Epilepsy and Behavior Reports最新文献

Ultra-long-term subcutaneous EEG recordings in ten epilepsy patients: Experiences and circadian rhythms in epileptiform discharges 10例癫痫患者的超长期皮下脑电图记录：癫痫样放电的经历和昼夜节律

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Epilepsy and Behavior Reports Pub Date : 2025-05-20 DOI: 10.1016/j.ebr.2025.100781

S.J. van Norden , K.H. Kho , A.M. Meppelink , J.J. Ardesch , M.C. Tjepkema-Cloostermans , M.J.A.M. van Putten

{"title":"Ultra-long-term subcutaneous EEG recordings in ten epilepsy patients: Experiences and circadian rhythms in epileptiform discharges","authors":"S.J. van Norden , K.H. Kho , A.M. Meppelink , J.J. Ardesch , M.C. Tjepkema-Cloostermans , M.J.A.M. van Putten","doi":"10.1016/j.ebr.2025.100781","DOIUrl":"10.1016/j.ebr.2025.100781","url":null,"abstract":"<div><div>Recently, a subcutaneous electroencephalography (sqEEG) electrode became available, enabling ultra-long-term EEG recordings. In our PREDYct study, we aim to predict the efficacy of vagus nerve stimulation (VNS) in epilepsy patients. The study records sqEEG for up to fifteen months, including a 2–3 month period before VNS implantation. Here we report on initial patient experiences, compliance and recordings of epileptiform discharges (EDs). We included the first 10 participants from our ongoing PREDYct study. We calculated recording compliance for each patient. Patients rated their pain during electrode implantation, wearing and explantation using the visual analogue scale (VAS). Approximately two weeks of data from each patient were visually assessed and all EDs were annotated. We used these annotations to evaluate circadian rhythms in ED rate and duration and to compare seizure diaries with annotated ictal patterns. Electrode implantation and explantation were well-tolerated with a median VAS of 4 and 2, respectively. Wearing the electrode was also well-tolerated with median VAS scores of 0 and 0.5 at two and fifteen months, respectively. On average, patients wore the electrode for 441 days with an overall compliance of 27 %, resulting in 28,331 h of EEG. A circadian rhythm in ED rate was observed in three patients, while one patient exhibited a circadian rhythm in ED duration. A comparison of reported seizures and annotated ictal patterns revealed discrepancies. Ultra-long-term sqEEG is well-tolerated and has the potential to be a valuable tool for monitoring treatment. Nevertheless, it remains a challenge but crucial to attain high recording compliance.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100781"},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental health intervention for a child with developmental and/or epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS) 发展性和/或癫痫性脑病伴睡眠尖波激活（D/EE-SWAS）儿童的心理健康干预

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Epilepsy and Behavior Reports Pub Date : 2025-05-17 DOI: 10.1016/j.ebr.2025.100780

C. Reilly , Roz Shafran , Helen Cross , Millie Wagstaff , Bhavna Sidhpara , J. Idowu , C. Meades , S.D. Bennett

{"title":"Mental health intervention for a child with developmental and/or epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS)","authors":"C. Reilly , Roz Shafran , Helen Cross , Millie Wagstaff , Bhavna Sidhpara , J. Idowu , C. Meades , S.D. Bennett","doi":"10.1016/j.ebr.2025.100780","DOIUrl":"10.1016/j.ebr.2025.100780","url":null,"abstract":"<div><div>Children with Developmental and Epileptic Encephalopathies experience neurodevelopmental problems from both the epileptic activity and the underlying cause of the condition. Children with Developmental and/or Epileptic Encephalopathy with spike-wave activation in sleep (D/EE-SWAS) experience cognitive and behavioral regression/stagnation that occurs in tandem with marked spike-wave activation in sleep (SWAS). Children with epilepsy often have co-occurring mental health problems that are often not recognized or supported. There is increasing evidence these co-occurring mental health problems can be treated with psychological interventions. The mental health and cognitive difficulties that accompany SWAS have a significant impact on child and family quality of life. There is limited data on the treatment of mental health difficulties for children with D/EE-SWAS. We describe the use of the Mental Health Intervention in Children with Epilepsy (MICE) in a child with D/EE-SWAS who had experienced significant cognitive regression and behavioral difficulties. The intervention was delivered with the child’s parents via video and consisted of 19 sessions delivered by an assistant psychologist. The focus of the intervention was reducing behaviours of concern via evidence-based behavioural parenting strategies. The intervention resulted in clear progress towards parental chosen goals (Goal Based Outcomes) and a reduction of symptoms on validated measures of behavior. Qualitative feedback via parental interview was that the intervention was very useful, giving the parents everyday strategies that they could effectively employ with the child in the home environment. This case demonstrates that a mental health intervention based on behavioural parenting strategies can be useful for children with D/EE-SWAS.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100780"},"PeriodicalIF":1.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The challenges in establishing and Upholding an adult Level III epilepsy center in an underserved area in the United states 在美国服务不足的地区建立和维护成人III级癫痫中心的挑战

