Epilepsy and Behavior Reports最新文献_第2页

Successful application of vagus nerve stimulation in super refractory status epilepticus associated with MERRF syndrome 成功应用迷走神经刺激治疗与 MERRF 综合征相关的超难治性癫痫状态

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Epilepsy and Behavior Reports Pub Date : 2025-04-14 DOI: 10.1016/j.ebr.2025.100769

Leyla Baysal , Sabrina Jobi , Simone Zimmermann , Ann-Kristin Helmers , Nils Gerd Margraf

引用次数: 0

Exploring determinants of time to school re-entry after pediatric epilepsy surgery 探讨儿童癫痫手术后重返学校时间的决定因素

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Epilepsy and Behavior Reports Pub Date : 2025-04-14 DOI: 10.1016/j.ebr.2025.100771

Evangeline A. Huis in 't Veld , Olga Braams , Willem M. Otte , Peter van Rijen , Kees P.J. Braun , Renske Schappin

{"title":"Exploring determinants of time to school re-entry after pediatric epilepsy surgery","authors":"Evangeline A. Huis in 't Veld , Olga Braams , Willem M. Otte , Peter van Rijen , Kees P.J. Braun , Renske Schappin","doi":"10.1016/j.ebr.2025.100771","DOIUrl":"10.1016/j.ebr.2025.100771","url":null,"abstract":"<div><div>After epilepsy surgery, it varies when children re-enter school. The aim of this study was to identify determinants for this variation. Parents of 21 school-attending children participated in semi-structured interviews during their child’s hospitalization for epilepsy surgery and one year afterward (based on the standard neuropsychological post-surgical follow-up). The mean time to school re-entry was 10.7 weeks (SD = 6.3). One child did not attend school after one year, whilst the fastest child resumed school 2 weeks after surgery. We performed univariable linear regression models with bootstrapped R<sup>2</sup> for all variables deemed theoretically or clinically relevant to school re-entry. We found that temporal surgery was significantly related to shorter time to school re-entry; and that longer hospitalization, and presurgical outpatient educational counseling were significantly related to longer time to school re-entry. In multivariable linear regression, these variables together predicted 57% of variance (bootstrapped) in time to school re-entry. In conclusion, our findings indicate that school re-entry varies considerably among children but can partly be explained by surgery related variables and the presence of counseling. Given the importance of school in children’s daily lives, we argue that school attendance should be stimulated by increasing professionals’ awareness of children’s school re-entry process.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100771"},"PeriodicalIF":1.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A functional seizure case in Wilson’s disease 威尔逊氏病的功能性癫痫病例

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Epilepsy and Behavior Reports Pub Date : 2025-04-12 DOI: 10.1016/j.ebr.2025.100768

Lucas D'Andrea, Raphael Mosqueira, Alcenor C. Miranda Filho, Renato L. Marchetti

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Personalized adherence interventions using medication adherence technologies in polypharmacy management in epilepsy: An interprofessional case report 在癫痫综合药房管理中使用药物依从性技术的个性化依从性干预：一份跨专业病例报告

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Epilepsy and Behavior Reports Pub Date : 2025-04-07 DOI: 10.1016/j.ebr.2025.100767

