Epilepsy and Behavior Reports最新文献

Autosomal dominant Kufs disease in a Georgian adult woman: A case report 常染色体显性库夫斯病在格鲁吉亚成年妇女：1例报告

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Epilepsy and Behavior Reports Pub Date : 2025-07-10 DOI: 10.1016/j.ebr.2025.100805

Nikoloz Papiashvili , Sopio Gagua , Nana Gonjilashvili , Natela Okujava , Aleksandre Tsereteli

引用次数: 0

The role of cannabis in epilepsy illustrated by two case reports 两个病例报告说明了大麻在癫痫中的作用

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Epilepsy and Behavior Reports Pub Date : 2025-07-08 DOI: 10.1016/j.ebr.2025.100804

Santiago Philibert-Rosas , Cameron J. Brace , Sanaa Semia , Barry E. Gidal , Bradley T. Nix , Anne F. Josiah , Melanie Boly , Aaron F. Struck

{"title":"The role of cannabis in epilepsy illustrated by two case reports","authors":"Santiago Philibert-Rosas , Cameron J. Brace , Sanaa Semia , Barry E. Gidal , Bradley T. Nix , Anne F. Josiah , Melanie Boly , Aaron F. Struck","doi":"10.1016/j.ebr.2025.100804","DOIUrl":"10.1016/j.ebr.2025.100804","url":null,"abstract":"<div><div>Cannabis use is increasingly prevalent among individuals with epilepsy, yet its impact on seizure control remains poorly understood. While cannabidiol (CBD) has demonstrated antiseizure properties and gained FDA approval for specific epileptic syndromes, tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, may alter neuronal excitability and potentially exacerbate seizure activity. We present two illustrative case reports of male patients with focal epilepsy and chronic cannabis use who underwent treatment with antiseizure medications and responsive neurostimulation (RNS). In both cases, cannabis use was temporally associated with breakthrough seizures and poor seizure control. These cases highlight the complex and multifactorial relationship between cannabis use and seizure outcomes, including potential pharmacokinetic interactions with antiseizure medications (ASM) and the possibility that cannabis may blunt the neuromodulation effects of RNS. Given the retrospective data and limited detail on cannabis use, these findings should be interpreted with caution. As cannabis use rises among individuals with epilepsy, further research is needed to clarify its potential effects on seizures and treatment response, including neuromodulation.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100804"},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lateralization discordance between stereo EEG and scalp EEG in temporal epilepsy: A case report 颞叶癫痫立体脑电图与头皮脑电图侧位不一致1例

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Epilepsy and Behavior Reports Pub Date : 2025-07-05 DOI: 10.1016/j.ebr.2025.100803

Spencer Gunnell, Audrey Nath, Patrick Karas, Todd Masel

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Brain tumours as an unrecognized etiology of infantile epileptic spasms syndrome (IESS): The role of resective epilepsy surgery 脑肿瘤作为婴儿癫痫痉挛综合征（IESS）的未知病因：切除癫痫手术的作用

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Epilepsy and Behavior Reports Pub Date : 2025-07-04 DOI: 10.1016/j.ebr.2025.100802

Rowan Pentz , Kevin Jones , Ronit Mesterman , Rajesh RamachandranNair , Hiroshi Otsubo , Ayako Ochi , Ivanna Yau , Elizabeth J Donner , George M Ibrahim , Puneet Jain , Robyn Whitney

