Journal of Inorganic Biochemistry最新文献

{"title":"Influence of the second coordination sphere on O₂ activation by a nonheme iron(II) thiolate complex.","authors":"Sudha Yadav, Robert S Lyons, Zoe Readi-Brown, Maxime A Siegler, David P Goldberg","doi":"10.1016/j.jinorgbio.2024.112776","DOIUrl":"https://doi.org/10.1016/j.jinorgbio.2024.112776","url":null,"abstract":"<p><p>The synthesis and characterization of a new ligand, 1-(bis(pyridin-2-ylmethyl) amino)-2-methylpropane-2-thiolate (BPA^Me2S^-) and its nonheme iron complex, Fe^II(BPA^Me2S)Br (1), is reported. Reaction of 1 with O₂ at -20 °C generates a high-spin iron(III)-hydroxide complex, [Fe^III(OH)(BPA^Me2S)(Br)] (2), that was characterized by UV-vis, ⁵⁷Fe Mössbauer, and electron paramagnetic resonance (EPR) spectroscopies, and electrospray ionization mass spectrometry (ESI-MS). Density functional theory (DFT) calculations were employed to support the spectroscopic assignments. In a previous report (J. Am. Chem. Soc.2024, 146, 7915-7921), the related iron(II) complex, Fe^II(BNPA^Me2S)Br (BNPA^Me2S^- = (bis((6-(neopentylamino)pyridinyl) methyl)amino)-2-methylpropane-2-thiolate) was reported and shown to react with O₂ at low temperature to give a rare iron(III)-superoxide intermediate, which then converts to an S‑oxygenated sulfinate as seen for the nonheme iron thiol dioxygenases. This complex includes two hydrogen bonding neopentylamino groups in the second coordination sphere. Complex 1 does not include these H-bonding groups, and its reactivity with O₂ does not yield a stabilized Fe/O₂ intermediate or S‑oxygenated products, although the data suggest an inner-sphere mechanism and formation of an iron‑oxygen species that is capable of abstracting hydrogen atoms from solvent or weak CH bond substrates. This study indicates that the H-bond donors are critical for stabilizing the Fe^III(O₂^-•) intermediate with the BNPA^Me2S^- ligand, which in turn leads to S‑oxygenation, as opposed to H-atom abstraction, following O₂ activation by the nonheme iron center_.</p>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"264 ","pages":"112776"},"PeriodicalIF":3.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological iron chelators pyrophosphate and citrate have different effects on the proportions of monoferric transferrin metalloforms","authors":"Shelby T. Harris,&nbsp;Jordan Gardner,&nbsp;Alexia Davis,&nbsp;Julia Steed,&nbsp;Steven Christiansen,&nbsp;Stewart Ryberg,&nbsp;Weston Ludlow,&nbsp;Mitchell Pendleton,&nbsp;Blake Grimshaw,&nbsp;Richard K. Watt","doi":"10.1016/j.jinorgbio.2024.112773","DOIUrl":"10.1016/j.jinorgbio.2024.112773","url":null,"abstract":"<div><div>Human serum transferrin can bind up to two iron atoms, one in each of its two domains which are known as the N-lobe and the C-lobe. Ferric pyrophosphate and ferric citrate have been shown to direct loading into the C-lobe and N-lobe, respectively. We report that the iron supplement ferric pyrophosphate citrate directs iron to the C-lobe. We also show that pyrophosphate directs iron to the C-lobe as a free anion even at the concentrations found in human plasma. This indicates that pyrophosphate may play a physiological role in transferrin iron loading and body iron homeostasis. We also present a validation of an existing micellar capillary electrophoresis technique for separating the four transferrin metalloforms, which has potential to be adapted for use in a clinical setting.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"263 ","pages":"Article 112773"},"PeriodicalIF":3.