Resveratrol derivative modified Ru(II) complexes: Synthesis, characterization, in vitro and in vivo anticancer study

IF 3.8 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Inorganic Biochemistry Pub Date : 2025-03-01 DOI:10.1016/j.jinorgbio.2025.112873

Wuyang Hua , Fenglin Li , Ping Yang , Zhongkui Lu , Yanxia Liu , Bao Zhong , Baoxing Shen

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Abstract

The diversification of ligands provides more opportunities to adjust the photophysical performance as well as the bio-function of Ru(II) complexes as novel photosensitizers. Herein, a kind of Ru(II) complexes carrying resveratrol derivative, amino-Res, as ligand was designed and synthesized. The representative complex (named Ru4) showed potent anticancer activity under the trigger of 520 nm-light. Lipophilicity and cellular accumulation experiments indicated that Ru4 possessed higher LogP_O/W value and cell up-take than Ru1-Ru3 and [Ru(bpy)₃]²⁺. Mechanism study revealed that Ru4 could inhibit cancer cell migration, invasion and cancer stemness. The bio-function of Ru4 was mainly inherited from the amino-Res ligand. The in vivo study demonstrated that Ru4 could inhibit the tumor growth without significant system toxicity.

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白藜芦醇衍生物修饰Ru（II）配合物：合成、表征及体内体外抗癌研究

配体的多样化提供了更多的机会来调整Ru（II）配合物作为新型光敏剂的光物理性能和生物功能。本文设计并合成了一种以白藜芦醇衍生物氨基- res为配体的Ru（II）配合物。具有代表性的配合物Ru4在520nm光激发下表现出较强的抗癌活性。亲脂性和细胞积累实验表明，Ru4比Ru1-Ru3和[Ru(bpy)3]2+具有更高的LogPO/W值和细胞摄取。机制研究表明，Ru4具有抑制癌细胞迁移、侵袭和肿瘤发生的作用。Ru4的生物功能主要遗传自氨基- res配体。体内实验表明，Ru4能抑制肿瘤生长，无明显的系统毒性。

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来源期刊

Journal of Inorganic Biochemistry 生物-生化与分子生物学

CiteScore

7.00

自引率

10.30%

发文量

336

审稿时长

41 days

期刊介绍： The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.