Micheline C. Sarbach , Stephan Rüegg , Samuel S. Allemann , Isabelle Arnet

{"title":"Personalized adherence interventions using medication adherence technologies in polypharmacy management in epilepsy: An interprofessional case report","authors":"Micheline C. Sarbach , Stephan Rüegg , Samuel S. Allemann , Isabelle Arnet","doi":"10.1016/j.ebr.2025.100767","DOIUrl":"10.1016/j.ebr.2025.100767","url":null,"abstract":"<div><div>We describe a male patient with symptomatic multifocal epilepsy struggling with medication adherence. He accepted escalating adherence interventions with conventional dosing aids such as pillboxes and medication adherence technologies (MATech) including a smart medication dispensing and adherence device (SMAD). Adherence metrics and drug levels were continuously monitored by electronic monitoring (EM) and therapeutic drug monitoring (TDM). Initially, adherence metrics with pre-filled punch cards supplied by a community pharmacy showed 64% taking adherence, 63% timing adherence, and 47% correctly dosed days, including a five-day medication holiday. Adherence improved with a pharmacy-filled SMAD, reaching 93% taking adherence, 90% timing adherence, 86% correctly dosed days, and no medication holiday. No epileptic seizures were noticed during periods with EM. The patient was satisfied with the SMAD while struggling with other adherence tools. Adherence tended to decrease once adherence reminders were removed. In conclusion, we emphasize the importance of personalized adherence strategies and shared decision-making. This case highlights the positive impact of an interprofessional adherence improvement program, integrating efforts from researchers, neurologists, and community pharmacists.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100767"},"PeriodicalIF":1.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the risk of subsequent ischemic stroke and mortality in patients with epilepsy and patients with ischemic stroke 癫痫患者与缺血性脑卒中患者继发缺血性脑卒中风险及死亡率的比较

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Epilepsy and Behavior Reports Pub Date : 2025-04-06 DOI: 10.1016/j.ebr.2025.100766

Po-Yu Lin , Sheng-Hsiang Lin , Pi-Shan Sung

{"title":"Comparing the risk of subsequent ischemic stroke and mortality in patients with epilepsy and patients with ischemic stroke","authors":"Po-Yu Lin , Sheng-Hsiang Lin , Pi-Shan Sung","doi":"10.1016/j.ebr.2025.100766","DOIUrl":"10.1016/j.ebr.2025.100766","url":null,"abstract":"<div><div>Patients with stroke or epilepsy face an elevated risk of subsequent strokes. This nationwide retrospective cohort study analyzed data from Taiwan’s National Health Insurance Research Database (2012–2020) to compare the risk of future ischemic stroke or transient ischemic attack (IS/TIA) among patients with epilepsy and those with prior IS/TIA. Patients were categorized into four groups: epilepsy with subsequent IS/TIA (E/S), epilepsy without IS/TIA (E), IS/TIA without epilepsy (S), and neither condition (C). Incidence rates and adjusted hazard ratios for IS/TIA and mortality were assessed across groups, which included 5,606, 11,212, 11,212, and 56,060 patients. The corresponding incidence rates of subsequent IS/TIA were 0.67, 0.03, 0.41, and 0.01 per 100 person-years in the E/S, E, S, and C groups, respectively. Compared to the S group, the E/S group had a higher adjusted hazard ratio for IS/TIA (aHR 1.68, 95% CI: 1.30–2.17), whereas the E group had a significantly lower adjusted hazard ratio (aHR 0.08, 95% CI: 0.04–0.14). Mortality risk was significantly elevated in both the E/S group (aHR 1.90, 95% CI: 1.75–2.05) and the E group (aHR 1.21, 95% CI: 1.12–1.30), compared to the S group. These findings suggest that epilepsy increases the risk of subsequent IS/TIA, though to a lesser extent than prior IS/TIA. They underscore the importance of condition-specific prevention strategies and the need for further research into the mechanisms linking epilepsy and stroke risk.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100766"},"PeriodicalIF":1.8,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coexistence of Charles Bonnet Syndrome and occipital epilepsy: A diagnostic challenge 查尔斯邦纳综合征和枕癫痫共存：一个诊断挑战

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Epilepsy and Behavior Reports Pub Date : 2025-04-03 DOI: 10.1016/j.ebr.2025.100764

Vijaya Lakshmi Valaparla , Aabishkar Bhattarai , Patrick J. Karas , Diosely C. Silveira

引用次数: 0

Neuropsychiatric disorders in Chinese pediatric tuberous sclerosis complex patients associated with drug-resistant epilepsy: A TAND checklist-based survey 中国儿童结节性硬化症合并耐药癫痫患者的神经精神障碍：一项基于TAND检查表的调查

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Epilepsy and Behavior Reports Pub Date : 2025-04-03 DOI: 10.1016/j.ebr.2025.100765

