Japanese Journal of Cancer and Chemotherapy最新文献

{"title":"[A Case of Hepatic Sarcoidosis Diagnosed by Liver Resection].","authors":"Yoshiaki Ohmura, Masaki Kashiwazaki, Hisataka Ogawa, Tomohiro Takahashi, Shogo Yanagi, Yoko Oga, Nobuo Takiguchi, Yoshitoshi Ichikawa, Haruna Furukawa, Shigeyoshi Higashi, Masakazu Miyake, Masami Imakita, Masahiro Tanemura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sarcoidosis is a systemic disease that causes noncaseating granulomas in multiple organs, primarily affecting the respiratory tract, eyes, skin, and heart. Although it also occurs in the liver, it is difficult to distinguish it from well-differentiated hepatocellular carcinoma based on imaging diagnosis alone. Here, we report a case in which it was difficult to distinguish it from well-differentiated hepatocellular carcinoma, but the diagnosis was made after surgical resection.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"224-226"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Case of Incidentally Resected Neuroendocrine Tumor in a Meckel's Diverticulum].","authors":"Norihito Shinkubo, Michitoshi Goto, Yuki Nakagawa, Yuta Murai, Megumi Kawaguchi, Masaaki Minagawa, Hirotsugu Morioka, Jun Aoki, Michihiro Orihata, Shigetaka Yamasaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The patient was a 54-year-old man. He developed a fever during chemotherapy for recurrent lung cancer and was admitted to the respiratory medicine department in our institution with a diagnosis of febrile neutropenia. During his hospitalization, he developed anemia and black stools, and a detailed examination revealed small intestinal bleeding, leading to a partial small intestinal resection. A 3 cm-sized diverticulum was accidentally found during surgery, located 60 cm from the terminal ileum, and was also resected. Histopathological examination revealed a diagnosis of Meckel's diverticulum neuroendocrine tumor(NET G1). Here, we report a case of a neuroendocrine tumor in a Meckel's diverticulum that was accidentally resected during surgery for small intestinal bleeding.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"215-217"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Case of Advanced Gastric Cancer with Early Recurrence after Surgery Treated by Nivolumab].","authors":"Kumi Hasegawa, Masaki Matsumura, Tomohiro Hayakawa, Jun Kaneko, Jun Isogai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The patient is a 65-year-old male. He underwent laparoscopic distal gastrectomy for advanced gastric cancer of the lower gastric body. Pathological findings were poorly differentiated adenocarcinoma, Stage ⅢC. The cancerous lesion extended over 15 cm and was extensively positive for margins on the oral side due to marked lymphatic invasion. Two months later, CT showed local peritoneal recurrence, so treatment with nivolumab+SOX was started. The recurrence was resolved, but due to appearance of anorexia 6 months later, the treatment was discontinued. His symptoms worsened further, and hospitalized to receive intravenous infusion. A marked decrease in blood cortisol and ACTH was observed, suggesting hypopituitarism as irAE. After steroid administration, the symptoms resolved quickly. Subsequently, nivolumab+SOX were administered, and a long-term complete response was achieved.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"204-206"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Case of Epithelioid-Type Small Intestinal Gastrointestinal Stromal Tumor with Positive PDGFRA Discovered Because of Small Intestinal Intussusception].","authors":"Tadafumi Fukata, Katsuki Danno, Takashi Takeda, Kei Yamamoto, Masaya Higashiguchi, Kozo Noguchi, Yasuhiro Toyoda, Shigeru Nakane, Takafumi Hirao, Itsuko Nakamichi, Mitsugu Sekimoto, Yoshio Oka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Adult intussusception is a rare condition, accounting for approximately 5% of all intussusception cases, and is often caused by organic lesions, such as tumors. We report a rare case of a small intestinal gastrointestinal stromal tumor(GIST)presenting with intussusception. The patient was an older adult woman in her 80s who presented with abdominal pain and loss of appetite. Abdominal contrast-enhanced CT revealed an intussusception with a 30-mm mass as the lead point, and emergency surgery was performed to remove the mass. Segmental resection of the small intestine was performed, and histopathological examination revealed a submucosal epithelioid tumor. Immunohistochemical analysis revealed that both KIT and DOG1 were negative, making diagnosis difficult. However, PDGFRA positivity was confirmed by additional testing, leading to a final diagnosis of GIST. Small intestinal GISTs are relatively uncommon, and epithelioid-type GISTs that are KIT-negative and DOG1-negative are extremely rare. This case highlights the importance of considering atypical GISTs in the differential diagnosis of small bowel tumors with unusual immunohistochemical features.