Journal of Hazardous Materials最新文献

{"title":"Efficient degradation of per- and polyfluoroalkyl substances on plasmonic surfaces with visible light","authors":"Qiang Xu, Bryan M. Wong","doi":"10.1016/j.jhazmat.2025.139939","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139939","url":null,"abstract":"Drinking water with per- and polyfluorosubstances (PFAS) contaminants poses serious public health risks, prompting intensive efforts to develop effective remediation strategies. Among these, photodegradation processes are particularly promising because of their efficiency and intrinsic environmental friendliness. However, the experimental identification of suitable photoactive materials and a detailed understanding of the underlying reaction mechanisms are challenging because of the inherent complexity of these excited-state processes. Using our recently developed real-time electron-nuclear dynamics approach (Xu et al., 2024), we demonstrate efficient photoinduced degradation of perfluorooctanoic acid (PFOA) on a plasmonic Au(111) surface with visible light at 530 nm. Our approach enables large-scale simulations (containing over 400 atoms) beyond conventional quantum calculations, which are required to capture the complex photo-induced degradation dynamics in realistic aqueous environments. In particular, our results highlight a complex interplay of collective excitations between the Au(111) surface and adsorbed PFOA molecule, where the surrounding water molecules play an active role in charge transfer that drives the degradation process. Our photo-induced dynamics approaches highlight the utility of plasmonic surfaces and water for efficient PFAS degradation; moreover, these predictive calculations can be used to prescreen candidate material surfaces, solvents, and photocatalytic conditions to remediate PFAS and other environmental contaminants.<strong>Environmental Implication:</strong> Our time-resolved electron-nuclear dynamics simulations reveal that the plasmonic Au(111) surface is an effective photoactive material that can enable PFOA degradation with visible light (530 nm). Moreover, our results surprisingly show that the surrounding water molecules are not merely spectators in the degradation process and actively participate to enhance charge transfer and promote PFOA decomposition.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"65 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Phragmites australis in bioremediation of Acid mine drainage: Enhancing water quality and remodeling aqueous microbial communities","authors":"Shili Zhang, Yanchao Lu, Hui Han, Hong Geng, Quanxi Zhang, Yuexia Zhang, Xianyun Zheng","doi":"10.1016/j.jhazmat.2025.139988","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139988","url":null,"abstract":"Acid Mine Drainage (AMD) is a significant global environmental challenge, while phytoremediation emerges as a promising bioremediation strategy for AMD treatment. In this study, <em>Phragmites australis</em>, <em>Miscanthus lutarioriparius</em>, and <em>Pennisetum alopecuroides</em> were used to assess their seed germination exposed to AMD to screen the excellent resistant species used for AMD phytoremediation. Our results suggested that compared to the other two species, <em>Phragmites australis</em> exhibited more tolerant characteristics, including its shortened mean germination time, higher fresh weight, increased tillering number, higher chlorophyll content, and superior seedling growth across all AMD concentrations. A 30-day cultivation of <em>Phragmites australis</em> plantlets can improve water quality by enhancing pH levels and effectively reducing the concentrations of metals (iron (Fe), nickel (Ni), and lead (Pb)) and sulfate (SO₄^2-) in AMD samples. <em>Phragmites australis</em> plantlets significantly remodeled the AMD microbial community by enhancing bacterial diversity, altering taxonomic composition, and enriching functional genes (e.g., acid resistance, metal tolerance, and sulfur metabolism), highlighting a key phytotolerance mechanism against AMD stress. This study reveals that <em>Phragmites australis</em> tolerates and remediates AMD through metal accumulation and translocation in plant tissues, formation of reddish-brown precipitates and white crystalline deposits, and substantial restructuring of aquatic microbial communities. These synergistic effects collectively enhance AMD water quality through both physicochemical and biological processes, establishing <em>Phragmites australis</em> as an effective phytoremediation candidate for AMD remediation.