[MRD Testing in Lung Cancer-Latest Insights and Developments].

Q4 Medicine
Takahiro Karasaki, Hidehito Horinouchi
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引用次数: 0

Abstract

In lung cancer, circulating tumor DNA(ctDNA)analysis has already been clinically implemented, for example, to detect resistance mutations to EGFR-TKIs. Recently, as in many other cancer types, postoperative detection of molecular residual disease (MRD) has been shown to correlate with poor prognosis. This article summarizes the latest findings on MRD research in lung cancer. A literature review as of May 2024 identified 41 studies on lung cancer MRD. Although no randomized trials have yet utilized MRD to guide treatment decisions in this field, retrospective studies consistently demonstrate its utility in predicting recurrence. In Japan, prospective studies such as JCOG2111A(MRDSEEKER trial, NCT06854939), which evaluates the kinetics and detection rate of MRD using a tumor-informed personalized assay, are currently underway. Notably, recent subset analyses of ctDNA/MRD assessments before and after treatment in randomized trials on perioperative chemoimmunotherapy and adjuvant therapy have garnered significant attention. However, the sensitivity of the assays used in these studies possibly remains suboptimal for lung cancer. Future prospective trials incorporating more sensitive, second-generation assays may be warranted.

[MRD检测在肺癌中的最新见解和发展]。
在肺癌中,循环肿瘤DNA(ctDNA)分析已经在临床上实施,例如用于检测对EGFR-TKIs的耐药突变。最近,与许多其他类型的癌症一样,术后分子残留病(MRD)的检测已被证明与不良预后相关。本文综述了近年来磁共振成像在肺癌研究中的最新进展。截至2024年5月,一项文献综述确定了41项关于肺癌MRD的研究。虽然还没有随机试验利用MRD来指导该领域的治疗决策,但回顾性研究一致证明其在预测复发方面的效用。在日本,JCOG2111A(MRDSEEKER试验,NCT06854939)等前瞻性研究目前正在进行中,该研究使用肿瘤信息个性化分析评估MRD的动力学和检出率。值得注意的是,在围手术期化疗免疫治疗和辅助治疗的随机试验中,最近对治疗前后ctDNA/MRD评估的亚组分析引起了极大的关注。然而,这些研究中使用的检测方法对肺癌的敏感性可能仍然不够理想。未来的前瞻性试验可能需要纳入更敏感的第二代测定法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
0.20
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发文量
337
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