Japanese Journal of Cancer and Chemotherapy最新文献_第3页

[Results of a Special Drug Use-Results Survey on Palonosetron Hydrochloride in Patients Aged 18 Years and Younger]. 【18岁及以下患者盐酸帕洛诺司琼特殊用药结果调查】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-08-01

Tomohiro Kojima, Takahiko Koyama, Yuji Kunitomi, Sun Chunlan, Hirokazu Mizuguchi, Kei Kurita

引用次数: 0

[Chemotherapeutic Strategy for Metastatic or Recurrent Appendiceal Adenocarcinoma]. 转移性或复发性阑尾腺癌的化疗策略。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-08-01

Koshiro Fukuda, Hiroki Osumi, Eiji Shinozaki

引用次数: 0

[Case Report of a Patient Who Underwent Open Left Hepatic Lobectomy Followed by Robot-Assisted High-Anterior Resection after Preoperative Chemotherapy for Multiple Simultaneous Liver Metastases of Rectal Cancer]. [一例同时发生多处肝癌转移的直肠癌术前化疗后行开放左肝叶切除术并机器人辅助高位前切除术的病例报道]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-08-01

Kento Nakamori, Yoshinori Kagawa, Yuki Ozato, Yujiro Nishizawa, Akira Inoue, Nobutaka Hayashi, Yusuke Kawabe, Miki Shindo, Ken Suzuki, Hisateru Komatsu, Masashi Hirota, Yasuhiro Miyazaki, Akira Tomokuni, Masaaki Motoori, Kazuhiro Iwase, Kazumasa Fujitani

{"title":"[Case Report of a Patient Who Underwent Open Left Hepatic Lobectomy Followed by Robot-Assisted High-Anterior Resection after Preoperative Chemotherapy for Multiple Simultaneous Liver Metastases of Rectal Cancer].","authors":"Kento Nakamori, Yoshinori Kagawa, Yuki Ozato, Yujiro Nishizawa, Akira Inoue, Nobutaka Hayashi, Yusuke Kawabe, Miki Shindo, Ken Suzuki, Hisateru Komatsu, Masashi Hirota, Yasuhiro Miyazaki, Akira Tomokuni, Masaaki Motoori, Kazuhiro Iwase, Kazumasa Fujitani","doi":"","DOIUrl":"","url":null,"abstract":"A woman in her 60s visited our hospital after colonoscopy revealed a circumferential type 2 lesion located 10 cm from the anal verge. Computed tomography revealed metastases in liver S4 and S8. The regional lymph nodes were markedly enlarged, compressing the sciatic nerve. The patient was diagnosed with unresectable advanced rectal cancer (cT4aN2bM1a, cStage Ⅳa), and treated with 5 courses of FOLFOXIRI+bevacizumab. The patient subsequently underwent open left lobectomy and cholecystectomy. One month later, a robotic high anterior resection of the primary tumor was performed. Although the patient had undergone laparotomy, robotic surgery was used to ensure complete R0 resection. Liver-first approaches may offer greater benefit for certain patient populations than other treatment strategies, including prior or concurrent resection of the primary lesion. Robotic surgery may also be a viable option for primary colorectal cancer even after open surgery.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 8","pages":"595-597"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Breast Cancer with Bone Marrow Metastasis in a Patient with a History of Systemic Lupus Erythematosus and Autoimmune Hemolytic Anemia]. 【系统性红斑狼疮合并自身免疫性溶血性贫血合并乳腺癌骨髓转移1例】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-08-01

Michiaki Tanaka, Kosei Kimura, Ayana Ikari, Hiroyo Oku, Tomo Tominaga, Saki Takai, Junna Sakane, Chinatsu Aoki, Monika Ota, Erika Minami, Sang-Woong Lee, Mitsuhiko Iwamoto