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"207-209"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Report of a Case of Unresectable Advanced Gastric Cancer with Long-Term Survival on Chemotherapy Alone].","authors":"Suzuka Imanishi, Atsushi Takeno, Masaaki Yamamoto, Shinji Tokuyama, Reishi Toshiyama, Yuuki Matsui, Kenji Kawai, Yusuke Takahashi, Kenji Sakai, Naoki Hama, Michihiko Miyazaki, Takeshi Kato, Koji Takami, Motohiro Hirao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 68-year-old male presented with upper abdominal pain and was referred to our hospital after endoscopy revealed a primary tumor in the gastric antrum. He was diagnosed with unresectable advanced gastric cancer(cT4b[liver, pancreas]N+M1[PUL], cStage ⅣB). S-1 and oxaliplatin were selected as first-line chemotherapeutic agents. After 2 courses, a CT scan showed that the primary tumor and lymph nodes had shrunk, but there was no change in the pulmonary metastases. After 7 courses, oxaliplatin was discontinued due to peripheral neuropathy, and only S-1 was subsequently administered as a single agent. Endoscopy revealed only a scar at the primary tumor site, without malignant findings on biopsy. Seven years after treatment, he continued with only S-1. The lung metastases remained unchanged, but the primary tumor and lymph nodes continued to disappear.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"198-200"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current Status and Future Perspectives of Microbiome Research in Lung Cancer].","authors":"Yuko Oya, Ichidai Tanaka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent advances in immune checkpoint inhibitors(ICIs)and molecular targeted therapies have substantially improved outcomes in lung cancer; however, marked inter-individual variability in efficacy and toxicity remains. Accumulating evidence suggests that the gut microbiota, acting through the\"gut-lung axis,\"is a key modifier of treatment response and tolerance in this setting. High microbial diversity and the abundance of beneficial taxa such as Akkermansia, Bifidobacterium, and Faecalibacterium have been associated with favorable ICI responses, whereas dysbiosis induced by antibiotics, proton pump inhibitors, cytotoxic chemotherapy, or lifestyle factors is linked to reduced efficacy and increased toxicity. Microbial metabolites, including short-chain fatty acids and tryptophan derivatives, shape antitumor immunity by modulating T-cell activation, regulatory T-cell differentiation, and the tumor immune microenvironment. In addition, emerging data indicate that the gut microbiota may influence the pharmacodynamics and adverse event profiles of EGFR tyrosine kinase inhibitors(EGFR- TKIs)and other targeted agents, particularly with respect to gastrointestinal toxicity. Smoking, a central etiological factor in lung carcinogenesis, also alters gut microbial composition, decreasing beneficial anti-inflammatory species and promoting pro-inflammatory taxa, thereby potentially aggravating systemic inflammation and impairing ICI responsiveness. Notably, partial restoration of a healthier microbiome appears possible with smoking cessation and rational supportive care. Interventions aimed at favorably modifying the gut ecosystem-such as high-fiber or plant-forward diets, probiotics, and fecal microbiotatransplantation-have begun to show promise in enhancing ICI efficacy without substantially increasing immune-related adverse events. Prospective trials in lung cancer are now underway to evaluate the clinical utility of microbiome-based biomarkers and interventions. Collectively, these findings position the gut microbiota as both a predictive biomarker and a modifiable therapeutic target, with the potential to refine patient stratification, optimize treatment selection, and advance truly personalized medicine in lung cancer.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"168-174"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Case of Intussusception Due to Small Intestinal Cancer Diagnosed by Laparoscopy].","authors":"Tsukasa Yoshida, Shun Miyanari, Tatsuro Ishikawa, Yasushi Takafuji, Kohei Fujinami, Takumi Hikawa, Takahiro Shimauchi, Yosuke Ueno, Michinori Murayama, Kazuo Hase","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Most cases of primary small intestinal cancer are diagnosed at an advanced stage, and when accompanied by intussusception or obstruction, emergency surgery may be required. Preoperative evaluation of small intestinal cancer is challenging. The patient was a 52-year-old man who was referred to our hospital with abdominal pain and vomiting, and was diagnosed with small intestinal intussusception. Abdominal CT at our hospital revealed bowel wall thickening at the site where the intussusception had resolved, raising suspicion for small intestinal cancer. Based on the patient's clinical history and physical findings, delayed small intestinal perforation was suspected, and emergency surgery was performed. Laparoscopy-assisted surgery was carried out to resect the small intestinal tumor and peritoneal dissemination nodules. Pathological examination revealed moderately differentiated adenocarcinoma. The final diagnosis was pT3, pN1, pM1, and Stage Ⅳ. Laparoscopic surgery for small bowel cancer can be useful both for treatment and intraoperative diagnosis. In this case, the decision to perform non-curative resection based on the Stage Ⅳ diagnosis enabled early discharge and prompt initiation of additional treatments.