Journal of Inorganic Biochemistry最新文献

{"title":"Metallophthalocyanine as ideal antibiotics without light: Mechanisms and applications","authors":"Dongsheng Zhu ,&nbsp;Wanting Shan ,&nbsp;Beibei Xu ,&nbsp;Xiaomeng Duan ,&nbsp;Shaohua Wei ,&nbsp;Jishuang Zhang ,&nbsp;Yicheng Wang ,&nbsp;Lin Zhou","doi":"10.1016/j.jinorgbio.2024.112599","DOIUrl":"10.1016/j.jinorgbio.2024.112599","url":null,"abstract":"<div><p>The urgent global health problem of antimicrobial resistance (AMR) calls for the discovery of new antibiotics with innovative modes of action while considering the low toxicity to mammalian cells. This paper proposes a novel strategy for designing antibiotics with selective bacterial toxicity by exploiting the positional differences of electron transport chains (ETC) in bacterial and mammalian cells. The focus is on cytochrome <em>c</em> (cyt C) and its maturation system in <em>E. coli</em>. The catalytic oxidative activity of metallophthalocyanine (MPc), which have a distinctive M-N4 structure, is being investigated. Unlike previous applications based on light-activated reactive oxygen species (ROS) generation, this study exploits the ability of MPcs to oxidize Fe²⁺ to Fe³⁺ in cyt C and catalyze the formation of disulfide bonds between cysteine residues to interfere with cyt C maturation, disrupt the bacterial respiratory chain and selectively kills bacteria. In contrast, in mammalian cells, these MPcs are located in the lysosomes and cannot access the ETC in the mitochondria, thus achieving selective bacterial toxicity. Two MPcs that showed effective antibacterial activity in a wound infection model were identified. This study provides a valuable reference for the design of novel antibiotics based on M-N4-based metal complex molecules.</p></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binuclear palladacycles with ionisable and non-ionisable tethers as anticancer agents","authors":"A. van Niekerk ,&nbsp;S. Chakraborty ,&nbsp;C. Bellis ,&nbsp;P. Chellan ,&nbsp;S. Prince ,&nbsp;S.F. Mapolie","doi":"10.1016/j.jinorgbio.2024.112608","DOIUrl":"10.1016/j.jinorgbio.2024.112608","url":null,"abstract":"<div><p>The search for novel anticancer agents to replace the current platinum-based treatments remains an ongoing process. Palladacycles have shown excellent promise as demonstrated by our previous work which yielded <strong>BTC2</strong>, a binuclear palladadycle with a non-ionisable polyethylene glycol (PEG) tether. Here, we explore the importance of the PEG-tether length on the anticancer activity of the binuclear palladacycles by comparing three analogous binuclear palladacycles, <strong>BTC2</strong>, <strong>BTC5</strong> and <strong>BTC6</strong>, in the oestrogen receptor positive MCF7 and triple-negative MDA-MB-231 breast cancer cell lines. In addition, these are compared to another analogue with an ionisable morpholine tether, <strong>BTC7</strong>. Potent anticancer activity was revealed through cell viability studies (MTT assays) revealed that while <strong>BTC6</strong> showed similar potent anticancer activity as <strong>BTC2</strong>, it was less toxic towards non-cancerous cell lines. Interestingly, <strong>BTC7</strong> and <strong>BTCF</strong> were less potent than the PEGylated palladacycles but showed significantly improved selectivity towards the triple-negative breast cancer cells. Cell death analysis showed that <strong>BTC7</strong> and <strong>BTCF</strong> significantly induced apoptosis in both the cancer cell lines while the PEGylated complexes induced both apoptosis and secondary necrosis. Furthermore, experimental and computational DNA binding studies indicated partial intercalation and groove binding as the modes of action for the PEGylated palladacycles. Similarly, experimental and computational BSA binding studies indicated and specific binding sites in BSA dependent on the nature of the tethers on the complexes.