Epilepsy and Behavior Reports最新文献_第10页

Prosopagnosia in the context of right handedness, left hemisphere perinatal stroke, epileptogenic cyst, and focal epilepsy: A pre-surgical case report 右撇子、围产期左半球中风、致痫性囊肿和局灶性癫痫背景下的前视障症：手术前病例报告

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100706

Alanna Kessler-Jones , Tayler M. Cieminski , Aaron Field , Andrew Knox

引用次数: 0

Laser amygdalohippocampotomy reduces contralateral hippocampal sub-clinical activity in bitemporal epilepsy: A case illustration of responsive neurostimulator ambulatory recordings 激光杏仁海马切断术可减少位颞叶癫痫患者对侧海马的亚临床活动：反应性神经刺激器动态记录的病例说明

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2023-12-01 DOI: 10.1016/j.ebr.2023.100636

Hael F. Abdulrazeq , Anna R. Kimata , Belinda Shao , Konstantina Svokos , Neishay Ayub , Duyu Nie , Wael F. Asaad

{"title":"Laser amygdalohippocampotomy reduces contralateral hippocampal sub-clinical activity in bitemporal epilepsy: A case illustration of responsive neurostimulator ambulatory recordings","authors":"Hael F. Abdulrazeq , Anna R. Kimata , Belinda Shao , Konstantina Svokos , Neishay Ayub , Duyu Nie , Wael F. Asaad","doi":"10.1016/j.ebr.2023.100636","DOIUrl":"https://doi.org/10.1016/j.ebr.2023.100636","url":null,"abstract":"<div><p>Responsive neurostimulation (RNS) is a valuable tool in the diagnosis and treatment of medication refractory epilepsy (MRE) and provides clinicians with better insights into patients’ seizure patterns. In this case illustration, we present a patient with bilateral hippocampal RNS for presumed bilateral mesial temporal lobe epilepsy. The patient subsequently underwent a right sided LITT amygdalohippocampotomy based upon chronic RNS data revealing predominance of seizures from that side. Analyzing electrocorticography (ECOG) from the RNS system, we identified the frequency of high amplitude discharges recorded from the left hippocampal lead pre- and post- right LITT amygdalohippocampotomy. A reduction in contralateral interictal epileptiform activity was observed through RNS recordings over a two-year period, suggesting the potential dependency of the contralateral activity on the primary epileptogenic zone. These findings suggest that early targeted surgical resection or laser ablation by leveraging RNS data can potentially impede the progression of dependent epileptiform activity and may aid in preserving neurocognitive networks. RNS recordings are essential in shaping further management decisions for our patient with a presumed bitemporal epilepsy.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"25 ","pages":"Article 100636"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986423000540/pdfft?md5=f5b564dac1f9219ab93dee4897e186e1&pid=1-s2.0-S2589986423000540-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138548863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifocal drug-resistant epilepsy in a patient with a newly discovered mutation in tuberous sclerosis complex 1 gene treated by deep brain stimulation in the anterior thalamic nucleus 丘脑前核深部脑刺激术治疗一名新发现结节性硬化症复合体 1 基因突变患者的多灶性耐药性癫痫

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2023-12-01 DOI: 10.1016/j.ebr.2023.100637

