铁蛋白辅助生物矿化和给药：这是一个硬与软的问题

IF 3.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Inorganic Biochemistry Pub Date : 2025-09-29 DOI:10.1016/j.jinorgbio.2025.113090

Lucrezia Cosottini , Veronica Ghini , Paola Turano

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引用次数: 0

摘要

本文综述了我们小组在过去15年中研究的两个主要活动，即i)跟踪铁蛋白笼中到达铁氧化酶位点或成核位点的铁（II）途径，以及确定蛋白质基质与铁（III）产物之间的相互作用；ii)确定金(I)金属化合物与笼表面的结合模式，以便将其靶向递送到癌细胞。蛋白质笼中产生的金属相互作用位点可以根据它们与硬阳离子或软阳离子结合的偏好进行分类。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ferritin-assisted biomineralization and drug delivery: It's a matter of hard and soft

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Ferritin-assisted biomineralization and drug delivery: It's a matter of hard and soft

This review focuses on two main activities that have been the subject of research in our group during the last 15 years that concerns i) tracking of the iron(II) pathways in the ferritin cage to reach the ferroxidase site or the nucleation sites as well as identifying the interactions between the protein matrix and the iron(III) products; ii) identifying the binding mode of gold(I) metal compounds to the cage surface for their targeted delivery towards cancer cells. The resulting metal interaction sites in the protein cage can be categorized based on their preference for binding to hard or soft cations.

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来源期刊

Journal of Inorganic Biochemistry 生物-生化与分子生物学

CiteScore

7.00

自引率

10.30%

发文量

336

审稿时长

41 days

期刊介绍： The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.