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myxinidin-analogs able to sequester Fe(III): Metal-based gun to combat Pseudomonas aeruginosa biofilm","authors":"Rosa Bellavita ,&nbsp;Bruno Casciaro ,&nbsp;Valeria Nocerino ,&nbsp;Sara Palladino ,&nbsp;Maria Rosa Loffredo ,&nbsp;Principia Dardano ,&nbsp;Luca De Stefano ,&nbsp;Lucia Falcigno ,&nbsp;Gabriella D'Auria ,&nbsp;Stefania Galdiero ,&nbsp;Annarita Falanga","doi":"10.1016/j.jinorgbio.2024.112774","DOIUrl":"10.1016/j.jinorgbio.2024.112774","url":null,"abstract":"<div><div>Bacteria have developed a tendency to form biofilms, where bacteria live in organized structures embedded in a self-produced matrix of DNA, proteins, and polysaccharides. Additionally, bacteria need iron(III) as an essential nutrient for bacterial growth and secrete siderophore groups that sequester it from the environment. To design a molecule able both to inhibit the bacteria and to sequester iron, we developed two hydroxamate-based peptides derived from an analog (WMR-4), previously developed in our lab, of the antimicrobial peptide myxinidin.</div><div>In detail, we proposed a combination of WMR-4 with the hydroxamic acid resulting in the peptides WMR-7 and WMR-16 which differ for the length of the linker between the antimicrobial moiety and the siderophore. Both peptides were characterized through a set of different biophysical experiments to investigate their ability to sequester Fe³⁺. The peptide‑iron(III) complexes were studied through the UV–visible spectroscopy in organic solvent to eliminate water competition, and in acidic water to avoid iron precipitation. The complexes were also characterized by performing electrochemistry, circular dichroism and NMR spectroscopy experiments. In addition, we demonstrated the ability of peptide‑iron(III) complexes to inhibit the biofilm of <em>Pseudomonas aeruginosa</em> and to have an impact on the cell motility. This metal-based approach consisting in a hydroxamic acid conjugation represents a promising strategy to enhance the antibiofilm activity of antimicrobial peptides against one of most dangerous bacteria such as <em>Pseudomonas aeruginosa.</em></div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"263 ","pages":"Article 112774"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting bacterial efflux pump effectively enhances the efficacy of Ru-based antibacterial agents against Gram-negative pathogen","authors":"Yun Song ,&nbsp;Jing Wang ,&nbsp;Yajun Sun ,&nbsp;Shijia Dong ,&nbsp;Guangying Yu ,&nbsp;Wenjing Lin ,&nbsp;Yinhua Xiong ,&nbsp;Yanhui Tan ,&nbsp;Yanshi Xiong ,&nbsp;Guijuan Jiang ,&nbsp;Jintao Wang ,&nbsp;Xiangwen Liao ,&nbsp;Lianghong Liu","doi":"10.1016/j.jinorgbio.2024.112772","DOIUrl":"10.1016/j.jinorgbio.2024.112772","url":null,"abstract":"<div><div>The rise of antibiotic resistance has posed a great threat to human's life, thus develop novel antibacterial agents is urgently needed. It worthies to noted that Ru-based antibacterial agents often showed robust potency against Gram-positive pathogens, disrupted bacterial membrane and avoided bacterial resistance, making they promising antibiotic candidates. However, they are generally less active when applied to negative pathogens. To address this problem, a Ru-based metalloantibiotic (<strong>RuN</strong>) modified with a nitrothiophene moiety, which can target bacterial efflux pump, was designed and evaluated in this work. A series of assays demonstrated that <strong>RuN</strong> not only fully retained the advantages of Ru-based agents, such as destroyed bacterial membrane and induced reactive oxygen species production, but also can targeted bacterial efflux pumps. Of course, these properties make it effective in killing both Gram-positive and negative pathogens, its MIC values against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em> lies at 3.125 and 6.25 μg/mL, respectively. Importantly, <strong>RuN</strong> also showed low toxicity and has robust anti-infective potency in two animal infection models. Together, our results paved an alternative way to enhance the anti-infective efficacy of Ru-based agents against resistant negative bacteria.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"263 ","pages":"Article 112772"},"PeriodicalIF":3.