Michał Sobstyl , Paweł Jezierski , Magdalena Konopko , Angelika Stapińska-Syniec

{"title":"Multifocal drug-resistant epilepsy in a patient with a newly discovered mutation in tuberous sclerosis complex 1 gene treated by deep brain stimulation in the anterior thalamic nucleus","authors":"Michał Sobstyl , Paweł Jezierski , Magdalena Konopko , Angelika Stapińska-Syniec","doi":"10.1016/j.ebr.2023.100637","DOIUrl":"https://doi.org/10.1016/j.ebr.2023.100637","url":null,"abstract":"<div><p>Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the tumor suppressor genes TSC1 or TSC2. TSC is characterized by the formation of multiple tumors in various organs. The most common neurological manifestation of the disorder is epilepsy present in 79–90% of cases. At least one-third of TSC patients develop drug-resistant epilepsy (DRE) which remains a great challenge for clinicians. Neuromodulation is an option in cases of multifocal epilepsy, epilepsy originating in eloquent areas, or the inability to identify the ictal onset zone. Deep brain stimulation of the anterior thalamic nucleus (ANT-DBS) may be used in the treatment of multifocal DRE. Here, we present a case of a patient with multifocal DRE caused by TSC, who was treated with ANT-DBS. A follow-up period of eight months showed that the patient's multifocal DRE was successfully treated by ANT-DBS.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"25 ","pages":"Article 100637"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986423000552/pdfft?md5=e3cc36b3e77f6c09976d6802cca4175a&pid=1-s2.0-S2589986423000552-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138490298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seizure control with treatment of delayed sleep-wake phase disorder in juvenile myoclonic epilepsy: A case report 用延迟睡眠-觉醒期障碍治疗青少年肌阵挛性癫痫控制发作:1例报告

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2023-01-01 DOI: 10.1016/j.ebr.2023.100614

Erafat Rehim , Snow Pinxue Li , Martina Vendrame

{"title":"Seizure control with treatment of delayed sleep-wake phase disorder in juvenile myoclonic epilepsy: A case report","authors":"Erafat Rehim , Snow Pinxue Li , Martina Vendrame","doi":"10.1016/j.ebr.2023.100614","DOIUrl":"10.1016/j.ebr.2023.100614","url":null,"abstract":"<div><p>Juvenile Myoclonic Epilepsy (JME) is an idiopathic generalized epilepsy associated with a characteristic sleep/wake rhythm, with the tendency to go to bed later at night, to get up later in the morning. In the pediatric population, we have previously observed specific circadian and sleep/wake patterns of generalized seizures (6 am-12 pm) and myoclonic seizures (in wakefulness, 6 am to noon). Delayed Sleep-Wake Phase Disorder (DSWPD) is characterized by sleep initiation insomnia when attempting sleep at conventional times and difficulty waking at the required time. Here we present the case of a 20-year-old man with JME, diagnosed DSWPD (sleep schedule 3 am to 11 am), presenting with nocturnal seizures out of sleep, always between 5 and 6am. Improvements in seizure control (seizure frequency from 8 per month to 0 per month) were achieved with timed evening melatonin, combined with behavioral sleep-wake scheduling (sleep schedule 10 pm to 6 am) and morning light therapy. Recognition and characterization of DSWPD in JME, together with assessment of circadian and diurnal seizure patterns, may offer therapeutic consideration for better control of seizures.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"23 ","pages":"Article 100614"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/55/main.PMC10368759.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10245246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SEEG-RF for revealing and treating Geschwind syndrome's epileptic network: A case study SEEG-RF显示和治疗Geschwind综合征的癫痫网络:一个案例研究

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2023-01-01 DOI: 10.1016/j.ebr.2023.100617

Mikael Levy , Maya Weinstein , Alexie Mirson , Sandi Madar , Mordechai Lorberboym , Nir Getter , Moshe Zer-Zion , Jehuda Sepkuty

