflux but gradually progressed to include focal impaired consciousness seizures. Brain magnetic resonance imaging revealed a mass lesion involving the right optic nerve, hypothalamus, and medial temporal lobe, leading to the diagnosis of focal epilepsy owing to a structural etiology. Histopathological assessment confirmed a low-grade glioma (LGG). Because OSP persisted despite lacosamide therapy, perampanel (PER) was introduced based on prior reports of its efficacy in epilepsy associated with glioma; however, instead of reducing, the OSP frequency increased after PER initiation. This case highlights the diagnostic challenge posed by nonmotor seizures with subtle clinical presentations and underscores the importance of considering epilepsy in patients with recurrent, unexplained sensory symptoms such as abnormal smells or nausea. It also contributes to the limited literature on pediatric focal epilepsy associated with LGG, providing educational value for physicians less familiar with atypical seizure semiology.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100830"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers to delivering optimal care in epilepsy surgery candidates during transition of care: a short case series 在护理过渡期间癫痫手术候选人提供最佳护理的障碍：一个简短的病例系列

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-09-17 DOI: 10.1016/j.ebr.2025.100828

Quynh Vo , Kathryn Lalor

{"title":"Barriers to delivering optimal care in epilepsy surgery candidates during transition of care: a short case series","authors":"Quynh Vo , Kathryn Lalor","doi":"10.1016/j.ebr.2025.100828","DOIUrl":"10.1016/j.ebr.2025.100828","url":null,"abstract":"<div><div>Transition of care is becoming an increasingly discussed topic and is a necessary process that all young adults requiring medical care should undergo. The lack of transition of care in epilepsy can often lead to poor outcomes for young adults. Youths with drug-resistant epilepsy (DRE) requiring surgical intervention often face a more difficult transition and clinicians have more complexities to consider. Here we present four unique cases of surgical candidates undergoing transition of care, and highlight common issues encountered by young adults and pediatric and adult clinicians during this time. Cases 1 to 3 focus on young adults transitioning care after completion of surgical intervention, in the middle of a surgical workup, and before the consideration of surgical interventions, respectively. These cases examine how transition of care can affect treatment options and outcome. Case 4 highlights the impact considering surgical intervention can have on the transition process. Each case presents unique challenges facing young adults and their epilepsy surgical team. By highlighting barriers to care, changes can be made to facilitate better epilepsy management.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100828"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereo-EEG associated anti-GAD65 autoimmune encephalitis – A report of two cases 立体脑电图相关抗gad65自身免疫性脑炎2例报告

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-10-25 DOI: 10.1016/j.ebr.2025.100835

Claude Steriade , Andrew Christiana , Giovanna Dane , Peter A. Rozman , Daniel Friedman

引用次数: 0