Rui Zhou , Jian Chen , Haobo Bian , Lu Li , Tao Zhang , Lei Liao , Haobo Niu , Leyi Yin , Guoxin Huang
{"title":"A framework for spatial correlations between industrial pollution sources and groundwater vulnerabilities based on machine learning and spatial cluster analysis: Implications for risk control","authors":"Rui Zhou , Jian Chen , Haobo Bian , Lu Li , Tao Zhang , Lei Liao , Haobo Niu , Leyi Yin , Guoxin Huang","doi":"10.1016/j.jhazmat.2025.138492","DOIUrl":"10.1016/j.jhazmat.2025.138492","url":null,"abstract":"<div><div>The efficacy of groundwater pollution risk control is often limited by a lack of information on spatial correlations between industrial pollution sources and groundwater vulnerabilities. To overcome this limitation, a novel data-driven framework was established to reveal the spatial correlations between industrial pollution sources and groundwater vulnerabilities in Guangdong Province, China, mainly using a combination of genetic algorithm (GA), back propagation neural network (BPNN), kernel density estimation (KDE) and bivariate local Moran’s I (BLMI). The subjectivity in the indicator weighting of a DRASTICL model was successfully reduced by GA-BPNN, and then the groundwater vulnerability map was created by the GA-BPNN-DRASTICL model. A smoother surface of the industrial pollution source distribution was produced by KDE. The spatial clustering map between industrial pollution sources and groundwater vulnerabilities was generated by BLMI, explicitly showing their distribution characteristics and implying that the specific measures should be taken for controlling risks of groundwater pollution in the different parts of the study area.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138492"},"PeriodicalIF":12.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nourin I. Seenthia , Wael Abdelraheem , Samuel A. Beal , Joseph J. Pignatello , Wenqing Xu
{"title":"Simultaneous adsorption and hydrolysis of insensitive munition compounds by pyrogenic carbonaceous matter (PCM) and functionalized PCM in soils","authors":"Nourin I. Seenthia , Wael Abdelraheem , Samuel A. Beal , Joseph J. Pignatello , Wenqing Xu","doi":"10.1016/j.jhazmat.2025.138501","DOIUrl":"10.1016/j.jhazmat.2025.138501","url":null,"abstract":"<div><div>Military training with insensitive munitions (IM) deposits a large amount of post-detonation residues on range soils that may contaminate groundwater. This study investigated the effectiveness of pyrogenic carbonaceous matter (PCM) and functionalized PCM as a soil amendment to retain and transform IM compounds (e.g., 5-nitro-1,2-dihydro-3H-1,2,4-triazin-3-one (NTO), nitroguanidine (NQ), and 2,4-dinitroanisole (DNAN)). Initial hydrolysis tests showed quaternary ammonium (QA)-modified PCM accelerated NQ hydrolysis, while NTO formed charge-assisted hydrogen bonds with PCM's surface groups instead of hydrolyzing. We amended three soils with a subset of PCM materials and monitored the removal of NTO, NQ, and DNAN under varying pH conditions (i.e., 8.0, 10.0, and 12.0) and amendment dosages (i.e., 0, 2, 3, and 5 % (w)) in batch reactors. We also assessed the reactivity and reusability of the best-performing PCM by consecutive addition of IM post-detonation residues. Our results indicate that PCM can significantly enhance the removal of NTO, NQ, and DNAN in soils by 50–300-fold compared to soil controls, and QA-modified activated carbon (AC) performed the best. Increasing pH from 8.0 to 10.0 enhanced the DNAN hydrolysis with PCM, whereas NQ hydrolysis only occurred at pH 12.0. However, increasing PCM dosage from 2 % to 5 % (w) did not significantly increase the removal of NTO, NQ, and DNAN. QA-modified AC maintained its reactivity over three consecutive additions of IM post-detonation residues at pH 10.0, with an average NTO and NQ removal of 98.8 ± 0.6 % and 84.2 ± 3.2 %, respectively, and DNAN decay of 55.3 ± 2.9 %. Overall, our findings highlight the effectiveness of the functionalized PCM in simultaneously retaining and transforming IM compounds, providing a strategy for using reactive amendment <em>in-situ</em> to sustain military operation and mitigate pollution.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138501"},"PeriodicalIF":12.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Sung Kim , Seulgidaun Lee , Moonhee Park , Hyemi Jang , Mira Choi , Ji Yi Lee , Mijung Song , Changhyuk Kim , Junyoung Ahn , Zhijun Wu , Amgalan Natsagdorj , Jungju Seo , Tae Kwon Lee , Young Hwan Kim , Kyoung-Soon Jang
