Journal of Hazardous Materials最新文献_第5页

An integrated evaluation of potentially toxic elements and microplastics in the highland soils of the northeastern Qinghai-Tibetan Plateau

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137453

Apurva Kakade, Qunying Zhang, Tao Wu, Xin Yang, Jiandui Mi, Xiaoping Jing, Ruijun Long

{"title":"An integrated evaluation of potentially toxic elements and microplastics in the highland soils of the northeastern Qinghai-Tibetan Plateau","authors":"Apurva Kakade, Qunying Zhang, Tao Wu, Xin Yang, Jiandui Mi, Xiaoping Jing, Ruijun Long","doi":"10.1016/j.jhazmat.2025.137453","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137453","url":null,"abstract":"As gateways to the scenic Qinghai-Tibetan Plateau (QTP), some underexplored five grassland (GLs) and three farmland (FLs) soil locations of northeastern counties were investigated. Preliminary detection showed that in the grazing and agricultural soils, elemental concentrations (Fe>Zn>Cr>Cu>Pb>Co>As>Cd) were up to 37 and 10 mg/g, but within the China soil standards, except Cd, while microplastics (MPs) abundances were 200-3,640 and 280-973 particles/kg, respectively. Polypropylene (PP: 40-55%) dominated in GLs mostly as fragments, whereas polyethylene (PE: 72-92%) in FLs as films. Adsorption results demonstrated that potentially toxic elements (PTEs)-MPs' interaction may chiefly depend on their types and speciation in soils, the physiochemical structure of MPs, and surrounding conditions. The integrated two-dimensional risk assessment categorized three of five GLs under Risk Level VI (high pollution), whereas one of three FLs displayed Risk Level III (moderate pollution). Correlation analysis revealed that altitude, organic matter, soil clay content, and precipitation significantly affected PTEs (p≤0.01), whereas MPs were influenced by altitude, soil clay content, precipitation (p≤0.001), and population density (p≤0.05). Comparison with low-land soils globally designated QTP as a vulnerable region to MPs due to the expanding development. Overall, our study provides a data set to understand the pollution scenario of highlands for its targeted management.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"61 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fissure channeling caused anomalous uranium concentration in groundwater downstream of a uranium mine tailings impoundment site

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137492

Tian Xie, Jun Zhu, Xiaona Liu, Ying Hao, Ruiqing Wang, Pengliang Liang, Zhaoming Wang, Aiming Zhang, Tianwei Qian, Dongye Zhao

{"title":"Fissure channeling caused anomalous uranium concentration in groundwater downstream of a uranium mine tailings impoundment site","authors":"Tian Xie, Jun Zhu, Xiaona Liu, Ying Hao, Ruiqing Wang, Pengliang Liang, Zhaoming Wang, Aiming Zhang, Tianwei Qian, Dongye Zhao","doi":"10.1016/j.jhazmat.2025.137492","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137492","url":null,"abstract":"Widespread uranium mining resulted in large amounts of radioactive wastes. While impoundment has been commonly used to store U-laden wastes, information has been lacking on the secondary contamination potential. We conducted a field-scale study at a prototype uranium mine tailings impoundment site in China to understand the abnormally high concentrations (0.90-36.7 μg/L) of uranium recently observed in the downstream groundwater. Based on on-site hydrogeological measurements and modelling analysis, fracture channels were identified in the aquifer. To consider the fissure channeling flow in the solute transport modeling, a modified discrete-continuum coupled modelling approach was established, which considers the flow dynamics within both the matrix domain and the preferential flow through the main fractures. The model was not only able to simulate the observed uranium concentrations at various locations, but also to reveal the U release rate from the impoundment. Moreover, the contaminant transport modeling supported that the abnormal uranium concentrations were attributed to the channeling flow in the aquifer fractures, which was confirmed through geological analysis. In addition to valuable field data, this work offered an effective modeling approach for assessing contaminant transport through fissure channeling and the associated environmental impact of waste disposal facilities in complex hydrogeological settings.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"123 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Sorption of Diverse Organic Compounds in Soil-Water Systems: Meta-analysis, Machine Learning Modeling, and Global Soil Mapping

