Epilepsy and Behavior Reports最新文献

Comparing the risk of subsequent ischemic stroke and mortality in patients with epilepsy and patients with ischemic stroke

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-04-06 DOI: 10.1016/j.ebr.2025.100766

Po-Yu Lin , Sheng-Hsiang Lin , Pi-Shan Sung

{"title":"Comparing the risk of subsequent ischemic stroke and mortality in patients with epilepsy and patients with ischemic stroke","authors":"Po-Yu Lin , Sheng-Hsiang Lin , Pi-Shan Sung","doi":"10.1016/j.ebr.2025.100766","DOIUrl":"10.1016/j.ebr.2025.100766","url":null,"abstract":"<div><div>Patients with stroke or epilepsy face an elevated risk of subsequent strokes. This nationwide retrospective cohort study analyzed data from Taiwan’s National Health Insurance Research Database (2012–2020) to compare the risk of future ischemic stroke or transient ischemic attack (IS/TIA) among patients with epilepsy and those with prior IS/TIA. Patients were categorized into four groups: epilepsy with subsequent IS/TIA (E/S), epilepsy without IS/TIA (E), IS/TIA without epilepsy (S), and neither condition (C). Incidence rates and adjusted hazard ratios for IS/TIA and mortality were assessed across groups, which included 5,606, 11,212, 11,212, and 56,060 patients. The corresponding incidence rates of subsequent IS/TIA were 0.67, 0.03, 0.41, and 0.01 per 100 person-years in the E/S, E, S, and C groups, respectively. Compared to the S group, the E/S group had a higher adjusted hazard ratio for IS/TIA (aHR 1.68, 95% CI: 1.30–2.17), whereas the E group had a significantly lower adjusted hazard ratio (aHR 0.08, 95% CI: 0.04–0.14). Mortality risk was significantly elevated in both the E/S group (aHR 1.90, 95% CI: 1.75–2.05) and the E group (aHR 1.21, 95% CI: 1.12–1.30), compared to the S group. These findings suggest that epilepsy increases the risk of subsequent IS/TIA, though to a lesser extent than prior IS/TIA. They underscore the importance of condition-specific prevention strategies and the need for further research into the mechanisms linking epilepsy and stroke risk.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100766"},"PeriodicalIF":1.8,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropsychiatric disorders in Chinese pediatric tuberous sclerosis complex patients associated with drug-resistant epilepsy: A TAND checklist-based survey

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-04-03 DOI: 10.1016/j.ebr.2025.100765

Jie Fu , Qinrui Li , Genfu Zhang , Zhixian Yang , Jiong Qin

{"title":"Neuropsychiatric disorders in Chinese pediatric tuberous sclerosis complex patients associated with drug-resistant epilepsy: A TAND checklist-based survey","authors":"Jie Fu , Qinrui Li , Genfu Zhang , Zhixian Yang , Jiong Qin","doi":"10.1016/j.ebr.2025.100765","DOIUrl":"10.1016/j.ebr.2025.100765","url":null,"abstract":"<div><div>Tuberous sclerosis complex (TSC) is an autosomal-dominant genetic disorder frequently accompanied by neuropsychiatric disorders, especially in patients who have drug-resistant epilepsy (DRE). This study aimed to evaluate the distribution of neuropsychiatric disorders in Chinese children with TSC-related epilepsy using the TAND (Tuberous Sclerosis Complex Associated Neuropsychiatric Disorders) checklist, comparing those with DRE to those achieving seizure freedom. A total of 47 children, aged 6 to 18 years, diagnosed with TSC at Peking University People’s Hospital, participated in this cross-sectional study.All participants met the latest diagnostic criteria for TSC. Based on the definition of drug-resistant epilepsy, participants were categorized into DRE group and seizure-free group. Neurodevelopmental disorders were evaluated using the TAND checklist. The study found that 66 % of participants exhibited varying degrees of intellectual disability, with the DRE group demonstrating significantly poorer performance in intelligence, behavior, neuropsychological, and learning skills compared to the seizure-free group. The DRE group also had higher rates of attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), alongside greater impairments in psychosocial functioning. This study indicates that DRE is strongly associated with neuropsychiatric development in children with TSC, but also that all children with TSC are at increased risk of TAND. Our findings highlight the importance of regular assessment and intervention to support TAND and improve quality of life in this vulnerable group.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100765"},"PeriodicalIF":1.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tramadol use and risk of seizure: A report of two cases and a review of recent literature