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"42 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Hydroxylamine Hydrochloride and Hydrogen Peroxide in Activated Fe(VI) for Fracturing Flowback Fluid Treatment: Efficiency, Mechanism, and Toxicity Analysis","authors":"Lili Ma, Jia Wei, Chen Miao, Jiahao Ren, Wanxi Jiang, Bing Yang, Yucheng Liu","doi":"10.1016/j.jhazmat.2025.139985","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139985","url":null,"abstract":"Ferrate(VI) oxidation is an effective approach for organic wastewater treatment. However, its application in fracturing flowback fluid with high salinity and complex contaminants requires further investigation. In this study, two distinct Fe(VI) activation strategies, hydroxylamine hydrochloride and hydrogen peroxide, were applied to enhance contaminants oxidation in fracturing flowback fluid. The results showed HA facilitated Fe(IV)/Fe(V) generation by electron transfer, whereas exogenous H₂O₂ enhanced ·OH generation. Both Fe(VI) activated systems improved pollutant degradation compared with Fe(VI) alone. Under optimal conditions, Fe(VI)-H₂O₂ system dominated by ·OH exhibited better organic removal (TOC removal 46.0%, UV₂₅₄ removal 66.6%, and the BOD₅/COD value (the B/C) 0.436) than Fe(VI)-HA system dominated by Fe(IV)/Fe(V) (TOC removal 33.7%, UV₂₅₄ removal 61.5%, and the B/C 0.332). The organic species number in the Fe(VI)-H₂O₂ system was reduced by nearly half than Fe(VI)-HA, and the system can completely remove the alcohols, acids, and ether substances. In addition, toxicity tests showed that in high salinity wastewater (Cl^- and salinity concentration of 5498.9 and 10332.0<!-- --> <!-- -->mg/L), both HA and H₂O₂ activated Fe(VI) strategies can decrease the acute toxicity and phytotoxicity. Overall, both HA and H₂O₂-activated Fe(VI) oxidation are feasible for treating fracturing flowback fluid, with H₂O₂-activated Fe(VI) oxidation exhibiting higher efficacy.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"17 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per- and polyfluoroalkyl substances in sewage sludge: A global synthesis of persistence mechanisms, analytical complexities, and sustainable remediation strategies","authors":"Yiqun Guo, Yu Hua, Xuhao Chen, Yan Li, Chong Chen, Xiaohu Dai","doi":"10.1016/j.jhazmat.2025.139989","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139989","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFASs), known as “forever chemicals” because of their persistent carbon–fluorine bonds, pose critical environmental risks. Sewage sludge is a major reservoir and secondary pollution source of PFASs. This review synthesizes the environmental behavior, analytical methods, global distribution, regulatory landscape, and mitigation strategies of PFASs in sludge. It also addresses complex interactions between PFAS and sludge components (organic matter, inorganic particles, extracellular polymeric substances, and microbial communities), which drive PFAS accumulation via hydrophobic interactions, ion bridging, and complexation. Analytical challenges arise from sludge heterogeneity, high moisture content, and diverse PFAS species. To address these challenges, integrated targeted/non-targeted approaches and total organic fluorine analysis are required. Global monitoring reveals stark regional disparities: U.S. sludge shows ∑PFAS up to 3,390<!-- --> <!-- -->ng/g (dry weight) with dominant long-chain PFOS/PFOA, while Nordic countries exhibit lower levels (PFOS &lt; 10<!-- --> <!-- -->ng/g) owing to early regulations. Notably, the contents of short-chain PFASs and precursors (e.g., MeFOSAA and EtFOSAA) are increasing, reflecting industrial substitutions and incomplete wastewater treatment. Although regulatory frameworks are shifting from compound-specific limits (e.g., a PFOS of 5.2<!-- --> <!-- -->ng/g in Maine, US) to class-based controls (e.g., ∑11 PFASs ≤ 3<!-- --> <!