Epilepsy and Behavior Reports最新文献_第2页

Factors associated with epileptiform discharges in patients visiting a memory clinic: A retrospective study 访问记忆诊所的患者癫痫样放电相关因素：一项回顾性研究。

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.ebr.2026.100853

Katsunori Yokoi , Masashi Tsujimoto , Keisuke Suzuki , Akinori Takeda , Kentaro Horibe , Akiko Yamaoka , Eriko Okada , Osamu Kawakami , Masahisa Katsuno , Yutaka Arahata

{"title":"Factors associated with epileptiform discharges in patients visiting a memory clinic: A retrospective study","authors":"Katsunori Yokoi , Masashi Tsujimoto , Keisuke Suzuki , Akinori Takeda , Kentaro Horibe , Akiko Yamaoka , Eriko Okada , Osamu Kawakami , Masahisa Katsuno , Yutaka Arahata","doi":"10.1016/j.ebr.2026.100853","DOIUrl":"10.1016/j.ebr.2026.100853","url":null,"abstract":"<div><div>Epilepsy is a common comorbidity in older adults, particularly those with neurodegenerative diseases such as Alzheimer’s disease. However, recognizing epilepsy in patients with dementia can be challenging, as its symptoms often mimic cognitive fluctuations. Reliable clinical indicators validated by electroencephalography (EEG) are needed for timely diagnosis and management. This study investigated predictors of epileptiform discharges in patients visiting a memory clinic, focusing on the diagnostic role of EEG. We retrospectively screened 159 patients who underwent medical interviews with physicians and EEG testing between April 2022 and March 2023. Data from dementia-related questionnaires, comprehensive geriatric assessments, EEG, magnetic resonance imaging, and single-photon emission computed tomography were evaluated. Among the 156 patients with dementia (after excluding 3 with epilepsy), 77 exhibited epileptiform discharges, predominantly left temporal (87%) or bilateral (13%), and female patients were more often affected (p < 0.05). Logistic regression analysis revealed that discharges were associated with variable cognitive decline. Approximately two-thirds of patients with epileptiform discharges answered “yes” to the interview item assessing “cognitive decline with variability,” highlighting the predictive value of this symptom. However, the remaining cases required EEG testing for detection. Our findings underscore the importance of recognizing epilepsy during dementia screening. While clinical interviews provide valuable insights, EEG remains indispensable for accurate diagnosis and treatment.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100853"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcortical band heterotopia in a child with new-onset seizures: A case report 新发癫痫患儿皮质下带异位1例。

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.ebr.2026.100852

Nebil Abdella Shukralla , Wengele Mathewos Hunde , Messifn Tibebe , Metti Kuma Dida

{"title":"Subcortical band heterotopia in a child with new-onset seizures: A case report","authors":"Nebil Abdella Shukralla , Wengele Mathewos Hunde , Messifn Tibebe , Metti Kuma Dida","doi":"10.1016/j.ebr.2026.100852","DOIUrl":"10.1016/j.ebr.2026.100852","url":null,"abstract":"<div><div>Subcortical band heterotopia (SBH), also known as “double cortex” syndrome, is a rare neuronal migration disorder characterized by symmetric bands of heterotopic gray matter located between the cerebral cortex and lateral ventricles. It predominantly affects females and typically presents in childhood or adolescence with epilepsy and variable cognitive or motor impairment. We report a 9-year-old girl with normal antenatal, perinatal, developmental, and academic history who presented with a one‑month history of frequent generalized tonic–clonic seizures accompanied by new onset generalized limb weakness. Neurological examination revealed mild, symmetric weakness with brisk deep tendon reflexes but preserved cranial nerve and sensory function. Routine laboratory tests and electroencephalography were unremarkable. Brain magnetic resonance imaging demonstrated classic features of SBH, including bilateral, well-defined bands of gray matter deep to and paralleling the cortical surface, separated from the overlying cortex by intervening white matter and isointense to normal cortex on all sequences. A diagnosis of SBH was made based on these characteristic imaging findings. The patient was started on phenytoin, reflecting local prescribing practices and formulary availability in resource‑limited settings, resulting in effective seizure control and clinical stability on follow‑up; genetic testing for DCX or other implicated genes was not performed due to resource limitations. This case highlights that SBH can present in a developmentally normal child with new-onset generalized seizures and limb weakness, underscores the crucial role of MRI in diagnosis where genetic testing is unavailable, and emphasizes the importance of early recognition and tailored antiepileptic therapy to optimize long‑term neurological outcomes.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100852"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trigeminal neuralgia-like pain in a vagus nerve stimulation super-responder with drug-resistant idiopathic generalized epilepsy: A case report 迷走神经刺激超反应患者伴耐药性特发性全身性癫痫三叉神经痛样疼痛1例报告

