Japanese Journal of Cancer and Chemotherapy最新文献

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[A Case of Rectal Cancer Where the Intestinal Separation Line Was Significantly Altered by the Implementation of Intraoperative ICG Fluorescence Imaging]. [术中应用ICG荧光显像改变肠分隔线的直肠癌1例]。
Yuki Takano, Masatoshi Shigoka, Eiji Hidaka, Satoshi Tabuchi, Naokazu Chiba, Tetsuo Ishizaki, Yuichi Nagakawa, Shigeyuki Kawachi
{"title":"[A Case of Rectal Cancer Where the Intestinal Separation Line Was Significantly Altered by the Implementation of Intraoperative ICG Fluorescence Imaging].","authors":"Yuki Takano, Masatoshi Shigoka, Eiji Hidaka, Satoshi Tabuchi, Naokazu Chiba, Tetsuo Ishizaki, Yuichi Nagakawa, Shigeyuki Kawachi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>ICG fluorescence imaging is a technique used for evaluating blood flow in rectal stumps and can prevent anastomotic insufficiency. An 83-year-old male underwent laparoscopic low anterior resection for rectal cancer. After anal-intestinal tract dissection, we performed an oral-mesenteric division 10 cm above the tumor by extracorporeal operation guided by ICG fluorescence imaging. The blood flow boundary was observed 25 cm from the division site, and no blood flow was detected in the divided section. We performed mesenteric division and dissection at the ICG blood flow boundary. The postoperative course was favorable, and the patient was recurrence-free 1 year later. ICG has become the accepted method of blood flow evaluation and is a valuable tool for the prevention of anastomotic insufficiency. In some cases of rectal cancer, a few reports have shown significantly different results when mesentery division and ICG fluorescence imaging were performed; thus, the outcomes obtained in our case are meaningful.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"471-474"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Successful Hemostasis with Chemoradiotherapy for Unresectable Large HER2-Positive Advanced Gastric Cancer with Massive Bleeding-A Case Report]. 放化疗成功止血治疗晚期不可切除大her2阳性胃癌大出血1例
Hiroaki Miyake, Yuki Fujii, Ayumi Yokoyama, Kota Tanuma, Tomohide Adachi, Shigemichi Hirose, Shinsuke Funakoshi
{"title":"[Successful Hemostasis with Chemoradiotherapy for Unresectable Large HER2-Positive Advanced Gastric Cancer with Massive Bleeding-A Case Report].","authors":"Hiroaki Miyake, Yuki Fujii, Ayumi Yokoyama, Kota Tanuma, Tomohide Adachi, Shigemichi Hirose, Shinsuke Funakoshi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this case report, we explored the effectiveness of chemoradiotherapy(CRT)for an unresectable large HER2-positive advanced gastric cancer in a 67-year-old male patient. The patient presented with upper abdominal distension and severe anemia. Contrast-enhanced CT scan revealed a 13 cm large tumor in the stomach, with multiple metastases to the liver and lungs. The patient was treated with CRT, combining radiotherapy with FOLFOX chemotherapy to manage persistent massive bleeding. Bleeding was successfully controlled within approximately 2 weeks, eliminating the need for further transfusions and allowing the patient to resume oral intake. Following CRT, trastuzumab-based chemotherapy resulted in significant tumor shrinkage, enabling continued treatment. This case highlights the potential of CRT as an effective treatment option for unresectable HER2-positive advanced gastric cancer complicated by massive bleeding. The successful control of bleeding using CRT might improve both the prognosis and quality of life(QOL)for such patients. We present this case to highlight the therapeutic benefits of CRT in similar clinical scenarios.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"463-466"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[MRD Testing in Lung Cancer-Latest Insights and Developments]. [MRD检测在肺癌中的最新见解和发展]。
Takahiro Karasaki, Hidehito Horinouchi