-- -->ng/g in Sweden), many thresholds are insufficient to address contamination levels. Treatment technologies—from physical separation (adsorption and membrane treatments) and thermal destruction (incineration, pyrolysis and hydrothermal liquefaction) to advanced oxidation/reduction processes, plasma/supercritical water oxidation, and biological methods—show varying efficiencies. Thermal destruction approaches (≥650°C) achieve &gt;99% mineralization but incur high energy costs, while biological routes achieve limited precursor transformation. Environmental fate assessments highlight three key behaviors of PFAS: migration in amended soils, plant uptake (particularly short-chain PFAS in leafy crops), and “delayed release” from precursor degradation. These behaviors threaten food chains and microbial ecosystems. Key future directions include developing high-sensitivity detection, elucidating binding mechanisms, establishing life-cycle risk models, innovating cost-effective green technologies, and advancing policy-driven management—providing a scientific basis for PFAS control and sustainable sludge utilization.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"104 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidation of urea to nitrate via persulfate activation under far-UVC light improves ultrapure water production","authors":"Youn-Jun Lee, Sung-Hyo Jung, Chang-Gu Lee","doi":"10.1016/j.jhazmat.2025.139987","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139987","url":null,"abstract":"Low-molecular-weight organic pollutants present in feed water pose a significant challenge to maintaining ultrapure water (UPW) quality, as they are not readily removed by conventional treatment processes. Urea is a low-molecular-weight, nonionic, persistent organic pollutant resistant to conventional UPW production processes. Therefore, suitable oxidation technologies must be explored to convert urea to inorganic nitrogen ions, which are more easily removed in post-UPW treatment steps. In this study, the far-UVC (peak wavelength centered at 222<!-- --> <!-- -->nm) coupled persulfate (PS) activation system was used for the effective oxidation of urea to nitrate (NO₃⁻). In the degradation of urea (10<!-- --> <!-- -->μM, PS 0.4<!-- --> <!-- -->mM, pH 7), far-UVC/PS systems (k_urea,222/PDS= 1.69 × 10⁻³ cm²∙mJ⁻¹, k_urea,222/PMS= 2.69×10⁻⁴ cm²∙mJ⁻¹) were found to be superior to conventional 254<!-- --> <!-- -->nm LPUV/PS systems (k_urea,254/PDS= 1.07×10⁻⁴ cm²∙mJ⁻¹, k_urea,254/PMS= 7.01×10⁻⁵ cm²∙mJ⁻¹). The far-UVC/PDS system showed the highest efficiency, achieving complete urea removal after 5,241.0 mJ∙cm⁻² of irradiation. The dominant role of SO₄^•− in urea degradation was systematically investigated, with urea removal showing a strong correlation with the steady-state concentration of SO₄^•−. Moreover, the evolution of inorganic nitrogen species and the reduction of total organic carbon were examined to assess the applicability of the system as a pretreatment technology in UPW production. The results provide valuable insights into the integration of the far-UVC process for the removal of low-molecular weight pollutants during UPW production.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"96 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Microplastic Exposure and Macrolide Resistance in Mycoplasma pneumoniae pneumonia among Younger Children: A Cross-Sectional Study in China","authors":"Wendi Ma, Lili Zhong, Jingli Yang, Kent E Pinkerton, Shuli Zhao, Huimin Li, Yinze Xu, Xiuqin Feng, Xuelin Lv, Qiong Wang, Chuyun Yan, Jingjing Zhang, Aimin Yang","doi":"10.1016/j.jhazmat.2025.139981","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139981","url":null,"abstract":"Microplastics (MPs) are emerging environmental contaminants that pose potential health risks through inhalation, ingestion, and dermal contact. However, data on MP exposure and its impact on the pediatric respiratory system remain limited. This study aimed to assess MP levels in bronchoalveolar lavage fluid (BALF) and evaluate their associations with macrolide resistance in children with Mycoplasma pneumoniae pneumonia (MPP). BALF samples from 195 children aged 1-16 years were analyzed using Laser Direct Infrared (LDIR) spectroscopy and Pyrolysis-Gas Chromatography/Mass Spectrometry (Py-GC/MS). Six types of MPs were identified: Polyamide 66 (PA66) (92.31%), Polyvinyl Chloride (PVC) (81.54%), Polystyrene (PS) (78.97%), Polyethylene (PE) (51.28%), Polymethyl Methacrylate (PMMA) (21.02%), and Polypropylene (PP) (11.28%). MPs were detected in 194 out of 195 samples, with an overall detection rate of 99.48%. Logistic regression showed that moderate exposure to PE (0.32-1.05<!-- --> <!