{"title":"Region-specific characterization and ecotoxicity assessment of PAH compounds in winter PM2.5 from three capital cities in Northeast Asia","authors":"Min Sung Kim , Seulgidaun Lee , Moonhee Park , Hyemi Jang , Mira Choi , Ji Yi Lee , Mijung Song , Changhyuk Kim , Junyoung Ahn , Zhijun Wu , Amgalan Natsagdorj , Jungju Seo , Tae Kwon Lee , Young Hwan Kim , Kyoung-Soon Jang","doi":"10.1016/j.jhazmat.2025.138536","DOIUrl":"10.1016/j.jhazmat.2025.138536","url":null,"abstract":"<div><div>Industrialization and urbanization in Northeast Asia have heightened PM<sub>2.5</sub> pollution, posing significant public health risks. This study examined the spatial and chemical variability of polycyclic aromatic hydrocarbons (PAHs) and their ecotoxicity in winter PM<sub>2.5</sub> from three capitals—Ulaanbaatar (UB, Mongolia), Beijing (BJ, China), and Seoul (SE, South Korea)—using two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOF MS). PM<sub>2.5</sub> samples collected between December 15, 2020 and January 14, 2021 revealed UB had the highest concentrations (85.7 ± 36.7 μg m<sup>−3</sup>) and PAH levels (758.9 ± 224.7 ng m<sup>−3</sup>), primarily from coal combustion and biomass burning. BJ (30.3 ± 16.9 μg m<sup>−3</sup>; 41.4 ± 18.4 ng m<sup>−3</sup>) and SE (26.0 ± 14.4 μg m<sup>−3</sup>; 6.2 ± 2.4 ng m<sup>−3</sup>) had lower PAH levels but a higher share of secondary products, including oxygenated (OPAHs) and nitrogen-containing PAHs (NPAHs). Overall, 646 PAH compounds were identified: UB was dominated by methylated alkyl and sulfur-containing PAHs, while BJ and SE had more hydroxylated and carbonylated PAHs. QSAR ecotoxicity analysis indicated the highest toxicity in SE from hydroxylated PAHs and a broader toxic range in UB. These findings support air quality strategies to reduce coal combustion in UB and secondary PAH formation in BJ and SE.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138536"},"PeriodicalIF":12.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Runze Liu , Xiaokang Guo , Guangjian Yang , Shuangqing Lu , Feihu Chen , Wenxiao Jia , Ji Li , Jiling Niu , Hongbo Guo , Hui Zhu
{"title":"Formation of metal-microplastic complexes in lung adenocarcinoma is associated with increased risk of cancer progression","authors":"Runze Liu , Xiaokang Guo , Guangjian Yang , Shuangqing Lu , Feihu Chen , Wenxiao Jia , Ji Li , Jiling Niu , Hongbo Guo , Hui Zhu","doi":"10.1016/j.jhazmat.2025.138517","DOIUrl":"10.1016/j.jhazmat.2025.138517","url":null,"abstract":"<div><div>Metal-microplastic complexes (m-MPs) represent an emerging environmental health concern. However their presence and pathological implications in lung adenocarcinoma (LUAD) remain underexplored. This study employed a multimodal approach to characterize m-MPs in 15 LUAD patients, integrating several techniques, including laser direct infrared imaging (LDIR), pyrolysis gas chromatography-mass spectrometry (Py-GCMS), inductively coupled plasma analysis (ICP), and Sequencing at the transcriptome level. Totally, 34 distinct microplastic types were identified in lung tissues, with polyvinyl chloride (PVC) predominant in tumor tissues. Notably, the levels of aluminum (Al) and calcium (Ca) exhibited strong positive correlations with microplastics (MPs) content in tumors (<em>p</em> < 0.05). In this study, a novel approach was applied to assess the influences of m-MPs on tumor, through which we found that m-MPs accumulation could activate pro-tumorigenic pathways, leading to reduced overall survival (HR=1.59, <em>p</em> = 0.002) and disease-specific survival (HR=1.64, <em>p</em> = 0.01). Moreover, SYNE1 and RORA genes were identified as diagnostic/prognostic biomarkers for the assessment of m-MPs exposure in LUAD. Our findings revealed that m-MPs have the capacity for promoting metal ion deposition and oncogenic signaling, thereby involved in LUAD progression. This work also provides evidence using human tissue to demonstrate the association of m-MPs with lung cancer outcomes and advocate the development and application of therapeutic strategies targeting m-MPs.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138517"},"PeriodicalIF":12.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiyoung Jeong, Songyeon Kim, Muruganantham Rethinasabapathy, Yu-Jeong Yang, Yun Suk Huh, Wan-Seob Cho