{"title":"[MRD Testing in Lung Cancer-Latest Insights and Developments].","authors":"Takahiro Karasaki, Hidehito Horinouchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In lung cancer, circulating tumor DNA(ctDNA)analysis has already been clinically implemented, for example, to detect resistance mutations to EGFR-TKIs. Recently, as in many other cancer types, postoperative detection of molecular residual disease (MRD) has been shown to correlate with poor prognosis. This article summarizes the latest findings on MRD research in lung cancer. A literature review as of May 2024 identified 41 studies on lung cancer MRD. Although no randomized trials have yet utilized MRD to guide treatment decisions in this field, retrospective studies consistently demonstrate its utility in predicting recurrence. In Japan, prospective studies such as JCOG2111A(MRDSEEKER trial, NCT06854939), which evaluates the kinetics and detection rate of MRD using a tumor-informed personalized assay, are currently underway. Notably, recent subset analyses of ctDNA/MRD assessments before and after treatment in randomized trials on perioperative chemoimmunotherapy and adjuvant therapy have garnered significant attention. However, the sensitivity of the assays used in these studies possibly remains suboptimal for lung cancer. Future prospective trials incorporating more sensitive, second-generation assays may be warranted.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"443-447"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Current Status of Molecular Residual Disease Testing in Genitourinary Cancers]. [泌尿生殖系统肿瘤分子残留病检测现状]。
Taigo Kato
{"title":"[Current Status of Molecular Residual Disease Testing in Genitourinary Cancers].","authors":"Taigo Kato","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent advancements of surgery including robotic surgery have improved the clinical outcomes of resectable solid tumors. Although preoperative chemotherapy is often performed for high-risk cancers, the risk of postoperative recurrence remains a critical issue. So far, recurrence has been monitored through periodic imaging tests; however, molecular residual disease (MRD)has caught much attention as the means to detect minimal cancerous lesions at an earlier stage. With the rapid advancements in circulating tumor DNA(ctDNA)analysis using next-generation sequencing, MRD testing is emerging as a promising tool for predicting recurrence in multiple types of cancer. Thus, in this article, we discuss the current status of MRD testing in urogenital cancers and its potential impact on future treatment strategies.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"448-450"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Overview of Current Status of Clinical Development by Molecular Residual Disease(MRD)]. [分子残留病(MRD)的临床发展现状综述]。
Shin Kobayashi, Yoshiaki Nakamura
{"title":"[Overview of Current Status of Clinical Development by Molecular Residual Disease(MRD)].","authors":"Shin Kobayashi, Yoshiaki Nakamura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In October 2024, \"Japan society of clinical oncology position paper on appropriate clinical use of molecular residual disease( MRD)testing\"was issued. MRD is defined as\"molecular residual disease detected by the detection of circulating tumor DNA(ctDNA)prior to the appearance of clinical, biologic, or radiologic evidence of recurrence after curative resection\" and has been strongly associated with recurrence after curative resection across multiple cancer types. The attempt to develop personalized perioperative treatment based on MRD testing has been called the\"liquid revolution\", and competition for development is intensifying worldwide. The MRD testing is expected to be a game changer not only in terms of its validity in predicting recurrence, but also in terms of changing the framework of clinical trials for perioperative treatment development and further promoting the development of new therapies. This paper presents the current status and discusses the near future of clinical development based on MRD testing.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"438-442"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Case of a Patient with Lung Adenocarcinoma on Hemodialysis Treated with Atezolizumab+Carboplatin+Nab-Paclitaxel]. [阿特唑单抗+卡铂+ nab -紫杉醇治疗血液透析肺腺癌1例]。
Junichi Hanaka, Mariko Kasuga, Yoshitaka Sakamoto, Mizuki Hagiya, Jun Nakauchi, Takahito Komiyama, Yugo Fukamizu, Takanori Ohata
