Epilepsy and Behavior Reports最新文献_第2页

Stigma, overprotection, and suicidal ideation in epilepsy: a cross-sectional study on psychosocial predictors 癫痫的病耻感、过度保护和自杀意念：一项社会心理预测因素的横断面研究

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2025-08-05 DOI: 10.1016/j.ebr.2025.100815

Harun Yetkin , Ozdem Erturk Cetin , Esra Nur Sancar , Inci Su Tascan

{"title":"Stigma, overprotection, and suicidal ideation in epilepsy: a cross-sectional study on psychosocial predictors","authors":"Harun Yetkin , Ozdem Erturk Cetin , Esra Nur Sancar , Inci Su Tascan","doi":"10.1016/j.ebr.2025.100815","DOIUrl":"10.1016/j.ebr.2025.100815","url":null,"abstract":"<div><div>Patients with epilepsy (PWE) are at elevated risk for suicide, with psychosocial factors such as felt stigma and perceived overprotection contributing to this vulnerability. This cross-sectional study examined the associations among suicidal ideation, felt stigma, and perceived overprotective behaviors in 92 adult PWE not currently receiving psychiatric treatment. Participants completed self-report measures including the Felt Stigma Scale (FSS), Perceived Overprotection Scale (POS), Beck Depression Inventory-II (BDI-II), and Suicide Probability Scale (SPS). SPS scores were significantly correlated with FSS (r = 0.405, p < 0,001) and BDI-II (r = 0.765, p < 0.001), while FSS and POS were also correlated (r = 0.399, p < 0.001). POS was not directly associated with SPS. In hierarchical regression, FSS was a significant predictor of suicidal ideation (p < 0.001), but BDI-II emerged as the strongest predictor (p < 0.001), explaining 58 % of the variance in SPS scores. These findings highlight the mediating role of depression in the relationship between felt stigma and suicidal ideation, and suggest that addressing felt stigma and depressive symptoms in epilepsy care may help reduce suicide risk.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100815"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current best medical practices survey in vagus nerve stimulation programming 当前迷走神经刺激规划的最佳医学实践调查。

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.ebr.2026.100849

Debra T. Moore-Hill , Molly Butler , Danielle L Weiss , Leila A.T. Hill , Hunter Smith , Brandon Pope , Chasitie McIntosh , Luca Debs , Amir A. Mbonde , Anthony Murro , Fernando L. Vale

{"title":"Current best medical practices survey in vagus nerve stimulation programming","authors":"Debra T. Moore-Hill , Molly Butler , Danielle L Weiss , Leila A.T. Hill , Hunter Smith , Brandon Pope , Chasitie McIntosh , Luca Debs , Amir A. Mbonde , Anthony Murro , Fernando L. Vale","doi":"10.1016/j.ebr.2026.100849","DOIUrl":"10.1016/j.ebr.2026.100849","url":null,"abstract":"<div><div>Vagal Nerve Stimulator Therapy (VNS) uses programmable duty cycle (DC) and three modes of stimulation: normal mode (NM), heart-rate responsive automatic stimulation mode (AS), and on-demand magnet mode (MM). VNS therapy guidelines exist however; they may not represent real-world best clinical practices. This study aims to identify current best medical practices in VNS programming. Epilepsy VNS practitioners received an anonymous, deidentified IRB-approved online survey at the American Epilepsy Society Meeting (12/3/2023, Orlando Florida). The majority of respondents were US-practicing (n = 45, 78%) epileptologists (n = 43, 74%) programming VNS devices in 50 patients or less in the preceding two years prior to the creation of the survey (n = 39, 67%). Most programmed VNS independently and trained others how to program VNS devices (n = 49, 84%). Large variations in programming of NM, AS, and DC occurred. The median initial and maximum target NM output was 1–1.25 mA (n = 18, 31%) and 2–2.5 mA (n = 23, 40%) respectively. Most (n = 37, 64%) programmed AS current higher than NM. A third subset programmed initial and final AS heart-rate increase thresholds at 40% and 20% respectively (n = 19, 33%). The median anticipated final DC target was 35%. Most achieved final VNS settings at or before 40 weeks (n = 47, 81%) and declared VNS non-responders at 13–36 months after initial programming (n = 37, 64%). Our study identifies variability in VNS programming practices amongst epilepsy practitioners highlighting gaps between guideline recommendations and their clinical application. This study offers critical insights into optimal VNS therapy settings and optimization of VNS therapy outcomes for patients with DRE.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100849"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interictal focal epileptic discharges in a pediatric patient with absence status epilepsy: a mimicker of focal epilepsy 癫痫缺乏症患儿间期局灶性癫痫放电：局灶性癫痫的模拟。