-- -->µg/ml) significantly increased the odds of macrolide-resistant MPP compared to low exposure (OR = 1.39; 95% CI: 1.01-1.92; P &lt; 0.05). Among children aged ≤6 years, high PE exposure was strongly associated with odds of macrolide-resistant MPP (OR = 2.62; 95% CI: 1.37-5.02; P &lt; 0.05), with a significant dose-response trend (P trend = 0.004). These findings provide the first evidence linking lower respiratory tract MP exposure with antibiotic resistance in pediatric MPP, particularly among younger children, and underscore the importance of minimizing environmental MP exposure in vulnerable populations.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"88 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From waste to resource: A review on biological and physicochemical metal remediation and recovery in the light of the circular economy","authors":"Cristina Povedano-Priego, Fadwa Jroundi, Margarita Lopez-Fernandez, Miguel A. Ruiz-Fresneda, Antonio Newman-Portela, Veronika Hlavackova, Frances Burrell, Phil E. Warwick, Nhung H.A. Nguyen, Alena Sevcu, Miroslav Cernik, Mohamed L. Merroun, Andrew B. Cundy","doi":"10.1016/j.jhazmat.2025.139991","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139991","url":null,"abstract":"Remediating metal-contaminated sites, particularly those impacted by the extraction or processing of critical raw materials (CRMs), poses significant environmental and health challenges. This topic has typically been approached from either a physicochemical or a biological perspective, depending on the disciplinary focus. The present review seeks to bridge that gap by integrating both approaches into a unified and comprehensive framework, exploring their interconnections and highlighting the insights that emerge from their synthesis. It describes current advances in both methods groups for the treatment of metal-containing wastes, focusing on the removal of toxic metal(loid)s, and the recovery of CRMs within the framework of the circular economy. Physicochemical techniques play a crucial role in waste decontamination, while biological methods may offer environmentally sustainable alternatives for mitigating metal pollution. Microbial strategies are particularly advantageous due to their high specificity and effectiveness even at low contaminant concentrations, while also facilitating site restoration with minimal ecological damage. Integrating biological and physicochemical treatments may significantly enhance remediation performance, for more efficient and sustainable solutions. In particular, “treatment trains” or sequential treatment approaches combine multiple remediation methods to enhance efficiency while enabling recovery and reuse of valuable metals. Successful implementation of these strategies requires the optimization of treatment conditions and the integration of green remediation practices into large-scale applications. This review highlights the need for more comprehensive and in-depth studies (including field-scale applications) to address critical knowledge gaps and to further develop these potentially cost-effective and more sustainable methods for extracting valuable metals from mining waste.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"26 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effects of Micro/Nanoplastics and Cu(II) on Horizontal Transfer of Antibiotic Resistance Genes: New insight targeting on Cell Surface Properties","authors":"Baoxin Zhang, Qinglong Liu, Lan Wang, Jingchun Tang","doi":"10.1016/j.jhazmat.2025.139975","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139975","url":null,"abstract":"Microplastics (MPs) and nanoplastics (NPs) facilitate antibiotic resistance genes (ARGs) transfer through horizontal gene transfer (HGT). However, the combined effects of M-NPs and heavy metals on HGT remain poorly understood, and the effects of cell surface properties is neglected. In this study, an antibiotic co-existence heavy metal Cu was used to study its synergetic effect with M-NPs on HGT, with a specific focus on bacterial surface characteristics and physiological responses. Results reveal that NPs amplified Cu(II)'s effect on conjugative transfer of ARGs, while MPs showed mitigation effect. NPs+Cu(II) co-exposure yielded the highest conjugative transfer frequency (4.4-fold) and a 35-fold surge in transformation frequency compared to the control. These disparities stem from bacterial physiological responses, including 4–7-fold elevated reactive oxygen species (ROS), 3–4-fold increased membrane permeability, 1.5–1.8-fold enhanced ATP synthesis, altered drug-resistant efflux and metabolic pathways; Furthermore, cell surface property modulation—Cu(II) stimulated 1.2-fold lipopolysaccharide (LPS) production and M-NPs regulated outer membrane vesicles (OMVs) concentration/sizes, with extracellular polymeric substances (EPS) optimizing interbacterial aggregation for gene transfer. In addition, MPs+Cu(II) induced 49% viable but non-culturable (VBNC) bacteria and high-dose M-NPs caused excessive bacterial injury/death, reducing gene transfer (VBNC ratio indicating stress severity). These findings highlight co-exposure impacts and offer novel insights into the environmental risks posed by M-NPs and ARGs.