Epilepsy and Behavior Reports最新文献_第5页

“Amity Seizures”: A previously unreported semiology localizing to a circuit between the right hippocampus and orbitofrontal area "爱弥儿癫痫发作"：以前未曾报道过的一种定位在右侧海马和眶额区之间回路的半定型现象

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100649

Alexander Hedaya , Lawrence Ver Hoef

{"title":"“Amity Seizures”: A previously unreported semiology localizing to a circuit between the right hippocampus and orbitofrontal area","authors":"Alexander Hedaya , Lawrence Ver Hoef","doi":"10.1016/j.ebr.2024.100649","DOIUrl":"10.1016/j.ebr.2024.100649","url":null,"abstract":"<div><p>We describe a case of focal epilepsy with a semiology consisting of behaviors indicating an enthusiastic desire for those around him to get along and engage in friendly relations, which we refer to as “amity seizures”. The patient was a 41-year-old right-handed male with seizures since age 26. Semiology consisted of stereotyped enthusiastic behaviors such as expressing “Peace! Peace!… Come on, we all on the same team, right?!”, and giving hugs, kisses, and high-fives to those around him. On SEEG evaluation, 2 independent areas of seizure onset were identified, the right hippocampus and right posterior orbitofrontal area. Locally confined seizures had bland manifestation. However, spread from right hippocampus to right orbitofrontal area, or vice versa, elicited his typical amity seizure semiology. To our knowledge this is the first report of the seizure semiology we have coined “Amity seizures”. While emotions were once thought to localize to discrete brain regions, they are now accepted to arise from networks across multiple brain regions. The fact that this behavior only occurred when seizures spread from either of 2 onset zones to the other suggests that this semiology results from network engagement between, and likely beyond, either onset zone.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"25 ","pages":"Article 100649"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000066/pdfft?md5=d622d0ad96a02e2d0e641f96b41bc348&pid=1-s2.0-S2589986424000066-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139632159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epileptic dyskinetic encephalopathy in KBG syndrome: Expansion of the phenotype KBG 综合征中的癫痫性运动障碍脑病：表型的扩展

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100647

Eoin P. Donnellan , Kathleen M. Gorman , Amre Shahwan , Nicholas M. Allen

{"title":"Epileptic dyskinetic encephalopathy in KBG syndrome: Expansion of the phenotype","authors":"Eoin P. Donnellan , Kathleen M. Gorman , Amre Shahwan , Nicholas M. Allen","doi":"10.1016/j.ebr.2024.100647","DOIUrl":"10.1016/j.ebr.2024.100647","url":null,"abstract":"<div><p>KBG syndrome is characterised by developmental delay, dental (macrodontia of upper central incisors), craniofacial and skeletal anomalies. Since the identification of variants in the gene (<em>ANKRD11</em>) responsible for KBG syndrome, wider phenotypes are emerging. While there is phenotypic variability within many features of KBG syndrome, epilepsy is not usually markedly severe and movement disorders largely undocumented. Here we describe a novel early onset phenotype of dyskinetic epileptic encephalopathy in a male, who presented during infancy with a florid hyperkinetic movement disorder and developmental regression. Initially he had epileptic spasms and tonic seizures, and EEGs revealed a modified hypsarrhythmia. The epilepsy phenotype evolved to Lennox-Gastaut syndrome with seizures resistant to multiple anti-seizure therapies and the movement disorder evolved to choreoathetosis of limbs and head with oro-lingual dyskinesias. Previous extensive neurometabolic and imaging investigations, including panel-based exome sequencing were unremarkable. Later trio exome sequencing identified a de novo pathogenic heterozygous frameshift deletion of <em>ANKRD11</em> (c.6792delC; p.Ala2265Profs*72). Review of the literature did not identify any individuals with such a hyperkinetic movement disorder presentation in combination with early-onset epileptic encephalopathy. This report expands the phenotype of <em>ANKRD11</em>-related KBG syndrome to include epileptic dyskinetic encephalopathy.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"25 ","pages":"Article 100647"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000042/pdfft?md5=fc07f0561c345be3477327fe0883b967&pid=1-s2.0-S2589986424000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

There is no clear epileptic heart syndrome, but there are various cardiac complications following seizures 没有明确的癫痫性心脏综合征，但癫痫发作后会出现各种心脏并发症

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100718

Josef Finsterer

引用次数: 0

Hemispherectomy for dominant hemisphere Rasmussen’s Encephalitis − how late is too late? 优势半球拉斯穆森脑炎的半球切除术--多晚才算晚？

