Japanese Journal of Cancer and Chemotherapy最新文献_第5页

[A Case of Sigmoid Colon Cancer with Synchronous Pulmonary Metastases Diagnosed during Follow-Up after Primary Tumor Resection]. [1例乙状结肠原发肿瘤切除后随访诊断为肺同步转移]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Tomoyuki Yamaguchi, Serina Akai, Nozomi Uozumi, Koji Yasuda, Hiroshi Shintani

引用次数: 0

[Surgical Outcomes of Robot-Assisted Surgery for Elderly Patients with Colorectal Cancer at a Municipal Hospital]. [某市立医院老年结直肠癌机器人辅助手术疗效分析]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Masashi Takemura, Tsutomu Oshima, Katsuyuki Mayumi, Masanori Yamada, Mamiko Takii, Daiki Inazu, Hironari Miyamoto, Daiki Yamaguchi

{"title":"[Surgical Outcomes of Robot-Assisted Surgery for Elderly Patients with Colorectal Cancer at a Municipal Hospital].","authors":"Masashi Takemura, Tsutomu Oshima, Katsuyuki Mayumi, Masanori Yamada, Mamiko Takii, Daiki Inazu, Hironari Miyamoto, Daiki Yamaguchi","doi":"","DOIUrl":"","url":null,"abstract":"We investigated the outcomes of robot-assisted surgery for elderly patients with colorectal cancer at a municipal hospital after its introduction.Subjects and methods: From February 2024 to April 2025, we underwent 78 cases of robot-assisted colorectal cancer surgery.We divided these cases into cases over 80 years old and cases under 80 years old, and compared the short-term surgical outcomes to examine whether robot-assisted surgery could be safely introduced for elderly patients with colorectal cancer.Results: There were 25 patients over 80 years old(Group A)and 53 patients under 80 years old(Group B).Age was significantly higher in Group A, and there were more women.Robot-assisted surgery was completed in all patients, and there were no differences in the degree or number of lymph nodes dissected.There was no difference in operative time or blood loss, but console time tended to be longer in Group A.Postoperative complications and postoperative length of hospital stay were significantly higher in Group A, but there were no in-hospital deaths.Conclusions: Robot-assisted surgery for elderly patients with colorectal cancer can be safely implemented even in municipal hospitals, but careful attention to postoperative progress is required.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 1","pages":"40-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Emerging Radiotherapy for Esophageal Cancer]. [食管癌新出现的放疗]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Yoshinori Ito

{"title":"[Emerging Radiotherapy for Esophageal Cancer].","authors":"Yoshinori Ito","doi":"","DOIUrl":"","url":null,"abstract":"Radiotherapy plays a central role in the management of esophageal cancer, encompassing definitive, neoadjuvant, and palliative indications.Recent advances in linear accelerator-based technologies, such as intensity-modulated radiotherapy(IMRT)and volumetric-modulated arc therapy(VMAT), have enabled improved target coverage and significant reductions in cardiac and pulmonary doses, resulting in better treatment outcomes.Dynamic trajectory radiotherapy(DTRT), which synchronously controls gantry and couch motion, represents an innovative approach that allows three-dimensional beam trajectory optimization and further sparing of critical organs.Particle beam therapy using protons or carbon ions achieves highly conformal dose distributions with reduced cardiopulmonary toxicity and may enhance therapeutic efficacy when combined with systemic therapy or through the preservation of host immunity.Artificial intelligence(AI)is transforming radiotherapy workflows by enabling automatic contouring, adaptive replanning, and predictive modeling through radiomics.These technologies contribute to the standardization and individualization of treatment by improving prognostic and toxicity predictions.Concurrently, combined modality strategies integrating radiotherapy with immune checkpoint inhibitors and oncolytic viral therapies are under active clinical investigation.Early-phase trials have demonstrated favorable safety profiles and promising local control rates.Ongoing prospective multi-institutional trials and large-scale data analyses are essential to validate the clinical benefits and long-term safety of these novel modalities.The integration of technological innovations and biological insights is expected to drive further improvements in local control, toxicity reduction, and survival outcomes, establishing radiotherapy as an increasingly precise and biologically guided treatment modality for esophageal cancer.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Pancreatic Cancer Treated with Carbon Ion Radiotherapy for Oligohepatic Metastatic Recurrence after Conversion Surgery]. [碳离子放疗治疗胰腺癌转化术后少肝转移复发1例]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Saki Takei, Kazuma Takahashi, Michihisa Kono, Ryosuke Takahashi, Shuichiro Sugawara, Takashi Kaneko, Mayumi Ichikawa, Masashi Koto, Fuyuhiko Motoi

