Epilepsy and Behavior Reports最新文献_第5页

Electroconvulsive therapy in psychoses of epilepsy – A forgotten alternative 癫痫精神病的电休克疗法——一种被遗忘的替代疗法

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-07-12 DOI: 10.1016/j.ebr.2025.100806

Mariana Roque Gonçalves , Alzira Silva , Celeste Silveira

{"title":"Electroconvulsive therapy in psychoses of epilepsy – A forgotten alternative","authors":"Mariana Roque Gonçalves , Alzira Silva , Celeste Silveira","doi":"10.1016/j.ebr.2025.100806","DOIUrl":"10.1016/j.ebr.2025.100806","url":null,"abstract":"<div><div>This case report discusses a 35-year-old woman with refractory temporal lobe epilepsy and no prior psychiatric history who developed persecutory, erotomanic and megalomaniac ideations, auditory hallucinations, and dysphoric mood. Psychiatric symptoms, including psychosis, are well-documented in patients with epilepsy, posing unique management challenges due to potential interactions between antiepileptic and antipsychotic medications. In this case, the patient demonstrated persistent epileptiform activity on electroencephalogram despite treatment with three antiepileptic drugs. Concurrently, standard antipsychotic treatments were ineffective, suggesting drug-resistant psychosis. Notably, complete remission of psychotic symptoms was achieved with electroconvulsive therapy (ECT), a well-established intervention for various psychiatric conditions but rarely reported in the context of epilepsy-associated psychosis. This case underscores the need for novel therapeutic approaches in managing complex comorbidities like drug-resistant psychosis in epilepsy. It also highlights the potential role of ECT as a safe and effective treatment option in these challenging clinical scenarios.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100806"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network analysis of antiseizure medication use, efficacy, and safety in epilepsy: A retrospective cohort study in a tertiary care center 癫痫患者抗癫痫药物使用、疗效和安全性的网络分析：一项三级医疗中心的回顾性队列研究

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-11-03 DOI: 10.1016/j.ebr.2025.100836

Miguel Angel Morales-Morales , Emilio García-Gómez , Daniel San-Juan , Carlos Trenado , Daniela Carolina Pimentel-Saona , Yazmin Palomares-Salazar , Manuel Alejandro Del Río-Quiñones , Mónica Alejandra Montalvo-Hérnandez , Christopher De Jesús-Fernández , Jesús Iván Ruiz-Gutierrez , Clio Rubinos

{"title":"Network analysis of antiseizure medication use, efficacy, and safety in epilepsy: A retrospective cohort study in a tertiary care center","authors":"Miguel Angel Morales-Morales , Emilio García-Gómez , Daniel San-Juan , Carlos Trenado , Daniela Carolina Pimentel-Saona , Yazmin Palomares-Salazar , Manuel Alejandro Del Río-Quiñones , Mónica Alejandra Montalvo-Hérnandez , Christopher De Jesús-Fernández , Jesús Iván Ruiz-Gutierrez , Clio Rubinos","doi":"10.1016/j.ebr.2025.100836","DOIUrl":"10.1016/j.ebr.2025.100836","url":null,"abstract":"<div><div>Antiseizure medications (ASMs) remain the cornerstone of epilepsy treatment, yet data on prescription patterns, effectiveness, and safety in low- and middle-income countries are limited. This retrospective cohort study analyzed changes in ASM use, efficacy, and adverse effects across 10 years in a tertiary care center in Mexico, comparing two phases: 2011–2013 (n = 100) and 2021–2023 (n = 128). Data on seizure freedom, adverse effects, and ASM patterns were analyzed using descriptive statistics and comparative tests. Network analysis and centrality measures were performed with MATLAB Version 9.12.0 to explore the relationships among prescribed ASMs and their influence on outcomes. A total of 228 patients were included. Seizure freedom rates increased from 9 % in the first phase to 25.8 % in the second (p = 0.001). Valproic acid remained the most frequently prescribed ASM, while levetiracetam use markedly increased (49 %). Adverse effects rose from 10 % to 17 % despite a modest reduction in polytherapy (93 % to 87.5 %). The network analysis revealed clusters of ASMs commonly prescribed together that were associated with seizure freedom (valproic acid, lamotrigine, topiramate), whereas combinations including phenobarbital and lamotrigine were linked to more adverse effects. Valproate continues to play a key role in seizure control due to its efficacy, accessibility, and broad-spectrum profile. Despite advances in newer ASM use and improved seizure outcomes, adverse effects remain a concern. Continued monitoring of ASM combinations is warranted to better understand evolving treatment patterns and guide epilepsy management in resource-limited settings.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100836"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of neurosarcoidosis presenting as hippocampal sclerosis: Clinicopathological correlation and proposed mechanistic link 以海马硬化为表现的神经结节病1例：临床病理相关性及提出的机制联系

