Journal of Food and Drug Analysis最新文献

{"title":"Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells.","authors":"Tinglin Song,&nbsp;Jiaye Chen,&nbsp;Sizhu Yang,&nbsp;Boqun Liu,&nbsp;Lingling Zhang,&nbsp;Qian Zhang,&nbsp;Jung-Chien Cheng,&nbsp;Lanlan Fang","doi":"10.38212/2224-6614.3460","DOIUrl":"https://doi.org/10.38212/2224-6614.3460","url":null,"abstract":"<p><p>Steroidogenic acute regulatory protein (StAR) plays a critical role in the regulation of progesterone (P4) production. Resveratrol (RSV), a natural polyphenol, has beneficial effects on reproductive function. However, its effects on StAR expression and P4 production in human granulosa cells remain undetermined. In this study, we showed that treatment of RSV upregulated StAR expression in human granulosa cells. G protein-coupled estrogen receptor (GPER) and ERK1/2 signaling were involved in RSV-stimulated StAR expression and P4 production. In addition, the expression of a transcriptional repressor, Snail, was downregulated by RSV, which contributed to the RSV-induced inductions of StAR expression and P4 production.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 2","pages":"315-325"},"PeriodicalIF":3.6,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/e1/jfda315-325.PMC10281732.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9762943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity.","authors":"Huang-Ju Tu,&nbsp;Chih-Jou Su,&nbsp;Chao-Shiang Peng,&nbsp;Tony Eight Lin,&nbsp;Wei-Chun HuangFu,&nbsp;Kai-Cheng Hsu,&nbsp;Tsong-Long Hwang,&nbsp;Shiow-Lin Pan","doi":"10.38212/2224-6614.3462","DOIUrl":"https://doi.org/10.38212/2224-6614.3462","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a devastating neurodegenerative disease with more than 50 million people suffer from it. Unfortunately, none of the currently available drugs is able to improve cognitive impairment in AD patients. Urolithin A (UA) is a metabolite obtained from ellagic acid and ellagitannin through the intestinal flora, and it has antioxidant and anti-inflammatory properties. Previous reports found that UA had neuroprotective effects in an AD animal model, but the detailed mechanism still needs to be elucidated. In this study, we performed kinase-profiling to show that dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is the main target of UA. Studies showed that the level of DYRK1A in AD patients' brains was higher than that of healthy people, and it was closely related to the occurrence and progression of AD. Our results revealed that UA significantly reduced the activity of DYRK1A, which led to de-phosphorylation of tau and further stabilized microtubule polymerization. UA also provided neuroprotective effects by inhibiting the production of inflammatory cytokines caused by Aβ. We further showed that UA significantly improved memory impairment in an AD-like mouse model. In summary, our results indicate that UA is a DYRK1A inhibitor that may provide therapeutic advantages for AD patients.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 2","pages":"358-370"},"PeriodicalIF":3.6,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/51/jfda358-370.PMC10281726.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10084951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What nature has to offer: Opportunities for immuno-oncology.","authors":"Rubina Kousar,&nbsp;Cheng-Han Lin,&nbsp;Bbumba Patrick,&nbsp;Miao He,&nbsp;Dong-Chuan Wu,&nbsp;Xing-Guo Li","doi":"10.38212/2224-6614.3459","DOIUrl":"https://doi.org/10.38212/2224-6614.3459","url":null,"abstract":"<p><p>Recent rapid development of cancer therapy has come about with the paradigm shift from the traditional goal of targeting cancer cells themselves, to reprograming the immune tumor microenvironment. Accumulating evidence shows that compounds that target epigenetic regulation, called epidrugs, play a crucial role in mediating the immunogenicity of cancer cells and in reshaping antitumor immunity. A large body of literature has recognized natural compounds as epigenetic modulators for their immunomodulatory effects and anticancer potential. Unifying our understanding of the role of these biologically active compounds in immuno-oncology may open new avenues for more effective cancer therapies. In this review, we explore how natural compounds modulate the epigenetic machinery to shape antitumor immune response, highlighting the promise offered by the Mother Nature that could be exploited therapeutically to improve outcomes for cancer patients.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 2","pages":"212-231"},"PeriodicalIF":3.6,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/a0/jfda212-231.PMC10281724.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9708937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of monacolin K, yellow pigments, and citrinin production capabilities of Monascus purpureus and Monascus ruber (Monascus pilosus).","authors":"Tzu-Shing Lin,&nbsp;Shih-Hau Chiu,&nbsp;Chien-Chi Chen,&nbsp;Chih-Hui Lin","doi":"10.38212/2224-6614.3438","DOIUrl":"https://doi.org/10.38212/2224-6614.3438","url":null,"abstract":"<p><p>Red mold rice (RMR) is a traditional Chinese medicine prepared using Monascus fermentation. Monascus ruber ( pilosus) and Monascus purpureus have a long history of use as food and medicine. As an economically important starter culture, the relationship between the taxonomy of Monascus and production capabilities of secondary metabolites is crucial for the Monascus food industry. In this study, monacolin K, monascin, ankaflavin, and citrinin production by M. purpureus and M. ruber were genomically and chemically investigated. Our findings suggest that M. purpureus can produce monascin and ankaflavin in a correlated manner, whereas M. ruber produces monascin with minimum ankaflavin. M. purpureus is capable of producing citrinin; however, it is unlikely able to produce monacolin K. In contrast, M. ruber produces monacolin K, but not citrinin. We suggest that the current monacolin K content-related regulation of Monascus food should be revised, and labeling of Monascus species should be considered.