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Epilepsy and Behavior Reports Pub Date : 2025-05-13 DOI: 10.1016/j.ebr.2025.100779

Kevin T. Dao , Clins Chacko , Shaan Braich , Lauren Liu , Neela Zalmay , Chrystal Nguyen , Kurupath Radhakrishnan , Charles Y. Liu , Hari Prasad Kunhi-Veedu

{"title":"The challenges in establishing and Upholding an adult Level III epilepsy center in an underserved area in the United states","authors":"Kevin T. Dao , Clins Chacko , Shaan Braich , Lauren Liu , Neela Zalmay , Chrystal Nguyen , Kurupath Radhakrishnan , Charles Y. Liu , Hari Prasad Kunhi-Veedu","doi":"10.1016/j.ebr.2025.100779","DOIUrl":"10.1016/j.ebr.2025.100779","url":null,"abstract":"<div><div>Despite vast improvement, even today, care of people with epilepsy (PWE) in many parts of the USA remains unevenly distributed and disjointed. We reviewed the experience of the Kern Medical Epilepsy Center (KMEC) to highlight the challenges in establishing and maintaining an epilepsy center in an underserved region of Southern California. We analyzed the prospectively collected data from 2018 through 2021 of KMEC, a National Association of Epilepsy Centers Level III accredited facility that serves PWE people residing in Central Valley, California. During the study period, there were 246 admissions to the Epilepsy Monitoring Unit, KMEC for detailed evaluation of difficult to treat epilepsy. Most patients were either of Hispanic descent or Caucasian. Thirty-seven patients underwent surgical interventions (8 resective surgery, and 23 vagus nerve stimulators and 6 responsive neurostimulators) with favorable outcomes in the majority. Many of them required referrals to the Level IV center at University of Southern California, Los Angeles, which were hindered by difficulties with getting appointments, transportation, insurance coverage, payment for treatment, and sluggish treatment processes. Our experience demonstrates that, despite considerable challenges, epilepsy care can be coordinated across complex and competing health systems separated by large geographic distances through creative, physician-driven strategies of resource sharing and goal alignment across the health care ecosystem. We hope that our experience will facilitate future efforts to integrate epilepsy care beyond this region in the USA, and elsewhere in the world. sluggish treatment processes. and elsewhere in the world.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100779"},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced VNS settings paradoxically decreases seizure burden in a patient following resolution of sleep disordered breathing 减少VNS设置矛盾地减少癫痫发作的负担，在解决睡眠呼吸障碍的病人

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Epilepsy and Behavior Reports Pub Date : 2025-05-06 DOI: 10.1016/j.ebr.2025.100778

Austin Sponaugle , Rebecca S. Stainman , Christopher M. Carosella

{"title":"Reduced VNS settings paradoxically decreases seizure burden in a patient following resolution of sleep disordered breathing","authors":"Austin Sponaugle , Rebecca S. Stainman , Christopher M. Carosella","doi":"10.1016/j.ebr.2025.100778","DOIUrl":"10.1016/j.ebr.2025.100778","url":null,"abstract":"<div><div>Vagus nerve stimulation (VNS) can be a highly effective treatment option for patients with drug resistant epilepsy. Notably, VNS has demonstrated side effects including a unique form of sleep disordered breathing known as vagus nerve stimulator associated sleep disordered breathing (VaS). However, the ways in which VaS interacts with seizure frequency is unknown. We report a case of a 28-year-old woman who presented to our department with complaints of worsening sleep quality 3 years following VNS implantation. Upon polysomnographic (PSG) evaluation, it was discovered that she suffered from VaS. The patient’s VNS output current was then down titrated during a subsequent PSG resulting in resolution of her VaS. Interestingly, despite downward titration of her nighttime VNS output current, the patient demonstrated a prolonged seizure free period, highlighting the complex interactions between VNS, VaS and seizure frequency. In cases where patients present with both epilepsy and VaS, physicians should be aware of this complex relationship. Further, this case highlights that down titration of VNS settings may result in not just improvement in VaS but may also result in improvement in seizure frequency.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100778"},"PeriodicalIF":1.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment of super-refractory focal status epilepticus: Surgery, vagus nerve stimulation, and botox for epilepsia partialis continua 成功治疗超难治性局灶性癫痫持续状态：手术、迷走神经刺激和肉毒杆菌毒素治疗部分持续性癫痫

