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[Development of Oncolytic Viruses against Cancer]. [抗癌溶瘤病毒的发展]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-06-01
Hiroshi Tazawa, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara
{"title":"[Development of Oncolytic Viruses against Cancer].","authors":"Hiroshi Tazawa, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Oncolytic virotherapy is a novel antitumor therapy using genetically modified oncolytic viruses(OVs)that specifically replicate and induce lytic cell death in tumor cells. OVs directly induce tumor cell death and indirectly enhance the antitumor efficacy of chemoradiotherapy by suppressing cell survival signaling. Moreover, OVs activate antitumor immunity by inducing immunogenic cell death and enhance the antitumor effect of immune checkpoint inhibitors. OVs including herpes simplex virus and adenovirus have been widely developed for clinical application. This review focuses on the therapeutic potential of OVs in monotherapy and combination therapy with conventional cancer treatment and summarizes representative OVs that are in the phases of clinical trials.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 6","pages":"431-437"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Case of Remarkable Immune-Cell Therapy Efficacy in a Patient with Renal Pelvic Cancer Refractory to Immune Checkpoint Inhibitors and Chemotherapy]. [1例免疫细胞治疗对免疫检查点抑制剂和化疗难治的肾盂癌患者疗效显著]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01
Rishu Takimoto, Takashi Kamigaki, Sachiko Okada, Hiroshi Ibe, Eri Oguma, Shigenori Goto
{"title":"[A Case of Remarkable Immune-Cell Therapy Efficacy in a Patient with Renal Pelvic Cancer Refractory to Immune Checkpoint Inhibitors and Chemotherapy].","authors":"Rishu Takimoto, Takashi Kamigaki, Sachiko Okada, Hiroshi Ibe, Eri Oguma, Shigenori Goto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 70s-year-old woman with a history of Lynch syndrome had ovarian, colon, and right renal pelvic cancers, all of which were detected early and surgically treated with no recurrence. Ten years have passed since the most recent surgical procedure. In September 2020, she developed hematuria and underwent an examination, which revealed left renal pelvic cancer with liver and lung metastases. Chemotherapy(GEM+CBDCA)was initiated in October 2020; however, imaging in April 2021 revealed disease progression. Treatment with an immune checkpoint inhibitor(ICI: pembrolizumab 240 mg/body)was initiated, but after 4 months, the disease progressed and the treatment was discontinued. The patient was then referred to our hospital. Immunological testing revealed a decrease in T cells; therefore, immune-cell therapy(αβT cell therapy)was initiated to improve this condition. After 4 sessions of αβT cell therapy at 2-week intervals, a CT scan in November 2021 revealed shrinkage of the liver metastases and renal pelvis tumor, and the patient was assessed as having a partial response. By February 2022, after a total of 7 sessions of αβT cell therapy, further tumor shrinkage was observed, and the tumor was almost completely resolved on imaging. Although further immunotherapy is rarely administered in patients for whom ICI is ineffective, our findings suggest the potential for significant immune-cell therapy efficacy even after ICI failure.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"423-426"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Case of Locally Advanced Rectal Cancer in Which Pathological Complete Response Was Achieved with CAPOX and Bevacizumab Chemotherapy]. [局部晚期直肠癌CAPOX联合贝伐单抗化疗病理完全缓解1例]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01
Noriaki Koizumi, Wataru Takaki, Tatsuya Matsumoto, Hiroshi Fujiki, Chouhei Sakakura
{"title":"[A Case of Locally Advanced Rectal Cancer in Which Pathological Complete Response Was Achieved with CAPOX and Bevacizumab Chemotherapy].","authors":"Noriaki Koizumi, Wataru Takaki, Tatsuya Matsumoto, Hiroshi Fujiki, Chouhei Sakakura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 39-year-old man patient was admitted to a nearby clinic with bloody stool. Digital rectal examination revealed a mass lesion in the lower rectum. The patient was referred to our hospital and finally diagnosed with cT4a, N1b, M0, and c-Stage Ⅲb locally advanced rectal cancer. Neoadjuvant chemotherapy(NAC)with CAPOX and bevacizumab was administered to facilitate R0 resection, permitting anal preservation. When the chemotherapeutic regimen was evaluated to have achieved a complete clinical response, the patient underwent laparoscopic low anterior resection. He was shortly discharged without complications. No residual cancer was revealed upon histopathological examination, demonstrating a complete pathological response. Although NAC for rectal cancer has not been recommended by the Japanese guidelines, high response rates have recently been reported. Herein, we present the utility of NAC in the treatment of rectal cancer.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"415-417"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cardio-Oncology-Addressing Unmet Needs through Guidelines and Evidence Gaps]. [心脏肿瘤学-通过指南和证据差距解决未满足的需求]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01
Kazuhiro Sase
