Epilepsy and Behavior Reports最新文献

Seizure control in glycine encephalopathy using the Ketamine-Dextromethorphan-Sodium benzoate triple therapy 氯胺酮-右美沙芬-苯甲酸钠三联疗法控制甘氨酸脑病的癫痫发作

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-19 DOI: 10.1016/j.ebr.2025.100797

Laith Haddad , Samah Trad , Lama Charafeddine , Pascale E. Karam

{"title":"Seizure control in glycine encephalopathy using the Ketamine-Dextromethorphan-Sodium benzoate triple therapy","authors":"Laith Haddad , Samah Trad , Lama Charafeddine , Pascale E. Karam","doi":"10.1016/j.ebr.2025.100797","DOIUrl":"10.1016/j.ebr.2025.100797","url":null,"abstract":"<div><div>Neonatal glycine encephalopathy is a rare genetic neurometabolic disorder secondary to glycine cleavage system deficiency. Patients typically present with early-onset intractable seizures, status epilepticus and encephalopathy. Seizures control remains challenging in view of their refractoriness to standard anti-seizure medications. Sodium benzoate is commonly used to control the elevated glycine level. Oral anti-NMDA receptor antagonists, ketamine and dextromethorphan, have been used in various combinations in the treatment of this complex disorder. In this report, we present a neonatal case of classical glycine encephalopathy with hypotonia and refractory myoclonic seizures. The status epilepticus was successfully treated using a combination of intravenous ketamine, oral dextromethorphan and sodium benzoate. Seizures resolved and the patient’s development showed improvement on follow-up. The intravenous form of ketamine in the neonatal period is rarely used, and it has been reported in only two glycine encephalopathy patients in the literature. This is the first report in the literature of the efficacy of intravenous ketamine using the above triple therapy. This intervention might have implications on the management of neonatal intractable seizures in glycine encephalopathy, which might improve the outcome of this devastating disorder.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100797"},"PeriodicalIF":1.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coexistence of epilepsy with eyelid myoclonia, schizoaffective disorder, and cavum septi pellucidi et vergae: A case report 癫痫并发眼睑肌挛症、分裂情感性障碍、透明中隔腔及膈腔1例

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-18 DOI: 10.1016/j.ebr.2025.100786

Samwel Sylvester Msigwa , Suluma Aslan , Elizabeth Mareale , Mercy Bingileki

{"title":"Coexistence of epilepsy with eyelid myoclonia, schizoaffective disorder, and cavum septi pellucidi et vergae: A case report","authors":"Samwel Sylvester Msigwa , Suluma Aslan , Elizabeth Mareale , Mercy Bingileki","doi":"10.1016/j.ebr.2025.100786","DOIUrl":"10.1016/j.ebr.2025.100786","url":null,"abstract":"<div><div>We report the first case of a 14-year-old boy presenting with the rare co-occurrence of cavum septi pellucidi et vergae (CSPV), epilepsy with eyelid myoclonia (EEM), and schizoaffective disorder (SAD). The patient initially presented with a one-month history of abnormal eye movements, including continuous blinking and upward rolling of the eyeballs, which occurred predominantly at night. There was no alteration in consciousness. A detailed history revealed that the patient had experienced mood disturbances, delusional beliefs, auditory and visual hallucinations, and significant behavioral dysregulation for one year. These symptoms had been partially managed with haloperidol. Magnetic resonance imaging (MRI) confirmed the presence of CSPV. At the same time, electroencephalography (EEG) during intermittent photic stimulation demonstrated brief generalized epileptiform discharges triggered by eye closure, consistent with a diagnosis of EEM. The simultaneous presence of psychotic and affective symptoms met the diagnostic criteria for SAD. The patient was treated with sodium valproate in addition to his existing low-dose haloperidol regimen. This led to the complete resolution of seizures and psycho-affective symptoms at one- and three-month follow-ups. However, a decline in academic performance was noted at the one-year follow-up. In resource-limited settings without access to genetic or autoimmune tests, care was guided by practical adaptations rather than standard protocols. This case highlights a potential neurodevelopmental link between CSPV and epileptic and psychiatric manifestations, underscores the value of neuroimaging and EEG in pediatric neuropsychiatric overlap, and calls for research into mechanisms connecting midline brain anomalies with complex neuropsychiatric disorders.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100786"},"PeriodicalIF":1.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late-onset unexplained epilepsy with dual amyloid and tau negativity: are alpha-synuclein seed amplification assays the next diagnostic step? 伴淀粉样蛋白和tau双阴性的迟发性不明原因癫痫：α -突触核蛋白种子扩增检测是下一个诊断步骤吗？