{"title":"[A Case of a Patient with Lung Adenocarcinoma on Hemodialysis Treated with Atezolizumab+Carboplatin+Nab-Paclitaxel].","authors":"Junichi Hanaka, Mariko Kasuga, Yoshitaka Sakamoto, Mizuki Hagiya, Jun Nakauchi, Takahito Komiyama, Yugo Fukamizu, Takanori Ohata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 70-year-old man presented with anorexia and cough, and CT showed an infiltrative shadow in the right upper lobe. Bronchoscopy revealed unresectable advanced lung carcinoma(cT4N2M1a, cStage ⅣA). The patient had chronic renal failure due to type 2 diabetes mellitus and had been undergoing hemodialysis for 6 years. Four courses of primary chemotherapy( atezolizumab+carboplatin[CBDCA]+nab-paclitaxel[nab-PTX][atezolizumab 1,200 mg/body weight, CBDCA target AUC=5, nab-PTX 100 mg/m2 every 3 weeks])were administered. Thereafter, 3 courses of maintenance treatment with atezolizumab alone(1,200 mg/body weight every 3 weeks)were administered. At this point, the primary tumor was enlarged, and the patient was diagnosed with progressive disease(PD). After 4 courses of second-line chemotherapy with docetaxel(DTX)+ramucirumab(RAM)(DTX 60 mg/m2 day 1, RAM 8 mg/kg day 1, 15, every 4 weeks), the primary tumor temporarily shrank but then re-expanded; therefore, the patient remained in a state of PD. The general condition deteriorated, and he was referred to the palliative care department where he died peacefully.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"475-477"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Case of Locally Advanced Appendiceal Cancer Successfully Resected after Treatment with mFOLFOX6 plus Bevacizumab]. [mFOLFOX6联合贝伐单抗治疗局部晚期阑尾癌成功切除1例]。
Nobuhisa Tanioka, Michio Kuwahara, Takashi Sakai, Yujiro Bunno, Shigeto Shimizu, Toyokazu Akimori
{"title":"[A Case of Locally Advanced Appendiceal Cancer Successfully Resected after Treatment with mFOLFOX6 plus Bevacizumab].","authors":"Nobuhisa Tanioka, Michio Kuwahara, Takashi Sakai, Yujiro Bunno, Shigeto Shimizu, Toyokazu Akimori","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An 80-year-old woman presented with lower abdominal distension for the past 3 days. Abdominal contrast-enhanced CT revealed an irregularly shaped mass measuring 80×50 mm in the right lower abdomen, with a contrast effect. The final diagnosis was locally advanced appendiceal cancer with multiple invasions into the adjacent ileum and retroperitoneum. After 7 courses of preoperative chemotherapy with mFOLFOX6 plus bevacizumab, the tumor reduced in size, and laparoscopic ileocecal resection with D3 lymph node dissection was performed 4 months after diagnosis. Histopathological examination revealed appendiceal cancer, tub1-tub2, ypT4aN0M0, pStage ⅡB, with a histological Grade of 2 and a curative degree of A. The patient had no signs of recurrence 2 years and 6 months after surgery without receiving adjuvant chemotherapy. We reported a case of locally advanced appendiceal cancer that was successfully treated with mFOLFOX6 plus bevacizumab as preoperative chemotherapy and was curatively resected without combined resection of surrounding organs, with a discussion of the relevant literature.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"467-469"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Case of Double Cancers of the Gallbladder and Duodenal Papilla]. 胆囊癌、十二指肠乳头癌1例
Kota Yamamoto, Takahiro Ishimori, Taiki Okada, Takeshi Sasaki, Yumi Mikajiri, Takahiro Terashima, Shunji Kawamoto
{"title":"[A Case of Double Cancers of the Gallbladder and Duodenal Papilla].","authors":"Kota Yamamoto, Takahiro Ishimori, Taiki Okada, Takeshi Sasaki, Yumi Mikajiri, Takahiro Terashima, Shunji Kawamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 65-year-old man was diagnosed with gallbladder cancer during a medical checkup that revealed liver dysfunction. He was referred to our hospital seeking bloodless treatment due to religious beliefs. Blood tests revealed elevated hepatobiliary enzyme levels, and abdominal echocardiography revealed a broad nodular protuberant lesion in the body of the gallbladder and marked dilatation of the common