Jie Fu , Qinrui Li , Genfu Zhang , Zhixian Yang , Jiong Qin

{"title":"Neuropsychiatric disorders in Chinese pediatric tuberous sclerosis complex patients associated with drug-resistant epilepsy: A TAND checklist-based survey","authors":"Jie Fu , Qinrui Li , Genfu Zhang , Zhixian Yang , Jiong Qin","doi":"10.1016/j.ebr.2025.100765","DOIUrl":"10.1016/j.ebr.2025.100765","url":null,"abstract":"<div><div>Tuberous sclerosis complex (TSC) is an autosomal-dominant genetic disorder frequently accompanied by neuropsychiatric disorders, especially in patients who have drug-resistant epilepsy (DRE). This study aimed to evaluate the distribution of neuropsychiatric disorders in Chinese children with TSC-related epilepsy using the TAND (Tuberous Sclerosis Complex Associated Neuropsychiatric Disorders) checklist, comparing those with DRE to those achieving seizure freedom. A total of 47 children, aged 6 to 18 years, diagnosed with TSC at Peking University People’s Hospital, participated in this cross-sectional study.All participants met the latest diagnostic criteria for TSC. Based on the definition of drug-resistant epilepsy, participants were categorized into DRE group and seizure-free group. Neurodevelopmental disorders were evaluated using the TAND checklist. The study found that 66 % of participants exhibited varying degrees of intellectual disability, with the DRE group demonstrating significantly poorer performance in intelligence, behavior, neuropsychological, and learning skills compared to the seizure-free group. The DRE group also had higher rates of attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), alongside greater impairments in psychosocial functioning. This study indicates that DRE is strongly associated with neuropsychiatric development in children with TSC, but also that all children with TSC are at increased risk of TAND. Our findings highlight the importance of regular assessment and intervention to support TAND and improve quality of life in this vulnerable group.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100765"},"PeriodicalIF":1.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tramadol use and risk of seizure: A report of two cases and a review of recent literature 曲马多的使用和癫痫发作的风险：两个病例的报告和最近的文献综述

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Epilepsy and Behavior Reports Pub Date : 2025-03-24 DOI: 10.1016/j.ebr.2025.100763

Emma Dolan , Norman Delanty

{"title":"Tramadol use and risk of seizure: A report of two cases and a review of recent literature","authors":"Emma Dolan , Norman Delanty","doi":"10.1016/j.ebr.2025.100763","DOIUrl":"10.1016/j.ebr.2025.100763","url":null,"abstract":"<div><div>Tramadol is a common pain medication used in practice across numerous specialties. Increased incidence of tramadol abuse and overdose in recent decades has led to it being classified as a controlled drug in several countries. Tramadol appears to be an increasingly popular drug of abuse, possibly related to ease of access to it on prescription, and its potential euphoric effects.</div><div>We identified two cases of seizures directly related to tramadol exposure. We then reviewed recent literature on tramadol and its adverse effects, particularly looking at its effect on seizure risk and the incidence of seizures. We found that there were scarce recent studies on the relationship between tramadol and seizure risk. Of studies found, many were carried out in animal models. Tramadol-induced seizures were studied in humans more commonly in the context of overdose, and studies involving humans tended to have small patient cohorts and suggested further study in the area.</div><div>We suggest that tramadol may be useful as part of multi-modal analgesia in moderate to severe pain in specific contexts, but that greater awareness of its potential adverse effects, and particularly its potential to lower seizure threshold, is warranted. We feel that more readily available information specifically about tramadol’s effects on seizure threshold may be of interest to colleagues from any specialty prescribing opioid analgesia on a regular basis, but that colleagues treating patients with seizure disorders should be particularly aware of these potential adverse effects.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100763"},"PeriodicalIF":1.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and feasibility of exhaustive exercise testing for people with epilepsy 癫痫患者运动测试的安全性和可行性

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Epilepsy and Behavior Reports Pub Date : 2025-03-16 DOI: 10.1016/j.ebr.2025.100762

