抗癫痫药物及其对心血管风险的不同影响

IF 1.8 Q3 CLINICAL NEUROLOGY
Aleena Abbasi , Bassil Abbasi , Scott Mintzer , Carla LoPinto-Khoury
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引用次数: 0

摘要

这篇综述讨论了酶诱导和非诱导抗癫痫药物对心血管风险的不同影响及其对癫痫患者管理策略的影响。传统的风险标志物,包括低密度脂蛋白、高密度脂蛋白和甘油三酯,可以通过酶的诱导和抑制来改变。其他血管危险指标,包括c反应蛋白、非高密度脂蛋白和同型半胱氨酸,都受到抗癫痫药物的影响,尽管成人和儿童可能有不同的反应。由于神经内分泌功能和代谢综合征等间接影响,总的动脉粥样硬化风险情况更为复杂。大量数据显示,人们对心血管疾病风险的认识在不断发展。当研究单独检查药物时,酶诱导抗癫痫药物和丙戊酸的长期风险是明显的。最后,本文讨论了抗癫痫药物对心律和可能的自主神经控制的影响,以及它们与临床医生的临床相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antiseizure medications and their differing effects on cardiovascular risk
This review discusses the differing effects of enzyme-inducing and non-inducing antiseizure medications on cardiovascular risk and their implications for the management strategies of epilepsy patients. Traditional risk markers, including low density lipoprotein, high density lipoprotein and triglycerides, can be altered by both enzyme induction and inhibition. Other markers of vascular risk, including c-reactive protein, non-high-density lipoprotein and homocysteine, are affected by antiseizure medications, although adults and children may have different responses. The overall atherosclerotic risk picture is more complex due to indirect effects such as neuroendocrine function and the metabolic syndrome. Large scale data shows an evolving understanding of cardiovascular risk. Long term risks of enzyme inducing antiseizure medications and valproic acid are apparent when studies examine medications individually. Finally, effects of antiseizure medications on cardiac rhythm and possibly autonomic control are discussed with respect to their clinical relevance to the practicing clinician.
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来源期刊
Epilepsy and Behavior Reports
Epilepsy and Behavior Reports Medicine-Neurology (clinical)
CiteScore
2.70
自引率
13.30%
发文量
54
审稿时长
50 days
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