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"210-211"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Case of Long-Term Survival in a Patient with Adrenal Metastasis from Gastric Cancer Who Achieved Two Complete Responses from Chemotherapy Following Resection].","authors":"Hiroshi Noro, Toru Sasaki, Yu Takeda, Takehisa Matsuyama, Hideki Sakisaka, Shin Mizutani, Masato Minami","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The patient was a 70-year-old male with highly advanced gastric cancer, 2 liver metastases(S3 and S8), and pancreatic invasion. Three courses of S-1+L-OHP(SOX therapy)were administered as conversion surgery chemotherapy, and total gastrectomy and combined resection of the body and tail of the pancreas and spleen and partial resection of the liver(S3 and S8)were performed as conversion surgery. S-1 therapy was continued for 1 year as postoperative adjuvant chemotherapy. A left adrenal metastasis was detected on CT 1 year and 6 months after the operation. PET-CT revealed no other areas suspicious of recurrence; therefore, left adrenalectomy was performed through the retroperitoneal space. Radical resection was not performed because of severe adhesions and scarring from the previous surgery. Paclitaxel+ramucirumab chemotherapy was initiated, and after 10 courses, tumor disappearance was observed on enhanced CT and PET-CT. The re-enlargement was observed 1 year later. The patient underwent re-administration of paclitaxel+ramucirumab, SOX+ nivolumab therapy, and nivolumab monotherapy, but all showed PD on imaging. After 8 courses of CPT-11 monotherapy, CR was again observed on imaging. Five years and 3 months after the initial surgery and 3 years and 8 months after adrenal metastasis resection, the patient was alive and well without recurrence.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"195-197"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Case of Mesenteric Desmoid Tumor Arising during Follow-Up of the Clinical Course of Ulcerative Colitis].","authors":"Rika Ida, Jun Aoki, Michitoshi Goto, Hirotsugu Morioka, Masaaki Minagawa, Megumi Kawaguchi, Yuki Nakagawa, Michihiro Orihata, Shigetaka Yamasaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A man in his 50s with a known history of ulcerative colitis under regular surveillance in our gastroenterology department. He presented with right lower quadrant abdominal pain and a sense of abdominal distension. Contrast-enhanced CT revealed a well-circumscribed, mildly enhancing intra-abdominal mass measuring 12×8×13 cm. MRI showed a heterogeneously hyperintense lesion. Differential diagnoses included gastrointestinal stromal tumor(GIST)and other mesenteric tumors. For definitive diagnosis and treatment, an open surgical resection was performed. The tumor originated from the mesentery of the terminal ileum and was adherent to the descending portion of the duodenum. Ileocecal resection and wedge resection of the duodenum were performed, and the tumor was excised. Histopathological examination confirmed the diagnosis of an intra-abdominal desmoid tumor arising from the mesentery.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"212-214"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Microbiome and Colorectal Cancer].","authors":"Tatsuhiro Shibata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The number of colorectal cancer patients in Japan continues to rise, placing the country among the highest rates globally, surpassing even Western nations. Furthermore, the increase in colorectal cancer among younger individuals(under 50 years old)is a significant concern. This rapid rise in colorectal cancer patients cannot be explained solely by the adoption of Western lifestyles, suggesting the presence of unknown carcinogenic factors. Colibactin toxin, produced by certain gut bacteria (pks+ Escherichia coli), binds to AT-rich DNA and induces characteristic mutation patterns. An international collaborative study compared the differences in these mutation patterns across 981 colorectal cancer samples collected from 11 countries, including Japan. Surprisingly, it revealed that Japanese cases exhibited a significantly higher frequency of the colibactin toxin - induced mutation patterns(SBS88 and ID18)compared to other countries. Furthermore, SBS88 and ID18 were particularly prevalent in younger patients and notably prominent in the right colon, including the rectum. These findings suggest that interventions such as preventing infection with pks+ bacteria, eradicating them, or inhibiting the function of colibactin toxin could potentially reduce the incidence of colorectal cancer, particularly in younger patients. Such prevention is also considered likely to be effective in Japan, where infection is presumed to be highly prevalent.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 3","pages":"162-167"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}