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137480

Jiachun Sun, Kai Zhang, Huichun Zhang

{"title":"Predicting Sorption of Diverse Organic Compounds in Soil-Water Systems: Meta-analysis, Machine Learning Modeling, and Global Soil Mapping","authors":"Jiachun Sun, Kai Zhang, Huichun Zhang","doi":"10.1016/j.jhazmat.2025.137480","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137480","url":null,"abstract":"In recent decades, the environmental detection of various organic compounds (OCs) has highlighted the limitations of conventional soil-water sorption models, which simplify complex experimental conditions and often overlook OCs with polyfunctional and ionizable structures. To address these shortcomings, we compiled a comprehensive soil-water sorption dataset encompassing 20,945 data points for 419 OCs with various functional groups and 1037 different soils. Meta-analysis of the dataset revealed the trends of soil sorption associated with OC substructures, soil properties, and solution conditions. Machine learning models employing the XGBoost algorithm, in conjunction with MACCS fingerprints and experimental conditions, were developed to cover the entire spectrum of speciation for cationic, neutral, and anionic species. Among these, the individual models tailored to each speciation achieved an overall root-mean-square-error value of 0.32 for log Kd. Model interpretation revealed that the models correctly understood the contributions of various substructures, such as multiple aromatic rings and nitrogen or oxygen atoms, to sorption. The models were also found to accurately capture isotherm nonlinearity and the pH effect on the sorption of ionizable OCs. Finally, utilizing soil properties from the Harmonized World Soil Database, the models predicted the sorption of diverse OCs based on global soil properties under simulated environmental scenarios.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"61 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity evaluation and prioritization of recycled plastic food contact materials using in silico tools

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137467

Rachelle D. Arcega, Pei-Shan Chih, Pei-Chun Hsu, Wei-Hsiang Chang, Rong-Jane Chen, Trias Mahmudiono, Ching-Chang Lee, Hsiu-Ling Chen

{"title":"Toxicity evaluation and prioritization of recycled plastic food contact materials using in silico tools","authors":"Rachelle D. Arcega, Pei-Shan Chih, Pei-Chun Hsu, Wei-Hsiang Chang, Rong-Jane Chen, Trias Mahmudiono, Ching-Chang Lee, Hsiu-Ling Chen","doi":"10.1016/j.jhazmat.2025.137467","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137467","url":null,"abstract":"This study assessed the toxicity of virgin and recycled plastic food contact materials (FCMs) at various recycling stages, migrated in four food simulants (water, 20% ethanol, 4% acetic acid, and n-heptane), using cytotoxicity and high-content screening (HCS) bioassays. Toxicity was correlated with migrating substances identified through chemical analyses, and samples were ranked by toxicity priority. Recycled polyethylene terephthalate (rPET) and 20% ethanol exhibited the highest reduction in cell viability, whereas virgin PET (vPET) showed even lower viability. Pellets did not trigger oxidative responses in HepaRG and HK-2 cells; however, bales and flakes affected their cell morphology and mitochondrial function. rPET-flake migration in 4% acetic acid was most toxic to HepaRG cells, while rPET-bale migration in 20% ethanol and rPP-flake migration in water were most toxic to HK-2 cells. Nonetheless, the negative effects on cell viability and HCS parameters were mostly mitigated at the final pellet stage. In HepaRG cells exposed to 4% acetic acid, antimony negatively correlated with cell viability and positively with cellular area, indicating its role in rPET-induced necrosis. ToxPi ranking identified vPET migration in n-heptane and water as top priorities given the nephrotoxic risks. This study emphasizes refining recycling methods and testing plastics to minimize FCM cytotoxicity.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"47 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplastics and the freshwater plankton: effects on grazing and mortality

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137497

Anita Galir, Dubravka Špoljarić Maronić, Filip Stević, Tanja Žuna Pfeiffer, Matea Dent, Tena Minarik