{"title":"[A Case of Breast Cancer with Bone Marrow Metastasis in a Patient with a History of Systemic Lupus Erythematosus and Autoimmune Hemolytic Anemia].","authors":"Michiaki Tanaka, Kosei Kimura, Ayana Ikari, Hiroyo Oku, Tomo Tominaga, Saki Takai, Junna Sakane, Chinatsu Aoki, Monika Ota, Erika Minami, Sang-Woong Lee, Mitsuhiko Iwamoto","doi":"","DOIUrl":"","url":null,"abstract":"A 45-year-old female with a medical history of systemic lupus erythematosus presented with breast cancer. On postoperative day 26 after undergoing left mastectomy and axillary lymph node dissection, she reported fever and anorexia at the outpatient clinic. Laboratory findings showed pancytopenia, and a subsequent bone marrow biopsy confirmed metastatic breast cancer involving the bone marrow. Tamoxifen and goserelin therapy was started initially. However, on the day after treatment initiation, the patient experienced rapid progression of anemia, with laboratory evidence of hemolysis and clinical signs of jaundice and splenomegaly; this led to a diagnosis of autoimmune hemolytic anemia(AIHA). Steroid pulse therapy resulted in a dramatic halt in anemia progression. Given that AIHA is a paraneoplastic syndrome with suspected resistance to endocrine therapy, chemotherapy with paclitaxel was initiated. AIHA recurrence was not observed after this intervention. In cases of breast cancer with bone marrow metastasis and acute anemia, especially in patients with an autoimmune history, a differential diagnosis beyond marrow suppression from metastasis should be carefully considered.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 8","pages":"591-594"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical Features and Management of Pseudomyxoma Peritonei Appendiceal Origin]. 腹膜阑尾源性假性黏液瘤的临床特点及治疗

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-08-01

Yoshimasa Gohda, Tomomichi Kiyomatsu, Hiroshi Takeuchi, Kazuhito Sato, Kensuke Otani, Fuyuki Inagaki, Joji Kitayama, Norihiro Kokudo, Hideaki Yano

{"title":"[Clinical Features and Management of Pseudomyxoma Peritonei Appendiceal Origin].","authors":"Yoshimasa Gohda, Tomomichi Kiyomatsu, Hiroshi Takeuchi, Kazuhito Sato, Kensuke Otani, Fuyuki Inagaki, Joji Kitayama, Norihiro Kokudo, Hideaki Yano","doi":"","DOIUrl":"","url":null,"abstract":"Pseudomyxoma peritonei(PMP)is a rare clinical entity that typically arises from the rupture of a low-grade appendiceal mucinous neoplasm(LAMN), resulting in accumulation of gelatinous mucinous material throughout the peritoneal cavity. Despite its low-grade histological features, PMP can be clinically aggressive due to continuous mucin production, progressive peritoneal dissemination, and organ compression. Patients often present with abdominal distension, palpable mass, or gastrointestinal symptoms, and the disease may occasionally be discovered during surgery for presumed appendicitis or ovarian tumors. Computed tomography(CT)is the key imaging modality for diagnosis, revealing characteristic findings such as scalloping of visceral surfaces, omental cake, and mucinous ascites. Although the majority of cases are appendiceal in origin, misdiagnosis as ovarian tumors is common, especially in women. Diagnostic pitfalls include failure to recognize mucinous nature on imaging and insufficient suspicion preoperatively. The standard of care is complete cytoreductive surgery(CRS)combined with hyperthermic intraperitoneal chemotherapy(HIPEC). This aggressive but potentially curative approach requires substantial expertise and should ideally be performed at specialized centers. In cases where PMP is unexpectedly encountered during surgery, initial management should avoid extensive procedures that may compromise future CRS. Referral to a specialized institution is strongly recommended. In this review, we discuss the clinical pathophysiology, diagnostic strategies, and treatment approaches for PMP, with particular emphasis on the importance of early recognition and appropriate surgical referral pathways to optimize patient outcomes.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 8","pages":"563-566"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sulfur Metabolism in Cancer Malignancy and Its Potential for Therapeutic Application]. [恶性肿瘤中的硫代谢及其治疗应用潜力]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-08-01