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-11-07 DOI: 10.1016/j.ebr.2025.100837

Elham Rahimian , Guive Sharifi , Hans Jürgen Huppertz , Majid Reza Tahsini , Behnam Safarpour Lima , Elham Naderi , Yalda Nilipour , Melika Javani , Soudeh Ghafouri-Fard

{"title":"A case of neurosarcoidosis presenting as hippocampal sclerosis: Clinicopathological correlation and proposed mechanistic link","authors":"Elham Rahimian , Guive Sharifi , Hans Jürgen Huppertz , Majid Reza Tahsini , Behnam Safarpour Lima , Elham Naderi , Yalda Nilipour , Melika Javani , Soudeh Ghafouri-Fard","doi":"10.1016/j.ebr.2025.100837","DOIUrl":"10.1016/j.ebr.2025.100837","url":null,"abstract":"<div><div>Neurosarcoidosis is a rare manifestation of systemic sarcoidosis, typically affecting the meninges, cranial nerves, and hypothalamic–pituitary axis. Parenchymal brain involvement—particularly of the hippocampus—is uncommon and only rarely associated with epilepsy or hippocampal sclerosis (HS). Here, we describe a rare coexistence of biopsy-proven neurosarcoidosis and hippocampal sclerosis, suggesting secondary hippocampal injury due to chronic inflammation presenting with drug-resistant right mesial temporal lobe epilepsy (MTLE). We reviewed the clinical electrophysiological imaging and histopathological findings of a 47-year-old male who underwent anterior temporal lobectomy (ATL) after seizure onset which was localized to the right anterior to mid temporal region. Preoperative MRI was consistent with mesial temporal sclerosis. Histopathological analysis revealed both classic features of HS (neuronal loss and gliosis) and non-caseating granulomas diagnostic of neurosarcoidosis distributed within the medial temporal lobe and involving the amygdala. These findings suggest chronic inflammation may have contributed to hippocampal injury and epileptogenesis. The patient became seizure-free postoperatively. This case underscores the potential for neurosarcoidosis to mimic isolated MTLE and coexist with HS as a rare co-localized pathology. It raises the hypothesis that immune-mediated inflammation may play a pathogenic role in hippocampal degeneration. Recognition of such cases may enhance diagnostic accuracy and inform surgical planning in epilepsy associated with systemic inflammatory disorders.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100837"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing knowledge, attitudes, and misconceptions about epilepsy among University of Venda students: A call for enhanced education and awareness 评估文达大学学生对癫痫的知识、态度和误解：呼吁加强教育和认识

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-07-12 DOI: 10.1016/j.ebr.2025.100807

A.E. Ndou , L. Makhado , O.P. Netshisaulu

{"title":"Assessing knowledge, attitudes, and misconceptions about epilepsy among University of Venda students: A call for enhanced education and awareness","authors":"A.E. Ndou , L. Makhado , O.P. Netshisaulu","doi":"10.1016/j.ebr.2025.100807","DOIUrl":"10.1016/j.ebr.2025.100807","url":null,"abstract":"<div><div>Epilepsy is a neurological disorder affecting individuals of all ages, often surrounded by stigma and misconceptions. Despite its prevalence, awareness about epilepsy is limited, particularly among university students. This study investigates the knowledge, attitudes, and perceptions of students at the University of Venda regarding epilepsy to identify gaps and improve educational strategies. A cross-sectional survey was conducted with students from various faculties at the University of Venda. Participants completed a structured questionnaire that collected demographic information and assessed their knowledge about epilepsy, attitudes towards individuals with the condition, and perceptions of public awareness. The survey included questions about awareness of epilepsy, understanding its causes and management, and views on the rights of people living with epilepsy. A total of 326 students participated in the survey. The survey showed that approximately 92.9% of students had heard of epilepsy, but many misconceptions remained. A significant number believed that epilepsy is untreatable and that those with the condition should not drive or participate in certain activities. Only 18.7% knew the correct management practices for seizures. Furthermore, 67% of students felt that insufficient attention was given to epilepsy, yet the study increased interest in learning more, as over 92.9% expressed a desire for additional information. The findings highlight the need for better education about epilepsy among university students to dispel myths and promote informed attitudes. Educational initiatives focused on seizure management and inclusivity could create a more supportive environment for individuals with epilepsy at the University of Venda and beyond.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100807"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electro-clinical correlation of rinch and peri-ictal vegetative symptoms 颈部和周周植物性症状的电临床相关性