{"title":"Microplastics and the freshwater plankton: effects on grazing and mortality","authors":"Anita Galir, Dubravka Špoljarić Maronić, Filip Stević, Tanja Žuna Pfeiffer, Matea Dent, Tena Minarik","doi":"10.1016/j.jhazmat.2025.137497","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137497","url":null,"abstract":"When studying the effects of microplastics (MP) on zooplankton in freshwater environments, there is a knowledge gap at the community level, as most studies use monocultures under laboratory conditions with limited comparability to field studies. The aim of our study was to investigate the uptake of MP at environmentally relevant concentrations by a natural zooplankton community feeding on native phytoplankton. Rotifers and cladocerans comprised more than 96% of total zooplankton community, while nauplii and copepodites dominated the copepod community. To test the possible change in phytoplankton grazing and zooplankton mortality after MP exposure, zooplankton were exposed to three different polyethylene MP sizes: A (1-5 µm), B (27-32 µm), and C (45-53 µm) during 96 hours. Ingestion in group A was observed in 34% of rotifers, 20% of cladocerans and 67% of copepods. In group B, only cladocerans ingested MP, and to a much lower extent (2%), which could be due to the composition of the community. None of the zooplankton studied ingested MP particles in group C. The ingestion of MP decreased phytoplankton consumption, and phytoplankton abundance varied greatly between samples. The highest phytoplankton abundance was observed in the A samples with the highest proportion of ingested MP, indicating a significant reduction in grazing pressure that allowed phytoplankton to proliferate. This result, combined with the highest mortality of cladocerans in the A samples (12.7 ± 0.91%), indicates the negative impact of MP on the normal functioning of the freshwater plankton food web.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"22 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Driving forces of agricultural ammonia emissions in semi-arid areas of China: a spatial econometric approach

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137484

Yunrui Ai, Liyang Xue, Yong Li, Quanxi Xu, Xuan Dai, Yancong Wu, Ning Kang, Tingting Zhang, Jianfeng Gou, Yan Tao

{"title":"Driving forces of agricultural ammonia emissions in semi-arid areas of China: a spatial econometric approach","authors":"Yunrui Ai, Liyang Xue, Yong Li, Quanxi Xu, Xuan Dai, Yancong Wu, Ning Kang, Tingting Zhang, Jianfeng Gou, Yan Tao","doi":"10.1016/j.jhazmat.2025.137484","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137484","url":null,"abstract":"Ammonia emissions contribute to PM2.5 formation, posing significant threats to public health, including respiratory and cardiovascular diseases, and causing various ecological issues, such as soil and water acidification. This study investigates ammonia emissions in the semi-arid region of central Gansu Province, China, by establishing a county-level agricultural ammonia emission inventory for 2014–2020 using the emission factor method. A spatial econometric model, integrated with the STIRPAT (Stochastic Impacts by Regression on Population, Affluence, and Technology) model, is employed to identify key drivers of emissions. This approach is crucial because it accounts for the spatial dependencies of emissions across regions and incorporates socio-economic factors, providing a more comprehensive understanding of emission patterns. Results indicate that livestock and poultry farming (58.76%) and nitrogen fertilizer application (37.73%) are major contributors to ammonia emissions. Regional agricultural ammonia emissions are concentrated in the east, river basins, and parts of the southwest. The study also reveals positive spatial clustering and spillover effects of ammonia emissions. In the central region of Gansu Province, a 1% increase in per capita GDP, population, agricultural structure, and rural electricity consumption leads to changes in agricultural ammonia emissions of 0.059%, -1.181%, -0.109%, and 0.133%, respectively. Rural electricity consumption, population dynamics, and agricultural structure improvements influence not only locally but also across neighboring regions. The findings emphasize the need for targeted, collaborative regional strategies to mitigate emissions and underscore the importance of considering spatial interactions in emission reduction policies.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"44 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formation of halonitromethanes, dichloroacetonitrile, and trichloromethane in the presence of E. coli and nitrophenols during UV/post-chlorination

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137499

Tao Wang, Qian Tang, Lin Deng, Chaoqun Tan, Yulin Fu, Jun Hu, Rajendra Prasad Singh

