Epilepsy and Behavior Reports最新文献_第3页

Electroconvulsive therapy in psychoses of epilepsy – A forgotten alternative 癫痫精神病的电休克疗法——一种被遗忘的替代疗法

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-07-12 DOI: 10.1016/j.ebr.2025.100806

Mariana Roque Gonçalves , Alzira Silva , Celeste Silveira

{"title":"Electroconvulsive therapy in psychoses of epilepsy – A forgotten alternative","authors":"Mariana Roque Gonçalves , Alzira Silva , Celeste Silveira","doi":"10.1016/j.ebr.2025.100806","DOIUrl":"10.1016/j.ebr.2025.100806","url":null,"abstract":"<div><div>This case report discusses a 35-year-old woman with refractory temporal lobe epilepsy and no prior psychiatric history who developed persecutory, erotomanic and megalomaniac ideations, auditory hallucinations, and dysphoric mood. Psychiatric symptoms, including psychosis, are well-documented in patients with epilepsy, posing unique management challenges due to potential interactions between antiepileptic and antipsychotic medications. In this case, the patient demonstrated persistent epileptiform activity on electroencephalogram despite treatment with three antiepileptic drugs. Concurrently, standard antipsychotic treatments were ineffective, suggesting drug-resistant psychosis. Notably, complete remission of psychotic symptoms was achieved with electroconvulsive therapy (ECT), a well-established intervention for various psychiatric conditions but rarely reported in the context of epilepsy-associated psychosis. This case underscores the need for novel therapeutic approaches in managing complex comorbidities like drug-resistant psychosis in epilepsy. It also highlights the potential role of ECT as a safe and effective treatment option in these challenging clinical scenarios.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100806"},"PeriodicalIF":1.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing knowledge, attitudes, and misconceptions about epilepsy among University of Venda students: A call for enhanced education and awareness 评估文达大学学生对癫痫的知识、态度和误解：呼吁加强教育和认识

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-07-12 DOI: 10.1016/j.ebr.2025.100807

A.E. Ndou , L. Makhado , O.P. Netshisaulu

{"title":"Assessing knowledge, attitudes, and misconceptions about epilepsy among University of Venda students: A call for enhanced education and awareness","authors":"A.E. Ndou , L. Makhado , O.P. Netshisaulu","doi":"10.1016/j.ebr.2025.100807","DOIUrl":"10.1016/j.ebr.2025.100807","url":null,"abstract":"<div><div>Epilepsy is a neurological disorder affecting individuals of all ages, often surrounded by stigma and misconceptions. Despite its prevalence, awareness about epilepsy is limited, particularly among university students. This study investigates the knowledge, attitudes, and perceptions of students at the University of Venda regarding epilepsy to identify gaps and improve educational strategies. A cross-sectional survey was conducted with students from various faculties at the University of Venda. Participants completed a structured questionnaire that collected demographic information and assessed their knowledge about epilepsy, attitudes towards individuals with the condition, and perceptions of public awareness. The survey included questions about awareness of epilepsy, understanding its causes and management, and views on the rights of people living with epilepsy. A total of 326 students participated in the survey. The survey showed that approximately 92.9% of students had heard of epilepsy, but many misconceptions remained. A significant number believed that epilepsy is untreatable and that those with the condition should not drive or participate in certain activities. Only 18.7% knew the correct management practices for seizures. Furthermore, 67% of students felt that insufficient attention was given to epilepsy, yet the study increased interest in learning more, as over 92.9% expressed a desire for additional information. The findings highlight the need for better education about epilepsy among university students to dispel myths and promote informed attitudes. Educational initiatives focused on seizure management and inclusivity could create a more supportive environment for individuals with epilepsy at the University of Venda and beyond.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100807"},"PeriodicalIF":1.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autosomal dominant Kufs disease in a Georgian adult woman: A case report 常染色体显性库夫斯病在格鲁吉亚成年妇女：1例报告

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-07-10 DOI: 10.1016/j.ebr.2025.100805

Nikoloz Papiashvili , Sopio Gagua , Nana Gonjilashvili , Natela Okujava , Aleksandre Tsereteli