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-03-24 DOI: 10.1016/j.ebr.2025.100763

Emma Dolan , Norman Delanty

{"title":"Tramadol use and risk of seizure: A report of two cases and a review of recent literature","authors":"Emma Dolan , Norman Delanty","doi":"10.1016/j.ebr.2025.100763","DOIUrl":"10.1016/j.ebr.2025.100763","url":null,"abstract":"<div><div>Tramadol is a common pain medication used in practice across numerous specialties. Increased incidence of tramadol abuse and overdose in recent decades has led to it being classified as a controlled drug in several countries. Tramadol appears to be an increasingly popular drug of abuse, possibly related to ease of access to it on prescription, and its potential euphoric effects.</div><div>We identified two cases of seizures directly related to tramadol exposure. We then reviewed recent literature on tramadol and its adverse effects, particularly looking at its effect on seizure risk and the incidence of seizures. We found that there were scarce recent studies on the relationship between tramadol and seizure risk. Of studies found, many were carried out in animal models. Tramadol-induced seizures were studied in humans more commonly in the context of overdose, and studies involving humans tended to have small patient cohorts and suggested further study in the area.</div><div>We suggest that tramadol may be useful as part of multi-modal analgesia in moderate to severe pain in specific contexts, but that greater awareness of its potential adverse effects, and particularly its potential to lower seizure threshold, is warranted. We feel that more readily available information specifically about tramadol’s effects on seizure threshold may be of interest to colleagues from any specialty prescribing opioid analgesia on a regular basis, but that colleagues treating patients with seizure disorders should be particularly aware of these potential adverse effects.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100763"},"PeriodicalIF":1.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and feasibility of exhaustive exercise testing for people with epilepsy

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-03-16 DOI: 10.1016/j.ebr.2025.100762

Franziska van den Bongard , Catharina Petersen , Claus Reinsberger

{"title":"Safety and feasibility of exhaustive exercise testing for people with epilepsy","authors":"Franziska van den Bongard , Catharina Petersen , Claus Reinsberger","doi":"10.1016/j.ebr.2025.100762","DOIUrl":"10.1016/j.ebr.2025.100762","url":null,"abstract":"<div><div>People with epilepsy (PWE) are encouraged to participate in exercise and be physically active, but some PWE may report exercise-associated seizures (EAS). However, there is a lack of objective tools to inform individual recommendations for physical activity and exercise participation in PWE. This study investigated the feasibility and safety of exhaustive exercise testing in PWE. 29 patients underwent an objectively and subjectively exhaustive exercise test on a bicycle ergometer and resting state EEG was obtained before and after exercise. One patient with a history of EAS experienced a seizure immediately after exercising. In patients without EAS, an asymptomatic subclinical electrographic seizure was observed in one patient, and two patients revealed interictal epileptiform discharges only after exercise. All EEG changes occurred in the setting of non-REM sleep, while the respective pre-exercise EEG recordings revealed less sleep. No seizures or significant EEG changes after exercise were observed in any other patient. EEG investigations before and after exhaustive exercise were feasible in PWE, but safety protocols need to be established, especially in patients with EAS. Investigation of a higher number of PWE with and without EAS with repeat exercise-associated EEG may provide information about the clinical utility of exercise-associated EEGs when counseling PWE.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100762"},"PeriodicalIF":1.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-03-15 DOI: 10.1016/j.ebr.2025.100761

