The therapeutic potential of curcumin and its related substances in turmeric: From raw material selection to application strategies.

IF 2.6 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Food and Drug Analysis Pub Date : 2023-06-15 DOI:10.38212/2224-6614.3454

Kai-Yu Hsu, Chi-Tang Ho, Min-Hsiung Pan

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引用次数: 4

Abstract

Turmeric (Curcuma longa L.) is a medicinal plant used extensively in Chinese and Indian traditional medicine as a home remedy for various diseases. It has been used for medical purposes for centuries. Today, turmeric has become one of the most popular medicinal herbs, spices, and functional supplements worldwide. Curcuminoids are linear diary-lheptanoids from the rhizomes that include curcumin and two related compounds: demethoxycurcumin and bisdemethoxycurcumin, which are the active components of the C. longa plant, play a crucial role in numerous functions. This review summarises the composition of turmeric and the properties of curcumin regarding its antioxidant, anti-inflammatory, anti-diabetic, anti-colorectal cancer, and other physiological activity. In addition, the dilemma of the application of curcumin due to its low water solubility and bioavailability was discussed. Finally, this article provides three novel application strategies based on previous studies: using curcumin analogues and related substances, gut microbiota regulation, and using curcumin-loaded exosome vesicles and turmeric-derived exosome-like vesicles to overcome application limitations.

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姜黄中姜黄素及其相关物质的治疗潜力:从原料选择到应用策略。

姜黄(Curcuma longa L.)是一种药用植物，广泛用于中国和印度传统医学中，作为各种疾病的家庭疗法。几个世纪以来，它一直被用于医疗目的。今天，姜黄已成为世界上最受欢迎的草药、香料和功能性补充剂之一。姜黄素是一种从姜黄根茎中提取的线性日记-七烷类化合物，包括姜黄素和两种相关化合物:去甲氧基姜黄素和双去甲氧基姜黄素，它们是姜黄植物的活性成分，在许多功能中起着至关重要的作用。本文综述了姜黄的组成及姜黄素的抗氧化、抗炎、抗糖尿病、抗结直肠癌等生理活性。此外，还讨论了姜黄素水溶性低、生物利用度低的应用困境。最后，本文在前人研究的基础上提出了三种新的应用策略:利用姜黄素类似物及相关物质，调节肠道微生物群，利用姜黄素负载外泌体囊泡和姜黄衍生外泌体样囊泡来克服应用局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Food and Drug Analysis 医学-食品科技

CiteScore

6.30

自引率

2.80%

发文量

审稿时长

3.8 months

期刊介绍： The journal aims to provide an international platform for scientists, researchers and academicians to promote, share and discuss new findings, current issues, and developments in the different areas of food and drug analysis. The scope of the Journal includes analytical methodologies and biological activities in relation to food, drugs, cosmetics and traditional Chinese medicine, as well as related disciplines of topical interest to public health professionals.