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 1","pages":"85-94"},"PeriodicalIF":3.6,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6b/71/jfda-31-01-085.PMC10208672.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9691404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of 24 sulfonamide antibiotics in instant pastries by modified QuEChERS coupled with ultra performance liquid chromatography-tandem mass spectrometry.","authors":"Shuo Li,&nbsp;Can Zhang,&nbsp;Hui-Xin Tang,&nbsp;Yue Gu,&nbsp;Ai-Jing Guo,&nbsp;Ke Wang,&nbsp;Kao-Qi Lian","doi":"10.38212/2224-6614.3434","DOIUrl":"https://doi.org/10.38212/2224-6614.3434","url":null,"abstract":"<p><p>There were few reports about antibiotic residues in egg-containing products. In the study, an effective method for the simultaneous determination of 24 sulfonamide antibiotics in two instant pastries based on a modified QuEChERS sample preparation technique coupled with ultra performance liquid chromatography-tandem mass spectrometry was developed. The results show that the average recoveries of the SAs at 5, 10, and 50 μg kg^-1 levels were 67.6%-103.8%, with relative standard deviations (RSD) of 0.80-9.23%. The limit of detections (LODs) and limit of quantitations (LOQs) were 0.01-0.14 μg kg^-1 and 0.02-0.45 μg kg^-1, respectively. This method was suitable for analysis of 24 SAs in instant pastries.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 1","pages":"73-84"},"PeriodicalIF":3.6,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/86/jfda-31-01-073.PMC10208667.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9691406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyvinylpyrrolidone-passivated fluorescent iron oxide quantum dots for turn-off detection of tetracycline in biological fluids.","authors":"Sri Sudewi,&nbsp;Lutfi Chabib,&nbsp;Muhammad Zulfajri,&nbsp;Gangaraju Gedda,&nbsp;Genin G Huang","doi":"10.38212/2224-6614.3440","DOIUrl":"https://doi.org/10.38212/2224-6614.3440","url":null,"abstract":"<p><p>Tetracycline is an antibiotic that has been prescribed for COVID-19 treatment, raising concerns about antibiotic resistance after long-term use. This study reported fluorescent polyvinylpyrrolidone-passivated iron oxide quantum dots (IO QDs) for detecting tetracycline in biological fluids for the first time. The as-prepared IO QDs have an average size of 2.84 nm and exist a good stability under different conditions. The IO QDs' tetracycline detection performance could be attributed to a combination of static quenching and inner filter effect. The IO QDs displayed high sensitivity and selectivity toward tetracycline and achieved a good linear relationship with the corresponding detection limit being 91.6 nM.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 1","pages":"177-193"},"PeriodicalIF":3.6,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/ff/jfda-31-01-177.PMC10208663.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9691408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory considerations for generic products of non-biological complex drugs.","authors":"Yu-Hsuan Liu,&nbsp;Yi-Shuo Chen,&nbsp;Ting Tseng,&nbsp;Min-Lin Jiang,&nbsp;Churn-Shiouh Gau,&nbsp;Lin-Chau Chang","doi":"10.38212/2224-6614.3441","DOIUrl":"https://doi.org/10.38212/2224-6614.3441","url":null,"abstract":"<p><p>The Non-Biological Complex Drug (NBCD) Working Group defines an NBCD as \"a medicinal product, not being a biological medicine, where the active substance is not a homo-molecular structure, but consists of different (closely related and often nanoparticulate) structures that cannot be isolated and fully quantitated, characterized and/or described by physicochemical analytical means\". There are concerns about the potential clinical differences between the follow-on versions and the originator products and within the individual follow-on versions. In the present study, we compare the regulatory requirements for developing generic products of NBCDs in the European Union (EU) and the United States (US). The NBCDs investigated included nanoparticle albumin-bound paclitaxel (nab-paclitaxel) injections, liposomal injections, glatiramer acetate injections, iron carbohydrate complexes, and sevelamer oral dosage forms. The demonstration of pharmaceutical comparability between the generic products and the reference products through comprehensive characterization is emphasized for all product categories investigated. However, the approval pathways and detailed requirements in terms of non-clinical and clinical aspects may differ. The general guidelines in combination with product-specific guidelines are considered effective in conveying regulatory considerations. While regulatory uncertainties still prevail, it is anticipated that through the pilot program established by the European Medicines Agency (EMA) and the FDA, harmonization of the regulatory requirements will be achieved, thereby facilitating the development of follow-on versions of NBCDs.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 1","pages":"20-31"},"PeriodicalIF":3.6,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/06/jfda-31-01-020.PMC10208665.