{"title":"Brain tumours as an unrecognized etiology of infantile epileptic spasms syndrome (IESS): The role of resective epilepsy surgery","authors":"Rowan Pentz , Kevin Jones , Ronit Mesterman , Rajesh RamachandranNair , Hiroshi Otsubo , Ayako Ochi , Ivanna Yau , Elizabeth J Donner , George M Ibrahim , Puneet Jain , Robyn Whitney","doi":"10.1016/j.ebr.2025.100802","DOIUrl":"10.1016/j.ebr.2025.100802","url":null,"abstract":"<div><div>Brain tumours are a rare cause of infantile epileptic spasm syndrome (IESS). Epilepsy surgery may be utilized in refractory IESS due to tumours, although reports are limited. We report an illustrative case of IESS which resolved after tumour resection and performed a literature review of all reported cases of brain tumours causing IESS with hypsarrhythmia. We present a 10-month-old girl with drug-resistant symmetric epileptic spasms (ES). Initial EEG showed symmetric hypsarrhythmia and brain MRI demonstrated a left temporal lobe tumour. Despite non-focal clinical and EEG findings, she underwent tumour resection at 21 months (ganglioglioma). She subsequently had resolution of ES and hypsarrhythmia and developmental gains. Twenty-seven published cases of brain tumours and IESS were reviewed. ES were refractory to medical management in 74 % of reported cases (17/23). ES were symmetric in 17/21 (81 %) and asymmetric in 4/21 (19 %) specified cases. Hypsarrhythmia pattern was asymmetric in 10/20 (50 %) specified cases. Of 21 surviving patients who underwent surgery, 13 (62 %) were seizure free at follow-up and only 1 (5 %) had no improvement. Developmental outcomes were available in 19/21 (90 %) surviving surgical patients and 10/19 had improvements (52 %); 6/19 had normalized development (32 %). Various tumour types were reported and a temporal or frontal location was most common. Brain tumours can cause IESS with or without clinical or EEG focality and are amenable to surgical treatment. We emphasize that the absence of focal signs should not delay surgical assessment for patients with refractory IESS and brain tumours.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100802"},"PeriodicalIF":1.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GAD65-positive autoimmune-associated epilepsy presenting with Ictal Hand Kissing; an uncommon presentation of a rare disease gad65阳性的自身免疫相关癫痫，表现为纵向吻手；罕见病的罕见表现

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-07-01 DOI: 10.1016/j.ebr.2025.100801

Alia M.R. Fallatah, Hanan M. Abdulmutali, Majed H. Alhameed

引用次数: 0

Rash and edema shortly after initial exposure to low dose cenobamate 初次接触低剂量新奥马酸后不久出现皮疹和水肿

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-27 DOI: 10.1016/j.ebr.2025.100800

Christopher Saouda, Yamane Makke, Helen Edelberg, Mohamad Z. Koubeissi

引用次数: 0

The posterior insula as an independent pain center: Two cases of isolated facial pain-type epilepsy revealed by stereo-electroencephalography 脑岛后部作为独立的疼痛中枢：立体脑电图显示孤立性面部疼痛型癫痫2例

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-21 DOI: 10.1016/j.ebr.2025.100798

Jun Zhuang , Lingxia Fei , Hua Li , Qiang Guo

引用次数: 0

Seizure control in glycine encephalopathy using the Ketamine-Dextromethorphan-Sodium benzoate triple therapy 氯胺酮-右美沙芬-苯甲酸钠三联疗法控制甘氨酸脑病的癫痫发作

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-19 DOI: 10.1016/j.ebr.2025.100797

Laith Haddad , Samah Trad , Lama Charafeddine , Pascale E. Karam

{"title":"Seizure control in glycine encephalopathy using the Ketamine-Dextromethorphan-Sodium benzoate triple therapy","authors":"Laith Haddad , Samah Trad , Lama Charafeddine , Pascale E. Karam","doi":"10.1016/j.ebr.2025.100797","DOIUrl":"10.1016/j.ebr.2025.100797","url":null,"abstract":"<div><div>Neonatal glycine encephalopathy is a rare genetic neurometabolic disorder secondary to glycine cleavage system deficiency. Patients typically present with early-onset intractable seizures, status epilepticus and encephalopathy. Seizures control remains challenging in view of their refractoriness to standard anti-seizure medications. Sodium benzoate is commonly used to control the elevated glycine level. Oral anti-NMDA receptor antagonists, ketamine and dextromethorphan, have been used in various combinations in the treatment of this complex disorder. In this report, we present a neonatal case of classical glycine encephalopathy with hypotonia and refractory myoclonic seizures. The status epilepticus was successfully treated using a combination of intravenous ketamine, oral dextromethorphan and sodium benzoate. Seizures resolved and the patient’s development showed improvement on follow-up. The intravenous form of ketamine in the neonatal period is rarely used, and it has been reported in only two glycine encephalopathy patients in the literature. This is the first report in the literature of the efficacy of intravenous ketamine using the above triple therapy. This intervention might have implications on the management of neonatal intractable seizures in glycine encephalopathy, which might improve the outcome of this devastating disorder.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100797"},"PeriodicalIF":1.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coexistence of epilepsy with eyelid myoclonia, schizoaffective disorder, and cavum septi pellucidi et vergae: A case report 癫痫并发眼睑肌挛症、分裂情感性障碍、透明中隔腔及膈腔1例