Daniel Uher , Gerhard S. Drenthen , Christianne M. Hoeberigs , Rick H.G.J. van Lanen , Albert J. Colon , Roy A.M. Haast , Vivianne H.J.M. van Kranen-Mastenbroek , Guido Widman , Paul A.M. Hofman , Louis G. Wagner , Jan C. Beckervordersandforth , Jacobus F.A. Jansen , Olaf E.M.G. Schijns , Walter H. Backes , on behalf of the ACE study group

{"title":"The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study","authors":"Daniel Uher , Gerhard S. Drenthen , Christianne M. Hoeberigs , Rick H.G.J. van Lanen , Albert J. Colon , Roy A.M. Haast , Vivianne H.J.M. van Kranen-Mastenbroek , Guido Widman , Paul A.M. Hofman , Louis G. Wagner , Jan C. Beckervordersandforth , Jacobus F.A. Jansen , Olaf E.M.G. Schijns , Walter H. Backes , on behalf of the ACE study group","doi":"10.1016/j.ebr.2025.100761","DOIUrl":"10.1016/j.ebr.2025.100761","url":null,"abstract":"<div><div>This case study demonstrates the value of combined 7 T structural and functional MRI in the presurgical workup of a 24-year-old male with drug-resistant focal epilepsy who was initially considered MRI-negative on clinical 3 T MRI. The patient underwent extensive presurgical workup with 7 T MRI, magnetoencephalography, stereo-electroencephalography, and resection of the suspected right frontal epileptogenic zone. Histopathology showed focal cortical dysplasia (FCD) type IIb. The patient remained 11 months after surgery seizure-free. Retrospective analysis revealed that both structural and functional 7 T MRI showed abnormalities within the resected area. Morphometric Analysis Program (MAP18) detected abnormalities on both 3 T and 7 T images. However, abnormalities were more conspicuous on 7 T. Resting-state functional MRI metrics, particularly regional homogeneity and fractional amplitude of low-frequency fluctuations, demonstrated significantly increased values in both a MAP18-defined region of interest and the entire resected area compared to a healthy control group (p < 0.05). However, extensive unspecific abnormalities were also observed outside the resected region, highlighting the importance of a multimodal approach. This case study illustrates that advanced image processing of ultra-high field structural and resting-state functional MRI scans may enhance the detection of subtle epileptogenic lesions in presurgical evaluation, potentially improving post-operative seizure outcome and associated quality of life.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100761"},"PeriodicalIF":1.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beamforming of ictal MEG aiding subtle focal cortical dysplasia localization

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-03-12 DOI: 10.1016/j.ebr.2025.100759

Natascha C. da Fonseca , Afsaneh Talai , Daniel Veltkamp , Fabricio S. Feltrin , Dallas Armstrong , Angela Price , Joseph A. Maldjian , Elizabeth M. Davenport

{"title":"Beamforming of ictal MEG aiding subtle focal cortical dysplasia localization","authors":"Natascha C. da Fonseca , Afsaneh Talai , Daniel Veltkamp , Fabricio S. Feltrin , Dallas Armstrong , Angela Price , Joseph A. Maldjian , Elizabeth M. Davenport","doi":"10.1016/j.ebr.2025.100759","DOIUrl":"10.1016/j.ebr.2025.100759","url":null,"abstract":"<div><div>A case is presented of a 17-year-old right-handed male with drug-resistant epilepsy (DRE), initially presenting with non-lesional MRI findings, where ictal MEG beamforming successfully localized a subtle Focal Cortical Dysplasia (FCD). His seizure onset began at age 13, with episodes evolving into bilateral tonic-clonic seizures. Despite various medication trials and normal initial electroencephalograms, his seizures escalated in frequency and severity by age 16. Subsequent diagnostics were unable to reveal definitive lesions, including a high-resolution MRI and various functional imaging techniques. MEG was performed, capturing two electroclinical seizures but without interictal epileptiform discharges. Frequency-based beamforming analysis localized the seizure onset to the right anterior precuneus and superior parietal lobule. This result prompted a re-evaluation of the same MRI images, revealing subtle cortical abnormalities and pinpointing an FCD. Subsequent stereoelectroencephalography confirmed these findings, and the patient underwent successful Laser Interstitial Thermal Therapy, resulting in seizure freedom. This case highlights the utility of frequency-based ictal MEG beamforming in identifying epileptogenic zones and its potential as a powerful tool in the presurgical assessment of DRE patients and non-invasive identification of subtle FCD, especially when traditional methods are unable to localize.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100759"},"PeriodicalIF":1.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic insights into progressive myoclonic epilepsies: A case study of KCTD7 mutation in an Iranian-Azeri-Turkish family