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-10-09 DOI: 10.1016/j.ebr.2025.100831

Divya Nagabushana , Francesco Pucci , Huan Huynh , Julia Bodnya , Anna Serafini

{"title":"Electro-clinical correlation of rinch and peri-ictal vegetative symptoms","authors":"Divya Nagabushana , Francesco Pucci , Huan Huynh , Julia Bodnya , Anna Serafini","doi":"10.1016/j.ebr.2025.100831","DOIUrl":"10.1016/j.ebr.2025.100831","url":null,"abstract":"<div><div>Rhythmic ictal non-clonic hand (RINCH) movements and <em>peri</em>-ictal vegetative symptoms (PIVS) are rare semiological signs in temporal lobe epilepsy (TLE). RINCH refers to rhythmic, low-amplitude, complex hand movements that typically lateralize to the contralateral hemisphere, while PIVS includes manifestations such as ictal spitting and post-ictal coughing, more frequently associated with non-dominant TLE. We report a unique case of a 40-year-old woman with drug-resistant dominant TLE who exhibited both RINCH and PIVS as part of her habitual seizures. Non-invasive EEG and imaging localized the seizure onset to the left anterior temporal region. Stereoelectroencephalography (SEEG) confirmed seizure onset in the left mesial temporal pole with rapid propagation to the hippocampus, amygdala, and other limbic structures. Notably, RINCH was observed only in seizures that showed ictal spread to the superior temporal gyrus (STG) and superior temporal sulcus (STS), suggesting their role in mediating semi-automatic motor behaviors. Ictal spitting and other PIVS were linked to the spread to the entorhinal and parahippocampal regions. The patient underwent left anterior temporal lobectomy with histopathological confirmation of hippocampal sclerosis and has remained seizure-free at one-year follow-up. This case provides a rare anatomo-electro-clinical correlation of RINCH and PIVS using SEEG and emphasizes that while RINCH retains lateralizing value, PIVS may not. Our findings underscore the importance of invasive EEG in characterizing complex semiology and refining the epileptogenic zone in dominant TLE.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100831"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vagus nerve stimulation in KCNB1-related developmental and epileptic encephalopathy: A case of seizure reduction and review of literature 迷走神经刺激治疗与kcnb1相关的发育性和癫痫性脑病：一例癫痫发作减少和文献复习

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-08-30 DOI: 10.1016/j.ebr.2025.100826

Taichi Sayanagi , Kenzo Kosugi , Eri Ogawa , Toshiki Takenouchi , Mamiko Yamada , Kenjiro Kosaki , Ichiro Sugiyama , Masahiro Toda

{"title":"Vagus nerve stimulation in KCNB1-related developmental and epileptic encephalopathy: A case of seizure reduction and review of literature","authors":"Taichi Sayanagi , Kenzo Kosugi , Eri Ogawa , Toshiki Takenouchi , Mamiko Yamada , Kenjiro Kosaki , Ichiro Sugiyama , Masahiro Toda","doi":"10.1016/j.ebr.2025.100826","DOIUrl":"10.1016/j.ebr.2025.100826","url":null,"abstract":"<div><div>Developmental and epileptic encephalopathies (DEEs) are devastating syndromes characterized by early-onset, treatment-resistant seizures, and significant developmental delays. <em>KCNB1</em>-related DEE, arising from pathogenic variants in the <em>KCNB1</em> gene, presents with profound cognitive impairment and persistent seizures despite multiple antiseizure medications (ASMs). Vagus nerve stimulation (VNS) has emerged as a valuable adjunctive therapy for medically intractable epilepsy, yet its effectiveness in rare genetic DEEs remains unknown. We report the first case of VNS in a 5-year-old child with <em>KCNB1</em>-related DEE, achieving about 90% seizure reduction after one year. Prior treatments with multiple ASMs had minimal effect. After VNS implantation, optimized stimulation parameters combined with fenfluramine markedly improved seizure control. Although concurrent medication adjustments and transient seizure cessation during infection complicated interpretation, the sustained seizure improvement strongly suggests VNS’s efficacy in this genetic epilepsy.</div><div>This case illustrates VNS’s potential benefit and possible synergy with fenfluramine in <em>KCNB1</em>-related DEE. Further accumulation of case reports is necessary to confirm these findings.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100826"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified Atkins Diet therapy during pregnancy for refractory idiopathic generalized epilepsy 妊娠期改良阿特金斯饮食治疗难治性特发性全身性癫痫