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-18 DOI: 10.1016/j.ebr.2025.100786

Samwel Sylvester Msigwa , Suluma Aslan , Elizabeth Mareale , Mercy Bingileki

{"title":"Coexistence of epilepsy with eyelid myoclonia, schizoaffective disorder, and cavum septi pellucidi et vergae: A case report","authors":"Samwel Sylvester Msigwa , Suluma Aslan , Elizabeth Mareale , Mercy Bingileki","doi":"10.1016/j.ebr.2025.100786","DOIUrl":"10.1016/j.ebr.2025.100786","url":null,"abstract":"<div><div>We report the first case of a 14-year-old boy presenting with the rare co-occurrence of cavum septi pellucidi et vergae (CSPV), epilepsy with eyelid myoclonia (EEM), and schizoaffective disorder (SAD). The patient initially presented with a one-month history of abnormal eye movements, including continuous blinking and upward rolling of the eyeballs, which occurred predominantly at night. There was no alteration in consciousness. A detailed history revealed that the patient had experienced mood disturbances, delusional beliefs, auditory and visual hallucinations, and significant behavioral dysregulation for one year. These symptoms had been partially managed with haloperidol. Magnetic resonance imaging (MRI) confirmed the presence of CSPV. At the same time, electroencephalography (EEG) during intermittent photic stimulation demonstrated brief generalized epileptiform discharges triggered by eye closure, consistent with a diagnosis of EEM. The simultaneous presence of psychotic and affective symptoms met the diagnostic criteria for SAD. The patient was treated with sodium valproate in addition to his existing low-dose haloperidol regimen. This led to the complete resolution of seizures and psycho-affective symptoms at one- and three-month follow-ups. However, a decline in academic performance was noted at the one-year follow-up. In resource-limited settings without access to genetic or autoimmune tests, care was guided by practical adaptations rather than standard protocols. This case highlights a potential neurodevelopmental link between CSPV and epileptic and psychiatric manifestations, underscores the value of neuroimaging and EEG in pediatric neuropsychiatric overlap, and calls for research into mechanisms connecting midline brain anomalies with complex neuropsychiatric disorders.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100786"},"PeriodicalIF":1.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Dravet syndrome and Catatonia: a case report Dravet综合征与紧张症的关系：1例报告

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Epilepsy and Behavior Reports Pub Date : 2025-06-16 DOI: 10.1016/j.ebr.2025.100785

Rishi Katragadda , Kyung Eun Paik , D. Dilara Ertenu , Ahmad Marashly , Jay A. Salpekar , Aaron Hauptman

{"title":"Association between Dravet syndrome and Catatonia: a case report","authors":"Rishi Katragadda , Kyung Eun Paik , D. Dilara Ertenu , Ahmad Marashly , Jay A. Salpekar , Aaron Hauptman","doi":"10.1016/j.ebr.2025.100785","DOIUrl":"10.1016/j.ebr.2025.100785","url":null,"abstract":"<div><div>Catatonia is a neurobehavioral and motor syndrome that can occur in persons with epilepsy (PWE), though it is rarely described in individuals with developmental and genetic epilepsies such as Dravet syndrome. This case report describes a young adult with Dravet syndrome who developed catatonia after improving seizure control. In this report we explore forced normalization (FN) as a potential mediating mechanism. An 18-year-old male with Dravet syndrome experienced significant seizure reduction after zonisamide was added to his antiseizure regimen. Within two weeks, he developed catatonic features, including mutism, catalepsy, and psychomotor retardation. Bush Francis Catatonia Rating Scale (BFCRS) scores ranged from 17 to 22. Catatonia improved with lorazepam, though seizure frequency increased after zonisamide taper. He later experienced a decline in both neurological and psychiatric function following status epilepticus. EEG was not performed at the time of symptom onset, which limits the ability to diagnose this patient with FN. However, the clinical criteria for FN were partially met, and the timing of zonisamide initiation and catatonia emergence supports its consideration. Non-convulsive status epilepticus (NCSE) remains a plausible alternative mechanism for the catatonia seen in this patient, particularly in those with developmental encephalopathies. This case demonstrates an interesting temporal relationship between improved seizure control and emergence of catatonia in a patient with genetic epilepsy. Further research is required to clarify the relationship between catatonia and FN in epilepsy.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100785"},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0