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2025-12-24 DOI: 10.1016/j.ebr.2025.100844

Javier Peña-Ceballos , Tenzin Choekyi , Aoife Walsh , Breege Staunton-Grufferty , Vicente Casitas-Hernando , Donncha O’Brien , Norman Delanty

引用次数: 0

Influence of cannabis use on length of stay in patients admitted to the epilepsy monitoring unit 大麻使用对癫痫监测单位收治患者住院时间的影响

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2026-01-02 DOI: 10.1016/j.ebr.2025.100846

Oliver Hoerth , Ejerzain Aniles-Renova , Nan Zhang , Emily Thompson , Kristin A. Kirlin , Joseph Drazkowski

{"title":"Influence of cannabis use on length of stay in patients admitted to the epilepsy monitoring unit","authors":"Oliver Hoerth , Ejerzain Aniles-Renova , Nan Zhang , Emily Thompson , Kristin A. Kirlin , Joseph Drazkowski","doi":"10.1016/j.ebr.2025.100846","DOIUrl":"10.1016/j.ebr.2025.100846","url":null,"abstract":"<div><h3>Purpose</h3><div>Epilepsy affects approximately 50 million people worldwide, many of whom undergo evaluation in Epilepsy Monitoring Units (EMUs) for seizure classification, medication management, or presurgical assessment. With increasing numbers of states legalizing marijuana use, a growing number of EMU admissions involve individuals who use cannabis-based products. If cannabis users are unable to use cannabis products during their EMU admission, this may lead patients to be discharged before recording typical events. This study evaluates the impact of cannabis use on EMU outcomes, specifically length of stay (LOS) and likelihood of capturing a clinical event.</div></div><div><h3>Methods</h3><div>A retrospective chart review was conducted using a REDCap database including demographics, epilepsy risk factors, anti-seizure medication use, social history, urine drug screen results, and final diagnoses. Patients were categorized as users (self-reported use, positive urine test, or both) or non-users (negative test and no self-report). Primary outcomes in the analysis were LOS and event capture rates.</div></div><div><h3>Results</h3><div>Cannabis use was associated with a 0.9 day LOS reduction compared to non-users. Among patients admitted for spell classification, event capturability was 18.1 % higher in cannabis users. Additionally, cannabis users had increased prevalence of psychosocial comorbidities: 12.6 % reported physical abuse, 11.1 % sexual abuse, and 10.2 % mental abuse. Psychiatric diagnoses were also more prevalent; users were 18.9 % more likely to have Major Depressive Disorder and 22.1 % more likely to have Generalized Anxiety Disorder.</div></div><div><h3>Conclusions</h3><div>Cannabis use significantly affects EMU evaluation outcomes and correlates with distinct psychosocial and psychiatric profiles. These findings support a holistic approach in epilepsy patient management.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100846"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility and impact of virtual reality exposure therapy on epilepsy-specific anxiety: Phase 3 of the AnxEpiVR pilot clinical trial 虚拟现实暴露疗法对癫痫特异性焦虑的可行性和影响：AnxEpiVR临床试验3期

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2026-01-03 DOI: 10.1016/j.ebr.2025.100845

Hannah Gabrielle Gray , Danielle Tchao , Samantha Lewis-Fung , Glenda Carman-Gray , Susanna Pardini , Laurence R. Harris , Lora Appel