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100689

James Butler , Aayesha Soni , Roger Melvill

{"title":"Hemispherectomy for dominant hemisphere Rasmussen’s Encephalitis − how late is too late?","authors":"James Butler , Aayesha Soni , Roger Melvill","doi":"10.1016/j.ebr.2024.100689","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100689","url":null,"abstract":"<div><p>It is unclear whether a dominant hemispherectomy/hemispherotomy in someone with Rasmussen’s Encephalitis (RE) may produce a satisfactory outcome when performed over the age of 40 years. Important questions include whether RE may continue to evolve three decades after onset, and whether a hemispherectomy may adequately shift language function when performed in older ages. Two cases illustrate seizure, language, motor and functional outcomes after dominant hemispherotomies. The cases were selected from an epilepsy surgery database of procedures performed at a private hospital in Cape Town, South Africa, spanning the period 1998–2023. A man in his 40s with epilepsy since childhood and dominant hemisphere RE partially regained impaired comprehension and ambulation, while expressive language function did not recover post-hemispherotomy. By contrast, a young teenage patient with dominant hemisphere RE demonstrated considerable recovery of expressive and receptive language and ambulation post-surgery. Both remain seizure-free. These two cases demonstrate that a dominant hemispherotomy, when performed on a quadragenarian, may produce a satisfactory, albeit inferior, functional outcome in comparison to when performed in childhood. RE may cause progressive neurological dysfunction in the late thirties and older and should be considered in patients presenting with functional decline decades after disease onset.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100689"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000467/pdfft?md5=004e2e29dbba91b0db4a679af461b615&pid=1-s2.0-S2589986424000467-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of large language model chatbots for application to epilepsy: Let’s talk about physical exercise 大语言模型聊天机器人应用于癫痫的潜力：谈谈体育锻炼

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100692

Rizia Rocha-Silva , Bráulio Evangelista de Lima , Geovana José , Douglas Farias Cordeiro , Ricardo Borges Viana , Marília Santos Andrade , Rodrigo Luiz Vancini , Thomas Rosemann , Katja Weiss , Beat Knechtle , Ricardo Mario Arida , Claudio Andre Barbosa de Lira

{"title":"The potential of large language model chatbots for application to epilepsy: Let’s talk about physical exercise","authors":"Rizia Rocha-Silva , Bráulio Evangelista de Lima , Geovana José , Douglas Farias Cordeiro , Ricardo Borges Viana , Marília Santos Andrade , Rodrigo Luiz Vancini , Thomas Rosemann , Katja Weiss , Beat Knechtle , Ricardo Mario Arida , Claudio Andre Barbosa de Lira","doi":"10.1016/j.ebr.2024.100692","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100692","url":null,"abstract":"<div><p>In this paper, we discuss how artificial intelligence chatbots based on large-scale language models (LLMs) can be used to disseminate information about the benefits of physical exercise for individuals with epilepsy. LLMs have demonstrated the ability to generate increasingly detailed text and allow structured dialogs. These can be useful tools, providing guidance and advice to people with epilepsy on different forms of treatment as well as physical exercise. We also examine the limitations of LLMs, which include the need for human supervision and the risk of providing imprecise and unreliable information regarding specific or controversial aspects of the topic. Despite these challenges, LLM chatbots have demonstrated the potential to support the management of epilepsy and break down barriers to information access, particularly information on physical exercise.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100692"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000492/pdfft?md5=69ab5dbd0af04928d74ed073a01f1ca9&pid=1-s2.0-S2589986424000492-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical outcomes following resection in patients with language dominant posterior quadrant epilepsy 语言优势后象限癫痫患者切除术后的手术效果

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100695

Satvir Saggi , Joseph H. Garcia , Faraz Behzadi , Arka N. Mallela , Paul A. Garcia , Edward F. Chang , Robert C. Knowlton

{"title":"Surgical outcomes following resection in patients with language dominant posterior quadrant epilepsy","authors":"Satvir Saggi , Joseph H. Garcia , Faraz Behzadi , Arka N. Mallela , Paul A. Garcia , Edward F. Chang , Robert C. Knowlton","doi":"10.1016/j.ebr.2024.100695","DOIUrl":"10.1016/j.ebr.2024.100695","url":null,"abstract":"<div><p>Posterior quadrant epilepsy surgery, involving the occipital lobe, parietal lobe, or the posterior border of the temporal lobe, accounts for a small percentage of focal resections for medically refractory epilepsy. Prior studies investigating seizure control from posterior quadrant epilepsy surgery are limited. In this study, a retrospective database of patients undergoing surgery for left sided posterior cortex epilepsy at a single large level 4 epilepsy center was analyzed between August 2008 to April 2021 in order to characterize seizure control outcomes. Nine patients presented with epileptogenic foci in the left posterior cortex with a malformation of cortical development deemed as the etiology of seizures for all but one patient. Absolute seizure freedom (Engel I) was achieved in 4 of 9 patients, with the remaining 5 patients achieving an improvement in the frequency of seizures (Engel II/III). Complete resection of the anatomic and physiologic abnormalities was performed in 3 of 4 patients with Engel 1 outcomes and 1 of 5 patients with Class II/III outcomes. Five patients developed new right sided visual field defects, all of which were expected based on the sub-lobar, occipital localization and were viewed as acceptable by the patients and did not interfere with activities of daily living. Overall, our study demonstrates the potential for surgical resection to yield excellent seizure-control outcomes with anticipated, tolerable neurological deficits. This information is important for patients with disabling seizures who may not benefit sufficiently from palliative procedures.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100695"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000522/pdfft?md5=2f3b67eb9e981e688d4b3f340434be77&pid=1-s2.0-S2589986424000522-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141697007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of physical activity on cognition and psychosocial functioning in pediatric epilepsy: A systematic review 体育锻炼对小儿癫痫患者认知和社会心理功能的影响：系统回顾

