Journal of Inorganic Biochemistry最新文献

{"title":"Evaluating indole‑gold(I) based complexes as potential anti lymphoma agents by disrupting the thioredoxin reductase/glutathione peroxidase axis","authors":"Sicong Wang ,&nbsp;Min Shan ,&nbsp;Zhongren Xu ,&nbsp;Guizhi Jiang ,&nbsp;Mengshi Wang ,&nbsp;Yanyu Zhou ,&nbsp;Xiao Zhao ,&nbsp;Kathryn F. Tonissen ,&nbsp;Wukun Liu ,&nbsp;Giovanna Di Trapani","doi":"10.1016/j.jinorgbio.2025.113004","DOIUrl":"10.1016/j.jinorgbio.2025.113004","url":null,"abstract":"<div><div>Antioxidant systems, especially the thioredoxin (Trx) and glutathione (GSH) systems, represent promising targets for cancer therapy. Overexpression of these systems has been reported in many cancers, including lymphoma and considered as a mechanism of protection for cancer cells from the high levels of reactive oxygen species (ROS). Over several decades, metal-based complexes including gold complexes such as auranofin have shown anticancer activity by targeting thiols and selenol groups in the active site of thioredoxin reductase (TrxR). However, lack of selectivity, severe side effects or resistance to therapy have been widely reported. Recently, glutathione peroxidase (Gpx) has been reported as one of the key proteins that regulate ferroptosis in cells. To expand the armory for targeting antioxidant systems, in this study eleven new indole-metal complexes were synthesized and assessed for their antiproliferative activity in lymphoma cell lines. The indole‑gold(I)-based complexes showed the best anti-lymphoma activity <em>via</em> inhibiting TrxR and Gpx, but not glutathione reductase (GR), when compared to the indole‑iron-based and cobalt-based complexes. Further investigation revealed that two of the indole‑gold(I)-based complexes, <strong>3h</strong> and <strong>3i</strong>, induced the expression of ferroptosis-related genes and an increase in lipid peroxidation, indicating activation of ferroptosis in these cells. The <em>in vivo</em> study also revealed that these complexes significantly inhibited angiogenesis by reducing formation of blood vessels in zebra fish embryos. Overall, these results show the potential of <strong>3h</strong> and <strong>3i</strong> as TrxR and Gpx inhibitors in lymphoma cells, warranting further assessment as anticancer agents and potential inducers of ferroptosis.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 113004"},"PeriodicalIF":3.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iridium(III) complexes as type I photosensitizers for hypoxic two-photon photodynamic therapy","authors":"Zanru Tan ,&nbsp;Jiang Feng ,&nbsp;Zixin Tang ,&nbsp;Tao Feng ,&nbsp;Taihong Liu ,&nbsp;Yukun Zhao ,&nbsp;Hui Chao","doi":"10.1016/j.jinorgbio.2025.113006","DOIUrl":"10.1016/j.jinorgbio.2025.113006","url":null,"abstract":"<div><div>Photodynamic therapy (PDT), a non-invasive therapeutic modality, has significantly improved skin cancer treatment in recent years. Nonetheless, the limitations associated with conventional photosensitizers, such as their substantial dependence on oxygen and restricted light penetration, continue to pose considerable challenges for clinical applications. Herein, five Iridium(III) complexes have been developed as type I photosensitizers for two-photon PDT targeting melanoma. These complexes exhibit notable two-photon absorption (TPA) cross-sections (σ2 ≥ 100 GM) and high yields of reactive oxygen species (ROS) under hypoxic conditions, leading to mitochondrial damage and subsequent apoptosis through ROS generation with low doses of single or two-photon excitation. Notably, <strong>Ir4@PEG</strong> exhibits an IC₅₀ value of 2.1 μM and a phototoxicity index (PI) of 47 under hypoxic conditions. Cellular assays indicate that <strong>Ir4@PEG</strong> initially targets and localizes within lysosomes, where the lysosomal membrane is subsequently compromised upon light stimulation, resulting in <strong>Ir4</strong> transferring and damaging mitochondria, causing cell apoptosis. Additionally, <strong>Ir4@PEG</strong> demonstrates improved tumor penetration, significant ROS production, and marked phototoxicity in hypoxic three-dimensional tumor spheroids. These findings provide new insights into designing oxygen-independent, metal-based two-photon photodynamic therapies against hypoxic melanoma.