{"title":"[Cardio-Oncology-Addressing Unmet Needs through Guidelines and Evidence Gaps].","authors":"Kazuhiro Sase","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With advancements in cancer treatment, the number of cancer survivors is increasing, underscoring the growing importance of cardio-oncology. For the safe and effective completion of cancer treatment, managing cardiovascular risk factors and cancer therapy-related cardiovascular complications is essential. Recently, several cardio-oncology clinical guidelines have been published both domestically and internationally. However, a significant evidence gap remains, as the majority of high-class recommendations are based on low-level supporting evidence. Additionally, the rapid advancements in both oncology and cardiology pose challenges in maintaining the relevance of guidelines. Therefore, interdisciplinary collaboration focused on the validity, feasibility, and sustainability of clinical practice guidelines is crucial for the future. Japan, as a super-aged society ahead of the rest of the world, could serve as a valuable source of real-world evidence, positioning itself as a global leader in education, clinical practice, and research in cardio-oncology.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"383-388"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Characteristics of Cardiotoxicity in Breast Cancer Treatment and the Importance of Onco-Cardiology]. [乳腺癌治疗中心脏毒性的特点及肿瘤学的重要性]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01
Masataka Sawaki
{"title":"[Characteristics of Cardiotoxicity in Breast Cancer Treatment and the Importance of Onco-Cardiology].","authors":"Masataka Sawaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiovascular disease and dysfunction in cancer patients is often a medical problem. Cancer therapeutics related cardiac dysfunction(CTRCD)has long been known as late toxicity of anthracycline use and irradiation of the preserved breast and chest wall in breast cancer patients, CTRCD has received increasing attention, but there is still little evidence for prevention or prediction. Breast cancer has a good treatment outcome, and there is a need to address late cardiotoxicity. In recent years, the introduction of new drugs has forced us to deal with patients with new cardiotoxic and cardiovascular complications, such as myocarditis, which, combined with the increase in the number of cancer survivors with improved outcomes, has increased the number of situations requiring the concurrent consultation of oncologists and cardiologists. The goal is to improve life outcomes with optimal cancer treatment while reducing cardiac disease through appropriately timed interventions. Since drugs play different roles in initial treatment aiming for cure and palliative drug therapy for metastatic or recurrent breast cancer, cardiotoxicity should be discussed separately in close communication with cardiologists when considering the risk-benefit ratio. Discussions regarding the continuation of cardiac treatment and cancer treatment need to be done separately in'close collaboration'between oncologists and cardiologists.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"389-393"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Complete Response Achieved by Gemcitabine+Cisplatin+Durvalumab Therapy for Lymph Node Recurrence of Intraductal Cholangiocarcinoma-A Case Report]. 【吉西他滨+顺铂+杜伐单抗治疗导管内胆管癌淋巴结复发完全缓解1例报告】。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01
Noriki Mitsui, Masahiro Fukada, Takeshi Horaguchi, Katsutoshi Murase, Nobuhisa Matsuhashi
{"title":"[Complete Response Achieved by Gemcitabine+Cisplatin+Durvalumab Therapy for Lymph Node Recurrence of Intraductal Cholangiocarcinoma-A Case Report].","authors":"Noriki Mitsui, Masahiro Fukada, Takeshi Horaguchi, Katsutoshi Murase, Nobuhisa Matsuhashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The prognosis for unresectable or recurrent biliary tract cancer is generally unfavorable. However, recent reports suggest that combination therapy with immune checkpoint inhibitors may improve outcomes. We report the case of a 79-year-old woman with intrahepatic cholangiocarcinoma who underwent radical resection. Three months post-surgery, she developed a recurrence in an intra-abdominal lymph node. Treatment with 4 courses of gemcitabine+cisplatin+durvalumab(GCD)resulted in a complete response, with no measurable lesions detected on imaging. The patient continued treatment and was subsequently transitioned to durvalumab monotherapy. Although treatment was discontinued due to drug-induced pneumonia, she has remained relapse-free since. To our knowledge, this is the first reported case of a complete response to GCD therapy in biliary tract cancer.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"407-409"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Efficacy of Scalp Cooling Therapy for Hair Loss Prevention and Recovery in Patients with Breast Cancer Receiving Chemotherapy at Our Hospital]. [头皮冷却疗法在我院乳腺癌化疗患者预防和恢复脱发中的疗效]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01
Ayaka Tateno, Shun Kudo, Takatoshi Makino