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Ru(III)/Fe3O4/DNA nanoplatform for photothermal-enhanced photodynamic and chemodynamic cancer therapy","authors":"Jinfeng Zheng ,&nbsp;Xiufeng Wang ,&nbsp;Huan Du ,&nbsp;Ruyan Zhang ,&nbsp;Xiaobing Huo ,&nbsp;Ting Zhou ,&nbsp;Guodong Zhang ,&nbsp;Fang Wang ,&nbsp;Qianxiong Zhou ,&nbsp;Zhiqing Zhang","doi":"10.1016/j.jinorgbio.2024.112771","DOIUrl":"10.1016/j.jinorgbio.2024.112771","url":null,"abstract":"<div><div>Among the many cancer treatment methods, there have been many reports on the use of nanoplatforms with single treatment methods such as photothermal, photodynamic or chemodynamic for cancer treatment. In this study, Ru(III) with photodynamic effect and Fe₃O₄ nanoparticles with photothermal and chemodynamic effects are connected through long DNA chains with efficient active targeting rolling circle amplification to construct Ru(III)/Fe₃O₄/DNA nano-platform realizes the combination of photothermal, photodynamic and chemodynamic treatment, which significantly improves the therapeutic effect of the nano-platform. Its multiple active targeting capabilities reduce the damage to normal cells. Ru(III) has excellent photodynamic effect and can catalyze the respiration product NADH (Nicotinamide adenine dinucleotide)to produce highly oxidizing H₂O₂. Fe₃O₄ NPs has weak absorption at 808 nm indicates that it can perform mild photothermal treatment, and the Fe²⁺ in it can react with H₂O₂ to produce ·OH and participate in chemodynamic treatment. Each repeating unit on the rolling circle amplified DNA long chain is connected to the AS1411 aptamer that can actively target cancer cells. Unlike the passive targeting of other nanomedicines, active and efficient targeting is achieved, and a small amount of drugs can achieve high efficacy. The therapeutic effect also reduces the damage to normal cells. The comprehensive killing effect of Ru(III)/Fe₃O₄/DNA can reach 85.1 %. Its high targeting of cancer cells can also be used for imaging detection of cancer cells. This new nanoplatform provides an idea for the synergy of multiple cancer treatments.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"262 ","pages":"Article 112771"},"PeriodicalIF":3.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring divalent metal ion coordination. Unraveling binding modes in Staphylococcus aureus MntH fragments","authors":"Valentyn Dzyhovskyi ,&nbsp;Maurizio Remelli ,&nbsp;Kamila Stokowa-Sołtys","doi":"10.1016/j.jinorgbio.2024.112769","DOIUrl":"10.1016/j.jinorgbio.2024.112769","url":null,"abstract":"<div><div>Metal ion coordination is crucial in bacterial metabolism, while divalent metal ions serve as essential cofactors for various enzymes involved in cellular processes. Therefore, bacteria have developed sophisticated regulatory mechanisms to maintain metal homeostasis. These involve protein interactions for metal ion uptake, efflux, intracellular transport, and storage. <em>Staphylococcus aureus</em>, a member of the commensal flora, colonizes the anterior nares and skin harmlessly but can cause severe illness. MntH transporter is responsible for acquiring divalent metal ions necessary for metabolic functions and virulence. It is a 450-amino-acid protein analogous to Nramp1 (Natural Resistance-Associated Macrophage Protein 1) in mammals. Herein, the coordination modes of copper(II), iron(II), and zinc(II) ions with select fragments of the MntH were established employing potentiometry, mass spectrometry, and spectroscopic methods. Four model peptides, MNNKRHSTNE–NH₂, Ac-KFDHRSS–NH₂, Ac-IMPHNLYLHSSI–NH₂, and Ac-YSRHNNEE–NH₂, were chosen for their metal-binding capabilities and examined to determine their coordination properties and preferences. Our findings suggest that under physiological pH conditions, the N-terminal fragment of MntH demonstrates the highest thermodynamic stability with copper(II) and iron(II) ions. Furthermore, a comparison with other peptides from the <em>S. aureus</em> FeoB transporter indicates different binding affinities.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"263 ","pages":"Article 112769"},"PeriodicalIF":3.