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9690953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent developments in detection and therapeutic approaches for antibiotic-resistant bacterial infections.","authors":"Kavya Moorthy,&nbsp;Kai-Chih Chang,&nbsp;Hsueh-Hui Yang,&nbsp;Wen-Min Su,&nbsp;Cheng-Kang Chiang,&nbsp;Zhiqin Yuan","doi":"10.38212/2224-6614.3433","DOIUrl":"https://doi.org/10.38212/2224-6614.3433","url":null,"abstract":"<p><p>Owing to the widespread emergence and proliferation of antibiotic-resistant bacteria, the therapeutic benefits of antibiotics have been reduced. In addition, the ongoing evolution of multidrug-resistant pathogens poses a challenge for the scientific community to develop sensitive analytical methods and innovative antimicrobial agents for the detection and treatment of drug-resistant bacterial infections. In this review, we have described the antibiotic resistance mechanisms that occur in bacteria and summarized the recent developments in detection strategies for monitoring drug resistance using different diagnostic methods in three aspects, including electrostatic attraction, chemical reaction, and probe-free analysis. Additionally, to understand the effective inhibition of drug-resistant bacterial growth by recent nano-antibiotics, the underlying antimicrobial mechanisms and efficacy of biogenic silver nanoparticles and antimicrobial peptides, which have shown promise, and the rationale, design, and potential improvements to these methods are also highlighted in this review. Finally, the primary challenges and future trends in the rational design of facile sensing platforms and novel antibacterial agents against superbugs are discussed.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 1","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/7e/jfda-31-01-001.PMC10208662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9690954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation.","authors":"Chun-Yu Lin,&nbsp;Yi-Ju Chen,&nbsp;Chih-Hsuan Hsu,&nbsp;Yu-Hsuan Lin,&nbsp;Peng-Tzu Chen,&nbsp;Ting-Han Kuo,&nbsp;Chris T Ho,&nbsp;Hsin-Hua Chen,&nbsp;Sih-Jia Huang,&nbsp;Ho-Chieh Chiu,&nbsp;Chin-Chu Chen,&nbsp;Eric Hwang","doi":"10.38212/2224-6614.3446","DOIUrl":"https://doi.org/10.38212/2224-6614.3446","url":null,"abstract":"<p><p>Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 1","pages":"32-54"},"PeriodicalIF":3.6,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b5/10/jfda-31-01-032.PMC10208670.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9637805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical transformation of cannabidiol into psychotropic cannabinoids under acidic reaction conditions: Identification of transformed products by GC-MS.","authors":"Minsun Jeong,&nbsp;Sangin Lee,&nbsp;Chaeyoung Seo,&nbsp;Eunjeong Kwon,&nbsp;Soohyang Rho,&nbsp;Mansoo Cho,&nbsp;Moon Yeon Kim,&nbsp;Wonwoong Lee,&nbsp;Yong Sup Lee,&nbsp;Jongki Hong","doi":"10.38212/2224-6614.3452","DOIUrl":"https://doi.org/10.38212/2224-6614.3452","url":null,"abstract":"<p><p>Recently, cannabidiol (CBD), one of the major components of the Cannabis species, has been a focus in the cannabis industry due to its various pharmacological effects. Interestingly, CBD can be converted into several psychoactive cannabinoids, such as 9-tetrahydrocannabinol (Δ⁹-THC) and its structural isomers, under acidic reaction conditions. In this study, chemical transformation of CBD in ethanol solution was conducted with variation in pH at 2.0, 3.5, and 5.0 by addition of 0.1 M hydrochloric acid (HCl). These resulting solutions were derivatized with trimethylsilyl (TMS) reagent and analyzed using GC/MS-scan mode. Time profiles of CBD degradation and transformation of products were examined according to variations in pH and temperature. Several transformed products produced after the acidic reaction of CBD were identified by matching retention times and mass spectra to authentic standards. Regarding the identification of products without authentic standards, the EI-mass spectra of such cannabinoid-OTMS derivatives were interpreted according to structural class, suggesting mass fragmentation pathways. From the GC/MS data, Δ⁹-THC, CBC, and ethoxy-hexahydrocannabinol (HHC) analogs were shown to be major components, and THC isomers (Δ⁸- and Δ¹⁰-THCs) and 9-hydroxy-HHC were observed as minor components. Using time profile data, the acidity of the reaction solution was an important factor in degradation of CBD. Degradation of CBD and formation of THC rarely occurred at pH 5.0, even at 70 °C with a long process time of 24 h. In contrast, degradation of CBD occurred readily at pH 3.5 and 30 °C over a short process time and was further accelerated by lowering pH, increasing temperature, and lengthening the process time. Based on profile data and identified transformed products, formation pathways from the degradation of CBD under acidic reaction conditions are suggested. Among the transformed products, seven components are known to have psychoactive effects. Thus, industrial CBD manufacturing processes in food and cosmetic products should be carefully controlled. These results will provide important guidelines on the control of manufacturing processes, storage, fermentation processes, and new regulation in industrial applications of CBD.</p>","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"31 1","pages":"165-176"},"PeriodicalIF":3.6,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/09/jfda-31-01-165.PMC10208661.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9637807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}