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-13 DOI: 10.1016/j.ebr.2025.100783

Augustin Moreau , Elisabeth Ruppert , Frédéric Blanc , Olivier BOUSIGES , Benjamin Cretin

{"title":"Late-onset unexplained epilepsy with dual amyloid and tau negativity: are alpha-synuclein seed amplification assays the next diagnostic step?","authors":"Augustin Moreau , Elisabeth Ruppert , Frédéric Blanc , Olivier BOUSIGES , Benjamin Cretin","doi":"10.1016/j.ebr.2025.100783","DOIUrl":"10.1016/j.ebr.2025.100783","url":null,"abstract":"<div><div>Late-onset epilepsy of unknown etiology (LOEU) is associated with an increased risk of dementia. Current biomarkers, including cerebrospinal fluid (CSF) and positron emission tomography (PET) assessments for amyloid and tau, often fail to predict cognitive decline in a substantial proportion of LOEU patients.This case report presents a 67-year-old man with LOEU who later developed dementia with Lewy bodies (DLB). As cognitive decline progressed, emerging mild clinical features raised suspicion for DLB. Notably, cerebrospinal fluid analysis at this stage revealed negative amyloid and tau biomarkers but was positive for pathological alpha-synuclein using alpha-synuclein seed amplification assay (CSF ASyn-SAA). This finding highlights the potential clinical utility of CSF ASyn-SAA in achieving both earlier and more accurate DLB diagnosis. For LOEU patients exhibiting early signs of synucleinopathy, incorporating CSF ASyn-SAA into diagnostic panels could significantly improve diagnostic certainty, prognostic stratification, and opportunities for targeted therapeutic interventions. Further research is needed to investigate the yield of adding ASyn-SAA to CSF dementia panels in people with LOEU and progressive cognitive symptoms.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100783"},"PeriodicalIF":1.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A french real-world experience with cenobamate in patients with drug-resistant focal epilepsy: A retrospective observational study 法国对耐药局灶性癫痫患者使用cenobamate的实际经验：一项回顾性观察研究

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-02 DOI: 10.1016/j.ebr.2025.100782

Antoine Plaquevent , Floriane Le Goff , Nathalie Chastan

{"title":"A french real-world experience with cenobamate in patients with drug-resistant focal epilepsy: A retrospective observational study","authors":"Antoine Plaquevent , Floriane Le Goff , Nathalie Chastan","doi":"10.1016/j.ebr.2025.100782","DOIUrl":"10.1016/j.ebr.2025.100782","url":null,"abstract":"<div><div>Epilepsy is a common and disabling neurological disorder. To significantly improve the quality of life of patients, the primary goal is to achieve seizure freedom. Unfortunately, 30 % of epilepsies are drug-resistant and seizure freedom is not acheived. Cenobamate is a new anti-seizure medication (ASM) used as a treatment for focal epilepsy in adults whose seizures have not been able to be controlled by two prior ASM. Two previous pivotal studies have showed an unusual seizure-free rate at 21 % and 28 %. A retrospective observational study was conducted to determine the effectiveness, safety and retention of cenobamate in 87 patients with highly focal drug-resistant epilepsy. The responder rate was 48 % with a seizure-free rate of 18 % at the last follow-up, with a mean dose of cenobamate at 216 mg. Adverse events were reported in 74 % patients, the most frequent being somnolence/fatigue and dizziness. No cases of DRESS or death were reported during the study. Cenobamate was discontinued in 34 % of patients, for a lack of efficacy despite an adequate dosage (≥ 200 mg) in 30 %, a poor tolerance in 27 %, for both insufficient efficacy and poor tolerance in 40 %, or for pregnancy plans in 3 %. Cenobamate is an effective and well-tolerated ASM in drug-resistant focal epilepsy and should be tried for highly drug-resistant epilepsy, even if many previous ASM have failed. Moreover, the impressive seizure-free rate leads to introducing cenobamate to all patients before or during the evaluation for surgical candidacy, and in any case before any resective surgery.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100782"},"PeriodicalIF":1.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-long-term subcutaneous EEG recordings in ten epilepsy patients: Experiences and circadian rhythms in epileptiform discharges 10例癫痫患者的超长期皮下脑电图记录：癫痫样放电的经历和昼夜节律

