初次接触低剂量新奥马酸后不久出现皮疹和水肿

IF 1.5 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports Pub Date : 2025-06-27 DOI:10.1016/j.ebr.2025.100800

Christopher Saouda, Yamane Makke, Helen Edelberg, Mohamad Z. Koubeissi

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引用次数: 0

摘要

Cenobamate （CNB）是一种抗癫痫药物（ASM），被批准用于治疗局灶性癫痫。皮疹和水肿是罕见的不良反应，这种药物。我们报告了两例难治性癫痫（MRE）患者，他们接受了CNB，在初始剂量12.5 mg/d后出现胸部和面部皮疹和水肿，导致停药，随后皮疹和水肿消退。用CNB重新挑战也导致了类似的反应。我们的报告旨在提高人们对CNB的这些反应的认识。

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Rash and edema shortly after initial exposure to low dose cenobamate

Cenobamate (CNB) is an antiseizure medication (ASM) approved for the treatment of focal epilepsy. Rash and edema are uncommon adverse effects of this medication. We report two patients with medically refractory epilepsy (MRE) who received CNB and developed chest and facial rash and edema after the initial dose of 12.5 mg/d that prompted discontinuation of the medication with ensuing resolution of the rash and edema. Rechallenging with CNB resulted in similar reactions. Our report aims at increasing awareness of these reactions to CNB.

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来源期刊

Epilepsy and Behavior Reports Medicine-Neurology (clinical)

CiteScore

2.70

自引率

13.30%

发文量

审稿时长

50 days