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Epilepsy and Behavior Reports Pub Date : 2025-05-02 DOI: 10.1016/j.ebr.2025.100775

N. Zalmay , G. Nune , C.N. Heck , K.T. Dao , B.T. Ly , J. Ipe , C.Y. Liu , H.P. Kunhi Veedu

{"title":"Successful treatment of super-refractory focal status epilepticus: Surgery, vagus nerve stimulation, and botox for epilepsia partialis continua","authors":"N. Zalmay , G. Nune , C.N. Heck , K.T. Dao , B.T. Ly , J. Ipe , C.Y. Liu , H.P. Kunhi Veedu","doi":"10.1016/j.ebr.2025.100775","DOIUrl":"10.1016/j.ebr.2025.100775","url":null,"abstract":"<div><div>Super-refractory status epilepticus (SRSE) is a life-threatening condition characterized by persistent seizures lasting beyond seven days despite anesthetic therapy. Managing SRSE is challenging, particularly in cases resistant to conventional treatments. This case report presents a 41-year-old female with prolonged SRSE secondary to focal epilepsy, successfully treated with surgical resection, vagus nerve stimulation (VNS), and botulinum toxin (BoNT) therapy. The patient initially presented with left focal motor status epilepticus and a right frontal intracerebral hematoma. Despite an emergency craniotomy, her seizures persisted, leading to prolonged SRSE. After multiple failed sedation weaning attempts, a stepwise intervention approach was implemented consisting of an Electrocorticography (ECoG)-guided surgical resection of the residual epileptic focus, VNS implantation for long-term seizure modulation, BoNT therapy for residual epilepsia partialis continua (EPC). The combined approach of surgical resection and VNS implantation successfully terminated the status epilepticus. Residual Epilepsia Partialis Continua (EPC) was effectively managed with botulinum toxin therapy (BoNT). This case underscores the potential efficacy of combining surgical resection and VNS implantation in treating SRSE and highlights the beneficial effects of BoNT in managing residual EPC, offering a potential treatment pathway for similar refractory cases.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100775"},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Academic competence and special educational needs as outcomes of early onset epilepsy: A population-based prospective follow-up study 学术能力和特殊教育需求作为早发性癫痫的结局：一项基于人群的前瞻性随访研究

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Epilepsy and Behavior Reports Pub Date : 2025-04-30 DOI: 10.1016/j.ebr.2025.100777

Kati Rantanen , Jenna Mäntylä , Eeva Kettunen , Annina Saunajoki , Kai Eriksson

{"title":"Academic competence and special educational needs as outcomes of early onset epilepsy: A population-based prospective follow-up study","authors":"Kati Rantanen , Jenna Mäntylä , Eeva Kettunen , Annina Saunajoki , Kai Eriksson","doi":"10.1016/j.ebr.2025.100777","DOIUrl":"10.1016/j.ebr.2025.100777","url":null,"abstract":"<div><div>Epilepsy in children is associated with significant academic challenges, particularly among those with early-onset seizures and comorbid intellectual disabilities (ID). This study aims to bridge gaps in existing research by examining long-term academic outcomes and special educational needs (SEN) in a cohort of children with early-onset epilepsy, including those with complicated epilepsy (CE) and major comorbidities. The study followed a population-based cohort of 64 children with epilepsy (CWE) aged 3–6 years, identified from the Pediatric Neurology Unit at Tampere University Hospital. Six years later, 43 children (67 %) participated in the follow-up. Academic competence was assessed using the Teacher Report Form (TRF), which also provided data on SEN. The findings revealed that 67 % of participants had low academic competence, with a significant proportion requiring special educational support. Children with CE had notably lower academic performance compared to those with uncomplicated epilepsy (UE). The need for SEN was higher among children with CE (81 %) than those with UE (24 %), with epilepsy type emerging as a significant predictor for SEN. Despite the small sample size and limitations in generalizability, the study underscores the pervasive impact of early-onset epilepsy on academic outcomes and highlights the necessity for ongoing educational support. Future research should focus on larger cohorts and explore the efficacy of tailored educational interventions to improve the academic performance and quality of life for CWE. Regular screening and collaboration with educators are essential to address the unique needs of these children effectively.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100777"},"PeriodicalIF":1.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the relationship between 0.5–1200 Hz signal characteristics of cortical high-frequency oscillations and epileptogenicity through multivariate analysis 通过多变量分析探讨0.5 ~ 1200hz皮层高频振荡信号特征与致痫性的关系