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinoline- and coumarin-based ligands and their rhenium(I) tricarbonyl complexes: synthesis, spectral characterization and antiproliferative activity on T-cell lymphoma","authors":"Martina Piškor ,&nbsp;Ivan Ćorić ,&nbsp;Berislav Perić ,&nbsp;Katarina Mišković Špoljarić ,&nbsp;Srećko I. Kirin ,&nbsp;Ljubica Glavaš-Obrovac ,&nbsp;Silvana Raić-Malić","doi":"10.1016/j.jinorgbio.2024.112770","DOIUrl":"10.1016/j.jinorgbio.2024.112770","url":null,"abstract":"<div><div>Novel 6-substituted 2-(trifluoromethyl)quinoline <strong>5a</strong>–<strong>5e</strong> and coumarin <strong>6a</strong>–<strong>6d</strong> ligands with aldoxime ether linked pyridine moiety were synthesized by <em>O</em>-alkylation of quinoline and coumarin with (<em>E</em>)-picolinaldehyde oxime and subsequently with [Re(CO)₅Cl] gave rhenium(I) tricarbonyl complexes <strong>5a</strong>_{<strong>Re</strong>}–<strong>5e</strong>_{<strong>Re</strong>} and <strong>6a</strong>_{<strong>Re</strong>}–<strong>6d</strong>_{<strong>Re</strong>} that were fully characterized by NMR, single-crystal X-ray diffraction, IR and UV–Vis spectroscopy. The results of antiproliferative evaluation of quinoline and coumarin ligands and their rhenium(I) tricarbonyl complexes on various human tumor cell lines, including acute lymphoblastic leukemia (CCRF-CEM), acute monocytic leukemia (THP1), cervical adenocarcinoma (HeLa), colon adenocarcinoma (CaCo-2), T-cell lymphoma (HuT78), and non-tumor human fibroblasts (BJ) showed that the quinoline complexes <strong>5a</strong>_{<strong>Re</strong>}–<strong>5e</strong>_{<strong>Re</strong>} had higher inhibitory activity than coumarin complexes <strong>6a</strong>_{<strong>Re</strong>}–<strong>6d</strong>_{<strong>Re</strong>}, particularly against T-cell lymphoma (HuT78) cells. 6-Methoxy-2-(trifluoromethyl)quinoline <strong>5e</strong> and 6-methylcoumarin <strong>6d</strong>, and their rhenium(I) tricarbonyl complexes <strong>5e</strong>_{<strong>Re</strong>} and <strong>6d</strong>_{<strong>Re</strong>} were found to arrest the cell cycle of HuT78 cells by causing a significant accumulation of cells in the G0/G1 phase and a marked decrease in the number of cells in the G2/M phase. These rhenium(I) tricarbonyl complexes also slightly increased ROS production and significantly decreased the mitochondrial membrane potential by 50 % (<strong>5e</strong>_{<strong>Re</strong>}) and 45 % (<strong>6d</strong>_{<strong>Re</strong>}) compared to untreated cells and cells treated with <strong>5e</strong> and <strong>6d</strong>. These results suggest that the cytotoxic effects of these compounds are mediated by their effects on mitochondrial membrane potential and the subsequent increase in ROS production.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"262 ","pages":"Article 112770"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer behavior of cyclometallated iridium(III)-tributyltin(IV) carboxylate schiff base complexes with aggregation-induced emission","authors":"Xicheng Liu,&nbsp;Yiwei Sun,&nbsp;Yuan Gao,&nbsp;Xinru Zhang,&nbsp;Xiaoshuang Li,&nbsp;Wenya Zheng,&nbsp;Mengxian Liu,&nbsp;Ting Zhao,&nbsp;Xiang-Ai Yuan,&nbsp;Mingbo Yue,&nbsp;Zhe Liu","doi":"10.1016/j.jinorgbio.2024.112767","DOIUrl":"10.1016/j.jinorgbio.2024.112767","url":null,"abstract":"<div><div>Cyclometallated iridium(III) and organotin(IV) carboxylate complexes have shown potential application value in the field of anticancer. However, the widespread aggregation-caused quenching (ACQ) effect of these complexes is not conducive to the exploration of their targeting and anticancer mechanism, and the idea of aggregation-induced emission (AIE) effect can effectively solve this problem. Then, AIE-activated cyclometallated iridium(III)-tributyltin(IV) carboxylate Schiff base complexes were designed and prepared in this study. Complexes exhibited AIE effect in highly concentrated solution or aggregative state, which facilitated the investigation of subcellular tissue targeting (mitochondria) and cell morphology. Compared with cyclometallated iridium(III) complex and tributyltin(IV) carboxylate monomers, these complexes showed the better in-vitro anti-proliferative activity toward A549 cells, confirming the favorable synergistic anticancer activity. Even for A549/DDP (cisplatin-resistance) cells, these complexes also exhibited the better activity. In addition, complexes showed a mitochondrial apoptotic pathway. Therefore, cyclometallated iridium(III)-tributyltin(IV) carboxylate Schiff base complexes can be used as the potential substitutes for platinum-based drugs and gain further application.