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-02-27 DOI: 10.1016/j.ebr.2025.100757

Haneieh Honarmand , Mortaza Bonyadi , Mohammad Barzegar

{"title":"Genetic insights into progressive myoclonic epilepsies: A case study of KCTD7 mutation in an Iranian-Azeri-Turkish family","authors":"Haneieh Honarmand , Mortaza Bonyadi , Mohammad Barzegar","doi":"10.1016/j.ebr.2025.100757","DOIUrl":"10.1016/j.ebr.2025.100757","url":null,"abstract":"<div><div>Progressive Myoclonic Epilepsies (PMEs) are a rare and heterogeneous group of epileptic disorders often with progressive neurologic deterioration. The intensity of the clinical features varies depending on the underlying genetic etiology. This study aims to identify the genetic mutation associated with PME in a family belonging to the Iranian-Azeri-Turkish ethnic population. A 5-year-old boy and his 8-year-old sister, presenting with PME-related electroclinical features such as myoclonic seizures and progressive cognitive and motor decline, underwent comprehensive clinical evaluations, including pedigree analysis, laboratory tests, and EEG assessments, followed by Whole-Exome Sequencing (WES) to identify potential disease-causing mutations. We identified a novel homozygous mutation (c.14C > T) in the <em>KCTD7</em> gene in both siblings, confirmed through Sanger sequencing. This mutation was not observed in a cohort of 430 healthy individuals from the same Iranian-Azeri-Turkish ethnic background, providing strong evidence for its pathogenic role. This finding advances our understanding of the genetic basis and phenotypic diversity of PMEs, but further research is needed to elucidate how <em>KCTD7</em> mutations contribute to epilepsy and neurodegeneration.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100757"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Major depression, anxiety disorder and suicidality in epilepsy: What should neurologists do?

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-02-27 DOI: 10.1016/j.ebr.2025.100758

Andres M. Kanner

{"title":"Major depression, anxiety disorder and suicidality in epilepsy: What should neurologists do?","authors":"Andres M. Kanner","doi":"10.1016/j.ebr.2025.100758","DOIUrl":"10.1016/j.ebr.2025.100758","url":null,"abstract":"<div><div>Four to five patients with epilepsy (PWE) can suffer from Major Depressive episodes (MDE). Comorbid anxiety disorders (AD) frequently occur together with MDE. Failure to treat MDE can negatively affect several aspects of their life as well as the management of the epilepsy. Often, suicidal ideation is among its symptoms, which need to be addressed without delay to prevent suicidal attempts or a completed suicide. Unfortunately, access to health care professionals is very limited and, in many communities, non-existent. Accordingly, it falls upon the treating neurologist to begin a pharmacologic trial with psychotropic drugs. The purpose of this manuscript is to provide neurologists with very useful strategies on how to screen and identify MDEs with and without AD in the outpatient clinic and how to select the appropiate psychotropic drugs. Using an illustrative case, we discuss its differential diagnosis, particularly the recognition of iatrogenic episodes, and demonstrate the selection and mode of use of commonly used antidepressant in PWE. Finally, we provide a guide on how the neurologist can assess the suicidal risk of a patient that endorses suicidal ideation and the steps that need to be taken to minimize the risk of suicidal behavior.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100758"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing seizure control in ultra-refractory postencephalitic epilepsies using multinodal network neuromodulation

