荧光半salen苯氧亚胺锌配合物显示外源性和内源性H2S

IF 3.8 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Inorganic Biochemistry Pub Date : 2025-03-01 DOI:10.1016/j.jinorgbio.2025.112875

Alessio Trerotola , Giuseppe Gravina , Viktoriia Vykhovanets , Naym Blal , Daniela Guarnieri , Andrea Maranzana , Marina Lamberti , Mina Mazzeo , Maria Strianese

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引用次数: 0

摘要

本文报道了一类半硒锌配合物的合成及其与HS -的反应性。我们提供的证据表明，HS -结合锌中心的所有配合物的调查。通过DFT和CCSD(T)计算来模拟这些配合物与HS−的反应性。我们成功地应用了一种含有希夫基配体和吡啶垂臂的同眠锌配合物，作为监测活细胞中外源性和内源性H2S水平的探针。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Fluorescent half-salen phenoxy-imine zinc complexes to reveal exogenous and endogenous H2S

查看原文本刊更多论文

Fluorescent half-salen phenoxy-imine zinc complexes to reveal exogenous and endogenous H2S

In this contribution, the synthesis and the reactivity with HS⁻ of a family of half-salen Zn complexes are reported. We provide evidence that HS⁻ binds the zinc center of all the complexes under investigation. DFT and CCSD(T) calculations were performed to model the reactivity of these complexes with HS⁻.

We successfully applied a homoleptic zinc complex bearing a Schiff-based ligand with pyridine pendant arms as a probe for the monitoring of exogenous and endogenous H₂S levels in live cells.

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来源期刊

Journal of Inorganic Biochemistry 生物-生化与分子生物学

CiteScore

7.00

自引率

10.30%

发文量

336

审稿时长

41 days

期刊介绍： The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.