Franziska van den Bongard , Catharina Petersen , Claus Reinsberger

{"title":"Safety and feasibility of exhaustive exercise testing for people with epilepsy","authors":"Franziska van den Bongard , Catharina Petersen , Claus Reinsberger","doi":"10.1016/j.ebr.2025.100762","DOIUrl":"10.1016/j.ebr.2025.100762","url":null,"abstract":"<div><div>People with epilepsy (PWE) are encouraged to participate in exercise and be physically active, but some PWE may report exercise-associated seizures (EAS). However, there is a lack of objective tools to inform individual recommendations for physical activity and exercise participation in PWE. This study investigated the feasibility and safety of exhaustive exercise testing in PWE. 29 patients underwent an objectively and subjectively exhaustive exercise test on a bicycle ergometer and resting state EEG was obtained before and after exercise. One patient with a history of EAS experienced a seizure immediately after exercising. In patients without EAS, an asymptomatic subclinical electrographic seizure was observed in one patient, and two patients revealed interictal epileptiform discharges only after exercise. All EEG changes occurred in the setting of non-REM sleep, while the respective pre-exercise EEG recordings revealed less sleep. No seizures or significant EEG changes after exercise were observed in any other patient. EEG investigations before and after exhaustive exercise were feasible in PWE, but safety protocols need to be established, especially in patients with EAS. Investigation of a higher number of PWE with and without EAS with repeat exercise-associated EEG may provide information about the clinical utility of exercise-associated EEGs when counseling PWE.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100762"},"PeriodicalIF":1.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study 超高场MRI和图像处理在MRI阴性局灶性癫痫术前检查中的作用：一项经过验证的7T MRI病例研究

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Epilepsy and Behavior Reports Pub Date : 2025-03-15 DOI: 10.1016/j.ebr.2025.100761

Daniel Uher , Gerhard S. Drenthen , Christianne M. Hoeberigs , Rick H.G.J. van Lanen , Albert J. Colon , Roy A.M. Haast , Vivianne H.J.M. van Kranen-Mastenbroek , Guido Widman , Paul A.M. Hofman , Louis G. Wagner , Jan C. Beckervordersandforth , Jacobus F.A. Jansen , Olaf E.M.G. Schijns , Walter H. Backes , on behalf of the ACE study group

{"title":"The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study","authors":"Daniel Uher , Gerhard S. Drenthen , Christianne M. Hoeberigs , Rick H.G.J. van Lanen , Albert J. Colon , Roy A.M. Haast , Vivianne H.J.M. van Kranen-Mastenbroek , Guido Widman , Paul A.M. Hofman , Louis G. Wagner , Jan C. Beckervordersandforth , Jacobus F.A. Jansen , Olaf E.M.G. Schijns , Walter H. Backes , on behalf of the ACE study group","doi":"10.1016/j.ebr.2025.100761","DOIUrl":"10.1016/j.ebr.2025.100761","url":null,"abstract":"<div><div>This case study demonstrates the value of combined 7 T structural and functional MRI in the presurgical workup of a 24-year-old male with drug-resistant focal epilepsy who was initially considered MRI-negative on clinical 3 T MRI. The patient underwent extensive presurgical workup with 7 T MRI, magnetoencephalography, stereo-electroencephalography, and resection of the suspected right frontal epileptogenic zone. Histopathology showed focal cortical dysplasia (FCD) type IIb. The patient remained 11 months after surgery seizure-free. Retrospective analysis revealed that both structural and functional 7 T MRI showed abnormalities within the resected area. Morphometric Analysis Program (MAP18) detected abnormalities on both 3 T and 7 T images. However, abnormalities were more conspicuous on 7 T. Resting-state functional MRI metrics, particularly regional homogeneity and fractional amplitude of low-frequency fluctuations, demonstrated significantly increased values in both a MAP18-defined region of interest and the entire resected area compared to a healthy control group (p < 0.05). However, extensive unspecific abnormalities were also observed outside the resected region, highlighting the importance of a multimodal approach. This case study illustrates that advanced image processing of ultra-high field structural and resting-state functional MRI scans may enhance the detection of subtle epileptogenic lesions in presurgical evaluation, potentially improving post-operative seizure outcome and associated quality of life.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"30 ","pages":"Article 100761"},"PeriodicalIF":1.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0