Japanese Journal of Cancer and Chemotherapy最新文献_第5页

[A Case of Rectal Cancer with Lateral Lymph Node, Liver and Lung Metastases after Surgery, Successfully Undergoing Radical Resection with Multidisciplinary Treatment]. [直肠癌术后伴侧淋巴结、肝、肺转移1例，经多学科治疗根治性切除成功]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Yuji Ando, Masaya Kawai, Yuta Murai, Saki Kochi, Miyuki Toake, Hiromitsu Takahashi, Takahiro Irie, Hirotaka Momose, Yuki Tsuchiya, Kota Amemiya, Ryoichi Tsukamoto, Kumpei Honjo, Shun Ishiyama, Kiichi Sugimoto, Kazuhiro Sakamoto

引用次数: 0

[Investigation of Preoperative Chemotherapy Using Enterostomy for Advanced Gastric Cancer with Stenosis]. 进展期胃癌伴狭窄的肠造口术前化疗的探讨

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Hidetaka A Ono, Yohei Ota, Hirokazu Suwa, Kazunori Nojiri, Kenichi Yoshida, Hidenobu Masui, Kaoru Nagahori

{"title":"[Investigation of Preoperative Chemotherapy Using Enterostomy for Advanced Gastric Cancer with Stenosis].","authors":"Hidetaka A Ono, Yohei Ota, Hirokazu Suwa, Kazunori Nojiri, Kenichi Yoshida, Hidenobu Masui, Kaoru Nagahori","doi":"","DOIUrl":"","url":null,"abstract":"Background: Preoperative chemotherapy for gastric cancer with obstructive symptoms traditionally requires bypass surgery.Objective: To investigate the feasibility of preoperative enterostomy chemotherapy in patients with advanced gastric cancer who present with obstructive symptoms.Methods: A total of 47 patients with cStage Ⅲ gastric cancer who underwent preoperative chemotherapy between April 2013 and May 2024 were included. Patients with circumferential lesions underwent enterostomy during diagnostic laparoscopy, which was followed by chemotherapy.Results: The enterostomy and non-enterostomy groups included 20 and 27 patients, respectively. The chemotherapy regimens included SOX, SOX+nivolumab, SP, biweekly NAC-DCS, and XP+trastuzumab. Grade 3 or higher adverse events, including neutropenia, malaise, and diarrhea, were more common in the no-enterostomy group. The completion rates of at least 2 chemotherapy courses were similar between groups. Grade Ⅲa or higher complications during gastrectomy were slightly higher in the enterostomy group. The pathological responses were comparable between groups.Conclusion: Preoperative chemotherapy using enterostomy for advanced gastric cancer with obstructive symptoms showed efficacy and safety comparable to those of traditional methods, suggesting that it is a viable treatment option.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 4","pages":"363-365"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of cy1 Advanced Gastric Cancer That Achieved CR after Chemotherapy Via an Enterostomy]. [1例cy1晚期胃癌经肠造口化疗后达到CR]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Hidetaka A Ono, Yohei Ota, Hirokazu Suwa, Kazunori Nojiri, Kenichi Yoshida, Hidenobu Masui, Kaoru Nagahori

引用次数: 0

[Microphysiological System(MPS)for Drug Research, the Current Situation and the Future]. 微生理系统（MPS）在药物研究中的应用现状与未来

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Osamu Ando, Yuzuru Ito

{"title":"[Microphysiological System(MPS)for Drug Research, the Current Situation and the Future].","authors":"Osamu Ando, Yuzuru Ito","doi":"","DOIUrl":"","url":null,"abstract":"The development of new in vitro cell culture systems, the microphysiological systems(MPSs), is progressing rapidly around the world. MPS is a biomimetic cell culture system that recapitulate tissue biology(patho)physiologically using clinically derived specimens, organoids, or differentiated cells from stem cells on a culture device with circulation and detection devices. New disease model systems are being constructed using MPS and are used as proof-of-concept and drug evaluation systems, and are attracting attention as an approach to addressing unmet medical needs. In conventional anti-cancer drug research, in vitro culture systems are mainly used to evaluate the growth inhibitory potential of cancer cell line monocultures. On the other hand, MPS has made it possible to monitor cancer pathology, malignant traits, and pharmacological activity, such as reproduction of the cancer niche, interactions between cancer cells and various stroma in the tumor microenvironment, cancer cell movement, and immune cell accumulation in cancer tissue. MPS is also used to evaluate safety and adverse effects and pharmacokinetics, which are essential for anticancer drug development. Various MPSs have been developed and reported for these purposes also in Japan, MPS technology is being developed, including for use in the regulatory process for non-clinical studies. Through these efforts, it is expected to lead to innovation in drug discovery in the field of oncology.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 4","pages":"287-293"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Robot-Assisted Resection for Ascending Colon Cancer with a Tumor Thrombus in the Superior Mesenteric Vein after Neoadjuvant Chemotherapy-A Case of Report]. 【机器人辅助切除新辅助化疗后肠系膜上静脉肿瘤血栓一例】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Takahiro Ishii, Takatoshi Matsuyama, Satoshi Hatano, Noriyasu Chika, Takehiro Shiraishi, Aoi Sugino, Hiroyasu Ishikawa, Toshifumi Saito, Norimichi Chiyonobu, Tetsuya Ito, Yoshiko Mori, Toru Ishiguro, Yoichi Kumagai, Hideyuki Ishida