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-05-20 DOI: 10.1016/j.ebr.2025.100781

S.J. van Norden , K.H. Kho , A.M. Meppelink , J.J. Ardesch , M.C. Tjepkema-Cloostermans , M.J.A.M. van Putten

{"title":"Ultra-long-term subcutaneous EEG recordings in ten epilepsy patients: Experiences and circadian rhythms in epileptiform discharges","authors":"S.J. van Norden , K.H. Kho , A.M. Meppelink , J.J. Ardesch , M.C. Tjepkema-Cloostermans , M.J.A.M. van Putten","doi":"10.1016/j.ebr.2025.100781","DOIUrl":"10.1016/j.ebr.2025.100781","url":null,"abstract":"<div><div>Recently, a subcutaneous electroencephalography (sqEEG) electrode became available, enabling ultra-long-term EEG recordings. In our PREDYct study, we aim to predict the efficacy of vagus nerve stimulation (VNS) in epilepsy patients. The study records sqEEG for up to fifteen months, including a 2–3 month period before VNS implantation. Here we report on initial patient experiences, compliance and recordings of epileptiform discharges (EDs). We included the first 10 participants from our ongoing PREDYct study. We calculated recording compliance for each patient. Patients rated their pain during electrode implantation, wearing and explantation using the visual analogue scale (VAS). Approximately two weeks of data from each patient were visually assessed and all EDs were annotated. We used these annotations to evaluate circadian rhythms in ED rate and duration and to compare seizure diaries with annotated ictal patterns. Electrode implantation and explantation were well-tolerated with a median VAS of 4 and 2, respectively. Wearing the electrode was also well-tolerated with median VAS scores of 0 and 0.5 at two and fifteen months, respectively. On average, patients wore the electrode for 441 days with an overall compliance of 27 %, resulting in 28,331 h of EEG. A circadian rhythm in ED rate was observed in three patients, while one patient exhibited a circadian rhythm in ED duration. A comparison of reported seizures and annotated ictal patterns revealed discrepancies. Ultra-long-term sqEEG is well-tolerated and has the potential to be a valuable tool for monitoring treatment. Nevertheless, it remains a challenge but crucial to attain high recording compliance.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100781"},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental health intervention for a child with developmental and/or epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS) 发展性和/或癫痫性脑病伴睡眠尖波激活（D/EE-SWAS）儿童的心理健康干预

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-05-17 DOI: 10.1016/j.ebr.2025.100780

C. Reilly , Roz Shafran , Helen Cross , Millie Wagstaff , Bhavna Sidhpara , J. Idowu , C. Meades , S.D. Bennett

{"title":"Mental health intervention for a child with developmental and/or epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS)","authors":"C. Reilly , Roz Shafran , Helen Cross , Millie Wagstaff , Bhavna Sidhpara , J. Idowu , C. Meades , S.D. Bennett","doi":"10.1016/j.ebr.2025.100780","DOIUrl":"10.1016/j.ebr.2025.100780","url":null,"abstract":"<div><div>Children with Developmental and Epileptic Encephalopathies experience neurodevelopmental problems from both the epileptic activity and the underlying cause of the condition. Children with Developmental and/or Epileptic Encephalopathy with spike-wave activation in sleep (D/EE-SWAS) experience cognitive and behavioral regression/stagnation that occurs in tandem with marked spike-wave activation in sleep (SWAS). Children with epilepsy often have co-occurring mental health problems that are often not recognized or supported. There is increasing evidence these co-occurring mental health problems can be treated with psychological interventions. The mental health and cognitive difficulties that accompany SWAS have a significant impact on child and family quality of life. There is limited data on the treatment of mental health difficulties for children with D/EE-SWAS. We describe the use of the Mental Health Intervention in Children with Epilepsy (MICE) in a child with D/EE-SWAS who had experienced significant cognitive regression and behavioral difficulties. The intervention was delivered with the child’s parents via video and consisted of 19 sessions delivered by an assistant psychologist. The focus of the intervention was reducing behaviours of concern via evidence-based behavioural parenting strategies. The intervention resulted in clear progress towards parental chosen goals (Goal Based Outcomes) and a reduction of symptoms on validated measures of behavior. Qualitative feedback via parental interview was that the intervention was very useful, giving the parents everyday strategies that they could effectively employ with the child in the home environment. This case demonstrates that a mental health intervention based on behavioural parenting strategies can be useful for children with D/EE-SWAS.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100780"},"PeriodicalIF":1.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The challenges in establishing and Upholding an adult Level III epilepsy center in an underserved area in the United states 在美国服务不足的地区建立和维护成人III级癫痫中心的挑战