{"title":"Formation of halonitromethanes, dichloroacetonitrile, and trichloromethane in the presence of E. coli and nitrophenols during UV/post-chlorination","authors":"Tao Wang, Qian Tang, Lin Deng, Chaoqun Tan, Yulin Fu, Jun Hu, Rajendra Prasad Singh","doi":"10.1016/j.jhazmat.2025.137499","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137499","url":null,"abstract":"Nitrophenols and E. coli widely coexist in surface water and can form chlorinated disinfection byproducts (Cl-DBPs) in chlorine-based disinfection processes. However, the coexistence of nitrophenols and E. coli affecting Cl-DBPs formation has not been reported. Herein, the formation of chlorinated halonitromethanes (Cl-HNMs), dichloroacetonitrile (DCAN), and trichloromethane (TCM) in the simultaneous presence of nitrophenols and E. coli was investigated in the UV/post-chlorination process. Results indicated the coexistence of nitrophenols and E. coli ((1-2) × 105 CFU mL-1) enhanced Cl-DBPs formation, but excessive E. coli ((1-2) × 107 CFU mL-1) dramatically inhibited that. Moreover, appropriate UV fluences promoted Cl-DBPs formation, and increasing chlorine dose and nitrophenol concentration enhanced that. Besides, alkaline pH decreased Cl-HNMs and DCAN formation but facilitated TCM formation. Subsequently, the Cl-DBPs formation mechanisms and pathways were explored in the simultaneous presence of E. coli and nitrophenols. When nitrophenols and E. coli were present in real waters, more complicated formation phenomena of Cl-DBPs were observed compared to those in simulated waters (SWs). Finally, Cl-DBPs generated in real waters exhibited lower toxicities than those generated in SWs. This study provides new insights into Cl-DBPs formation in the presence of organic substances and bacteria, simultaneously contributing to a better UV/post-chlorination process application.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"122 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polystyrene nanoplastics amplify the toxic effects of PFOA on the Chinese mitten crab (Eriocheir sinensis)

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137488

Peng Huang, Liping Cao, Jinliang Du, Yiqing Guo, Quanjie Li, Yi Sun, Haojun Zhu, Gangchun Xu, Jiancao Gao

{"title":"Polystyrene nanoplastics amplify the toxic effects of PFOA on the Chinese mitten crab (Eriocheir sinensis)","authors":"Peng Huang, Liping Cao, Jinliang Du, Yiqing Guo, Quanjie Li, Yi Sun, Haojun Zhu, Gangchun Xu, Jiancao Gao","doi":"10.1016/j.jhazmat.2025.137488","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137488","url":null,"abstract":"Nanoplastics (NPs), the final form of degraded microplastics in the environment, can adsorb PFOA (an emerging organic pollutant in recent years) in several ways. Current research on these has focused on bony fishes and mollusks, however, the combined toxicity of PFOA and NPs remains unknown in Eriocheir sinensis. Therefore, the effects of single or combined exposure to PFOA and NPs were investigated. The results showed that NPs aggravated PFOA exposure-induced oxidative stress, serum lipid disorders, immune responses, and morphological damage. DEGs altered by NPs-PFOA exposure were predominantly enriched in GO terms for cell lumen, and organelle structure, and KEGG terms for spliceosome and endocrine disorders-related diseases. Notably, the apoptotic pathway plays a central role enriched under different exposure modes. PFOA or NPs-PFOA exposure disrupted the levels of lipids molecules-related metabolites by mediating the glycerophospholipid pathway, and the NPs mediated the ferroptosis pathway to exacerbate PFOA-induced metabolic toxicity. In addition, NPs exacerbated the inflammatory response and metabolic imbalance by mediating Fusobacterium ulcerans in the intestinal. In conclusion, this study provides a valuable reference for the characterization of NPs-PFOA combined pollution and a scientific basis for the development of environmental protection policies and pollution management strategies.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"29 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of Changes in PM2.5 Concentrations and Their Major Components on Blood Pressure during Pregnancy