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1016/j.ebr.2026.100850

Kento Ohta , Go Yoshino , Masami Togawa , Tohru Okanishi , Yoshihiro Maegaki

{"title":"Interictal focal epileptic discharges in a pediatric patient with absence status epilepsy: a mimicker of focal epilepsy","authors":"Kento Ohta , Go Yoshino , Masami Togawa , Tohru Okanishi , Yoshihiro Maegaki","doi":"10.1016/j.ebr.2026.100850","DOIUrl":"10.1016/j.ebr.2026.100850","url":null,"abstract":"<div><div>Absence status epilepsy (ASE) is a rare generalized epilepsy that usually manifests in adolescence or adulthood, although pediatric-onset cases have also been described. It is characterized by recurrent episodes of absence status epilepticus, presenting as prolonged confusion or unresponsiveness. Ictal electroencephalography (EEG) typically shows near-continuous generalized spike-and-wave (SW) or polyspike-and-wave (PSW) discharges. To date, interictal focal epileptic discharges have not been reported in ASE. A previously healthy 6-year-old girl presented with recurrent atypical absence seizures lasting several hours, during which she was confused, moved and spoke slowly, and made errors in daily activities. At age seven, ictal EEG revealed almost continuous, irregular generalized SW and PSW discharges with maximal amplitude over the frontal regions. Interictal EEG demonstrated occipital intermittent rhythmic delta activity, generalized SW and PSW, and focal epileptic discharges. Brain magnetic resonance imaging and laboratory tests were unremarkable. Despite initial treatment with levetiracetam and clobazam, absence status epilepticus recurred when continuous intravenous midazolam was discontinued. Introduction of valproic acid allowed successful withdrawal of midazolam, and the patient was discharged without seizure recurrence. This case illustrates that focal interictal epileptic discharges can occur in ASE. The interictal focal EEG abnormalities may lead to misdiagnosis of focal epilepsy, particularly when impairment of consciousness during absence seizures is mild. Diagnosing absence seizures in ASE is further complicated by their prolonged duration, which makes onset and termination difficult to document. Valproic acid was effective for long-term seizure control, whereas intravenous benzodiazepines achieved rapid seizure suppression.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100850"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“I’m lonely”: An underrecognized marker of silent suffering in PWE in underresourced settings? “我很孤独”：在资源不足的环境中，PWE沉默痛苦的一个未被认识的标志？

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2025-12-08 DOI: 10.1016/j.ebr.2025.100841

Amza Ali

{"title":"“I’m lonely”: An underrecognized marker of silent suffering in PWE in underresourced settings?","authors":"Amza Ali","doi":"10.1016/j.ebr.2025.100841","DOIUrl":"10.1016/j.ebr.2025.100841","url":null,"abstract":"<div><div>Loneliness is increasingly recognized as a significant psychosocial determinant of health, yet it remains comparatively underexplored in the context of epilepsy, and particularly in under-resourced environments. Unlike depression or anxiety, loneliness is less specifically sought, nor readily disclosed, despite its profound impact on well-being. This article draws on clinical experience and a small observational audit in Jamaica to highlight loneliness as a distinct and pervasive issue among people with epilepsy (PWE). While loneliness frequently co-occurs with depression, it may exist independently and may precede diagnosable mood disorders. Contributing factors include societal stigma, physician-advised safety restrictions, antiseizure medication side effects, and systemic gaps in epilepsy care, factors often greatly intensified in low-resource settings. By focusing on the lived experience of patients, this article argues that loneliness may silently erode quality of life, autonomy, and treatment adherence, in part also from its seemingly close association with depression. It proposes low-cost, socially focused interventions as potentially transformative and suggests the need for inclusion of loneliness as a modifiable factor in clinical practice and future research. A simple question, “Do you feel lonely?” could facilitate the identification of loneliness in PWE, and particularly in underserved communities and LMICs with high social stigma, may help improve psychosocial outcomes, and epilepsy control.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100841"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of a ketogenic diet clinic in Mexico: A pilot program in a resource-limited setting 墨西哥生酮饮食诊所的实施：资源有限环境下的试点项目