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 113006"},"PeriodicalIF":3.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The novel platinum(IV) prodrug of cisplatin axially conjugated with cannabidiol induces mitochondrial dysfunction and synergistically enhances anti-tumor effects","authors":"Rong Lv ,&nbsp;Pengmin Shi ,&nbsp;Zhiping Lu ,&nbsp;Tangli Wei ,&nbsp;Jing Yang ,&nbsp;Xiali Liao ,&nbsp;Bo Yang ,&nbsp;Chuanzhu Gao","doi":"10.1016/j.jinorgbio.2025.113003","DOIUrl":"10.1016/j.jinorgbio.2025.113003","url":null,"abstract":"<div><div>Classical cisplatin-based chemotherapeutic drugs are widely used in clinical practice. In recent years, novel platinum-based antitumor drugs have focused on replacing classical cisplatin-like Pt(II) complexes with relatively inert Pt(IV) prodrugs to overcome drug resistance and reduce toxic side effects. Based on the excellent physiological and pharmacological activities of cannabidiol (CBD), this study designed and synthesized novel Pt(IV) prodrugs W1-W6, which are axial conjugates of cisplatin with CBD and specific active small molecules. These prodrugs demonstrated more significant antitumor activity against tested tumor cell lines. Among them, the multifunctional Pt(IV) prodrug W5, conjugated with CBD and the PDK inhibitor DCA, exhibited excellent activity against both platinum-sensitive and cisplatin-resistant tumor strains. The IC₅₀ value of W5 for the A549R tumor strain was 8.53 ± 0.76 μM, significantly higher than that of the cisplatin group and 3.64 times the activity of CBD alone, demonstrating strong synergistic antitumor activity and potential to overcome cisplatin resistance. W5 is reduced by GSH in A549R cells, releasing CBD and Pt(II). Pt(II) binds to DNA, inducing damage and inhibiting repair, while CBD activates pro-apoptotic proteins, leading to mitochondrial dysfunction. Simultaneously, W5 reduces the levels of ROS scavengers, triggering endoplasmic reticulum dysfunction. These three mechanisms synergistically promote tumor cell apoptosis and overcome drug resistance. This design integrates multiple mechanisms through axial functionalization, breaking through the limitation of traditional platinum drugs targeting DNA alone, and achieves synergistic effects by regulating metabolism and intervening in the immune microenvironment.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 113003"},"PeriodicalIF":3.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor microenvironment responsive smart nanoplatform for synergistic tumor therapy through co-enhancement of GSH depletion and hypoxia relief","authors":"Pengfei Yang ,&nbsp;Jie Zhang ,&nbsp;Yi Chang ,&nbsp;Lingxue Tang ,&nbsp;Guanglei Ma ,&nbsp;Xinhe Liu ,&nbsp;Fangli Gao ,&nbsp;Xiaoming Ma ,&nbsp;Yuming Guo","doi":"10.1016/j.jinorgbio.2025.113005","DOIUrl":"10.1016/j.jinorgbio.2025.113005","url":null,"abstract":"<div><div>As innovative therapeutic strategy, chemodynamic therapy (CDT) and photodynamic therapy (PDT) show great promise for tumor therapy. However, their therapeutic efficacy is seriously limited by the hypoxia and insufficient H₂O₂ supply of the tumor microenvironment. Juglone (JUG), a naturally-occurring naphthoquinone, can increase the intracellular H₂O₂ concentration and serve as an inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1. Herein, a nanoplatform composed of Fe-based metal-organic framework core, MnO₂ layer, JUG payload, and hyaluronic acid (HA) decoration (Fe-TCPP@MnO₂@JUG@HA) was designed and prepared. The MnO₂ layer can prevent the phototoxicity of tetrakis (4-carboxyphenyl)porphyrin (TCPP) during transportation and catalyze H₂O₂ to produce O₂ to enhance the PDT efficacy. HA can improve the delivery efficiency to tumor. Then Fe³⁺ was reduced to Fe²⁺ and MnO₂ was reduced to Mn²⁺ because of the weak acidity and high concentration glutathione (GSH), causing the nanoplatform collapse, TCPP activation, and JUG release. GSH-depletion reduce the reactive oxygen species (ROS) scavenging effect and further enhance the PDT efficacy, inhibited the biosynthesis of lipid repair enzyme glutathione peroxidase 4 and promoted the ferroptosis efficiency by destroying redox balance. This PDT/CDT/chemotherapy triple synergistic apoptosis-ferroptosis strategy exhibited good tumor therapeutic efficacy and excellent biocompatibility, implying the promising future for efficient tumor treatment.