{"title":"SEEG-RF for revealing and treating Geschwind syndrome's epileptic network: A case study","authors":"Mikael Levy , Maya Weinstein , Alexie Mirson , Sandi Madar , Mordechai Lorberboym , Nir Getter , Moshe Zer-Zion , Jehuda Sepkuty","doi":"10.1016/j.ebr.2023.100617","DOIUrl":"10.1016/j.ebr.2023.100617","url":null,"abstract":"<div><p>Stereotypic neural networks are repeatedly activated in drug-refractory epilepsies (DRE), reinforcing the expression of certain psycho-affective traits. Geschwind syndrome (GS) can serve as a model for such phenomena among patients with temporal lobe DRE. We describe stereo-electroencephalogram (SEEG) exploration in a 34-year-old male with DRE and GS, and his treatment by SEEG-radiofrequency (SEEG-RF) ablation. We hypothesized that this approach could reveal the underlying epileptic network and map eloquent faculties adjacent to SEEG-RF targets, which can be further used to disintegrate the epileptic network. The patient underwent a multi-modal pre-surgical evaluation consisting of video EEG (VEEG), EEG source localization, 18-fluorodexyglucose-PET/MRI, neuropsychological and psychiatric assessments. Pre-surgical multi-modal analyses suggested a T4-centered seizure onset zone. SEEG further localized the SOZ within the right amygdalo-hippocampal region and temporal neocortex, with the right parieto-temporal region as the propagation zone. SEEG-RF ablation under awake conditions and continuous EEG monitoring confirmed the abolishment of epileptic activity. Follow-up at 20 months showed seizure suppression (Engel 1A/ILEA 1) and a significantly improved and stable psycho-affective state. To the best of our knowledge this is the first description of the intracranial biomarkers of GS and its further treatment through SEEG-RF ablation within the scope of DRE.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"24 ","pages":"Article 100617"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/a0/main.PMC10462843.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10130944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent cerebellar ischemic infarctions and stereotyped peri-ictal sympathetic responses in a near-SUDEP patient with cardiovascular risk factors 一例有心血管危险因素的近SUDEP患者的复发性小脑缺血性梗死和发作期典型交感神经反应

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2023-01-01 DOI: 10.1016/j.ebr.2023.100605

J.L. Vega , A. Carrasco , N. Karim , M. Stewart , W. Bell

{"title":"Recurrent cerebellar ischemic infarctions and stereotyped peri-ictal sympathetic responses in a near-SUDEP patient with cardiovascular risk factors","authors":"J.L. Vega , A. Carrasco , N. Karim , M. Stewart , W. Bell","doi":"10.1016/j.ebr.2023.100605","DOIUrl":"10.1016/j.ebr.2023.100605","url":null,"abstract":"<div><p>We report a 60-year-old woman who presented to the emergency department after experiencing a witnessed unknown onset bilateral tonic clonic seizure (GTCS) that culminated in cardiac arrest. A neurology consultant uncovered a years-long history of frequent episodic staring followed by confusion and expressive aphasia, which strongly suggested that she suffered from epilepsy. Thus, her cardiac arrest and subsequent resuscitation met criteria for a near-sudden unexpected death in epilepsy (SUDEP) diagnosis. Serial bloodwork demonstrated transient troponin I elevations and leukocytoses, while a brain MRI revealed global cerebral anoxic injury and a small acute right cerebellar ischemic infarction. A review of her medical record uncovered a hospitalization sixteen months earlier for a likely GTCS whose workup showed similar troponin I elevations and leukocytoses, and surprisingly, a different small acute right cerebellar ischemic infarction in the same vascular territory. To our knowledge, this is the first report of subcortical ischemic infarctions occurring concurrently with GTCSs in a near-SUDEP patient. Aside from illustrating the key role of inpatient neurologists in the diagnosis of near-SUDEP, this manuscript discusses the potential significance of postictal ischemic infarctions, transient asymptomatic troponin elevations, and transient non-infectious leukocytoses in epilepsy patients with cardiovascular risk factors.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"23 ","pages":"Article 100605"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of an advanced epilepsy treatment gap in a region in Japan 日本某地区晚期癫痫治疗差距特征

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2023-01-01 DOI: 10.1016/j.ebr.2023.100628

Tetsuhiro Fukuyama , Manami Yabe , Makoto Nishioka , Takenori Natsume , Yuumi Hoshino , Kohei Kanaya , Kyoko Takano , Norimoto Kobayashi , Yushi Inoue