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2025-12-16 DOI: 10.1016/j.ebr.2025.100842

Melissa Chavez-Castillo , Paloma Hurtado-Cuan , Maria Alejandra Soto-Blanquel , Amado Jimenez-Ruiz , Enrique Gomez-Figueroa , Rosa Marquez-Palacios

{"title":"Implementation of a ketogenic diet clinic in Mexico: A pilot program in a resource-limited setting","authors":"Melissa Chavez-Castillo , Paloma Hurtado-Cuan , Maria Alejandra Soto-Blanquel , Amado Jimenez-Ruiz , Enrique Gomez-Figueroa , Rosa Marquez-Palacios","doi":"10.1016/j.ebr.2025.100842","DOIUrl":"10.1016/j.ebr.2025.100842","url":null,"abstract":"<div><div>This study describes the implementation and outcomes of the first protocolized Ketogenic Diet Clinic (KDC) in Mexico for pediatric drug-resistant epilepsy (DRE). We conducted a retrospective analysis of 20 patients with DRE who initiated KDT between July 2022 and July 2024 in a multidisciplinary KDC at a public tertiary hospital. All patients were newly started on KDT under a structured protocol; none followed a classic 4:1 ketogenic diet, all received modified regimens. Clinical, nutritional, and socioeconomic data were collected. Seizure outcomes were categorized by percent reduction, and antiseizure medication (ASM) burden was evaluated through changes in cumulative daily dose and ASM count. Hospital admissions were recorded, and caregivers were asked about barriers to implementation. At the first follow-up visit (≈3 months), with complete data for all 20 patients, 10/20 (50 %) achieved ≥50 % seizure reduction and 4/20 (20 %) achieved ≥90 % reduction. Due to staggered recruitment, later visits included fewer patients (n = 18 and n = 14). Among the 14 patients who reached the third visit, 9/14 (64 %) achieved ≥90 % reduction. ASM dose decreased in 12/20 (60 %), and ASM count decreased in 6/20 (30 %). Hospital visits declined from 16 events the prior year to 4 after KDT initiation. Despite cultural, nutritional, educational, and access-related barriers, no patient discontinued the diet, as treatment plans were adapted to maintain feasibility. A structured KDC is feasible and clinically beneficial in a resource-limited setting. Modified KDT regimens reduced seizure burden and treatment intensity, supporting expansion of KDT programs in low-resource contexts.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100842"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CORE-VNS: Dosing and titration of VNS therapy in contemporary clinical practice CORE-VNS: VNS治疗在当代临床实践中的剂量和滴定。

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2026-01-22 DOI: 10.1016/j.ebr.2026.100847

Ryan Verner , Francesca Beraldi , Michal Tzadok , Firas Fahoum , Riëm El Tahry , Michael A. Gelfand , George Morris , Gholam K. Motamedi , Muhammad Zafar , Arjune Sen , Massimiliano Boffini , Charles Gordon , Maxine Dibué , For the CORE-VNS Study Group

