Journal of Food and Drug Analysis最新文献_第10页

Optimization, physicochemical stability and in vivo study of alginate-chitosan composites as nanocarriers for low molecular weight angiotensin I-converting enzyme (ACE)-inhibitory peptide. 海藻酸盐-壳聚糖复合材料作为低分子血管紧张素i转换酶抑制肽纳米载体的优化、理化稳定性及体内研究。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI: 10.38212/2224-6614.3522

Shehu Muhammad Auwal, Siti Balqis Muhammad Ghanisma, Nazamid Saari

{"title":"Optimization, physicochemical stability and in vivo study of alginate-chitosan composites as nanocarriers for low molecular weight angiotensin I-converting enzyme (ACE)-inhibitory peptide.","authors":"Shehu Muhammad Auwal, Siti Balqis Muhammad Ghanisma, Nazamid Saari","doi":"10.38212/2224-6614.3522","DOIUrl":"10.38212/2224-6614.3522","url":null,"abstract":"Chitosan and alginate, are non-toxic and biodegradable polymers used to enhance the stability of biotherapeutics by loading them into nanocarriers. In this study, the stone fish-derived low molecular weight peptide (Ala-Leu-Gly-Pro-Gln-Phe-Tyr), exhibited an in vitro ACE-inhibitory activity of 94.43 ± 2.05% and an IC50 of 0.012 ± 0.001 mM. The peptide was encapsulated via ionic gelation with alginate followed by polyelectrolyte complexation with chitosan. The resulting ACE-inhibitory peptide-loaded alginate-chitosan nanoparticles (ACE-I-ALG-CS NPs) were optimized to achieve small particle size (212.60 nm) and high encapsulation efficiency (EE, 74.48%). This was based on an optimum chitosan concentration (0.420%w/v), homogenization speed (6000 rpm), and homogenization time (30 min) using Box Behnken experimental design (BBED). Characterization of the ACE-I-ALG-CS NPs revealed a spherical, monodispersed morphology with high physicochemical stability during storage at 2 °C, 7 °C, and 12 °C for 12 weeks. Moreover, the in vivo study conducted on spontaneously hypertensive rats (SHRs) demonstrated a significantly higher (p < 0.05) systolic blood pressure (SBP)-lowering effect of the ACE-I-ALG-CS NPs compared to captopril and unencapsulated peptide. Hence, alginate and chitosan can be used as biocompatible coating materials to enhance the stability and in vivo anti-hypertensive effect of Ala-Leu-Gly-Pro-Gln-Phe-Tyr through encapsulation, thereby making it potentially valuable for various applications in pharmaceuticals and food industry.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"32 3","pages":"358-370"},"PeriodicalIF":2.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of carbon dots from fructus gardeniae (Zhi-zi) and gardenia charcoal (black Zhi-zi) via microwave-assisted extraction. 微波萃取栀子和栀子炭炭炭点的研究。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI: 10.38212/2224-6614.3513

Hung-Wen Tsai, Nelly Fitri Tampubolon, Tsunghsueh Wu, Mei-Yao Wu, Yang-Wei Lin

{"title":"Characterization of carbon dots from fructus gardeniae (Zhi-zi) and gardenia charcoal (black Zhi-zi) via microwave-assisted extraction.","authors":"Hung-Wen Tsai, Nelly Fitri Tampubolon, Tsunghsueh Wu, Mei-Yao Wu, Yang-Wei Lin","doi":"10.38212/2224-6614.3513","DOIUrl":"10.38212/2224-6614.3513","url":null,"abstract":"We employed a straightforward microwave-assisted extraction technique to investigate the presence of carbon dots (CDs) in Chinese herbal extracts derived from fructus gardeniae and gardenia charcoal, designated as CDs-1 and CDs-2, respectively. The found CDs exhibited unique photoluminescence with quantum yields of 0.95% for CDs-1 and 1.81% for CDs-2, indicating significant potential for bioimaging applications. Both CD types maintain approximately 80% of their fluorescence intensity after 120 min of continuous 365 nm UV exposure, underscoring their stability and suitability for prolonged biological studies. Moreover, antioxidant activity tests showed that CDs-2 have a higher scavenging capacity, with an SC-50 value of 21.7 μg/mL, compared to 35.9 μg/mL for CDs-1, attributed to their higher content of surface functional groups during the extraction procedure. Notably, the results indicated that the carbonization process of fructus gardeniae leads to the formation of CDs, suggesting a potential link between traditional herbal treatments and modern nanotechnology. This research demonstrates that active compounds in Chinese herbal medicine could possess therapeutic properties when adsorbed on the surface of CDs.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"32 3","pages":"371-381"},"PeriodicalIF":2.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production and characterization of encapsulated Thymoquinone loaded bacterial cellulose/chitosan composite nano film and investigation of its in vitro antibacterial activity. 百里醌包封细菌纤维素/壳聚糖复合纳米膜的制备、表征及体外抗菌活性研究。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI: 10.38212/2224-6614.3516