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 113005"},"PeriodicalIF":3.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiological applications of the saccharinatecopper(II) complex (Cu-Sac)","authors":"Patricia Appelt ,&nbsp;Aline B. Schons ,&nbsp;Lucéli Roloff ,&nbsp;Mário A.A. Cunha ,&nbsp;Juan C. Villalba ,&nbsp;Davi Back ,&nbsp;Henrique E. Toma ,&nbsp;Fauze J. Anaissi","doi":"10.1016/j.jinorgbio.2025.112990","DOIUrl":"10.1016/j.jinorgbio.2025.112990","url":null,"abstract":"<div><div>The tetraaqua-<em>bis</em>(saccharinato)copper(II) dihydrate complex (Cu-Sac) was synthesized, structurally characterized by single-crystal X-ray diffraction, and tested for antioxidant and antimicrobial activity. In this complex, deprotonated saccharin ligands coordinate monodentate via nitrogen in a trans configuration to copper, with four water molecules also bound. Its distorted octahedral geometry fits the formula [M(Sac)₂(H₂O)₄]·2H₂O. The Cu-Sac complex showed good antioxidant efficacy in DPPH and hydrogen peroxide scavenging assays and was effective against ten microorganisms in both pellet and solution forms. Notably, this study also assessed the use of the pigment in commercial white paint at 10 % and 20 % concentrations. MIC data indicated that the complex exhibits broad-spectrum antimicrobial activity, showing efficacy against Gram-negative and Gram-positive bacterial strains, and fungicidal activity against yeast strains. The copper saccharinate paint showed promising results in the disk diffusion test, producing inhibition zones of 27.50 ± 4.0 mm for <em>P. mirabilis</em>, exceeding the inhibition zones observed with standard antibiotics. An increase in the concentration of the complex in the paint was also shown to result in greater antibacterial efficacy. The activity index obtained for the paint samples showed good results, with the Cu-Sac 20 % sample being particularly noteworthy, especially against the <em>S. epidermidis</em> and <em>E. faecium</em> strains, with indices ≥1. These findings suggest that the Cu-Sac complex has potential as an antimicrobial pigment or surface-applied antibiotic agent, indicating promising prospects for industrial applications.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 112990"},"PeriodicalIF":3.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and anticancer activity of six tricyclohexyltin cinnamate complexes","authors":"Zhiyu Pan ,&nbsp;Wen Zhong ,&nbsp;Yanping Li ,&nbsp;Shijie Lin ,&nbsp;Shaofeng Chen ,&nbsp;Wei Tian","doi":"10.1016/j.jinorgbio.2025.112991","DOIUrl":"10.1016/j.jinorgbio.2025.112991","url":null,"abstract":"<div><div>Six tricyclohexyl tin cinnamate complexes (<strong>C1</strong> ∼ <strong>C6</strong>) were successfully synthesized and were characterized. The crystal structures of <strong>C1</strong>, <strong>C2</strong>, <strong>C4</strong>, and <strong>C5</strong> were determined. Among them, complexes <strong>C1</strong>, <strong>C2</strong> and <strong>C5</strong> form a one-dimensional infinite chain structure through Sn<img>O interactions or O-H…O hydrogen bonds. All complexes were tested for their inhibitory activity against human cancer cell lines A549, HepG2, and MDA-MB-231. The results showed that the <strong>C2</strong> complex demonstrated the most significant inhibitory effect on HepG2 cells, with an IC₅₀ value of 1.31 ± 0.47 μM. Preliminary studies indicate that the <strong>C2</strong> complex induces a reduction in mitochondrial membrane potential in HepG2 cells, triggering apoptosis via the mitochondrial pathway accompanied by cell cycle arrest at the G2 phase. The DNA binding activity of <strong>C2</strong> was investigated using ultraviolet-visible, fluorescence competition assays and molecular docking, revealing that <strong>C2</strong> can effectively intercalate the DNA groove.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 112991"},"PeriodicalIF":3.