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100700

Demy Alfonso , Alyssa Ailion , Nicole Semaan , Evie Davalbhakta , Donald J. Bearden

{"title":"Effects of physical activity on cognition and psychosocial functioning in pediatric epilepsy: A systematic review","authors":"Demy Alfonso , Alyssa Ailion , Nicole Semaan , Evie Davalbhakta , Donald J. Bearden","doi":"10.1016/j.ebr.2024.100700","DOIUrl":"10.1016/j.ebr.2024.100700","url":null,"abstract":"<div><p>Pediatric patients with epilepsy often have psychosocial and cognitive difficulties. Physical activity has emerged as a lifestyle modification that may reduce seizure burden, enhance brain plasticity, and improve cognitive and psychosocial comorbidities. We systematically reviewed published studies examining the effect of physical activity on cognitive and psychosocial function in children and adolescents with epilepsy. Studies were identified with PubMed and Emory Library databases. Eleven studies met inclusion criteria. Six of 10 studies related to psychosocial outcomes showed benefits of physical activity in children and adolescents with epilepsy, including improvements in internalizing symptoms, relationships, self-esteem, and psychological well-being, but four of the 10 studies showed no psychosocial benefits. Of the six studies evaluating cognitive outcomes, all six indicated that physical activity was associated with cognitive improvements in pediatric epilepsy, including areas of attention, processing speed, executive function, and memory. Our review was limited by the paucity of published studies on this topic, and the use of different measurement tools limited our ability to make direct comparisons between studies. Additional studies that compare pediatric epilepsy populations to non-epilepsy control groups are needed to better understand how physical activity affects seizure control and epilepsy-related comorbidities.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100700"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000571/pdfft?md5=58f89b7be088c081ff0ff9d7934b800c&pid=1-s2.0-S2589986424000571-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141843633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of anhedonia after epilepsy surgery 癫痫手术后的失神治疗

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100658

Gerardo Maria de Araujo Filho , Antonio L. Teixeira

引用次数: 0

Experimental assessment of seizure-like behaviors in a girl with Rett syndrome 对一名雷特综合征女孩癫痫样行为的实验评估

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100666

Magnus Starbrink , Svein Eikeseth , Sigmund Eldevik , Johanna Edervall

{"title":"Experimental assessment of seizure-like behaviors in a girl with Rett syndrome","authors":"Magnus Starbrink , Svein Eikeseth , Sigmund Eldevik , Johanna Edervall","doi":"10.1016/j.ebr.2024.100666","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100666","url":null,"abstract":"<div><p>Contextual events are recognized to affect seizure-like behaviors, yet there is limited research on procedures assessing contextual control. This study aimed to examine the utilization of a brief experimental precursor functional analysis within a clinical team assessment. Furthermore, the study explored if telehealth supervision could guide a parent administered replication of the functional analysis. The participants were a young female with Rett syndrome and a history of epilepsy as well as non-epileptic seizures and her mother. The functional analysis procedures consisted of the systematic alternations of contextual conditions that were hypothesized to either prevent or evoke seizure-like behaviors. The primary outcome measure was the occurrence of behavioral precursors that were identified to consequently signal subsequent seizure-like behaviors. In addition, procedure fidelity and interobserver agreement data were obtained alongside parent rating of the procedure’s social validity. The clinical functional analysis clearly suggested that the seizure-like behaviors served the function of access to attention and preferred activities. A parent administered functional analysis replicated clinical functional analysis findings. The parent’s fidelity to procedures was high and scores in social validity were excellent. The results show that functional analysis procedures could provide essential information in assessment of non-epileptic seizures. Strengths and limitations are discussed.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"26 ","pages":"Article 100666"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000236/pdfft?md5=cca650d44f0f5790ff84381e9c0a7378&pid=1-s2.0-S2589986424000236-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140620026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment of epileptic encephalopathy with spike wave activation in sleep with anakinra 阿纳金拉成功治疗睡眠中出现尖波激活的癫痫性脑病

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100678

Andy Cheuk-Him Ng , Morris H. Scantlebury

引用次数: 0