{"title":"CORE-VNS: Dosing and titration of VNS therapy in contemporary clinical practice","authors":"Ryan Verner , Francesca Beraldi , Michal Tzadok , Firas Fahoum , Riëm El Tahry , Michael A. Gelfand , George Morris , Gholam K. Motamedi , Muhammad Zafar , Arjune Sen , Massimiliano Boffini , Charles Gordon , Maxine Dibué , For the CORE-VNS Study Group","doi":"10.1016/j.ebr.2026.100847","DOIUrl":"10.1016/j.ebr.2026.100847","url":null,"abstract":"<div><div>In this analysis of dosing and titration in the CORE-VNS study, we aimed to replicate previously published findings related to dosing and titration of VNS Therapyand describe the impact of Scheduled Programming (SP).Participants who received their first VNS Therapy device during the CORE-VNS study and who attended at least one of either the 6- or 12-month follow-ups were selected for this analysis. Various statistical models (generalized linear mixed models, weighted Cox regression, Kaplan-Meier, and Poisson regression) were used to assess the relationship between VNS titration and clinical response. Participants who were predominantly manually titrated were compared to those who were predominantly titrated using SP. 526 participants met the inclusion criteria for this analysis. The majority were titrated manually (n = 364), compared with the SP feature (n = 162). We found a strong relationship between speed of titration and onset of clinical response but did not find SP use to significantly impact time-to-dose. The mean time-to-response in the SP group was 7.8 months, compared to a mean time-to-response of 10.7 months for manually titrated patients but this effect was not significant in the Cox regression. Patients who were titrated using SP were able to complete their titration phase with fewer required in-office visits than manually titrated patients (p < 0.0001). We replicate prior findings that titration speed of VNS impacts the time to response. Scheduled Programming does not appear to strongly impact titration speed but aids the clinical workflow and reduces patient burden by reducing the frequency of required in-office titration visits.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100847"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health economic analysis of seizure-related emergency visits of pediatric patients with drug-resistant epilepsy in Japan 日本儿童耐药癫痫患者癫痫相关急诊的卫生经济分析

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2025-12-08 DOI: 10.1016/j.ebr.2025.100840

Ayataka Fujimoto , Takuya Kumagai , Kazuaki Yamamoto , Katsuhiko Iwasaki , Kinya Kokubo , Ataru Igarashi

{"title":"Health economic analysis of seizure-related emergency visits of pediatric patients with drug-resistant epilepsy in Japan","authors":"Ayataka Fujimoto , Takuya Kumagai , Kazuaki Yamamoto , Katsuhiko Iwasaki , Kinya Kokubo , Ataru Igarashi","doi":"10.1016/j.ebr.2025.100840","DOIUrl":"10.1016/j.ebr.2025.100840","url":null,"abstract":"<div><div>This study estimates the cost of emergency transport and the total cost of medical care for pediatric patients with drug-resistant epilepsy (DRE) in Japan. We perform a retrospective analysis of patients aged less than 18 years with DRE. We use a health insurance claims database to identify the patients. The data are combined with published information, including government statistics and prior studies. We calculate the median medical cost for these patients after emergency and the cost per emergency transport service using recent data published by the Fire and Disaster Management Agency and calculation logic. The cost per emergency transport service is approximately 138,600 yen. Additionally, the cost of emergency transport for pediatric patients with DRE and the total medical cost in Japan are approximately 511,949,800 and 597,536,619 yen per year, respectively. This study is among the first to estimate the annual costs of seizure-related emergency transport and medical care for pediatric patients with DRE in Japan. These estimates can serve as baseline data for use in future assessments of the cost-effectiveness of acute medical care in this population.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100840"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with epileptiform discharges in patients visiting a memory clinic: A retrospective study 访问记忆诊所的患者癫痫样放电相关因素：一项回顾性研究。

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.ebr.2026.100853

Katsunori Yokoi , Masashi Tsujimoto , Keisuke Suzuki , Akinori Takeda , Kentaro Horibe , Akiko Yamaoka , Eriko Okada , Osamu Kawakami , Masahisa Katsuno , Yutaka Arahata