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-05-13 DOI: 10.1016/j.ebr.2025.100779

Kevin T. Dao , Clins Chacko , Shaan Braich , Lauren Liu , Neela Zalmay , Chrystal Nguyen , Kurupath Radhakrishnan , Charles Y. Liu , Hari Prasad Kunhi-Veedu

{"title":"The challenges in establishing and Upholding an adult Level III epilepsy center in an underserved area in the United states","authors":"Kevin T. Dao , Clins Chacko , Shaan Braich , Lauren Liu , Neela Zalmay , Chrystal Nguyen , Kurupath Radhakrishnan , Charles Y. Liu , Hari Prasad Kunhi-Veedu","doi":"10.1016/j.ebr.2025.100779","DOIUrl":"10.1016/j.ebr.2025.100779","url":null,"abstract":"<div><div>Despite vast improvement, even today, care of people with epilepsy (PWE) in many parts of the USA remains unevenly distributed and disjointed. We reviewed the experience of the Kern Medical Epilepsy Center (KMEC) to highlight the challenges in establishing and maintaining an epilepsy center in an underserved region of Southern California. We analyzed the prospectively collected data from 2018 through 2021 of KMEC, a National Association of Epilepsy Centers Level III accredited facility that serves PWE people residing in Central Valley, California. During the study period, there were 246 admissions to the Epilepsy Monitoring Unit, KMEC for detailed evaluation of difficult to treat epilepsy. Most patients were either of Hispanic descent or Caucasian. Thirty-seven patients underwent surgical interventions (8 resective surgery, and 23 vagus nerve stimulators and 6 responsive neurostimulators) with favorable outcomes in the majority. Many of them required referrals to the Level IV center at University of Southern California, Los Angeles, which were hindered by difficulties with getting appointments, transportation, insurance coverage, payment for treatment, and sluggish treatment processes. Our experience demonstrates that, despite considerable challenges, epilepsy care can be coordinated across complex and competing health systems separated by large geographic distances through creative, physician-driven strategies of resource sharing and goal alignment across the health care ecosystem. We hope that our experience will facilitate future efforts to integrate epilepsy care beyond this region in the USA, and elsewhere in the world. sluggish treatment processes. and elsewhere in the world.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100779"},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced VNS settings paradoxically decreases seizure burden in a patient following resolution of sleep disordered breathing 减少VNS设置矛盾地减少癫痫发作的负担，在解决睡眠呼吸障碍的病人

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-05-06 DOI: 10.1016/j.ebr.2025.100778

Austin Sponaugle , Rebecca S. Stainman , Christopher M. Carosella

{"title":"Reduced VNS settings paradoxically decreases seizure burden in a patient following resolution of sleep disordered breathing","authors":"Austin Sponaugle , Rebecca S. Stainman , Christopher M. Carosella","doi":"10.1016/j.ebr.2025.100778","DOIUrl":"10.1016/j.ebr.2025.100778","url":null,"abstract":"<div><div>Vagus nerve stimulation (VNS) can be a highly effective treatment option for patients with drug resistant epilepsy. Notably, VNS has demonstrated side effects including a unique form of sleep disordered breathing known as vagus nerve stimulator associated sleep disordered breathing (VaS). However, the ways in which VaS interacts with seizure frequency is unknown. We report a case of a 28-year-old woman who presented to our department with complaints of worsening sleep quality 3 years following VNS implantation. Upon polysomnographic (PSG) evaluation, it was discovered that she suffered from VaS. The patient’s VNS output current was then down titrated during a subsequent PSG resulting in resolution of her VaS. Interestingly, despite downward titration of her nighttime VNS output current, the patient demonstrated a prolonged seizure free period, highlighting the complex interactions between VNS, VaS and seizure frequency. In cases where patients present with both epilepsy and VaS, physicians should be aware of this complex relationship. Further, this case highlights that down titration of VNS settings may result in not just improvement in VaS but may also result in improvement in seizure frequency.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100778"},"PeriodicalIF":1.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment of super-refractory focal status epilepticus: Surgery, vagus nerve stimulation, and botox for epilepsia partialis continua 成功治疗超难治性局灶性癫痫持续状态：手术、迷走神经刺激和肉毒杆菌毒素治疗部分持续性癫痫