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-10-06 DOI: 10.1016/j.ebr.2025.100832

Ryoichi Inoue , Elizabeth Weinandy , Sarita Maturu , Nabil Khandker

{"title":"Modified Atkins Diet therapy during pregnancy for refractory idiopathic generalized epilepsy","authors":"Ryoichi Inoue , Elizabeth Weinandy , Sarita Maturu , Nabil Khandker","doi":"10.1016/j.ebr.2025.100832","DOIUrl":"10.1016/j.ebr.2025.100832","url":null,"abstract":"<div><div>The management of refractory epilepsy in pregnancy is challenging, and diet therapy has been rarely reported. We report a case of a 25-year-old woman with refractory idiopathic generalized epilepsy who achieved prolonged seizure freedom with the Modified Atkins Diet (MAD) during pregnancy. Her epilepsy began at age 3, with seizures occurring every two months despite multiple antiseizure medications and vagus nerve stimulation. Three months before her first pregnancy, MAD was initiated with a carbohydrate limit of 30 g daily, resulting in immediate seizure freedom. During the pregnancy, carbohydrate intake was gradually increased to 60–70 g daily to support fetal growth. She remained seizure-free for 10 months before experiencing breakthrough seizures in the third trimester. Oligohydramnios was subsequently detected, and she underwent induction of labor with vaginal delivery at 37 weeks. After delivery, she discontinued MAD for breastfeeding and remained seizure-free for 13 months. In her second pregnancy without MAD, she experienced two breakthrough seizures in the second trimester. She later achieved 23 months of seizure freedom. Both children have met developmental milestones appropriately.</div><div>This case adds to the limited literature on diet therapy in pregnancy and is, to our knowledge, the first involving generalized epilepsy. The case suggests MAD may provide seizure control during pregnancy, even with possible sustained benefit after discontinuation. However, given the occurrence of oligohydramnios and limited safety data, larger studies are needed to clarify the efficacy, safety, and long-term outcomes of diet therapy during pregnancy.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100832"},"PeriodicalIF":1.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late-onset unexplained epilepsy with dual amyloid and tau negativity: are alpha-synuclein seed amplification assays the next diagnostic step? 伴淀粉样蛋白和tau双阴性的迟发性不明原因癫痫：α -突触核蛋白种子扩增检测是下一个诊断步骤吗？

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-09-01 Epub Date: 2025-06-13 DOI: 10.1016/j.ebr.2025.100783

Augustin Moreau , Elisabeth Ruppert , Frédéric Blanc , Olivier BOUSIGES , Benjamin Cretin

{"title":"Late-onset unexplained epilepsy with dual amyloid and tau negativity: are alpha-synuclein seed amplification assays the next diagnostic step?","authors":"Augustin Moreau , Elisabeth Ruppert , Frédéric Blanc , Olivier BOUSIGES , Benjamin Cretin","doi":"10.1016/j.ebr.2025.100783","DOIUrl":"10.1016/j.ebr.2025.100783","url":null,"abstract":"<div><div>Late-onset epilepsy of unknown etiology (LOEU) is associated with an increased risk of dementia. Current biomarkers, including cerebrospinal fluid (CSF) and positron emission tomography (PET) assessments for amyloid and tau, often fail to predict cognitive decline in a substantial proportion of LOEU patients.This case report presents a 67-year-old man with LOEU who later developed dementia with Lewy bodies (DLB). As cognitive decline progressed, emerging mild clinical features raised suspicion for DLB. Notably, cerebrospinal fluid analysis at this stage revealed negative amyloid and tau biomarkers but was positive for pathological alpha-synuclein using alpha-synuclein seed amplification assay (CSF ASyn-SAA). This finding highlights the potential clinical utility of CSF ASyn-SAA in achieving both earlier and more accurate DLB diagnosis. For LOEU patients exhibiting early signs of synucleinopathy, incorporating CSF ASyn-SAA into diagnostic panels could significantly improve diagnostic certainty, prognostic stratification, and opportunities for targeted therapeutic interventions. Further research is needed to investigate the yield of adding ASyn-SAA to CSF dementia panels in people with LOEU and progressive cognitive symptoms.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100783"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective assessment of depression and suicidality in patients with epilepsy having baseline NDDI-E Scores > 13: Associations with seizure frequency and psychiatric treatment 基线NDDI-E评分bbbb13的癫痫患者抑郁和自杀的前瞻性评估：与癫痫发作频率和精神治疗的关系

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-09-01 Epub Date: 2025-07-24 DOI: 10.1016/j.ebr.2025.100810