{"title":"Feasibility and impact of virtual reality exposure therapy on epilepsy-specific anxiety: Phase 3 of the AnxEpiVR pilot clinical trial","authors":"Hannah Gabrielle Gray , Danielle Tchao , Samantha Lewis-Fung , Glenda Carman-Gray , Susanna Pardini , Laurence R. Harris , Lora Appel","doi":"10.1016/j.ebr.2025.100845","DOIUrl":"10.1016/j.ebr.2025.100845","url":null,"abstract":"<div><div>People with epilepsy (PwE) commonly experience interictal anxiety related to their epilepsy and seizures. However, therapeutic interventions have received minimal investigation. This study was the third phase of the “AnxEpiVR” pilot that examined the feasibility and effectiveness of a novel virtual reality exposure therapy (VR-ET) program to treat epilepsy-specific (ES) interictal anxiety in PwE. Participants (N = 5) completed the Epilepsy Anxiety Survey Instrument (EASI), Perceived Stress Scale, Igroup Presence Questionnaire, System Usability Scale, and an adapted version of the diagnostic protocol that Hingray et al. (2019) proposed. They also participated in a semi-structured interview. Participants were assigned to a personally relevant VR-ET scenario (dinner party, shopping mall, or a subway station/train). Over 12 to 14 days within a 14-day period, participants engaged in the VR-ET intervention, progressing through an individualized hierarchy of exposures. Preliminary findings suggest promising feasibility of VR-ET and high tolerability, achieving a 100% completion rate. The EASI scores showed that two of the four participants who scored above the cut-off for a probable anxiety disorder before VR-ET (brief EASI ≥ 7) scored below the cut-off after VR-ET (brief EASI < 7). Subjective reports of the VR-ET’s impact supported the intervention’s potential for reducing ES-interictal anxiety. This trial represents the inaugural use of VR-ET as a potential remote intervention for ES-interictal anxiety. Moreover, these findings support the feasibility of conducting larger clinical trials to further evaluate and to validate VR-ET as a therapeutic tool for managing interictal anxiety in PwE.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100845"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do generalized epilepsies exhibit more attentional or executive disorders? 广泛性癫痫是否表现出更多的注意力或执行障碍？

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2026-03-01 Epub Date: 2025-12-24 DOI: 10.1016/j.ebr.2025.100843

Bertille Lacour , Vincent Heintz , Natacha Forthoffer , Serge Chassagnon , Alain Jager , Louis Maillard , Helene Brissart

{"title":"Do generalized epilepsies exhibit more attentional or executive disorders?","authors":"Bertille Lacour , Vincent Heintz , Natacha Forthoffer , Serge Chassagnon , Alain Jager , Louis Maillard , Helene Brissart","doi":"10.1016/j.ebr.2025.100843","DOIUrl":"10.1016/j.ebr.2025.100843","url":null,"abstract":"<div><div>This study aimed to characterize attentional and executive dysfunctions in patients with genetic generalized epilepsies (GGE), using specific and validated neuropsychological tools. Secondary objectives included estimating the prevalence of cognitive impairments and exploring potential clinical and psychosocial determinants. A total of 69 adult patients with GGE were enrolled in this multicentric observational study. Participants completed screening questionnaires for anxiety and depression and underwent a battery of neuropsychological tests assessing four attentional components (alertness, sustained, selective, and divided attention), executive functions (flexibility, inhibition, verbal initiation and auditory working memory). Attentional and executive impairments were highly prevalent, affecting approximately 60–64 % of the cohort. Divided attention was the most frequently impaired attentional component (44.93 %), while mental flexibility was the most commonly affected executive function (39.68 %). Selective and sustained attention were relatively preserved. Working memory manipulation was impaired in 17.4 % of patients. Cognitive performance was weakly influenced by clinical and psychosocial factors. Anxiety or depression was associated with poorer divided attention, epilepsy duration with lower selective attention, and education and number of anti-seizure medications with better performance across selective, sustained, and executive attention domains. These findings highlight the need for targeted neuropsychological assessments in GGE, prioritizing divided attention and flexibility. Since divided attention reflects both attentional control and working memory interventions focusing on working memory may offer greater clinic utility. Given the scarcity of studies on cognition rehabilitation in epilepsy, further research is needed, particularly on divided attention as a potential cognitive remediation target.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"33 ","pages":"Article 100843"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cannabis in epilepsy illustrated by two case reports 两个病例报告说明了大麻在癫痫中的作用