{"title":"Biotransformation of iron oxide nanoparticles and their impact on biokinetics in rats after the intratracheal instillation","authors":"Jiyoung Jeong, Songyeon Kim, Muruganantham Rethinasabapathy, Yu-Jeong Yang, Yun Suk Huh, Wan-Seob Cho","doi":"10.1016/j.jhazmat.2025.138518","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138518","url":null,"abstract":"Understanding the biokinetics of inhaled nanomaterials is essential for evaluating their potential adverse effects, yet current analytical methods may not account for biotransformation—where nanoparticles are transformed into new particle types. This study compared the biokinetics of partially soluble Fe<sub>2</sub>O<sub>3</sub> and poorly soluble TiO<sub>2</sub> to investigate how biotransformation influences lung clearance kinetics. Test nanoparticles (140<!-- --> <!-- -->µg/rat) were instilled into the lungs of rats, and quantitative and qualitative assessments were performed on samples collected from the lungs on days 0, 1, 7, 14, 28, and 90 post-instillation. Notably, this study focused on the biokinetics of particulate forms within the lungs to specifically address particokinetics. Fe<sub>2</sub>O<sub>3</sub> exhibited biphasic clearance kinetics, with rapid clearance in the early phase (days 0 to 14; half-life of 13 days) and slow clearance in the late phase (days 14 to 90; half-life 123 days). This biphasic pattern was attributed to the erosion of Fe<sub>2</sub>O<sub>3</sub> into smaller, nanometer-sized particles, approximately 40% of which persisted in the lungs for over 3 months. These retained particles showed reduced oxidative potential and were sequestered in ferritin protein, mitigating potential toxicity. In contrast, TiO<sub>2</sub> exhibited a monophasic clearance pattern with a half-life of 88 days and did not exhibit particle degradation. These findings underscore the critical role of biotransformation in understanding the long-term safety and toxicity of inhaled nanomaterials, highlighting the need for comprehensive studies to assess their biological fate and potential risks. Further research should focus on potential adverse effects due to particle overload, interactions with biomolecules, and disruptions in metal homeostasis.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"35 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rui-Qi Liu, Yu-Tong Wu, Yue Cheng, Yuan-Hang Chang, Muhammad Asmat Ullah Saleem, Zi-Yan Hu, Shang-Jia Yang, Xue-Qi Wang, Yi-Jia Song, Xin-Yue Mao, Jing Zheng, Yi-Bo Wang, Ming Lou, Yi Zhao, Jin-Long Li
{"title":"TBBPA induced hepatocyte ferroptosis by PCBP1-mediated ferritinophagy","authors":"Rui-Qi Liu, Yu-Tong Wu, Yue Cheng, Yuan-Hang Chang, Muhammad Asmat Ullah Saleem, Zi-Yan Hu, Shang-Jia Yang, Xue-Qi Wang, Yi-Jia Song, Xin-Yue Mao, Jing Zheng, Yi-Bo Wang, Ming Lou, Yi Zhao, Jin-Long Li","doi":"10.1016/j.jhazmat.2025.138515","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138515","url":null,"abstract":"Tetrabromobisphenol A (TBBPA) is the most widely used brominated flame retardant and has been identified as emerging widespread pollutants. Ferroptosis, a recently characterized form of iron-dependent cell death, is related to a wide range of liver diseases. Ferritinophagy as a novel selective form of autophagy functions in iron processing is essential to induce ferroptosis. Poly(rC)-binding protein 1 (PCBP1) is an iron chaperone involved in iron loading to ferritin. Nevertheless, the potential health risk caused by TBBPA in mammals is unknown. Thus, this study is conducted to explore the molecular mechanism of TBBPA-induced liver injury and the unique role of PCBP1 in it. In this study, we found that TBBPA exposure caused hepatic pathological injury and hepatocyte mitochondrial morphological changes, such as decreased or absent mitochondrial crest, ruptured mitochondrial membranes and mitochondrial shrinkage. The result showed that TBBPA exposure exacerbated glutathione depletion and lipid peroxidation, which are hallmarks of ferroptosis. Consistent with the results in vivo, TBBPA exposure activated ferritinophagy and upregulated indicators related to ferroptosis in hepatocytes. Of note, overexpression of PCBP1 inhibited TBBPA-induced ferroptosis by reducing overstimulated ferritinophagy. Here, we uncover a new mechanism whereby TBBPA triggers hepatocyte ferroptosis through the activation of ferritinophagy. Of note, we identify PCBP1 as critical for liver iron homeostasis, link this molecule to liver disease. Taken together, our findings provide a new therapeutic strategy and potential target for the treatment of liver disease.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"31 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Buyun Du , Ruizhi Xia , Daniel Obrist , Yufang Sun , Ting Wang , Jun Zhou