bile duct. PET revealed marked abnormal accumulation of FDG in the gallbladder mass and duodenal papilla. Based on the imaging findings, double cancers of the gallbladder and duodenal papilla were diagnosed. A subtotal gastric-sparing pancreaticoduodenectomy was performed along with resection of the liver bed, gallbladder, and bile ducts, and D2 regional lymph node dissection. Both of postoperative histopathologic diagnosis were papillotubular adenocarcinoma. The patient has remained recurrence-free for 5 years postoperatively. Double cancers of the gallbladder and duodenal papilla are rare, and we report this case based on a review of the literature.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"479-482"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Current Status of ctDNA-Based MRD Testing in Breast Cancer]. [基于ctdna的乳腺癌MRD检测现状]。
Yukinori Ozaki, Hiroji Iwata
{"title":"[Current Status of ctDNA-Based MRD Testing in Breast Cancer].","authors":"Yukinori Ozaki, Hiroji Iwata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Treatment strategies for breast cancer are becoming increasingly complex, necessitating a deeper understanding of the disease and the personalization of therapy based on biomarkers. Circulating tumor DNA(ctDNA)allows for comprehensive tumor assessment in a minimally invasive manner, and therapeutic development in this area is actively progressing. Studies evaluating ctDNA during postoperative follow-up or after neoadjuvant chemotherapy across various breast cancer subtypes have consistently shown that ctDNA detection is associated with a higher risk of recurrence, regardless of the clinical setting. Clinical trials investigating therapeutic interventions guided by ctDNA testing are currently underway. Moving forward, the development of more sensitive assay and effective therapeutic strategies is needed. The clinical application of ctDNA is expected to further advance personalized treatment in breast cancer.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"451-455"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Operational Construction and Effectiveness Verification of an HBV Reactivation Management Protocol for Cancer Chemotherapy Patients Based on Medical Information System Safety Management]. [基于医疗信息系统安全管理的肿瘤化疗患者HBV再激活管理方案的操作构建及有效性验证]。
Masato Komuro, Yuri Toda, Sae Ishikawa, Hiroshi Hyakutake, Tomofumi Watanabe, Yumiko Shimanuki, Maho Tanaka, Komei Shimokawa, Takahiro Nishimura, Kengo Miyo
{"title":"[Operational Construction and Effectiveness Verification of an HBV Reactivation Management Protocol for Cancer Chemotherapy Patients Based on Medical Information System Safety Management].","authors":"Masato Komuro, Yuri Toda, Sae Ishikawa, Hiroshi Hyakutake, Tomofumi Watanabe, Yumiko Shimanuki, Maho Tanaka, Komei Shimokawa, Takahiro Nishimura, Kengo Miyo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatitis B virus(HBV)reactivation during cancer chemotherapy is a life-threatening condition with a high risk of severe or fulminant disease. Effective management is essential; however, individual physicians may lack a structured system for handling HBV-related risks, and both physicians and pharmacists often face significant administrative burdens, including making inquiries, entering orders for additional testing, and verifying appropriate orders. To address this challenge, we developed a pharmacist-initiated, protocol-based pharmacotherapy management system for HBV(PBPM-HBV), allowing pharmacists to order HBV-related tests on behalf of physicians in accordance with the Guidelines for the Safety Management of Medical Information Systems. Implementing PBPM-HBV under these guidelines reduced the number of HBV-related test requests from 224 to 50, resulting in an approximately 75.7% reduction in workload. The introduction of PBPM-HBV at our hospital has improved workflow efficiency for both physicians and pharmacists while ensuring the safety of the medical information system and cancer chemotherapy processes.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"457-461"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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