</p></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0162013424001326/pdfft?md5=8f2efe365dbb50a056e114c0cba39620&pid=1-s2.0-S0162013424001326-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tribute to Frances Ann Walker","authors":"Janet M. Walker ,&nbsp;Ursula Simonis ,&nbsp;Mario Rivera","doi":"10.1016/j.jinorgbio.2024.112606","DOIUrl":"10.1016/j.jinorgbio.2024.112606","url":null,"abstract":"","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141054439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of biomolecule interactions on the cytotoxic effects of rhenium(I) tricarbonyl complexes","authors":"Tayná Saraiva de Lavor ,&nbsp;Maria Henriqueta Silvestre Teixeira ,&nbsp;Patrícia Alves de Matos ,&nbsp;Ricardo Campos Lino ,&nbsp;Clara Maria Faria Silva ,&nbsp;Marcos Eduardo Gomes do Carmo ,&nbsp;Marcelo Emílio Beletti ,&nbsp;Antonio Otavio T. Patrocinio ,&nbsp;Robson José de Oliveira Júnior ,&nbsp;Tayana Mazin Tsubone","doi":"10.1016/j.jinorgbio.2024.112600","DOIUrl":"10.1016/j.jinorgbio.2024.112600","url":null,"abstract":"<div><p>Rhenium complexes show great promise as anticancer drug candidates. Specifically, compounds with a Re(CO)₃(NN)(py)⁺ core in their architecture have shown cytotoxicity equal to or greater than that of well-established anticancer drugs based on platinum or organic molecules. This study aimed to evaluate how the strength of the interaction between rhenium(I) tricarbonyl complexes <em>fac-</em>[Re(CO)₃(NN)(py)]⁺, NN = 1,10-phenanthroline (phen), dipyrido[3,2-f:2′,3′-h]quinoxaline (dpq) or dipyrido[3,2-a:2′3’-c]phenazine (dppz) and biomolecules (protein, lipid and DNA) impacted the corresponding cytotoxic effect in cells. Results showed that <em>fac-</em>[Re(CO)₃(dppz)(py)]⁺ has higher Log P_o/w and binding constant (K_b) with biomolecules (protein, lipid and DNA) compared to complexes of <em>fac-</em>[Re(CO)₃(phen)(py)]⁺ and <em>fac-</em>[Re(CO)₃(dpq)(py)]⁺. As consequence, <em>fac-</em>[Re(CO)₃(dppz)(py)]⁺ exhibited the highest cytotoxicity (IC₅₀ = 8.5 μM for HeLa cells) for <em>fac-</em>[Re(CO)₃(dppz)(py)]⁺ among the studied compounds (IC₅₀ &gt; 15 μM). This highest cytotoxicity of <em>fac-</em>[Re(CO)₃(dppz)(py)]⁺ are probably related to its lipophilicity, higher permeation of the lipid bilayers of cells, and a more potent interaction of the dppz ligand with biomolecules (protein and DNA). Our findings open novel avenues for rational drug design and highlight the importance of considering the chemical structures of rhenium complexes that strongly interact with biomolecules (proteins, lipids, and DNA).</p></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tribute to Frances Ann Walker","authors":"Abhik Ghosh ,&nbsp;Anabella Ivancich","doi":"10.1016/j.jinorgbio.2024.112604","DOIUrl":"10.1016/j.jinorgbio.2024.112604","url":null,"abstract":"","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141030120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the versatility of sulfur-containing heterocyclic metal complexes: Application in medical and prospects of visible-light-driven photocatalysis","authors":"Binitha Sreedharan Daisylet ,&nbsp;Selwin Joseyphus Raphael ,&nbsp;Praveen Kumar ,&nbsp;Pooja Parvathy Rajan ,&nbsp;Arish Dasan","doi":"10.1016/j.jinorgbio.2024.112603","DOIUrl":"10.1016/j.jinorgbio.2024.112603","url":null,"abstract":"<div><p>Numerous heterocyclic moieties serve as the foundational structure for clinically employed drugs, underscoring the significance of heterocycles in the innovation of pharmacologically active compounds. In the present investigation, a heterocyclic skeleton of thiophene-clubbed benzimidazole (tmb) was developed and utilized to synthesize seven novel series of metal (M(II) = Co, Ni, Cu, and Zn) complexes to explore diverse applications including pharmacological and photocatalytic performance. A sharp singlet peak appeared at 5.72 ppm (tmb) and 5.94 ppm for the Zn(II)-tmb complex corresponding to -CH₂ protons, as evidenced by ¹H NMR results, confirming the formation of targeted compounds. Antimicrobial assay and docking studies confirmed that the mixed metal complex; [Cu(tmb)₂(1,10-phen)Cl₂] possesses the highest activity and displayed significant biofilm inhibition, achieving 86.35 and 89.8% at concentrations of 1 and 0.020 mg/mL, respectively against <em>E. coli</em>. Furthermore, the photocatalytic activity was monitored by the degradation of methylene blue dye under direct sunlight and [Cu(tmb)₂Cl₂] exhibited a maximum degradation efficiency of 96.15% in 45 min. These findings could serve as inspiration for the development of benzimidazole-based metal complexes as effective anti-biofilm and photocatalytic agents.