{"title":"Characteristics of an advanced epilepsy treatment gap in a region in Japan","authors":"Tetsuhiro Fukuyama , Manami Yabe , Makoto Nishioka , Takenori Natsume , Yuumi Hoshino , Kohei Kanaya , Kyoko Takano , Norimoto Kobayashi , Yushi Inoue","doi":"10.1016/j.ebr.2023.100628","DOIUrl":"https://doi.org/10.1016/j.ebr.2023.100628","url":null,"abstract":"<div><p>To investigate the quality of epilepsy care in a region in Japan that lacked specialised care, we retrospectively evaluated patients who visited our newly established epilepsy division between April 2018 and March 2021, and had been treated with anti-seizure medications (ASMs) for at least 1 year prior.</p><p>Of the 231 patients included, 169 had ongoing seizure episodes at first visit (seizure-persist group) and 62 had no seizure episodes for more than a year (seizure-free group). Eighty-three patients in the seizure-persist group had not received specialised epilepsy care, 15 had been treated with unnecessary medications, and seven had experienced side effects from ASMs. Twelve patients in the seizure-free group had been treated with unnecessary ASMs, 10 had been treated with ASMs with teratogenic potential and four had experienced ASM side effects. These patients could be classified as having an advanced epilepsy treatment gap (ETG) because they had not previously received necessary specialised care. The progressive decline in the number of patients with advanced ETG suggests that our new epilepsy division has addressed this issue.</p><p>This study highlights that a significant number of patients with advanced ETGs exist in Japan and that proper countermeasures are required to address this gap.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"24 ","pages":"Article 100628"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49856302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early onset developmental and epileptic encephalopathy and Rett-like phenotype in a 15-year-old girl affected by Cornelia de Lange syndrome type 2 due to a SMC1A gene mutation 一名15岁女孩因SMC1A基因突变而患2型科妮莉亚综合征的早发性发育性和癫痫性脑病和ret样表型

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2023-01-01 DOI: 10.1016/j.ebr.2023.100634

L. Parmeggiani , F. Stanzial , E. Menna , E. Boni , F. Manzoni , F. Benedicenti , S. Pellegrin

{"title":"Early onset developmental and epileptic encephalopathy and Rett-like phenotype in a 15-year-old girl affected by Cornelia de Lange syndrome type 2 due to a SMC1A gene mutation","authors":"L. Parmeggiani , F. Stanzial , E. Menna , E. Boni , F. Manzoni , F. Benedicenti , S. Pellegrin","doi":"10.1016/j.ebr.2023.100634","DOIUrl":"10.1016/j.ebr.2023.100634","url":null,"abstract":"<div><p>Developmental and epileptic encephalopathies (DEE) are conditions in which a mutated gene may cause abnormal functioning of the central nervous system, resulting in both encephalopathy and epileptogenesis. We present a case of a girl with a DEE characterized by a Rett-like phenotype in association with febrile and afebrile clusters of focal seizures. The girl presented typical development until the age of 18 months, followed by regression. The first febrile bilateral tonic-clonic seizure was observed at 30 months of age, and the following month seizures recurred in clusters of several episodes per day every 10 days. These seizures were characterized by behavioural arrest, emotional symptoms, head turning, and followed by bilateral tonic-clonic seizures. The administration of valproic acid and levetiracetam led to prolonged seizure control. However, from the age of 7 years, she had monthly recurrent clusters of focal seizures and non-convulsive status epilepticus which occurred at different ages. Brain and spinal cord MRI showed mild non-progressive hemispheric cerebellar atrophy. A next generation sequencing panel for epilepsy identified the <em>de novo</em> splicing mutation c.2973+1G>A of the <em>SMC1A</em> gene.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"24 ","pages":"Article 100634"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986423000527/pdfft?md5=9ef24d613f19aebe03f443c676cd0fa6&pid=1-s2.0-S2589986423000527-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135763705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal encephalocele: An epileptogenic focus confirmed by direct intracranial electroencephalography 颞叶脑膨出:一种经直接颅内脑电图证实的致痫灶

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2023-01-01 DOI: 10.1016/j.ebr.2023.100601

Shruti Agashe , Brian N. Lundstrom , Benjamin H. Brinkmann , Elson So , Gregory D. Cascino , Nicholas Gregg , W. Richard Marsh , Madeline Cross , Jamie J. Van Gompel , Kelsey M. Smith