{"title":"Factors associated with epileptiform discharges in patients visiting a memory clinic: A retrospective study","authors":"Katsunori Yokoi , Masashi Tsujimoto , Keisuke Suzuki , Akinori Takeda , Kentaro Horibe , Akiko Yamaoka , Eriko Okada , Osamu Kawakami , Masahisa Katsuno , Yutaka Arahata","doi":"10.1016/j.ebr.2026.100853","DOIUrl":"10.1016/j.ebr.2026.100853","url":null,"abstract":"<div><div>Epilepsy is a common comorbidity in older adults, particularly those with neurodegenerative diseases such as Alzheimer’s disease. However, recognizing epilepsy in patients with dementia can be challenging, as its symptoms often mimic cognitive fluctuations. Reliable clinical indicators validated by electroencephalography (EEG) are needed for timely diagnosis and management. This study investigated predictors of epileptiform discharges in patients visiting a memory clinic, focusing on the diagnostic role of EEG. We retrospectively screened 159 patients who underwent medical interviews with physicians and EEG testing between April 2022 and March 2023. Data from dementia-related questionnaires, comprehensive geriatric assessments, EEG, magnetic resonance imaging, and single-photon emission computed tomography were evaluated. Among the 156 patients with dementia (after excluding 3 with epilepsy), 77 exhibited epileptiform discharges, predominantly left temporal (87%) or bilateral (13%), and female patients were more often affected (p < 0.05). Logistic regression analysis revealed that discharges were associated with variable cognitive decline. Approximately two-thirds of patients with epileptiform discharges answered “yes” to the interview item assessing “cognitive decline with variability,” highlighting the predictive value of this symptom. However, the remaining cases required EEG testing for detection. Our findings underscore the importance of recognizing epilepsy during dementia screening. While clinical interviews provide valuable insights, EEG remains indispensable for accurate diagnosis and treatment.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100853"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcortical band heterotopia in a child with new-onset seizures: A case report 新发癫痫患儿皮质下带异位1例。

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.ebr.2026.100852

Nebil Abdella Shukralla , Wengele Mathewos Hunde , Messifn Tibebe , Metti Kuma Dida

{"title":"Subcortical band heterotopia in a child with new-onset seizures: A case report","authors":"Nebil Abdella Shukralla , Wengele Mathewos Hunde , Messifn Tibebe , Metti Kuma Dida","doi":"10.1016/j.ebr.2026.100852","DOIUrl":"10.1016/j.ebr.2026.100852","url":null,"abstract":"<div><div>Subcortical band heterotopia (SBH), also known as “double cortex” syndrome, is a rare neuronal migration disorder characterized by symmetric bands of heterotopic gray matter located between the cerebral cortex and lateral ventricles. It predominantly affects females and typically presents in childhood or adolescence with epilepsy and variable cognitive or motor impairment. We report a 9-year-old girl with normal antenatal, perinatal, developmental, and academic history who presented with a one‑month history of frequent generalized tonic–clonic seizures accompanied by new onset generalized limb weakness. Neurological examination revealed mild, symmetric weakness with brisk deep tendon reflexes but preserved cranial nerve and sensory function. Routine laboratory tests and electroencephalography were unremarkable. Brain magnetic resonance imaging demonstrated classic features of SBH, including bilateral, well-defined bands of gray matter deep to and paralleling the cortical surface, separated from the overlying cortex by intervening white matter and isointense to normal cortex on all sequences. A diagnosis of SBH was made based on these characteristic imaging findings. The patient was started on phenytoin, reflecting local prescribing practices and formulary availability in resource‑limited settings, resulting in effective seizure control and clinical stability on follow‑up; genetic testing for DCX or other implicated genes was not performed due to resource limitations. This case highlights that SBH can present in a developmentally normal child with new-onset generalized seizures and limb weakness, underscores the crucial role of MRI in diagnosis where genetic testing is unavailable, and emphasizes the importance of early recognition and tailored antiepileptic therapy to optimize long‑term neurological outcomes.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100852"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trigeminal neuralgia-like pain in a vagus nerve stimulation super-responder with drug-resistant idiopathic generalized epilepsy: A case report 迷走神经刺激超反应患者伴耐药性特发性全身性癫痫三叉神经痛样疼痛1例报告

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2025-12-24 DOI: 10.1016/j.ebr.2025.100844

Javier Peña-Ceballos , Tenzin Choekyi , Aoife Walsh , Breege Staunton-Grufferty , Vicente Casitas-Hernando , Donncha O’Brien , Norman Delanty

引用次数: 0