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"136 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking the Invisible Threat: Persistent Explosive Residues in Raw and Drinking Water Bodies","authors":"Dani Khoury, Christelle Pallez, Sophie Lardy-Fontan, Christophe Rosin","doi":"10.1016/j.jhazmat.2025.139986","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139986","url":null,"abstract":"This study provides a comprehensive nationwide assessment of explosive residues and their degradation products in French water resources and drinking water, including mainland and overseas territories. A total of 54 target compounds were selected based on historical usage, environmental persistence, and analytical feasibility. Between 2020 and 2022, water samples from nearly 300 sites—representing resources for 20–25% of the French population—were analyzed using high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS) and gas chromatography–tandem mass spectrometry (GC-MS/MS). Explosive residues were detected in 11% of the 797 samples, mainly in raw groundwater. Frequently identified compounds included 2,6-dinitrotoluene (2,6-DNT), diphenylamine (DPA), and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), while others appeared less often but sometimes at high levels. These contaminants were largely linked to historical battlefields and former munitions storage areas, especially in the <em>Grand-Est</em> region bordering Germany. Degradation products like aminodinitrotoluenes (ADNTs) were more common in drinking water, possibly due to incomplete removal or transformation during treatment. Significant correlations between DNT, nitrotoluene (NT), and perchlorate suggest a shared origin tied to historical military activity. The findings highlight the need for continued monitoring of explosive residues, not only in France but in other regions affected by historical or current military operations.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"9 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to 3H-lysine during lactation causes longer retention of organically bound tritium in the lens of mouse eyes","authors":"Haruki Nagashima, Hideki Kakiuchi, Tsuyoshi Masuda","doi":"10.1016/j.jhazmat.2025.139977","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139977","url":null,"abstract":"To investigate differences in the long-term retention of organically bound tritium among organs depending on the time of ingestion, we administered drinking water containing 50 MBq L^{-1 3}H-lysine to mice in four groups at specific stages of development for 3 weeks. Mice born to dams that had ingested ³H-lysine solution throughout pregnancy, mice fed maternal milk from dams administered ³H-lysine during lactation, adolescent mice that had ingested ³H-lysine during the growing stage, and mice that had ingested ³H-lysine during adulthood were sacrificed at the same age of 20 weeks. Subsequent measurements of tritium concentrations in organs revealed that, among the groups corresponding to different developmental stages, concentrations of organically bound tritium in the eye lens of mice fed milk from dams that had ingested ³H-lysine solution were higher than those in mice in the other three groups, whereas those in liver and muscle were higher in mice administered ³H-lysine during adulthood. These findings indicate that the hazardous effects associated with environmental tritium derived through ingestion need to be evaluated with a consideration of the stage of development at the time of exposure. To date, however, this approach has yet to be implemented in the system of radiological protection adopted by the International Commission on Radiological Protection.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"473 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}