{"title":"Temporal encephalocele: An epileptogenic focus confirmed by direct intracranial electroencephalography","authors":"Shruti Agashe , Brian N. Lundstrom , Benjamin H. Brinkmann , Elson So , Gregory D. Cascino , Nicholas Gregg , W. Richard Marsh , Madeline Cross , Jamie J. Van Gompel , Kelsey M. Smith","doi":"10.1016/j.ebr.2023.100601","DOIUrl":"10.1016/j.ebr.2023.100601","url":null,"abstract":"<div><p>Several studies have suggested the epileptogenic potential of temporal encephaloceles. However, there is limited literature describing the results of intracranial EEG monitoring for patients with temporal encephaloceles. We describe a 19 year-old right-handed woman with drug-resistant epilepsy who presented with seizure onset at age 16 in the setting of a left temporal encephalocele where the seizure onset zone was confirmed to be the encephalocele via stereo EEG (sEEG). She had focal impaired awareness seizures occurring weekly that would progress to focal to bilateral tonic-clonic seizures monthly. Imaging showed a left anterior inferior temporal lobe encephalocele and a left choroidal fissure cyst that were stable on repeat imaging. Prolonged scalp recorded video EEG recorded seizures that showed either near simultaneous onset in the bitemporal head regions or a transitional left temporal sharp wave followed by maximum evolution in the left temporal region. Invasive monitoring with sEEG electrodes targeting primarily the left limbic system with one electrode directly in the encephalocele captured seizures with onset in the left temporal pole encephalocele. A limited resection was performed based on the results of the sEEG and except for one seizure in the immediate postop period in the setting of infection, patient remains seizure free at her 4 month follow up. This report describes a case of drug-resistant focal epilepsy where sEEG monitoring confirmed a temporal encephalocele to be the seizure onset zone without simultaneous onset at mesial temporal or other neocortical structures that were sampled. Our findings support the potential for epileptogenicity within an encephalocele with direct intracranial monitoring.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"22 ","pages":"Article 100601"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/cb/main.PMC10131120.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9745633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible post-COVID epilepsy: A review of epilepsy monitoring unit admissions during the two years of COVID-19 pandemic 可能的后COVID-19癫痫:回顾在COVID-19大流行的两年中癫痫监测单位入院

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2023-01-01 DOI: 10.1016/j.ebr.2023.100584

Eric Dunn , Faisal Ibrahim , Silvia Neme-Mercante , Dileep Nair , Spencer Morris , Irene Wang , Vineet Punia

{"title":"Possible post-COVID epilepsy: A review of epilepsy monitoring unit admissions during the two years of COVID-19 pandemic","authors":"Eric Dunn , Faisal Ibrahim , Silvia Neme-Mercante , Dileep Nair , Spencer Morris , Irene Wang , Vineet Punia","doi":"10.1016/j.ebr.2023.100584","DOIUrl":"10.1016/j.ebr.2023.100584","url":null,"abstract":"<div><p>Large scale healthcare data shows that new-onset epilepsy is noted in 0.3 % patients within 6 months of COVID-19 infection. We analyzed diagnostic epilepsy monitoring unit (EMU) evaluations to identify and report such cases. We thoroughly reviewed our EMU database and identified patients having “COVID” or “Corona” virus mention in their medical record from 03/15/2020 to 02/28/2022. Patients with epilepsy prior to COVID infection were excluded. Among 62 patients without prior epilepsy evaluated in the EMU for new-onset spells after confirmed COVID-19 infection, three patients were diagnosed with focal epilepsy. These three women without epilepsy risk factors had seizure onset at the time of, or within one to three months of, COVID-19 diagnosis. Their 3 T MRI imaging was non-lesional but revealed bilateral enlarged perivascular spaces. The video EEG monitoring was consistent with temporal or fronto-temporal lobe epilepsy in all three patients. Two of them developed drug-resistant epilepsy within six months of seizure onset. Our thorough analysis of diagnostic EMU evaluations during the two years of pandemic reveals three cases of post-COVID-19 epilepsy after non-symptomatic to mild disease. Although coincidental epilepsy onset cannot be ruled out, larger multicenter or national database investigations are needed to further analyze the possibility of post-COVID epilepsy.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"21 ","pages":"Article 100584"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/57/main.PMC9847010.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10613296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1