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-02-17 DOI: 10.1016/j.ebr.2025.100755

Subhiksha Srinivasan , Surya Suresh , Ganne Chaitanya , Manoj Saranathan , Nitin Tandon , Sandipan Pati

{"title":"Enhancing seizure control in ultra-refractory postencephalitic epilepsies using multinodal network neuromodulation","authors":"Subhiksha Srinivasan , Surya Suresh , Ganne Chaitanya , Manoj Saranathan , Nitin Tandon , Sandipan Pati","doi":"10.1016/j.ebr.2025.100755","DOIUrl":"10.1016/j.ebr.2025.100755","url":null,"abstract":"<div><div>This case series reports the formidable challenge posed by postencephalitic epilepsies, characterized by frequent drug-resistant seizures and neuropsychiatric and cognitive comorbidities. Polypharmacy is frequently required, and surgical resection may not be feasible due to multifocality. Neuromodulation therapies, including Deep Brain Stimulation (DBS) and Responsive Neurostimulation (RNS), offer a potential lifeline. In this case series, we shed light on the intricate landscape of seizure management and neuropsychiatric comorbidities in five individuals with frequent seizures (often weekly) and ultra-refractory epilepsy (defined as resistance to more than six different antiseizure medications, including failed epilepsy surgery) following catastrophic encephalitis. Four out of five patients achieved at least 50% reduction in seizure frequency following multimodal neuromodulation interventions. Moreover, we underscore the pivotal role of RNS electrocorticography (ECoG) in monitoring the epileptiform burden to guide therapy. Postencephalitic patients often present with a complex interplay of epileptic and nonepileptic (including neuropsychiatric) events, necessitating distinct therapeutic approaches. RNS ECoG emerges as a critical tool for differentiation and tailored therapy. While our findings highlight the potential effectiveness of neuromodulation in managing postencephalitic epilepsy, further research is needed to identify predictors of treatment response and explore the application of these therapies in chronic epilepsy caused by encephalitis. Overall, neuromodulation offers hope for improving these patients’ quality of life.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100755"},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the role of physical activity in older adults with epilepsy

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-02-17 DOI: 10.1016/j.ebr.2025.100756

Stephen P. Klaus , Serdar Akkol , Smitha K. Achuthan , Annie He , Cynthia Zheng , Ed Faught , Halley B. Alexander

{"title":"Examining the role of physical activity in older adults with epilepsy","authors":"Stephen P. Klaus , Serdar Akkol , Smitha K. Achuthan , Annie He , Cynthia Zheng , Ed Faught , Halley B. Alexander","doi":"10.1016/j.ebr.2025.100756","DOIUrl":"10.1016/j.ebr.2025.100756","url":null,"abstract":"<div><div>Epilepsy disproportionately affects older adults due to acquired conditions including stroke, neurodegeneration and head trauma secondary to falls. Current literature lacks adequate representation of specific therapies and considerations for this cohort. Furthermore, older adults are more susceptible to the adverse effects of anti-seizure medications necessitating increased caution when treating. Non-pharmacological interventions, including physical activity (PA), are underrecognized, particularly in older adults where they may be of greatest benefit. The following narrative review describes how older adults are uniquely impacted by epilepsy and associated comorbidities. It examines the current literature with respect to PA in epilepsy and, where available, evidence for PA in older adults. This includes how PA can affect pathogenesis and reduce the incidence of epilepsy onset through the reduction of neuroinflammation. PA may also be utilized by older adults with epilepsy to improve cardiovascular function, seizure control, prevent falls and secondary head injury, as an adjunct treatment for mood disorders and cognitive decline, and to promote general well-being. PA has a large and underappreciated role to play in older adults with epilepsy and is increasingly being recognized by healthcare providers and incorporated into practice guidelines.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100756"},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0