引用次数: 0

[A Therapeutic Strategy Targeting Virus-Antigen in Cancer Treatment]. 一种针对病毒抗原的肿瘤治疗策略

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Tomohiro Enokida

引用次数: 0

[A Case of Pulmonary Tuberculosis Developed During Neoadjuvant Chemotherapy for HER2-Enriched Breast Cancer]. 【her2富集型乳腺癌新辅助化疗中发生肺结核1例】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-03-01

Yoko Mizuyama, Tsutomu Takashima

{"title":"[A Case of Pulmonary Tuberculosis Developed During Neoadjuvant Chemotherapy for HER2-Enriched Breast Cancer].","authors":"Yoko Mizuyama, Tsutomu Takashima","doi":"","DOIUrl":"","url":null,"abstract":"In the 1990s, the number of newly registered tuberculosis patients in Japan was about 40,000 per year. It has been gradually decreasing and the number of new patients became 10,235 in 2022 with the incidence rate of 8.2 per 100,000 population. However it is still occasionally encountered even in recent years. Herein, we report a case of human epidermal growth factor receptor 2(HER2)-enriched breast cancer patient developed pulmonary tuberculosis just after finishing neoadjuvant chemotherapy and was successfully treated for both disease simultaneously. A 68 years old woman presented due to right breast mass was diagnosed with hormonal receptor-negative, HER2-positive invasive ductal carcinoma. Neoadjuvant chemotherapy with paclitaxel, trastuzumab and pertuzumab was started. After 12 courses of chemotherapy, CT scan revealed disappearance of the right breast tumor and infiltrating shadow in the left lower lung field. Sputum polymerase chain reaction test for tuberculosis was positive. Anti-tuberculosis chemotherapy was started. Four days after starting isoniazid, partial mastectomy was performed under local anesthesia and radiation therapy for the breast was omitted. There are no signs of recurrence of breast cancer and pulmonary tuberculosis for 5 years. Chemotherapy for breast cancer and premedication with corticosteroid may have inhibited cellular immunity, causing endogenous relapse of tuberculosis.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 3","pages":"252-254"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Partial Nephrectomy and Focal Therapy in Small Renal Tumors]. [小肾肿瘤的肾部分切除术和病灶治疗]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-03-01

Yoshiyuki Matsui

{"title":"[Partial Nephrectomy and Focal Therapy in Small Renal Tumors].","authors":"Yoshiyuki Matsui","doi":"","DOIUrl":"","url":null,"abstract":"With the increasing use of robot-assisted surgery, partial nephrectomy is recommended for small renal tumors(T1a)with a tumor size of 4 cm or less and is now considered a standard treatment. However, with the rise in incidental detection of small renal tumors during routine screenings, especially in elderly patients or those with comorbidities who may hesitate to undergo general anesthesia, there is a growing need for alternative treatments such as focal therapy to partial nephrectomy. The main methods of focal therapy include ablation techniques such as cryotherapy and radiofrequency ablation. Recently, stereotactic body radiotherapy has also been approved for insurance coverage, emerging as a minimally invasive option for renal cell carcinoma with a tumor size of 5 cm or less. Additionally, although not a focal therapy, active surveillance is also considered an effective option for very small renal tumors. Among these various treatment options, shared decision making between patients and healthcare providers, considering factors such as tumor characteristics and patient-specific conditions, is considered crucial in determining the appropriate treatment strategy for small renal tumors. In the absence of large-scale prospective comparative trials on partial nephrectomy, ablation therapy, stereotactic radiotherapy, and active surveillance, this paper provides an overview of the characteristics of each treatment modality and their respective outcomes and discusses the future perspectives in the treatment of small renal tumors.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 3","pages":"205-209"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of an Older Patient with MSI-High Colorectal Cancer with Distant Lymph Node Metastasis Successfully Treated with Pembrolizumab]. [彭博利珠单抗成功治疗一例 MSI 高、伴有远处淋巴结转移的老年结直肠癌患者】。］