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-heterocyclic carbene gold(I) derivatives with long aliphatic side chains as potential anticancer agents in colon cancer","authors":"Javier Quero ,&nbsp;Adrián Alconchel ,&nbsp;Sara Ortega ,&nbsp;Seyed Hesamoddin Bidooki ,&nbsp;Mª. Concepción Gimeno ,&nbsp;Mª. Jesús Rodriguez-Yoldi ,&nbsp;Elena Cerrada","doi":"10.1016/j.jinorgbio.2025.112987","DOIUrl":"10.1016/j.jinorgbio.2025.112987","url":null,"abstract":"<div><div>Mild hyperthermia has emerged as a powerful tool in cancer therapy, prompting the development of materials that respond to heat with enhanced therapeutic action. Gold(I)-NHC complexes are emerging as promising anticancer agents due to their stability, tunability, and ability to inhibit sulfur- and selenium-dependent enzymes overexpressed in tumors. In this study, we synthesised carbene–gold(I) derivatives bearing fluorous and hydrocarbon chains to assess the role of polyfluorinated groups and the impact of mild hyperthermia (41 °C) on their cytotoxic activity. The compounds exhibited significant antiproliferative effects against Caco-2/TC7 colon carcinoma cells at both 37 °C and 41 °C. This activity may be associated with alterations in the levels of ROS (reactive oxygen species) within the cells and the activity of TrxR (thioredoxin reductase), resulting in modifications to the intracellular redox state and subsequent disruptions to the cell cycle. Under hyperthermic conditions, cytotoxicity was further enhanced via mitochondrial depolarization and activation of caspase-3-mediated apoptosis. Notably, fluorinated complexes displayed superior cytotoxicity compared to their alkylated analogues, highlighting the relevance of polyfluorinated chains in boosting therapeutic efficacy under heat-triggered conditions.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 112987"},"PeriodicalIF":3.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of σ and π reaction channels in hydrogen atom transfer reactions","authors":"Faiza Ahsan ,&nbsp;Mursaleem Ansari ,&nbsp;Johannes E.M.N. Klein ,&nbsp;Marcel Swart","doi":"10.1016/j.jinorgbio.2025.112989","DOIUrl":"10.1016/j.jinorgbio.2025.112989","url":null,"abstract":"<div><div>C(sp³)–H bond activation mechanisms typically involve σ- and π-channel pathways, as characterized by FeOH (or FeOC) angles of ca. 180° and 120°, respectively. It is well known that the preference for either the σ- or π-channel depends on the spin state, but doubts exist on what would be characteristic values for the FeOX (X = H or C) angles. Here we study the oxidation of methane and ethane mediated by an Fe(IV)oxo model complex through density functional theory. A systematic comparison of dispersion-corrected B3LYP (B3LYP-D2, B3LYP-D3, B3LYP-D3BJ, B3LYP-D4) and the uncorrected counterpart (B3LYP) was conducted to evaluate the role of dispersion interactions in both gas and solvent phases. Our results reveal that dispersion corrections significantly influence barriers at transition states (TSs), particularly in the solvent phase, where dispersion contributions enhance stabilization of TS structures. The σ-channel pathway dominates for high spin (<em>S</em> = 2), while intermediate spin (<em>S</em> = 1) states favor the π-channel. Dispersion effects were found to be more pronounced for ethane, where larger non-covalent interactions between the substrate and Fe(IV)oxo complex arise. The FeOX angles vary substantially depending on the choice of dispersion correction, and between gas phase and solution phase. Indeed, for the reaction with ethane the FeOX values of the σ-channel approach values that are typically associated with the π-channel. Fortunately, the Spin-Resolved Charge Displacement Function provides a clear visual tool to distinguish the two channels. These insights advance the understanding of hydrocarbon functionalization by high-valent iron-oxo species, with implications for synthetic catalyst design in homogeneous and enzymatic catalysis.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 112989"},"PeriodicalIF":3.