Keito Okazaki, Takaaki Akaike, Hozumi Motohashi

引用次数: 0

[Pathological Complete Response to Chemotherapy in Four Cases of Pancreatic Cancer]. [4例胰腺癌化疗病理完全缓解]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-08-01

Masanori Akashi, Kazuaki Hashimoto, Ryuta Midorikawa, Shogo Fukutomi, Shoichiro Arai, Yuichi Goto, Hisamune Sakai, Fumihiko Fujita, Toru Hisaka

引用次数: 0

[Risk Benefit of Single Vial Multiple Use(DVO)Using Anti-Cancer Drug Preparation Robot-DVO Drug Selection Aimed at Both Improving Operational Efficiency and Reducing Medical Costs]. [单瓶多用途（DVO）使用抗癌药物制备机器人的风险收益-DVO选药旨在提高操作效率和降低医疗成本]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-08-01

Akihiro Moriya, Hiroki Asano, Michio Kimura, Eiseki Usami

{"title":"[Risk Benefit of Single Vial Multiple Use(DVO)Using Anti-Cancer Drug Preparation Robot-DVO Drug Selection Aimed at Both Improving Operational Efficiency and Reducing Medical Costs].","authors":"Akihiro Moriya, Hiroki Asano, Michio Kimura, Eiseki Usami","doi":"","DOIUrl":"","url":null,"abstract":"A cancer drug preparation robot was used to select an optimal drug for drug vial optimization(DVO)and thus reduce medical costs and improve the risk benefit profile. We administered DVO for paclitaxel(PTX)30 mg/100 mg, etoposide(VP-16)100 mg, and oxaliplatin(L-OHP)50 mg/100 mg at Ogaki Municipal Hospital. Comparisons were made for preparation time and drug waste(cost)before and after DVO implementation for each drug over 5, 2, and 2 months respectively. PTX was consolidated from 2 specifications into a single specification(100 mg)with the introduction of DVO. Changes in median preparation times for each drug after implementation of DVO were as follows: for PTX, it decreased from 433 s before implementation to 410 s after implementation(p=0.043). Conversely, for VP-16 and L-OHP, the time increased from 320 and 348 s before implementation to 375 and 362 s after implementation, respectively(both p<0.001). The amounts of drug waste(cost of waste)before and after DVO implementation were as follows: for PTX, it decreased from 1,269.26 mg(77,277 yen)to 327.99 mg(19,037 yen); for VP-16, it decreased from 1,275.6 mg(43,600 yen)to 99 mg (3,384 yen); and for L-OHP, it decreased from 3,563.9 mg(975,660 yen)to 4.48 mg(1,143 yen)(all p<0.001). For the implementation of DVO, drugs must be selected based on waste reduction rates and efficiency gains, especially for high-cost anticancer drugs.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 8","pages":"577-581"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Liver and Axillary Lymph Node Metastasis 32 Years after Breast Cancer Surgery]. [1例乳腺癌术后32年发生肝腋窝淋巴结转移]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-07-01

Ayaka Aikawa, Masanori Oshi, Kei Kawashima, Mahato Sasamoto, Yoshie Fujiwara, Shoko Adachi, Kazutaka Narui, Hiroki Takase, Shoji Yamanaka, Satoshi Fujii, Akimitsu Yamada, Itaru Endo

引用次数: 0

[A Case of Lower Rectal GIST with Anorectal Preservation by Laparoscopic Low Anterior Resection after Imatinib Mesylate Neoadjuvant Therapy]. [1例下直肠间质瘤经甲磺酸伊马替尼新辅助治疗后经腹腔镜下前切除术保留肛门直肠]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-07-01

Tomonori Himan, Hideki Machishi, Hideo Suzuki, Naomi Konishi, Naoki Takahashi, Aya Sugisawa, Kousuke Mizukoshi, Sayuri Hattori

引用次数: 0