引用次数: 0

The role of cannabis in epilepsy illustrated by two case reports 两个病例报告说明了大麻在癫痫中的作用

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-07-08 DOI: 10.1016/j.ebr.2025.100804

Santiago Philibert-Rosas , Cameron J. Brace , Sanaa Semia , Barry E. Gidal , Bradley T. Nix , Anne F. Josiah , Melanie Boly , Aaron F. Struck

{"title":"The role of cannabis in epilepsy illustrated by two case reports","authors":"Santiago Philibert-Rosas , Cameron J. Brace , Sanaa Semia , Barry E. Gidal , Bradley T. Nix , Anne F. Josiah , Melanie Boly , Aaron F. Struck","doi":"10.1016/j.ebr.2025.100804","DOIUrl":"10.1016/j.ebr.2025.100804","url":null,"abstract":"<div><div>Cannabis use is increasingly prevalent among individuals with epilepsy, yet its impact on seizure control remains poorly understood. While cannabidiol (CBD) has demonstrated antiseizure properties and gained FDA approval for specific epileptic syndromes, tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, may alter neuronal excitability and potentially exacerbate seizure activity. We present two illustrative case reports of male patients with focal epilepsy and chronic cannabis use who underwent treatment with antiseizure medications and responsive neurostimulation (RNS). In both cases, cannabis use was temporally associated with breakthrough seizures and poor seizure control. These cases highlight the complex and multifactorial relationship between cannabis use and seizure outcomes, including potential pharmacokinetic interactions with antiseizure medications (ASM) and the possibility that cannabis may blunt the neuromodulation effects of RNS. Given the retrospective data and limited detail on cannabis use, these findings should be interpreted with caution. As cannabis use rises among individuals with epilepsy, further research is needed to clarify its potential effects on seizures and treatment response, including neuromodulation.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"32 ","pages":"Article 100804"},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lateralization discordance between stereo EEG and scalp EEG in temporal epilepsy: A case report 颞叶癫痫立体脑电图与头皮脑电图侧位不一致1例

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-07-05 DOI: 10.1016/j.ebr.2025.100803

Spencer Gunnell, Audrey Nath, Patrick Karas, Todd Masel

引用次数: 0

Brain tumours as an unrecognized etiology of infantile epileptic spasms syndrome (IESS): The role of resective epilepsy surgery 脑肿瘤作为婴儿癫痫痉挛综合征（IESS）的未知病因：切除癫痫手术的作用

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-07-04 DOI: 10.1016/j.ebr.2025.100802

Rowan Pentz , Kevin Jones , Ronit Mesterman , Rajesh RamachandranNair , Hiroshi Otsubo , Ayako Ochi , Ivanna Yau , Elizabeth J Donner , George M Ibrahim , Puneet Jain , Robyn Whitney

{"title":"Brain tumours as an unrecognized etiology of infantile epileptic spasms syndrome (IESS): The role of resective epilepsy surgery","authors":"Rowan Pentz , Kevin Jones , Ronit Mesterman , Rajesh RamachandranNair , Hiroshi Otsubo , Ayako Ochi , Ivanna Yau , Elizabeth J Donner , George M Ibrahim , Puneet Jain , Robyn Whitney","doi":"10.1016/j.ebr.2025.100802","DOIUrl":"10.1016/j.ebr.2025.100802","url":null,"abstract":"<div><div>Brain tumours are a rare cause of infantile epileptic spasm syndrome (IESS). Epilepsy surgery may be utilized in refractory IESS due to tumours, although reports are limited. We report an illustrative case of IESS which resolved after tumour resection and performed a literature review of all reported cases of brain tumours causing IESS with hypsarrhythmia. We present a 10-month-old girl with drug-resistant symmetric epileptic spasms (ES). Initial EEG showed symmetric hypsarrhythmia and brain MRI demonstrated a left temporal lobe tumour. Despite non-focal clinical and EEG findings, she underwent tumour resection at 21 months (ganglioglioma). She subsequently had resolution of ES and hypsarrhythmia and developmental gains. Twenty-seven published cases of brain tumours and IESS were reviewed. ES were refractory to medical management in 74 % of reported cases (17/23). ES were symmetric in 17/21 (81 %) and asymmetric in 4/21 (19 %) specified cases. Hypsarrhythmia pattern was asymmetric in 10/20 (50 %) specified cases. Of 21 surviving patients who underwent surgery, 13 (62 %) were seizure free at follow-up and only 1 (5 %) had no improvement. Developmental outcomes were available in 19/21 (90 %) surviving surgical patients and 10/19 had improvements (52 %); 6/19 had normalized development (32 %). Various tumour types were reported and a temporal or frontal location was most common. Brain tumours can cause IESS with or without clinical or EEG focality and are amenable to surgical treatment. We emphasize that the absence of focal signs should not delay surgical assessment for patients with refractory IESS and brain tumours.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100802"},"PeriodicalIF":1.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GAD65-positive autoimmune-associated epilepsy presenting with Ictal Hand Kissing; an uncommon presentation of a rare disease gad65阳性的自身免疫相关癫痫，表现为纵向吻手；罕见病的罕见表现