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-05-02 DOI: 10.1016/j.ebr.2025.100775

N. Zalmay , G. Nune , C.N. Heck , K.T. Dao , B.T. Ly , J. Ipe , C.Y. Liu , H.P. Kunhi Veedu

{"title":"Successful treatment of super-refractory focal status epilepticus: Surgery, vagus nerve stimulation, and botox for epilepsia partialis continua","authors":"N. Zalmay , G. Nune , C.N. Heck , K.T. Dao , B.T. Ly , J. Ipe , C.Y. Liu , H.P. Kunhi Veedu","doi":"10.1016/j.ebr.2025.100775","DOIUrl":"10.1016/j.ebr.2025.100775","url":null,"abstract":"<div><div>Super-refractory status epilepticus (SRSE) is a life-threatening condition characterized by persistent seizures lasting beyond seven days despite anesthetic therapy. Managing SRSE is challenging, particularly in cases resistant to conventional treatments. This case report presents a 41-year-old female with prolonged SRSE secondary to focal epilepsy, successfully treated with surgical resection, vagus nerve stimulation (VNS), and botulinum toxin (BoNT) therapy. The patient initially presented with left focal motor status epilepticus and a right frontal intracerebral hematoma. Despite an emergency craniotomy, her seizures persisted, leading to prolonged SRSE. After multiple failed sedation weaning attempts, a stepwise intervention approach was implemented consisting of an Electrocorticography (ECoG)-guided surgical resection of the residual epileptic focus, VNS implantation for long-term seizure modulation, BoNT therapy for residual epilepsia partialis continua (EPC). The combined approach of surgical resection and VNS implantation successfully terminated the status epilepticus. Residual Epilepsia Partialis Continua (EPC) was effectively managed with botulinum toxin therapy (BoNT). This case underscores the potential efficacy of combining surgical resection and VNS implantation in treating SRSE and highlights the beneficial effects of BoNT in managing residual EPC, offering a potential treatment pathway for similar refractory cases.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100775"},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Academic competence and special educational needs as outcomes of early onset epilepsy: A population-based prospective follow-up study 学术能力和特殊教育需求作为早发性癫痫的结局：一项基于人群的前瞻性随访研究

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-04-30 DOI: 10.1016/j.ebr.2025.100777

Kati Rantanen , Jenna Mäntylä , Eeva Kettunen , Annina Saunajoki , Kai Eriksson

{"title":"Academic competence and special educational needs as outcomes of early onset epilepsy: A population-based prospective follow-up study","authors":"Kati Rantanen , Jenna Mäntylä , Eeva Kettunen , Annina Saunajoki , Kai Eriksson","doi":"10.1016/j.ebr.2025.100777","DOIUrl":"10.1016/j.ebr.2025.100777","url":null,"abstract":"<div><div>Epilepsy in children is associated with significant academic challenges, particularly among those with early-onset seizures and comorbid intellectual disabilities (ID). This study aims to bridge gaps in existing research by examining long-term academic outcomes and special educational needs (SEN) in a cohort of children with early-onset epilepsy, including those with complicated epilepsy (CE) and major comorbidities. The study followed a population-based cohort of 64 children with epilepsy (CWE) aged 3–6 years, identified from the Pediatric Neurology Unit at Tampere University Hospital. Six years later, 43 children (67 %) participated in the follow-up. Academic competence was assessed using the Teacher Report Form (TRF), which also provided data on SEN. The findings revealed that 67 % of participants had low academic competence, with a significant proportion requiring special educational support. Children with CE had notably lower academic performance compared to those with uncomplicated epilepsy (UE). The need for SEN was higher among children with CE (81 %) than those with UE (24 %), with epilepsy type emerging as a significant predictor for SEN. Despite the small sample size and limitations in generalizability, the study underscores the pervasive impact of early-onset epilepsy on academic outcomes and highlights the necessity for ongoing educational support. Future research should focus on larger cohorts and explore the efficacy of tailored educational interventions to improve the academic performance and quality of life for CWE. Regular screening and collaboration with educators are essential to address the unique needs of these children effectively.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100777"},"PeriodicalIF":1.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0