引用次数: 0

A Case of Diffuse Large B-Cell Lymphoma(DLBCL)Who Died of Acute Exacerbation of Interstitial Pneumonia after Treatment with R-mini-CHP in Combination with Polatuzumab Vedotin (Pola-R-mini-CHP). 弥漫性大b细胞淋巴瘤（DLBCL）在R-mini-CHP联合Polatuzumab Vedotin （Pola-R-mini-CHP）治疗后死于间质性肺炎急性加重1例。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Yasunobu Sekiguchi, Hiroki Tsutsumi, Masahisa Kudo, Nobuo Maseki, Yoshie Iizaki, Machiko Kawamura, Kazuhiko Kobayashi, Daisuke Takei, Tomoya Abe, Makoto Hanai, Sayaka Endo, Yu Kakusaka, Toshiaki Nakayama, Yu Nishimura, Takashi Maekawa, Yasumasa Shimano, Hirofumi Kobayashi

引用次数: 0

[Experience with Thoracoepigastric Flap Reconstruction after Mastectomy]. 乳房切除术后胸腹皮瓣重建的经验。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Hirofumi Terakawa, Chihiro Kawata, Yuki Kurokawa, Kazuyoshi Mita, Ryosuke Mohri, Reiko Sato, Hiroto Saito, Miki Hirata, Toshikatsu Tsuji, Daisuke Yamamoto, Tomomi Kitahara, Hideki Moriyama, Jun Kinoshita, Hiroko Kawashima, Noriyuki Inaki

{"title":"[Experience with Thoracoepigastric Flap Reconstruction after Mastectomy].","authors":"Hirofumi Terakawa, Chihiro Kawata, Yuki Kurokawa, Kazuyoshi Mita, Ryosuke Mohri, Reiko Sato, Hiroto Saito, Miki Hirata, Toshikatsu Tsuji, Daisuke Yamamoto, Tomomi Kitahara, Hideki Moriyama, Jun Kinoshita, Hiroko Kawashima, Noriyuki Inaki","doi":"","DOIUrl":"","url":null,"abstract":"We report 2 cases in which skin grafting was avoided by utilizing thoracoepigastric following mastectomy with extensive skin defects due to advanced breast cancer extensively involving the breast.Case 1: A 53-year-old woman was diagnosed with right breast cancer extending to the midline of the chest.She underwent total mastectomy of the right breast, resection of the midline chest skin, and sentinel lymph node biopsy.Intraoperative frozen section analysis revealed positive sentinel nodes, prompting additional axillary lymph node dissection.Due to the extensive skin defect caused by resection of the midline chest skin, a thoracoepigastric flap was created to achieve wound closure.The postoperative course was uneventful.Case 2: A 64-year-old woman developed an intramammary recurrence of right breast cancer during follow-up after prior surgery.The recurrent tumor had extensively spread throughout the breast, with widespread erythema noted on the overlying skin.Multiple axillary lymph node metastases were also present, and neoadjuvant chemotherapy was initiated.Following chemotherapy, she underwent right total mastectomy and axillary lymph node dissection.A thoracoepigastric flap was used for wound closure.Her postoperative course was free of complications.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 1","pages":"43-44"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Assessment of Locally Advanced Colorectal Cancer Cases Successfully Resected after Chemotherapy]. 局部晚期结直肠癌化疗后成功切除病例的评估

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Hajime Yokomizo, Sachiyo Okayama, Shunsuke Iwamoto, Hana Kawahata, Shinichi Asaka, Takebumi Usui, Shunichi Shiozawa

引用次数: 0

[A Case of Perforated Ileum Due to Gangrenous Ischemic Enteritis after Cardiopulmonary Arrest with Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome]. 【心肺骤停合并糖尿病酮症酸中毒、高渗性高血糖综合征并发坏疽性缺血性肠炎致回肠穿孔1例】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Masanori Yamada, Hiroki Yamaguchi, Hironari Miyamoto, Daiki Inazu, Mamiko Takii, Tsutomu Oshima, Katsuyuki Mayumi, Masashi Takemura

{"title":"[A Case of Perforated Ileum Due to Gangrenous Ischemic Enteritis after Cardiopulmonary Arrest with Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome].","authors":"Masanori Yamada, Hiroki Yamaguchi, Hironari Miyamoto, Daiki Inazu, Mamiko Takii, Tsutomu Oshima, Katsuyuki Mayumi, Masashi Takemura","doi":"","DOIUrl":"","url":null,"abstract":"A 61-year-old man experienced cardiopulmonary arrest twice during treatment for diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome.He was successfully resuscitated with intensive treatment.Subsequently, anemia progressed and a fecal occult blood test was positive.Ischemic enteritis with multiple small ulcers in the cecum and deep ulcers in the ileum were observed with lower gastrointestinal endoscopy.Approximately 1 week after the examination, melena and intestinal obstruction developed.Fever and abdominal pain were intensified, and blood test findings markedly worsened and abdominal CT showed that the small intestine was dilated, the wall of the terminal ileum was thickened, and a small amount of ascites in the pelvis.Laparotomy was performed 32 days later.The wall of the terminal ileum was markedly thickened.Intestinal necrosis and perforation were observed in a segment of approximately 10 cm that was 5 cm proximal to the terminal ileum.Ileocecal resection and ileostomy were performed.We encountered a patient who experienced cardiac arrest during treatment for hyperosmolar hyperglycemic syndrome and diabetic ketoacidosis, developed necrotic ischemic enteritis with circumferential perforation, and required surgical treatment.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 1","pages":"45-47"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Gastric Cancer Diagnosed from Adrenal Metastasis after Left Adrenal Tumor Resection and Treated with Robot-Assisted Distal Gastrectomy after Chemotherapy]. 【左侧肾上腺肿瘤切除后诊断为肾上腺转移的胃癌1例，化疗后机器人辅助胃远端切除术治疗】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Megumi Watanabe, Eigo Oka, Mikoto Nosaka, Akari Masunaga, Maho Sato, Tomohiro Okura, Toshihiro Ogawa, Naoto Hori, Takashi Arata, Kou Katsuda, Kohji Tanakaya, Hideki Aoki