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"262 ","pages":"Article 112767"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cetirizine platinum(IV) complexes with antihistamine properties inhibit tumor metastasis by suppressing angiogenesis and boosting immunity","authors":"Yan Chen ,&nbsp;Shuaiqi Feng ,&nbsp;Ming Zhang ,&nbsp;Suying Li ,&nbsp;Ning Zhang ,&nbsp;Jun Han ,&nbsp;Zhifang Liu ,&nbsp;Meifeng Liu ,&nbsp;Qingpeng Wang","doi":"10.1016/j.jinorgbio.2024.112766","DOIUrl":"10.1016/j.jinorgbio.2024.112766","url":null,"abstract":"<div><div>The histamine (HA) in tumors plays critical roles in promoting metastasis. Herein, a series of cetirizine (CTZ) platinum(IV) complexes with antihistamine properties were developed as antimetastatic agents. Dual CTZ platinum(IV) complex with cisplatin core was screened out as a candidate displaying potent antiproliferative activities. More importantly, it exerted promising antimetastatic properties both <em>in vitro</em> and <em>in vivo</em>. Investigation of the mechanism revealed that serious DNA damage was induced, which further led to the upregulation of histone H2AX (<em>γ</em>-H2AX) and P53. The mitochondria-mediated apoptosis was ignited through the B-cell lymphoma-2 (Bcl-2)/Bcl-2 associated X protein (Bax)/caspase3 pathway. Moreover, the HA-histamine receptor H1 (HRH1) axis was inhibited, then the key signaling phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) was suppressed. Subsequently, the angiogenesis in tumors was restrained by suppressing the inflammatory and hypoxic microenvironment. Then, the antitumor immunity was reinforced by increasing the CD3⁺ and CD8⁺ T cells and promoting the polarization of macrophages from M2- to M1-type, which was associated with the blockade of programmed cell death ligand-1 (PD-L1) expression in tumors.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"262 ","pages":"Article 112766"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water-soluble neutral octahedral chalcogenide tungsten and molybdenum {M6Q8} clusters with P(C2H4CONH2)3 ligand","authors":"Alena D. Gassan ,&nbsp;Tatiana N. Pozmogova ,&nbsp;Ilia V. Eltsov ,&nbsp;Anton A. Ivanov ,&nbsp;Michael A. Shestopalov","doi":"10.1016/j.jinorgbio.2024.112768","DOIUrl":"10.1016/j.jinorgbio.2024.112768","url":null,"abstract":"<div><div>Developing the chemistry of octahedral chalcogenide molybdenum and tungsten cluster complexes in the context of applications in biology and medicine, in this work a series of water-soluble neutral cluster complexes [{M₆Q₈}(P(C₂H₄CONH₂)₃)₆] (M = Mo, W; Q = S, Se) have been obtained by simultaneous replacement of inner and terminal halide ligands in [{M₆I₈}I₆]²⁻ with chalcogenide and organic phosphine ligands and characterized by single-crystal X-ray diffraction analysis, ¹H and ³¹P NMR spectroscopies, elemental analysis, and UV–vis spectroscopy. The amide groups of the organic ligands, on the one hand, contribute to the solubility of the resulting clusters in water and, on the other hand, are able to form an extensive network of hydrogen bonds, leading to the crystallization of the complexes from aqueous solutions. Despite this fact, the complexes have sufficient solubility and stability in aqueous solutions, which made it possible to demonstrate their low cytotoxicity on Hep-2 cells (IC₅₀ were not reached even at concentration up to 4 mM). The resulting clusters are among the most biocompatible of the octahedral clusters studied to date and are the starting point for the development of a new family of X-ray contrast agents.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"262 ","pages":"Article 112768"},"PeriodicalIF":3.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}