Refractory inflammatory hydrocephalus: A case report of a rare and complicated delayed sequelae following cerebral hemispherectomy surgery for epilepsy

IF 1.8 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI:10.1016/j.ebr.2024.100694

Akshay Sharma , Efstathios Kondylis , Shaarada Srivatsa , Nehaw Sarmey , Deepak Lachhwani , Laura Nedorezov , William Bingaman

{"title":"Refractory inflammatory hydrocephalus: A case report of a rare and complicated delayed sequelae following cerebral hemispherectomy surgery for epilepsy","authors":"Akshay Sharma , Efstathios Kondylis , Shaarada Srivatsa , Nehaw Sarmey , Deepak Lachhwani , Laura Nedorezov , William Bingaman","doi":"10.1016/j.ebr.2024.100694","DOIUrl":null,"url":null,"abstract":"<div><p>Hydrocephalus is a known complication following surgical resection of a cerebral hemisphere for refractory epilepsy, yet the pathological mechanism remains poorly understood. We present a case of refractory aseptic inflammatory hydrocephalus following cerebral hemispherectomy surgery for refractory epilepsy treated with a combination of cerebral spinal fluid (CSF) diversion and immunosuppression via IL-1 receptor agonist, Anakinra. At 6 month follow up, the patient had returned to neurologic baseline, with improvement in school and physical therapy performance. Further investigation into the beneficial role of immunosuppressive therapy is needed to better understand the relationship between neuro-inflammation and improving outcomes following epilepsy surgery.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100694"},"PeriodicalIF":1.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000510/pdfft?md5=4039a2c825764ca223233eb7fc0729a3&pid=1-s2.0-S2589986424000510-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epilepsy and Behavior Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589986424000510","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Hydrocephalus is a known complication following surgical resection of a cerebral hemisphere for refractory epilepsy, yet the pathological mechanism remains poorly understood. We present a case of refractory aseptic inflammatory hydrocephalus following cerebral hemispherectomy surgery for refractory epilepsy treated with a combination of cerebral spinal fluid (CSF) diversion and immunosuppression via IL-1 receptor agonist, Anakinra. At 6 month follow up, the patient had returned to neurologic baseline, with improvement in school and physical therapy performance. Further investigation into the beneficial role of immunosuppressive therapy is needed to better understand the relationship between neuro-inflammation and improving outcomes following epilepsy surgery.

查看原文本刊更多论文

难治性炎性脑积水：一例罕见且复杂的癫痫大脑半球切除手术后延迟性后遗症报告

众所周知，脑积水是难治性癫痫手术切除大脑半球后的一种并发症，但对其病理机制仍知之甚少。我们介绍了一例难治性无菌性炎症性脑积水患者，该患者在接受大脑半球切除手术治疗难治性癫痫后，接受了脑脊液引流和通过IL-1受体激动剂Anakinra进行免疫抑制的综合治疗。在 6 个月的随访中，患者的神经功能已恢复到基线水平，在学校和物理治疗方面的表现也有所改善。我们需要进一步研究免疫抑制疗法的有益作用，以便更好地了解神经炎症与改善癫痫手术后疗效之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Epilepsy and Behavior Reports Medicine-Neurology (clinical)

CiteScore

2.70

自引率

13.30%

发文量

审稿时长

50 days