{"title":"Tracing atmospherically deposited cadmium accumulation in rice using stable isotopes","authors":"Buyun Du , Ruizhi Xia , Daniel Obrist , Yufang Sun , Ting Wang , Jun Zhou","doi":"10.1016/j.jhazmat.2025.138524","DOIUrl":"10.1016/j.jhazmat.2025.138524","url":null,"abstract":"<div><div>Understanding the plant uptake of atmospherically deposited cadmium (Cd) is limited. Factorial soil and atmospheric exposure experiments conducted in both field and greenhouse settings, in conjunction with stable Cd isotopes and synchrotron microscopic X-ray fluorescence (SR-μXRF), were performed to differentiate the impact of newly deposited Cd from legacy Cd in the soil. Root uptake of newly deposited Cd in soils contributed 43–48 %, 6.3–30 %, and 6.3–30 % to the leaves, stems, and grains, respectively. In contrast, foliar uptake contributed the most to rice leaves, which were subsequently limited in their translocation to stems and grains, accounting for 18–31 %, 5.7–12 %, and 5.7–11 % of Cd in leaves, stems, and grains, respectively. Stem nodes appear to restrict Cd translocation from leaves to grains while simultaneously facilitating both bi-directional xylem and phloem transport. Geochemical analyses and diffusive gradients in thin films extractions indicated that newly deposited Cd constituted the major bioavailable Cd fractions in soil solutions. In the rice growing season, the atmospherically deposited Cd only accounted 0.8–5.5 % of soil pools, but they substantially contributed 27–45 % to grains, raising important questions about how atmospheric Cd deposition may impact food security. The accumulation of Cd in rice grains from atmospheric deposition primarily occurs during the filling stage, making the management of emissions during this period crucial compared to the remediation of affected soils.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138524"},"PeriodicalIF":12.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Ahsan Farooq , Fakhir Hannan , Hui-Xi Zou , Weijun Zhou , Dong-Sheng Zhao , Toqueer Abbas , Rehan Ahmad , Ahsan Ayyaz , Xiufeng Yan
{"title":"Comparative transcriptome and physiological analyses reveal involvement of photosynthesis, phytohormone signaling, and cysteine-methionine metabolism in arsenic toxicity tolerance in Brassica napus","authors":"Muhammad Ahsan Farooq , Fakhir Hannan , Hui-Xi Zou , Weijun Zhou , Dong-Sheng Zhao , Toqueer Abbas , Rehan Ahmad , Ahsan Ayyaz , Xiufeng Yan","doi":"10.1016/j.jhazmat.2025.138521","DOIUrl":"10.1016/j.jhazmat.2025.138521","url":null,"abstract":"<div><div>This study investigates the physiological, biochemical, and molecular responses of two <em>Brassica napus</em> (<em>B. napus</em>) cultivars, ZD622 and ZD630, exposed to arsenic (As) stress. ZD630 was more resistant to As-induced toxicity, as demonstrated by higher biomass retention, less chlorophyll degradation, and less impairment of photosynthetic activity than ZD622. Photosynthetic parameters like as Pn and chlorophyll fluorescence were less influenced in ZD630, indicating a higher resilience in maintaining photosynthetic machinery integrity. Ultrastructural study demonstrated that ZD630 caused less damage to cellular components such thylakoid membranes and mitochondria. Moreover, ZD630 more efficient As exclusion mechanism, as seen by decreased arsenic accumulation in aerial tissues, led to its higher stress performance. Comparative transcriptome analysis was conducted to further dissect the molecular mechanisms underlying these morpho-physiological traits. KEGG pathway analysis revealed that the pathways for photosynthesis, auxin signaling, and amino acid metabolism were overrepresented suggesting these pathways may play important roles in the differential response to As between the two cultivars. ZD630 revealed activation of genes related to photosystem II repair, auxin transport, MAPK signaling, and ABA receptors, which might contribute to its improved stress response. Additionally, the differential control of cysteine and methionine metabolism contributes to ZD630 improved capacity to detoxify As via glutathione production.