Satoshi Saito , Go Taniguchi , Hideo Kato , Chihiro Nakata , Izumi Kuramochi

{"title":"Prospective assessment of depression and suicidality in patients with epilepsy having baseline NDDI-E Scores > 13: Associations with seizure frequency and psychiatric treatment","authors":"Satoshi Saito , Go Taniguchi , Hideo Kato , Chihiro Nakata , Izumi Kuramochi","doi":"10.1016/j.ebr.2025.100810","DOIUrl":"10.1016/j.ebr.2025.100810","url":null,"abstract":"<div><div>The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is commonly used to screen for major depressive disorder (MDD) in patients with epilepsy, yet little is known about longitudinal changes in NDDI-E scores in relation to seizure control and psychiatric care. This study evaluated temporal changes in NDDI-E total and Item 4 scores (ΔNDDI-E, ΔItem 4) over ≥6 months in 34 adults (≥18 years) with baseline NDDI-E scores >13. Patients were seen in a specialized outpatient psychiatry clinic within an epilepsy center. Data included Clinical Global Impression–Improvement (CGI-I) ratings by psychiatrists specialized in epilepsy care, seizure frequency, DSM-5-based psychiatric diagnoses, and treatment interventions (e.g., medication adjustments, psychotherapy, and psychosocial support). Patients also completed a self-report questionnaire. No significant difference in MDD diagnoses was found between those with baseline NDDI-E scores of 14–16 and ≥17 (6.7 % vs. 21.1 %, p = 0.36). Comorbidities included autism spectrum disorder, dissociative disorder, and other mental health conditions. Changes in seizure frequency did not correlate with ΔNDDI-E or CGI-I scores, while ΔNDDI-E and ΔItem 4 showed moderate correlations with CGI-I (<em>ρ</em> = 0.51 and 0.56). All patients with improved Item 4 scores had better CGI-I ratings (p < 0.001). Qualitative analysis indicated that emotional fluctuations and psychosocial stressors influenced NDDI-E scores. These results suggest that longitudinal improvement in NDDI-E Item 4 may serve as a marker for psychiatric benefit. Effective use of the NDDI-E requires considering the psychiatric and psychosocial dimensions beyond seizure control. To validate these findings, studies with larger sample sizes and longer follow-up are necessary.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100810"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental health intervention for a child with developmental and/or epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS) 发展性和/或癫痫性脑病伴睡眠尖波激活（D/EE-SWAS）儿童的心理健康干预

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-09-01 Epub Date: 2025-05-17 DOI: 10.1016/j.ebr.2025.100780

C. Reilly , Roz Shafran , Helen Cross , Millie Wagstaff , Bhavna Sidhpara , J. Idowu , C. Meades , S.D. Bennett

{"title":"Mental health intervention for a child with developmental and/or epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS)","authors":"C. Reilly , Roz Shafran , Helen Cross , Millie Wagstaff , Bhavna Sidhpara , J. Idowu , C. Meades , S.D. Bennett","doi":"10.1016/j.ebr.2025.100780","DOIUrl":"10.1016/j.ebr.2025.100780","url":null,"abstract":"<div><div>Children with Developmental and Epileptic Encephalopathies experience neurodevelopmental problems from both the epileptic activity and the underlying cause of the condition. Children with Developmental and/or Epileptic Encephalopathy with spike-wave activation in sleep (D/EE-SWAS) experience cognitive and behavioral regression/stagnation that occurs in tandem with marked spike-wave activation in sleep (SWAS). Children with epilepsy often have co-occurring mental health problems that are often not recognized or supported. There is increasing evidence these co-occurring mental health problems can be treated with psychological interventions. The mental health and cognitive difficulties that accompany SWAS have a significant impact on child and family quality of life. There is limited data on the treatment of mental health difficulties for children with D/EE-SWAS. We describe the use of the Mental Health Intervention in Children with Epilepsy (MICE) in a child with D/EE-SWAS who had experienced significant cognitive regression and behavioral difficulties. The intervention was delivered with the child’s parents via video and consisted of 19 sessions delivered by an assistant psychologist. The focus of the intervention was reducing behaviours of concern via evidence-based behavioural parenting strategies. The intervention resulted in clear progress towards parental chosen goals (Goal Based Outcomes) and a reduction of symptoms on validated measures of behavior. Qualitative feedback via parental interview was that the intervention was very useful, giving the parents everyday strategies that they could effectively employ with the child in the home environment. This case demonstrates that a mental health intervention based on behavioural parenting strategies can be useful for children with D/EE-SWAS.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100780"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0