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-03-01

Shintaro Takeda, Yasushi Yoshida, Tomoaki Noritomi, Jun Yanagisawa, Mitsuaki Morimoto, Hiroki Ureshino, Shuhei Ito, Fuminori Ishii, Kazune Komiya, Yasuhito Hosoda, Ren Nakamura, Kyohei Sakamoto, Yutaro Nakagawa, Kozue Nakahara

{"title":"[A Case of an Older Patient with MSI-High Colorectal Cancer with Distant Lymph Node Metastasis Successfully Treated with Pembrolizumab].","authors":"Shintaro Takeda, Yasushi Yoshida, Tomoaki Noritomi, Jun Yanagisawa, Mitsuaki Morimoto, Hiroki Ureshino, Shuhei Ito, Fuminori Ishii, Kazune Komiya, Yasuhito Hosoda, Ren Nakamura, Kyohei Sakamoto, Yutaro Nakagawa, Kozue Nakahara","doi":"","DOIUrl":"","url":null,"abstract":"The patient was a 90-year-old man with a PS score of 0 and no underlying disease. He visited our hospital with a fever and was diagnosed with cancer of the ascending colon with abscess formation due to retroperitoneal perforation. First, he underwent ileostomy with double orifices and abscess puncture drainage, followed by right semicolon resection plus ileostomy closure to resect the primary tumor. Three months after the surgery, metastases were found in the left cervical supraclavicular and periaortic lymph nodes. The primary tumor was a poorly differentiated adenocarcinoma, RAS wild, BRAF mutation(+), and MSI-high(+). Therefore, pembrolizumab therapy was initiated, which resulted in a complete response(CR) at the end of 6 courses. After 2 years of pembrolizumab treatment, the patient's CR status was maintained, with only Grade 1 hypothyroidism. We believe that pembrolizumab therapy for MSI-high, unresectable, advanced, recurrent colorectal cancer is useful in older patients with good PS, no major underlying disease, and a medical system that can respond to irAE.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 3","pages":"258-259"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Resection of Oligometastasis Liver Metastases from Breast Cancer-Two-Case Report]. [乳腺癌寡转移肝转移灶切除术--两例报告]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-03-01

Yusuke Nishio, Satoshi Matsukuma, Shigeru Yamamoto, Masaki Iwado, Hiroaki Yamatani, Daiki Haraguchi, Atomu Suzuki, Naohiro Yamamoto, Sota Yoshimine, Kazuhisa Tokuno, Toru Kawaoka, Hisashi Sakano, Yuji Fujita, Norio Akiyama

{"title":"[Resection of Oligometastasis Liver Metastases from Breast Cancer-Two-Case Report].","authors":"Yusuke Nishio, Satoshi Matsukuma, Shigeru Yamamoto, Masaki Iwado, Hiroaki Yamatani, Daiki Haraguchi, Atomu Suzuki, Naohiro Yamamoto, Sota Yoshimine, Kazuhisa Tokuno, Toru Kawaoka, Hisashi Sakano, Yuji Fujita, Norio Akiyama","doi":"","DOIUrl":"","url":null,"abstract":"Resection of liver metastases from breast cancer is not widely accepted because the survival benefit of surgery has not been demonstrated. We report the cases of 2 patients who underwent resection of liver metastases from breast cancer. Case 1: This was a female patient in her 50s with synchronous metastasis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Resection was performed since the patient had exhausted all anti-HER2 therapies and had only a single liver metastasis. Immunohistochemical staining results of the resected specimens showed HER2 negativity. The patient had no recurrence 5 months postoperatively and received adjuvant chemotherapy with capecitabine. Case 2: This was a female patient in her 70s with metachronous metastasis of hormone receptor-positive disease. A single liver metastasis occurred 28 years after the primary tumor resection. During the 2-year hormone therapy, no new lesions appeared, and the tumor was stable; therefore, resection was performed. The resected specimen showed a complete pathological response. Furthermore, the patient has been recurrence-free for 1 year without any therapy.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 3","pages":"260-262"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0