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138521"},"PeriodicalIF":12.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Co-sorption of phthalate esters and Cd2+ on biochar-sulfhydryl modified montmorillonite composites","authors":"Wenjie Li, Pengfei Mao, Xuwen Chen, Wanting Ling, Chao Qin, Yanzheng Gao","doi":"10.1016/j.jhazmat.2025.138526","DOIUrl":"10.1016/j.jhazmat.2025.138526","url":null,"abstract":"<div><div>Developing efficient passivating sorption materials for the treatment of combined pollution by phthalate esters (PAEs) and Cd<sup>2+</sup> has become a critical focus in environmental protection and soil remediation. In this study, biochar-sulfhydryl modified montmorillonite composites (BC-SHMMT) were synthesized, characterized, and evaluated for the co-sorption of PAEs (DMP, DEP) and Cd<sup>2+</sup>. The integration of sulfhydryl-modified montmorillonite (MMT-SH) with biochar improved the material's surface structure, enhancing both co-sorption capacity and structural stability. Molecular dynamics simulation indicated a monolayer chemical sorption of pollutants by BC-SHMMT, in alignment with the sorption theoretical model. In the co-sorption system, the coexistence of pollutants increased the adsorption of Cd<sup>2+</sup> and decreased the sorption of PAEs. The smaller molecular size and higher diffusion coefficient of Cd<sup>2+</sup> facilitated its pore filling and interaction with oxygen-containing functional groups of the material, leading to competition with PAEs for sorption sites. Notably, the ion exchange and complexation of Cd<sup>2+</sup> adsorption by MMT-SH are pivotal in enhancing BC-SHMMT co-sorption capacity. These findings provide valuable insights into the development of eco-friendly novel materials and the improvement of co-pollution remediation efficiency.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138526"},"PeriodicalIF":12.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qigang Fan, Yi Sun, Qingjun Shen, Yuxin Wang, Jisheng Nie, Yanbing Lin, Shuaishuai Xing, Yan Li, Benhong Xu, Jianjun Liu, Xiaoting Shen, Guangbo Qu, Jun Xie, Liqin Zeng, Huidong Zhang
{"title":"Organ-specific lithium accumulation and its toxic effects on female reproduction","authors":"Qigang Fan, Yi Sun, Qingjun Shen, Yuxin Wang, Jisheng Nie, Yanbing Lin, Shuaishuai Xing, Yan Li, Benhong Xu, Jianjun Liu, Xiaoting Shen, Guangbo Qu, Jun Xie, Liqin Zeng, Huidong Zhang","doi":"10.1016/j.jhazmat.2025.138516","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138516","url":null,"abstract":"Li exposure is becoming a new prominent major issue in energy-environment-health field. However, its reproductive health risk has been less explored. In this study, we find that exposure to 28-fold REED (<u>r</u>eally <u>e</u>nvironmental <u>e</u>xposure <u>d</u>ose) of Li is enough to induce mouse miscarriage by altering the structures and functions of placenta. Exposure to ≥ 5.6-fold REED of Li is enough to alter the structure and functions of ovary and placenta, and exposure to ≥ 28-fold REED of Li alters fetus morphology and uterus functions, showing a susceptibility to Li exposure as the order ovary > placenta > fetus > uterus. Some characteristics (such as AMH (anti-müllerian hormone) levels in serum, the mRNA levels of Pgr (progesterone receptor) and Nr2f2 in placenta, and the mRNA levels of Cyp19A1 and Sohlh2 in Ovary) are significantly altered with exposure to 5.6-fold REED of Li, which could be used as sensitive targets to predict reproductive health risk with Li exposure. Moreover, the doses of Li in clinical Li treatment (28- or 56-fold REED of Li) should be more cautious, especially for women. Collectively, this study identifies Li exposure as a new risk factor for female reproductive healthy in energy-environment-health field, which deserves the critical attention by governments, enterprises, and hospitals.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"35 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}