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Epilepsy and Behavior Reports Pub Date : 2025-04-24 DOI: 10.1016/j.ebr.2025.100776

Takashi Shibata , Hiroki Tsuchiya , Mari Akiyama , Tomoyuki Akiyama , Masao Matsuhashi , Katsuhiro Kobayashi

{"title":"Investigation of the relationship between 0.5–1200 Hz signal characteristics of cortical high-frequency oscillations and epileptogenicity through multivariate analysis","authors":"Takashi Shibata , Hiroki Tsuchiya , Mari Akiyama , Tomoyuki Akiyama , Masao Matsuhashi , Katsuhiro Kobayashi","doi":"10.1016/j.ebr.2025.100776","DOIUrl":"10.1016/j.ebr.2025.100776","url":null,"abstract":"<div><div>Fast ripples (FRs) (250–500 Hz) on the electroencephalogram (EEG) are closely related to epileptogenicity and are important to determine cortical regions resected in epilepsy surgery. However, FR-related epileptogenicity may be variable, and may depend on information associated with FRs. We enrolled nine epilepsy patients who had undergone intracranial 5 kHz-sampling-rate EEG for surgical treatment and had final Engel class I outcomes. Three electrodes were selected from each epileptogenic area (EA) and the unlikely EA (the region outside the EA) in each patient. Up to 100 candidate FRs were automatically detected from interictal nocturnal EEG at each of the selected electrodes and were visually reviewed independently by two researchers. Multivariate logistic regression analysis was performed using the frequency and log-power value of the corresponding FRs, presence of concurrent spike, ripple, very-high-frequency oscillations (vHFO)1 (500–600 Hz), and vHFO2 (600–1200 Hz), and whether the timing of the spectral peak of corresponding FRs was in the peak–trough or trough–peak transition of each slow activity (0.5–1, 1–2, 2–3, 3–4, and 4–8 Hz) as independent variables. Factors significantly related to epileptogenicity were FR power, the concurrent presence of spike and vHFO2, coupling with 0.5–1 and 1–2 Hz slow waves in the peak–trough transition, and coupling with 3–4 and 4–8 Hz slow waves in the trough–peak transition. Multifactorial analysis of FRs may increase their usefulness, potentially leading to improved treatment outcomes in epilepsy surgery.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100776"},"PeriodicalIF":1.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ictal cold shiver caused by autoimmune limbic encephalitis: A case report and literature review 自身免疫性边缘脑炎致急性寒颤1例并文献复习

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Epilepsy and Behavior Reports Pub Date : 2025-04-22 DOI: 10.1016/j.ebr.2025.100773

Yosuke Takeuchi , Teruaki Masuda , Hiroyuki Matsuta , Kenichi Yabuuchi , Nobuhiro Hata , Minoru Fujiki , Konen Obayashi , Etsuro Matsubara , Noriyuki Kimura