</p></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A remarkable peroxidase-like behavior of the catalase KatA from the pathogenic bacteria Helicobacter pylori: The oxidation reaction with formate as substrate and the stabilization of an [Fe(IV) = O Trp•] intermediate assessed by multifrequency EPR spectroscopy","authors":"Jacek Switala ,&nbsp;Lynda Donald ,&nbsp;Anabella Ivancich","doi":"10.1016/j.jinorgbio.2024.112594","DOIUrl":"https://doi.org/10.1016/j.jinorgbio.2024.112594","url":null,"abstract":"<div><p>We have characterized the catalytic cycle of the <em>Helicobacter pylori</em> KatA catalase (HPC). <em>H. pylori</em> is a human and animal pathogen responsible for gastrointestinal infections. Multifrequency (9–285 GHz) EPR spectroscopy was applied to identify the high-valent intermediates (5 ≤ pH ≤ 8.5). The broad (2000 G) 9-GHz EPR spectrum consistent with the [Fe(IV) = O Por^•+] intermediate was detected, and showed a clear pH dependence on the exchange-coupling of the radical (delocalized over the porphyrin moiety) due to the magnetic interaction with the ferryl iron. In addition, Trp^• (for pH ≤ 6) and Tyr^• (for 5 ≤ pH ≤ 8.5) species were distinguished by the advantageous resolution of their g-values in the 285-GHz EPR spectrum. The unequivocal identification of the high-valent intermediates in HPC by their distinct EPR spectra allowed us to address their reactivity towards substrates. The stabilization of an [Fe(IV) = O Trp^•] species in HPC, unprecedented in monofunctional catalases and possibly involved in the oxidation of formate to the formyloxyl radical at pH ≤ 6, is reminiscent of intermediates previously identified in the catalytic cycle of bifunctional catalase-peroxidases. The 2e⁻ oxidation of formate by the [Fe(IV) = O Por^•+] species, both at basic and acidic pH conditions, involving a 1H^{<strong>+</strong>}/2e^{<strong>−</strong>} oxidation in a cytochrome P450 peroxygenase-like reaction is proposed. Our findings demonstrate that moonlighting by the <em>H. pylori</em> catalase includes formate oxidation, an enzymatic reaction possibly related to the unique strategy of the neutrophile bacterium for gastric colonization, that is the release of CO₂ to regulate the pH in the acidic environment.</p></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140917946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of chelating compounds on Cu2+, Fe2+/3+, and Zn2+ ions in Alzheimer's disease treatment","authors":"Tomasz Mazur,&nbsp;Magdalena Malik,&nbsp;Dariusz C. Bieńko","doi":"10.1016/j.jinorgbio.2024.112601","DOIUrl":"https://doi.org/10.1016/j.jinorgbio.2024.112601","url":null,"abstract":"<div><p><strong>Alzheimer's disease (AD)</strong> is a neurodegenerative disorder characterized by the accumulation of amyloid – β extracellular plaques and tau interfibrillar tangles, leading to memory loss, cognitive decline, and behavioral changes. With dementia posing a growing global health concern, there is an urgent need for comprehensive strategies to address its challenges. The economic burden of dementia is projected to rise significantly, emphasizing the necessity for collaborative efforts in research and healthcare. In the United States alone, millions are affected by <strong>AD</strong>, with prevalence increasing with age and even affecting younger individuals. The complexity of <strong>AD</strong> involves intricate biological processes, including the aggregation of amyloid beta, oxidative stress, and metal ion dysregulation. Metal ions, particularly those from copper, iron, and zinc, play pivotal roles in <strong>AD</strong> pathology, influencing Aβ deposition and tau protein accumulation. Current treatments offer symptomatic relief but do not address the underlying disease mechanisms. This paper explores the potential of various chelating compounds to target metal ions involved in <strong>AD</strong> pathology. <em>N</em>-acylhydrazones, morpholine, chrysin, quinoline, oxindole, cyclam, catechol-based, and quinazolinone-based derivatives show promising chelation activity and therapeutic effects.</p><p>Metal chelation therapy offers a targeted approach to <strong>AD</strong> treatment by addressing the core pathology. By selectively binding to metal ions implicated in disease progression, chelators may minimize side effects associated with broad-spectrum treatments. Additionally, chelators may offer neuroprotective effects beyond metal binding, further enhancing their therapeutic potential. Overall, metal chelation therapy presents a promising strategy in combating <strong>AD</strong>, with the potential to significantly impact disease progression and improve patient outcomes.