{"title":"[Efficacy of Scalp Cooling Therapy for Hair Loss Prevention and Recovery in Patients with Breast Cancer Receiving Chemotherapy at Our Hospital].","authors":"Ayaka Tateno, Shun Kudo, Takatoshi Makino","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We herein report the hair loss and recovery rates of patients treated with scalp cooling therapy at our hospital. Overall, 14 Japanese women with breast cancer who were scheduled to undergo chemotherapy and who used the Paxman Scalp Cooling SystemTM between May 2022 and May 2023 participated in our study. We retrospectively evaluated the efficacy of the scalp cooling therapy in preventing hair loss. We also assessed the extent of hair recovery at 1, 3, 6, and 12 months after chemotherapy using the scalp cooling therapy. Data were evaluated using the Dean scale. Post-chemotherapy, 8 patients (57.1%)experienced Grade 4 hair loss(defined as hair loss of >75%). No statistically significant difference was observed. A month after chemotherapy ended, the number of patients with Grade 4 hair loss reduced to 2/14(14.3%). No patient experienced Grade 4 hair loss after 3 months. By 6 months, all patients had recovered their pre-treatment hair volume. One year after chemotherapy, hair volume was sufficiently preserved. Our data indicate that scalp cooling during chemotherapy can reduce hair loss and accelerate hair regrowth.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"403-406"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Case of Invasive Lobular Carcinoma Complicated by Disseminated Carcinomatosis of the Bone Marrow with Severe Bone Marrow Fibrosis and Acute Splenomegaly]. 浸润性小叶癌合并弥散性骨髓癌伴严重骨髓纤维化急性脾肿大1例。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01
Yumi Nozaki, Minori Yamamuro, Noriyoshi Tanaka, Nobuyuki Kamo, Mari Ueno, Tsuyoshi Ishida, Juichiro Konishi
{"title":"[A Case of Invasive Lobular Carcinoma Complicated by Disseminated Carcinomatosis of the Bone Marrow with Severe Bone Marrow Fibrosis and Acute Splenomegaly].","authors":"Yumi Nozaki, Minori Yamamuro, Noriyoshi Tanaka, Nobuyuki Kamo, Mari Ueno, Tsuyoshi Ishida, Juichiro Konishi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 60-year-old female presented at our hospital with a mass in her left breast. Needle biopsy of the breast mass confirmed a diagnosis of invasive lobular carcinoma, and the patient underwent left mastectomy and axillary lymph node dissection. The patient received adjuvant chemotherapy and was started on continuous endocrine therapy. Three years post-surgery, she experienced recurrence of multiple bone metastases and received a combination of hormone therapy and selective cyclin-dependent kinases 4/6 inhibitors. Therapeutic efficacy was poor, allowing bone metastases to spread. Four months post-recurrence, blood tests revealed moderate thrombocytopenia. Despite the switch to chemotherapy, the patient's platelet count did not recover. CT revealed splenomegaly, which was not present three months earlier. Bone marrow biopsy revealed severe myelofibrosis with infiltration of small dysplastic cells into dense fibrotic tissue. The patient developed microangiopathic hemolytic anemia, but DIC was not observed during the course of the disease. Ten months after recurrence, a brain metastasis was detected, and the patient died the following month.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"411-413"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Metastatic Squamous Cell Carcinoma with Unknown Primary Origin in the Mediastinal Lymph Node]. [原发来源不明的纵隔淋巴结转移性鳞状细胞癌]。
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01
Yuko Harada, Noriki Kamiya, Makoto Ohbu, Masashi Ogiso, Hinako Maeda, Hiroyuki Sako, Nobushige Yabe, Keiichi Sotome, Yoshiyuki Ishii, Ichiro Maeda
{"title":"[Metastatic Squamous Cell Carcinoma with Unknown Primary Origin in the Mediastinal Lymph Node].","authors":"Yuko Harada, Noriki Kamiya, Makoto Ohbu, Masashi Ogiso, Hinako Maeda, Hiroyuki Sako, Nobushige Yabe, Keiichi Sotome, Yoshiyuki Ishii, Ichiro Maeda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report a case of a patient with squamous cell carcinoma metastasis confined to a mediastinal lymph node, with no identifiable primary tumor. The patient remains cancer-free 2 years after diagnosis. Although various theories exist regarding the etiology of lymph node carcinoma of unknown primary origin, advances in elucidating its pathogenesis and integrating treatment strategies based on genetic profiling are expected to form the foundation of future clinical practice.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"427-429"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Case of Rectal Metastasis from Prostate Cancer]. 前列腺癌直肠转移1例
Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01
Tasuku Nishitani, Kiyonori Kanemitsu, Chonsu Kin, Mayumi Inaba, Chiharu Tamura, Takeshi Iwasaki
{"title":"[A Case of Rectal Metastasis from Prostate Cancer].","authors":"Tasuku Nishitani, Kiyonori Kanemitsu, Chonsu Kin, Mayumi Inaba, Chiharu Tamura, Takeshi Iwasaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 78-year-old male was under follow-up after gallbladder cancer surgery when CT imaging revealed thickening of the rectal wall, along with enlarged mesenteric and left-sided lymph nodes. Colonoscopy identified a semi-circumferential, tumor-like lesion in the lower rectum, and biopsy results confirmed a diagnosis of poorly differentiated adenocarcinoma. Pelvic MRI further revealed a separate tumor in the prostate, leading to a diagnosis of concurrent rectal and prostate cancer. The prostate cancer was managed with endocrine therapy following rectal resection. For the rectal cancer, neoadjuvant chemoradiotherapy(NACRT)was administered prior to surgical treatment. The resected specimen was evaluated for potential lymphatic metastasis of prostate cancer to the rectum. The patient is currently undergoing endocrine therapy and has remained recurrence-free for 2 years.</p>","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"419-421"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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