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-07-01 DOI: 10.1016/j.ebr.2025.100801

Alia M.R. Fallatah, Hanan M. Abdulmutali, Majed H. Alhameed

引用次数: 0

Rash and edema shortly after initial exposure to low dose cenobamate 初次接触低剂量新奥马酸后不久出现皮疹和水肿

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-27 DOI: 10.1016/j.ebr.2025.100800

Christopher Saouda, Yamane Makke, Helen Edelberg, Mohamad Z. Koubeissi

引用次数: 0

Synergistic seizure reduction in patient with persistently elevated N-desmethylclobazam levels, CYP450 genetic polymorphism, and responsive neurostimulator targeting centromedian nuclei of bilateral thalami 持续升高的n -去甲基氯巴唑水平、CYP450基因多态性和双侧丘脑正中核反应性神经刺激剂对癫痫发作的协同减少作用

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-25 DOI: 10.1016/j.ebr.2025.100799

Andrew Zillgitt , David E Burdette , Atheel Yako , Revati Rashingkar , Ashleigh Terrell , Sydney Jacobs , Michael D Staudt

{"title":"Synergistic seizure reduction in patient with persistently elevated N-desmethylclobazam levels, CYP450 genetic polymorphism, and responsive neurostimulator targeting centromedian nuclei of bilateral thalami","authors":"Andrew Zillgitt , David E Burdette , Atheel Yako , Revati Rashingkar , Ashleigh Terrell , Sydney Jacobs , Michael D Staudt","doi":"10.1016/j.ebr.2025.100799","DOIUrl":"10.1016/j.ebr.2025.100799","url":null,"abstract":"<div><div>Clobazam (CLB) and cenobamate (CNB) are commonly used antiseizure medications (ASMs) in the treatment of patients with drug-resistant epilepsy (DRE). However, concomitant use of these two ASMs may lead to significant treatment-related adverse events (TRAE). Furthermore, these TRAE may be exacerbated in individuals with genetic polymorphisms involving the P450 system. In patients with DRE, epilepsy surgery, including neuromodulation, may lead to improved seizure control and a reduction in systemic TRAE from ASMs. This case report describes a patient with drug-resistant idiopathic generalized epilepsy (IGE) who experienced persistent excessive somnolence correlated with elevated N-desmethylclobazam (N-CLB) levels. Pharmacogenetic testing revealed poor metabolism of CYP2C19, and N-CLB levels remained elevated and detectable for nearly one year after the discontinuation of treatment with CLB and CNB. Responsive neurostimulator (RNS) implantation within the bilateral centromedian nuclei (CMN) of the thalamus resulted in seizure freedom until N-CLB levels fell, after which there was an 83–93 % reduction in the frequency of generalized tonic-clonic seizures (GTC).</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"31 ","pages":"Article 100799"},"PeriodicalIF":1.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The posterior insula as an independent pain center: Two cases of isolated facial pain-type epilepsy revealed by stereo-electroencephalography 脑岛后部作为独立的疼痛中枢：立体脑电图显示孤立性面部疼痛型癫痫2例

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2025-06-21 DOI: 10.1016/j.ebr.2025.100798

Jun Zhuang , Lingxia Fei , Hua Li , Qiang Guo

引用次数: 0