{"title":"Ictal cold shiver caused by autoimmune limbic encephalitis: A case report and literature review","authors":"Yosuke Takeuchi , Teruaki Masuda , Hiroyuki Matsuta , Kenichi Yabuuchi , Nobuhiro Hata , Minoru Fujiki , Konen Obayashi , Etsuro Matsubara , Noriyuki Kimura","doi":"10.1016/j.ebr.2025.100773","DOIUrl":"10.1016/j.ebr.2025.100773","url":null,"abstract":"<div><div>Ictal cold shiver is a rare manifestation of seizures that originate in the temporal lobes; it is characterized by body trembling and sensations of cold. This study aims to investigate the clinical manifestations and etiological factors in patients with ictal cold shiver. We reviewed 59 cases of ictal cold shiver by using various keywords to search published original articles and case reports, and we described a new case of autoimmune limbic encephalitis. The median age at diagnosis was higher in patients with autoimmune encephalitis than in those with other etiologies (p = 0.007). Autoimmune encephalitis showed more frequent bilateral temporal lobe abnormalities on magnetic resonance imaging (MRI) (p = 0.027) and generalized or bilateral independent epileptiform discharges on electroencephalography (EEG) (p = 0.047). Anti-leucine-rich glioma-inactivated 1 antibodies were most commonly detected in patients with autoimmune encephalitis with ictal cold shiver (85.7 %). This study highlights the importance of considering autoimmune mechanisms in the presence of ictal cold shiver, especially in patients with bilateral temporal lobe lesions on MRI, generalized or bilateral independent epileptiform discharges on EEG, and older onset.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100773"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responsive neurostimulation for patients with refractory mesial temporal lobe epilepsy: A systematic review and meta-analysis 反应性神经刺激治疗难治性内侧颞叶癫痫：一项系统回顾和荟萃分析

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-04-22 DOI: 10.1016/j.ebr.2025.100774

Eshita Sharma , Beatriz Westphalen Pomianoski , Rabbia Jabbar , Ayesha Ayesha , Yasmin Picanco Silva , Paweł Łajczak , Aisha Rizwan Ahmed , Oguz Kagan Sahin , Mir Wajid Majeed , Mohammed Raake , Walter Fagundes , Giovani Noll

{"title":"Responsive neurostimulation for patients with refractory mesial temporal lobe epilepsy: A systematic review and meta-analysis","authors":"Eshita Sharma , Beatriz Westphalen Pomianoski , Rabbia Jabbar , Ayesha Ayesha , Yasmin Picanco Silva , Paweł Łajczak , Aisha Rizwan Ahmed , Oguz Kagan Sahin , Mir Wajid Majeed , Mohammed Raake , Walter Fagundes , Giovani Noll","doi":"10.1016/j.ebr.2025.100774","DOIUrl":"10.1016/j.ebr.2025.100774","url":null,"abstract":"<div><div>Responsive neurostimulation (RNS) is a well-established adjuvant therapy for reducing seizure frequency in adults with medically refractory partial-onset seizures, particularly in individuals who are either not candidates for surgical resection or remain seizure-prone post-surgery. However, its effectiveness in patients with mesial temporal lobe epilepsy (MTLE) remains unclear. This meta-analysis evaluates the efficacy of RNS therapy in individuals with medically refractory MTLE. A systematic search of PubMed, Cochrane, and Scopus databases was conducted to identify eligible studies. Outcomes assessed included mean seizure frequency reduction, responder rate (proportion of patients achieving ≥50 % reduction in seizure frequency), and the proportion of patients achieving seizure freedom within six months of follow-up. Statistical analyses were performed using STATA. Seven observational studies involving 207 patients were included. RNS was associated with a mean seizure frequency reduction of 68.76 % (95 % CI 57.16–80.37 %; I<sup>2</sup> = 81.68 %), a responder rate of 67.58 % (95 % CI 46.51–88.66 %; I<sup>2</sup> = 94 %), and seizure freedom within six months in 28.94 % of patients (95 % CI 3.03–54.86 %; I<sup>2</sup> = 88 %). Moderate to high heterogeneity was observed across the studies. RNS may represent a viable therapeutic option for patients with MTLE, demonstrating substantial reductions in seizure frequency and a notable proportion of patients achieving seizure freedom. Additional studies are needed to confirm these findings and to explore the comparative efficacy and safety of RNS therapy in relation to other treatment options.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100774"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebrotendinous Xanthomatosis: Novel EEG finding of Fixation-Off Sensitivity 脑腱黄瘤病：新的脑电图发现的固定-关闭敏感性

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Epilepsy and Behavior Reports Pub Date : 2025-04-18 DOI: 10.1016/j.ebr.2025.100770

Zachary Mills, James Thomas Houston, Ashley Thomas, Kelsey Shoenmeyer

引用次数: 0