Aytul Bayraktar, Tuba Tunç

引用次数: 0

Enhancing mango shelf life through natural preservation: Investigating the efficacy of polysaccharide edible coating and leaf extracts. 通过自然保存提高芒果的保质期：研究多糖可食用涂层和叶片提取物的功效。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI: 10.38212/2224-6614.3512

Binh Minh Nguyen Dac, Khoa Hai Le, Van Anh Phan Thi, Van Minh Dao, Trung Dinh Do, Phuong Nguyen-Tri, S Woong Chang, D Duc Nguyen, Duong Duc La

{"title":"Enhancing mango shelf life through natural preservation: Investigating the efficacy of polysaccharide edible coating and leaf extracts.","authors":"Binh Minh Nguyen Dac, Khoa Hai Le, Van Anh Phan Thi, Van Minh Dao, Trung Dinh Do, Phuong Nguyen-Tri, S Woong Chang, D Duc Nguyen, Duong Duc La","doi":"10.38212/2224-6614.3512","DOIUrl":"10.38212/2224-6614.3512","url":null,"abstract":"A sustainable solution to prevent the waste of fruits and vegetables from spoilage is the use of edible coatings or films. This research project aimed to create a fresh coating recipe that could effectively extend the shelf life of mangoes. The coating was composed of chitosan, glycerol, and gum Arabic mixed with the extract obtained from the extraction of Cleistocalyx operculatus plant. The prepared exact has a total polyphenol content of 17% and showed potent free radical scavenging abilities in a dose-dependent manner. The chitosan/gum Arabic/Glycerol/extract edible coatings were analyzed using SEM and FTIR spectroscopy, revealing a smooth and uniform coating with a well-integration of components. Coating the mangoes with this formulation resulted in significant improvements in their appearance, brightness, weight loss, firmness, titratable acidity, and CO2 respiration rate compared to uncoated samples. The optimal concentration of the extract in the coating was determined to be 0.25% w/w for the best protective performance. After 21-day storage at room temperature, uncoated mangoes were found to be rotten, while coated mangoes remained fresh.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"32 3","pages":"325-337"},"PeriodicalIF":2.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI: 10.38212/2224-6614.3524

Chih-Ching Huang, Yang-Wei Lin, Amit Nain

引用次数: 0

Corrigendum to "Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference" [J Food Drug Anal 30 (2022) 440-453]. “Ficus pumila var. awkeotsang的成分解析及其对COVID-19症状的改善潜力和SARS-CoV-2干扰的计算机预测”[J].食品药品通报，30(2022)440-453。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI: 10.38212/2224-6614.3518

Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai, Fang-Rong Chang

引用次数: 0

Unlocking early detection of Alzheimer's disease: The emerging role of nanomaterial-based optical sensors. 开启阿尔茨海默病的早期检测：基于纳米材料的光学传感器的新兴作用。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI: 10.38212/2224-6614.3520

Chun-Hsien Chen, Hsin-Hua Liang, Chun-Chi Wang, Yi-Ting Yang, Yi-Hui Lin, Yen-Ling Chen

{"title":"Unlocking early detection of Alzheimer's disease: The emerging role of nanomaterial-based optical sensors.","authors":"Chun-Hsien Chen, Hsin-Hua Liang, Chun-Chi Wang, Yi-Ting Yang, Yi-Hui Lin, Yen-Ling Chen","doi":"10.38212/2224-6614.3520","DOIUrl":"10.38212/2224-6614.3520","url":null,"abstract":"Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder that affects millions of individuals worldwide. Researchers have conducted numerous studies to find accurate biomarkers for early AD diagnosis and develop more effective treatments. The main pathological hallmarks of AD are amyloid beta and Tau proteins. Other biomarkers, such as DNA, RNA, and proteins, can also be helpful in early AD diagnosis. To diagnose and treat AD promptly, it is essential to accurately measure the concentration of biomarkers in the cerebrospinal fluid or blood. However, due to the low concentrations of these biomarkers in the body, highly sensitive analytical techniques are required. To date, sensors have become increasingly important due to their high sensitivity, swift detection, and adaptable manipulation features. These qualities make them an excellent substitute for conventional instruments. Nanomaterials are commonly employed in sensors to amplify signals and improve sensitivity. This review paper summarized the integration of nanomaterials in optical sensor systems, including colorimetric, fluorescent, and surface-enhanced Raman scattering sensors for AD biomarkers detection.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"32 3","pages":"296-324"},"PeriodicalIF":2.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitive electrochemical sensor of levofloxacin using boron-doped diamond (BDD) electrode modified with Ti₃C₂T_X (MXene) material. 采用Ti3C2TX （MXene）材料修饰掺杂硼金刚石（BDD）电极制备左氧氟沙星敏感电化学传感器。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI: 10.38212/2224-6614.3517

Prastika Krisma Jiwanti, Indah Harindy Putri, Grandprix T M Kadja, Yasuaki Einaga, Laurencia Gabrielle Sutanto, Siti Wafiroh, Dewi Kartika Azizah Sukardi, Anis Puspita Sari, Tahta Amrillah, Ilma Amalina, Qonita Kurnia Anjani, Wan Jeffrey Basirun