</p></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0162013424001247/pdfft?md5=9baeb42d2d033a1610130b8633dc5a36&pid=1-s2.0-S0162013424001247-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140917945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoruthenium metallocycle induced mutation in gld-1 tumor suppression gene in JK1466 strain and appreciable lifespan expansion","authors":"S. Nandhini ,&nbsp;M. Ranjani ,&nbsp;G. Thiruppathi ,&nbsp;Y.M. Jaithanya ,&nbsp;G. Kalaiarasi ,&nbsp;M. Ravi ,&nbsp;G. Prabusankar ,&nbsp;J.G. Malecki ,&nbsp;P. Sundararaj ,&nbsp;R. Prabhakaran","doi":"10.1016/j.jinorgbio.2024.112593","DOIUrl":"https://doi.org/10.1016/j.jinorgbio.2024.112593","url":null,"abstract":"<div><p>Four Ru(II) complexes (<strong>A2</strong>-<strong>A5</strong>) were synthesized from the reaction of coumarin Schiff base ligands (<strong>7da2-tsc</strong>, <strong>7da3-mtsc</strong>, <strong>7da4-etsc</strong> and <strong>7da5-ptsc)</strong> with [RuHCl(CO)(PPh₃)₃]. The compounds were characterized by FT-IR, UV–Vis, ¹H, ¹³C and ³¹P NMR, mass spectrometry and crystallographic analysis. Calf Thymus DNA (CT-DNA) binding studies revealed the intercalative mode of binding of the complexes with DNA. The results of Bovine serum albumin (BSA) binding studies established the interaction between BSA followed static quenching mechanism. The cytotoxic effects of the complexes and the ligands were evaluated against breast (MCF-7 and MDA-MB-231) and lung carcinoma cell lines (A549 and NCI-H460) using MTT assay. Complex <strong>A4</strong> demonstrated potent cytotoxic effects on both breast and lung cancer cells. Furthermore, morphological observations and FACS analysis showed the decrease in cell density by complex <strong>A4</strong> by induced morphological changes and apoptotic body formation and cell death in both breast and lung cancer cells. Moreover, the invertebrate model <em>Caenorhabditis elegans</em> was employed to assess the <em>in vivo</em> anticancer activity of compound <strong>A4</strong>. The findings indicated that the treatment with <strong>A4</strong> reduced tumor development and significantly extended organismal lifespan by 64 % in the tumoral strain JK1466 without adversely affecting essential physiological functions of the worm. Additionally, <strong>A4</strong> demonstrated an upregulation of two crucial antioxidant defense genes. Overall, these results suggested that the compound <strong>A4</strong> can be a potential candidate with novel chemotherapeutic applications.</p></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc(II) coordination compound with N′-(pyridin-2-ylmethylene)nicotinohydrazide: Synthesis, crystal structure, computational and cytotoxicity studies","authors":"Suman Adhikari ,&nbsp;Sourav Nath ,&nbsp;Sevgi Kansız ,&nbsp;Nabajyoti Balidya ,&nbsp;Anirban Kumar Paul ,&nbsp;Necmi Dege ,&nbsp;Onur Sahin ,&nbsp;Ghodrat Mahmoudi ,&nbsp;Akalesh Kumar Verma ,&nbsp;Damir A. Safin","doi":"10.1016/j.jinorgbio.2024.112598","DOIUrl":"10.1016/j.jinorgbio.2024.112598","url":null,"abstract":"<div><p>In this work, we report on the synthesis of a novel zinc(II) coordination compound [ZnL₂] (<strong>1</strong>), which was readily obtained from the reaction of Zn(OAc)·2H₂O and <em>N′</em>-(pyridin-2-ylmethylene)nicotinohydrazide (<strong>HL</strong>) in methanol. Recrystallization of <strong>1</strong> from dimethylformamide under ambient conditions allowed to produce yellow block-like crystals of <strong>1</strong>·H₂O. Complex <strong>1</strong>·H₂O was characterized by FT-IR and ¹H NMR spectroscopy, while its optical properties were studied by UV–vis and spectrofluorimetry in methanol. The crystal structure of the title complex was revealed by single crystal X-ray diffraction and further explored in detail by the Hirshfeld surface analysis. Theoretical investigations based on the DFT calculations have also been applied to show the electronic properties of complex <strong>1</strong>. The antitumor activities of the parent ligand <strong>HL</strong> and complex <strong>1</strong> were studied using Dalton's lymphoma malignant cancer model. Both compounds were found to induce concentration-dependent cytotoxicity and apoptotic cell death, leading to a decrease in cell viability, body weight, and tumor volume in mice with the superior activity of complex <strong>1</strong> over <strong>HL</strong>. Mice treated with complex <strong>1</strong> demonstrated an increase in life span with a survival period of 23 days. Finally, using a molecular docking approach, we have probed complex <strong>1</strong> to inhibit the recombinant mouse tumor-necrosis factor alpha (mTNF).</p></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141054689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}