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-07-08 DOI: 10.1016/j.ebr.2025.100804

Santiago Philibert-Rosas , Cameron J. Brace , Sanaa Semia , Barry E. Gidal , Bradley T. Nix , Anne F. Josiah , Melanie Boly , Aaron F. Struck

{"title":"The role of cannabis in epilepsy illustrated by two case reports","authors":"Santiago Philibert-Rosas , Cameron J. Brace , Sanaa Semia , Barry E. Gidal , Bradley T. Nix , Anne F. Josiah , Melanie Boly , Aaron F. Struck","doi":"10.1016/j.ebr.2025.100804","DOIUrl":"10.1016/j.ebr.2025.100804","url":null,"abstract":"<div><div>Cannabis use is increasingly prevalent among individuals with epilepsy, yet its impact on seizure control remains poorly understood. While cannabidiol (CBD) has demonstrated antiseizure properties and gained FDA approval for specific epileptic syndromes, tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, may alter neuronal excitability and potentially exacerbate seizure activity. We present two illustrative case reports of male patients with focal epilepsy and chronic cannabis use who underwent treatment with antiseizure medications and responsive neurostimulation (RNS). In both cases, cannabis use was temporally associated with breakthrough seizures and poor seizure control. These cases highlight the complex and multifactorial relationship between cannabis use and seizure outcomes, including potential pharmacokinetic interactions with antiseizure medications (ASM) and the possibility that cannabis may blunt the neuromodulation effects of RNS. Given the retrospective data and limited detail on cannabis use, these findings should be interpreted with caution. As cannabis use rises among individuals with epilepsy, further research is needed to clarify its potential effects on seizures and treatment response, including neuromodulation.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100804"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroceuticals for Motherhood: Utility of responsive neurostimulation and Proactive antiseizure medication management in two pregnancies 母性电治疗：反应性神经刺激和主动抗癫痫药物管理在两次妊娠中的效用

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-11-18 DOI: 10.1016/j.ebr.2025.100838

Aisha Abdulrazaq , Dorothee Kasteleijn , Thomas Henry , Sandipan Pati

{"title":"Electroceuticals for Motherhood: Utility of responsive neurostimulation and Proactive antiseizure medication management in two pregnancies","authors":"Aisha Abdulrazaq , Dorothee Kasteleijn , Thomas Henry , Sandipan Pati","doi":"10.1016/j.ebr.2025.100838","DOIUrl":"10.1016/j.ebr.2025.100838","url":null,"abstract":"<div><div>Females with drug-resistant epilepsy (DRE) face unique challenges in balancing seizure control with the teratogenic risks of anti-seizure medications (ASMs) during pregnancy. This case study highlights the use of responsive neurostimulation (RNS) as an electroneuromodulatory strategy to enable safer pregnancies by reducing ASM burden while maintaining seizure control. A 25-year-old woman with bilateral limbic epilepsy secondary to autoimmune encephalitis underwent RNS implantation targeting the hippocampi. Over a multi-year preconception planning period, RNS optimization allowed for tapering of high-risk ASMs and stabilization of seizure frequency. Across two pregnancies, neuromodulation enabled stable epilepsy control and reduced reliance on polytherapy, despite pharmacokinetic ASM variability. Both pregnancies resulted in healthy infants with no major congenital anomalies, despite episodes of breakthrough seizures. This case underscores the transformative potential of RNS in the reproductive care of women with DRE—not only by improving maternal safety but also by reducing fetal exposure to teratogenic drugs. As the first report to demonstrate how RNS can facilitate pregnancy planning with details on how ASM was minimized and complex therapeutic monitoring, this study sets the stage for integrating electroneuromodulation into preconception counselling and epilepsy management for women of childbearing age.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100838"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early detection of antiseizure medication inefficacy using an implantable continuous EEG system and a personalized model: a case study 使用可植入连续脑电图系统和个性化模型早期检测抗癫痫药物无效：一个案例研究

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-09-23 DOI: 10.1016/j.ebr.2025.100829