{"title":"Sensitive electrochemical sensor of levofloxacin using boron-doped diamond (BDD) electrode modified with Ti3C2TX (MXene) material.","authors":"Prastika Krisma Jiwanti, Indah Harindy Putri, Grandprix T M Kadja, Yasuaki Einaga, Laurencia Gabrielle Sutanto, Siti Wafiroh, Dewi Kartika Azizah Sukardi, Anis Puspita Sari, Tahta Amrillah, Ilma Amalina, Qonita Kurnia Anjani, Wan Jeffrey Basirun","doi":"10.38212/2224-6614.3517","DOIUrl":"10.38212/2224-6614.3517","url":null,"abstract":"Overuse of levofloxacin (LEV) is often associated with bacterial resistance and serious health problems, underscoring the need for reliable sensing and monitoring of LEV molecules. Therefore, this study aimed to investigate LEV using boron-doped diamond (BDD) and boron-doped diamond modified with MXene (Ti3C2TX) (BDD-MXene) electrode. The successful deposition of MXene on the BDD surface was confirmed using scanning electron microscope (SEM). Cyclic voltammetry (CV) and square wave voltammetry (SWV) methods were also applied to evaluate the electrochemical behavior. The results showed that both electrodes had a linear response in the range of 30-100 μM. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 1.0 × 10-6 M and 3.37 × 10-6 M for bare-BDD, while on BDD-MXene, the values were 3.90 × 10-7 M and 1.30 × 10-6 M, respectively. Furthermore, both electrodes showed good responses on selectivity tests with glucose and another fluoroquinolone antibiotic such as ciprofloxacin. The results also indicated good precision with %RSD less than 5%. In real sample applications using wastewater, bare-BDD and BDD-MXene produced excellent %recovery of 92.96% and 101.29%, respectively.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"32 3","pages":"348-357"},"PeriodicalIF":2.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional gold nanoparticles for analysis and delivery of nucleic acids. 用于核酸分析和递送的功能性金纳米颗粒。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-09-13 DOI: 10.38212/2224-6614.3514

Po-Tsang Huang, Yen-Ling Chen, Yi-Hui Lin, Chun-Chi Wang, Huan-Tsung Chang

引用次数: 0

An acute herb-drug interaction of Magnoliae Officinalis Cortex with methotrexate via inhibiting multidrug resistance-associated protein 2. 厚朴通过抑制多药耐药性相关蛋白 2 与甲氨蝶呤产生急性草药-药物相互作用。

IF 2.6 3区农林科学

Journal of Food and Drug Analysis Pub Date : 2024-03-15 DOI: 10.38212/2224-6614.3495

Chung-Ping Yu, Pei-Ying Li, Szu-Yu Chen, Shiuan-Pey Lin, Ying-Chen Chen, Lu-Ching Ho, Yow-Wen Hsieh, Yu-Chi Hou

{"title":"An acute herb-drug interaction of Magnoliae Officinalis Cortex with methotrexate via inhibiting multidrug resistance-associated protein 2.","authors":"Chung-Ping Yu, Pei-Ying Li, Szu-Yu Chen, Shiuan-Pey Lin, Ying-Chen Chen, Lu-Ching Ho, Yow-Wen Hsieh, Yu-Chi Hou","doi":"10.38212/2224-6614.3495","DOIUrl":"10.38212/2224-6614.3495","url":null,"abstract":"Magnoliae Officinalis Cortex (MOC), an herbal drug, contains polyphenolic lignans mainly magnolol (MN) and honokiol (HK). Methotrexate (MTX), a critical drug for cancers and autoimmune deseases, is a substrate of multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP). This study investigated the effect of coadministration of MOC on the pharmacokinetics of MTX and relevant mechanisms. Sprague-Dawley rats were orally administered MTX alone and with single dose (2.0 and 4.0 g/kg) and repeated seven doses of MOC (2.0 g/kg thrice daily for 2 days, the 7th dose given at 0.5 h before MTX). The serum concentrations of MTX were determined by a fluorescence polarization immunoassay. The results showed that a single dose of MOC at 2.0 g/kg significantly increased the AUC0-t and MRT of MTX by 352% and 308%, and a single dose at 4.0 g/kg significantly enhanced the AUC0-t and MRT by 362% and 291%, respectively. Likewise, repeated seven doses of MOC at 2.0 g/kg significantly increased the AUC0-t and MRT of MTX by 461% and 334%, respectively. Mechanism studies indicated that the function of MRP2 was significantly inhibited by MN, HK and the serum metabolites of MOC (MOCM), whereas BCRP was not inhibited by MOCM. In conclusion, coadministration of MOC markedly enhanced the systemic exposure and mean residence time of MTX through inhibiting the MRP2-mediated excretion of MTX.","PeriodicalId":358,"journal":{"name":"Journal of Food and Drug Analysis","volume":"32 1","pages":"103-111"},"PeriodicalIF":2.6,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0