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Biginelli hybrids in the AI-driven development of ruthenium complexes: Anticancer activity, DNA/HSA binding study, impacts on apoptosis and BCL-2/BCL-XL suppression","authors":"Ana Rilak Simović ,&nbsp;Dejan Milenković ,&nbsp;Dragana Šeklić ,&nbsp;Milena Jovanović ,&nbsp;Emilija Milović ,&nbsp;Milica Međedović ,&nbsp;Milan Vraneš ,&nbsp;Nenad Janković","doi":"10.1016/j.jinorgbio.2025.112988","DOIUrl":"10.1016/j.jinorgbio.2025.112988","url":null,"abstract":"<div><div>Ruthenium-arene complexes are promising alternatives to platinum-based anticancer drugs due to their unique chemical properties and lower toxicity. These complexes typically have a “half-sandwich” structure where an arene ligand stabilizes the ruthenium center. This study aimed to design tetrahydropyrimidines (<strong>THPM</strong>) and their ruthenium <em>p</em>-cymene complexes with anticancer potential using deep learning models for binding affinity prediction. Ten compounds with binding energies lower than −31.3 kJ/mol were selected for further investigation. Molecular docking studies revealed that the ruthenium complexes <strong>5j</strong> and <strong>5g</strong> exhibited the most pronounced activity against <em>Caspase 3</em>. These complexes showed significant cytotoxic activity and selectivity against primary and metastatic cancer cell lines, inducing apoptosis as the preferred mode of cell death through the modulation of <em>Caspases</em> expression. The <em>K</em>_b and <em>K</em>_sv values for the interaction of <strong>5j</strong> with EB-DNA, Hoechst-DNA, HSA, HSA-Eosin Y, and HSA-Ibuprofen were higher compared to those of <strong>5m</strong>. Binding constants in the presence of the tested <strong>BIO-ILs</strong> followed the order <strong>IL1</strong> (ethanoate) &lt; <strong>IL2</strong> (butanoate) &lt; <strong>IL3</strong> (hexanoate), correlating with the length of the alkyl chain in the anions and the lipophilicity of the tested <strong>BIO-ILs</strong>. The best result of this study was that treatment with <strong>5g</strong> induced apoptosis and reduced the expression of anti-apoptotic markers (<em>BCL-2</em> and <em>BCL-XL</em>), which are associated with resistance acquisition. The research outcomes emphasize the integration of computational methods with experimental validation, underscoring the importance of collaboration between AI technologies and traditional chemistry in drug discovery.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 112988"},"PeriodicalIF":3.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coordination complexes of lanthanide(III) derived from 2-(pyridin-2-yl)-1H-benzo[d]imidazole (bimpy) and 2,2′-bipyridine (bpy): Spectroscopic analysis and cytotoxic evaluation","authors":"Luis E. Romero-Gutiérrez ,&nbsp;Miguel A. Vergara-Rodríguez ,&nbsp;J. Antonio Cruz-Navarro ,&nbsp;Sharon Rosete-Luna ,&nbsp;Aracely López-Monteon ,&nbsp;Angel Ramos-Ligonio ,&nbsp;Rodolfo Peña-Rodríguez ,&nbsp;Silvia Castillo-Blum ,&nbsp;Raúl Colorado-Peralta","doi":"10.1016/j.jinorgbio.2025.112985","DOIUrl":"10.1016/j.jinorgbio.2025.112985","url":null,"abstract":"<div><div>Seven novel coordination complexes (<strong>1</strong>–<strong>7</strong>) derived from trivalent lanthanides (La, Nd, Sm, Eu, Gd, Tb, Dy) and bidentate ligands 2,2′-bipyridine (<em>bpy</em>) and 2-(pyridin-2-yl)-1<em>H</em>-benzo[<em>d</em>]imidazole (<em>bimpy</em>) were synthesised. A series of analytical and spectroscopic techniques, including high-resolution mass spectrometry, unambiguously characterised all complexes. Using ligand mixtures to obtain coordination complexes with anticancer activity has shown promising results. Therefore, additional experiments were performed to evaluate the cytotoxic activity in non-transformed cells (NIH/3 T3 and J774A.1) and transformed cells (HeLa, Caco-2 and MCF-7), as well as erythrocyte lysis experiments in human red blood cells. The results revealed moderate but selective cytotoxicity against the studied cell lines. Additional PBE0/def2-SVP computational studies were carried out to elucidate the coordination number, geometry and structural organisation in agreement with the experimental data.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"272 ","pages":"Article 112985"},"PeriodicalIF":3.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}