A. Reynolds , A. Lai , D.B. Grayden , M.J. Cook , A. Peterson

{"title":"Early detection of antiseizure medication inefficacy using an implantable continuous EEG system and a personalized model: a case study","authors":"A. Reynolds , A. Lai , D.B. Grayden , M.J. Cook , A. Peterson","doi":"10.1016/j.ebr.2025.100829","DOIUrl":"10.1016/j.ebr.2025.100829","url":null,"abstract":"<div><div>Evaluating anti-seizure medication (ASM) efficacy can be limited by inaccurate seizure diaries and periodic fluctuations in seizure frequency, known as seizure cycles. These limitations may prolong monitoring of ineffective treatments. This study explores implantable continuous EEG monitoring (iCEM™) with Epiminder’s Minder® system and timeseries modelling to improve efficacy assessments.</div><div>This retrospective case study examines a 49-year-old female with drug-resistant focal epilepsy with iCEM (Nov. 2019). The participant maintained a seizure diary and was followed-up for 3 years. ASMs were changed in Aug.-Oct. 2020. A personalised autoregressive model incorporating interictal epileptiform discharge cycles to project 3-monthly seizure rates was trained and validated on post-drug data then tested on four held-out datasets (two pre-drug and two post-drug). The Kruskal-Wallis test assessed model performance between drug periods (α = 0.05).</div><div>Only 37 % of seizures were reported. Post-drug, diary-reported seizures increased while detected seizures decreased, but both remained within normal seizure rate variability. ASM inefficacy was addressed after 3 years. The autoregressive model mean squared error post-drug was 0.17 and 0.13 seizures per day over 3-months<sup>2</sup>, which were significantly different from pre-drug (0.49 and 0.58 seizures per day over 3-months<sup>2</sup>, <span><math><mi>H</mi></math></span>=336.82, p = 2.44exp.<sup>-89</sup>), suggesting the model could recognise when an altered drug regimen affected seizure rate and interictal epileptiform discharges.</div><div>Seizures identified using iCEM combined with an individualised model may be able to distinguish drug-induced changes in seizure rate from normal variability. This proof-of-concept study offers useful information towards the development of methods that can support early treatment assessments, potentially shortening the time to find an optimal therapy.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100829"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significant seizure frequency reduction in a patient with refractory bitemporal epilepsy following transition from high-frequency to low-frequency responsive neurostimulation 难治性双颞叶癫痫患者从高频反应性神经刺激过渡到低频反应性神经刺激后癫痫发作频率显著降低

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2025-12-01 Epub Date: 2025-08-11 DOI: 10.1016/j.ebr.2025.100822

Stacey Kim , Christel Benny , Alan Salim , Charles Liu , Brian Lee , Hari Prasad Kunhi Veedu

{"title":"Significant seizure frequency reduction in a patient with refractory bitemporal epilepsy following transition from high-frequency to low-frequency responsive neurostimulation","authors":"Stacey Kim , Christel Benny , Alan Salim , Charles Liu , Brian Lee , Hari Prasad Kunhi Veedu","doi":"10.1016/j.ebr.2025.100822","DOIUrl":"10.1016/j.ebr.2025.100822","url":null,"abstract":"<div><div>While many patients treated with Responsive Neurostimulation (RNS) experience a significant reduction in seizures, poor responders to traditional high frequency stimulation (HFS) may experience a meaningful reduction in seizure frequency when switched to low frequency stimulation (LFS). This case report presents a patient who developed post-traumatic pharmacoresistant bitemporal epilepsy and underwent unsuccessful treatments, including antiseizure polytherapy and implantation of a vagus nerve stimulator (VNS). Due to ongoing seizures, the patient underwent RNS System implantation with bilateral hippocampal depth electrodes. Prior to RNS implantation, the patient experienced a median frequency of 6.5 seizures per month. At traditional HFS settings applied for 30 months, the patient experienced a 31 % reduction from baseline. After switching to LFS for 8 months, the patient experienced an 85 % reduction. HFS delivered 6.02 min per day, compared to 113.77 min per day with LFS. This patient experienced a substantial and meaningful reduction in seizure frequency after switching to LFS, suggesting that LFS may be an effective alternative for RNS patients who do not have a satisfactory seizure reduction to traditional HFS. Furthermore, this case report highlights the importance of collaboration between academic medical centers with public safety net hospitals in delivering advanced epilepsy care to people in underserved communities.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100822"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0