{"title":"[A Case of Gastric Cancer Diagnosed from Adrenal Metastasis after Left Adrenal Tumor Resection and Treated with Robot-Assisted Distal Gastrectomy after Chemotherapy].","authors":"Megumi Watanabe, Eigo Oka, Mikoto Nosaka, Akari Masunaga, Maho Sato, Tomohiro Okura, Toshihiro Ogawa, Naoto Hori, Takashi Arata, Kou Katsuda, Kohji Tanakaya, Hideki Aoki","doi":"","DOIUrl":"","url":null,"abstract":"Adrenal metastasis from gastric cancer is often found as part of systemic metastasis, and is rarely an isolated tumor that requires resection.The patient was a 73-year-old man.Contrast CT scan performed to investigate anemia and positive stool for occult blood revealed a 5 cm mass in the left adrenal gland.Upper gastrointestinal endoscopy revealed gastric cancer in the lesser curvature of the gastric angle, and lower gastrointestinal endoscopy revealed rectal cancer.Laparoscopic left adrenalectomy was performed for the left adrenal mass, and a histopathological examination revealed that the tumor was adrenal metastasis from gastric cancer.After 3 courses of SOX therapy, robot-assisted distal gastrectomy, with D2 lymph node dissection, and Roux-en-Y reconstruction were performed.Postoperative pathological diagnosis was M, Less, ypType 4, 48×43 mm, por2>tub2>sig, ypT3(SS), INF c, Ly0, V0, ypPM0, ypDM0, ypN0, P0, CY0, H0, M1(ADR), ypStage Ⅳ.By appropriately combining systemic therapy(chemotherapy)and local therapy(surgical resection), it is expected that the prognosis can be improved even for isolated adrenal metastasis of gastric cancer.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 1","pages":"54-56"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Current Development of Perioperative Immune Checkpoint Inhibitor Therapy for Muscle-Invasive Bladder Cancer]. [免疫检查点抑制剂治疗肌肉浸润性膀胱癌的围手术期进展]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Yuki Kita

{"title":"[Current Development of Perioperative Immune Checkpoint Inhibitor Therapy for Muscle-Invasive Bladder Cancer].","authors":"Yuki Kita","doi":"","DOIUrl":"","url":null,"abstract":"Muscle-invasive bladder cancer(MIBC)carries a high risk of recurrence.The standard treatment has been cisplatin-based neoadjuvant chemotherapy(NAC)followed by radical cystectomy(RC), but nearly half of patients are cisplatin-ineligible and unable to receive optimal NAC.Furthermore, recurrence after NAC plus RC remains common, highlighting the need for effective adjuvant strategies.Recent advances in immune checkpoint inhibitors(ICIs)have revolutionized perioperative treatment paradigms.The phase Ⅲ CheckMate 274 trial demonstrated that adjuvant nivolumab significantly prolonged disease-free survival(DFS), particularly in PD-L1-positive patients.In the IMvigor010 trial, adjuvant atezolizumab did not improve DFS in the overall population, but a biomarker-driven subanalysis revealed marked benefit in patients with postoperative circulating tumor DNA(ctDNA)positivity.Based on these findings, the ongoing IMvigor011 trial restricts adjuvant atezolizumab to ctDNA-positive patients.The NIAGARA trial evaluated a comprehensive perioperative approach using neoadjuvant gemcitabine-cisplatin plus durvalumab followed by adjuvant durvalumab for 1 year.This regimen significantly improved DFS, overall survival(OS), and pathological complete response(pCR)rates without increasing Grade ≥3 toxicities.ctDNA has emerged as a promising biomarker for risk stratification and treatment monitoring, potentially enabling precision perioperative immunotherapy.This review summarizes pivotal phase Ⅲ trials of perioperative ICI therapy in MIBC and discusses the role of ctDNA-guided strategies, envisioning a shift from universal ICI administration to biomarker-driven, individualized perioperative approaches.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 1","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0