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137477

Peiyao Chen, Wenjie He, Yan Jin, Xueting Liu, Qiannan Wei, Jianling Shen, Qingqing Wang, Li Wen, Lijie Wang, Qing Wei, Qiansheng Hu, Weiwei Lin

{"title":"Impacts of Changes in PM2.5 Concentrations and Their Major Components on Blood Pressure during Pregnancy","authors":"Peiyao Chen, Wenjie He, Yan Jin, Xueting Liu, Qiannan Wei, Jianling Shen, Qingqing Wang, Li Wen, Lijie Wang, Qing Wei, Qiansheng Hu, Weiwei Lin","doi":"10.1016/j.jhazmat.2025.137477","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137477","url":null,"abstract":"Sulfate, nitrate, ammonium, organic matter, and black carbon account for more than two-thirds of the total mass of PM2.5 and have stronger cardiovascular toxicity than other components. However, evidence regarding the gestational cardiovascular toxicity of these PM2.5 components is lacking. A prospective cohort study was conducted among 1913 pregnant women in Guangzhou, Pearl River Delta, China, from 2017 to 2020. Each participant underwent two office blood pressure (BP) measurements: baseline BP was assessed during the first and second trimesters (mean gestational age: 13.77 ± 2.76 weeks) and follow-up BP was measured during the third trimester (mean gestational age: 39.00 ± 1.46 weeks.) The level of the five main PM2.5 components were estimated using a tracking air pollution dataset. Changes in PM2.5 component concentrations and BP levels were determined by calculating the differences between follow-up and baseline values. We found that changes in PM2.5 mass and components significantly affected gestational BP variations (β = 1.88-3.42, P < 0.001). Most associations exhibited an inverted U-shaped non-linear relationship, initially increasing steeply before leveling off, without a clear threshold. Systolic blood pressure (SBP) was more sensitive to concentration changes in PM2.5 components, with nitrate showing a particularly pronounced effect. Our findings suggest that changes in PM2.5 mass and its specific components levels were associated with maternal BP, especially increased SBP, with nitrate being the major contributor. Stricter emission reduction measures are needed to mitigate urban pollution sources associated with particulate nitrate.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"22 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a highly sensitive PbrR-based biosensor via directed evolution and its application for lead detection

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-02-03 DOI: 10.1016/j.jhazmat.2025.137489

Liang Shen, Yiwen Chen, Jiajie Pan, Xin Yu, Yubo Zhang, Bingxin Guo, Jiaqi Wang, Ying Liu, Xiang Xiao, Shaopeng Chen, Lingzhi Bao

{"title":"Development of a highly sensitive PbrR-based biosensor via directed evolution and its application for lead detection","authors":"Liang Shen, Yiwen Chen, Jiajie Pan, Xin Yu, Yubo Zhang, Bingxin Guo, Jiaqi Wang, Ying Liu, Xiang Xiao, Shaopeng Chen, Lingzhi Bao","doi":"10.1016/j.jhazmat.2025.137489","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137489","url":null,"abstract":"The Whole-cell biosensor (WCB) is a convenient and practical assay that can monitor bioavailable lead (Pb) contamination. However, existing Pb-responsive WCB struggle to meet practical detection needs due to the lack of sensitivity, specificity, and stability. In this study, we developed a Pb WCB using the Pb resistance transcriptional regulatory factor (PbrR) and green fluorescent protein (GFP), and improved its performance by directed evolution in conjunction with fluorescence-activated cell sorting (FACS). After 3 rounds of screening, we acquired a biosensor mutant (PbrR-E3). The evolved biosensor exhibited an approximately 11-fold increase in maximum fluorescence output signal compared to the non-evolved biosensor, resulting in an improvement of its sensitivity and specificity. This biosensor demonstrated a limit of detection (LOD) of 0.045 μg/L. Furthermore, the evolved biosensor showcased outstanding performance in the detection of Pb(II) in tea infusion and also demonstrated good stability in tests with spiked real water samples. These results highlight the potential of the evolved WCB as a viable approach for monitoring Pb.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"36 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0