Japanese Journal of Cancer and Chemotherapy最新文献_第3页

[Problem in the Prophylactic Management of Perioperative Venous Thromboembolism(VTE)in Japanese Cancer Patients]. [日本癌症患者围手术期静脉血栓栓塞（VTE）的预防管理问题]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01

Taishi Hata

{"title":"[Problem in the Prophylactic Management of Perioperative Venous Thromboembolism(VTE)in Japanese Cancer Patients].","authors":"Taishi Hata","doi":"","DOIUrl":"","url":null,"abstract":"In the field of oncological cardiology, the management of venous thromboembolism(VTE)in cancer patients is critical. Cancer patients have a 4-7 fold increased risk of developing VTE compared to non-cancer patients, and once symptomatic pulmonary thromboembolism(PTE)occurs, the mortality rate is high, about 20 according one report. The oncological cardiology guidelines also list future research questions concerning VTE management during chemotherapy. However, cancer patient treatment is not solely pharmacological; particularly in gastrointestinal surgery, operative treatment is crucial, and VTE prophylaxis is important due to the increased incidence during the perioperative period. An important consideration in devising strategies is that there are racial differences in the frequency of VTE occurrences and bleeding tendencies due to anticoagulation therapy. However, data in this field of our country is limited, and currently, Japanese guideline are based on Western guidelines adapted to suit the situation of Japan. Reviewing past data, the risk of VTE in Japanese is generally lower compared to Caucasian populations. In particular, as anticoagulant therapy can also influence postoperative bleeding, its indication requires thorough verification. It is considered one of the crucial challenges in the field of oncological cardiology to construct optimal prophylactic and management methods based on Japanese data moving forward.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"394-397"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Development of Oncolytic Virus Immunotherapy to Improve the Immunosuppressive Microenvironment in Pancreatic Cancer]. [溶瘤病毒免疫治疗改善胰腺癌免疫抑制微环境的进展]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01

Kanto Suemori, Hiroshi Tazawa, Motohiko Yamada, Naohiro Okada, Satoru Kikuchi, Shinji Kuroda, Kazuhiro Noma, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara

引用次数: 0

[Prediction of Anti-Tumor Immunity-Significance of a Novel Th1-Like CD4+ T-Cell Cluster]. [一种新型th1样CD4+ t细胞群的抗肿瘤免疫预测意义]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01

Hiroshi Kagamu

{"title":"[Prediction of Anti-Tumor Immunity-Significance of a Novel Th1-Like CD4+ T-Cell Cluster].","authors":"Hiroshi Kagamu","doi":"","DOIUrl":"","url":null,"abstract":"Anti-tumor T-cell immunity invigorated by immune checkpoint inhibitors(ICI)mediate anti-tumor effects over the years, resulting in long-term survival. However, the ICI effects vary greatly from patient to patient, and accurate prediction of the effects is still not possible. Long-term anti-tumor T-cell immunity requires that the cancer immunity cycle remain in operation. It is CD4+ T cells that direct the priming, migration and infiltration abilities, and the acquisition of cytolytic functions of CD8+ T cells and drive the cancer immunity cycle. CD4+ T cells undergo functional differentiation called polarization when they are primed in lymph nodes, and they perform their predetermined functions throughout the body. For this reason, the information collected from peripheral blood can reflect the tumor microenvironments. It has been shown in mouse models that CD4+ T cells that polarize into type 1 helper T cells(Th1)are important for anti-tumor immunity. On the other hand, it has been reported that CD4+ T cells that are responsible for the anti-tumor effects of anti-PD-1 antibody and anti-CTLA-4 antibody therapy are Th1-like, but differ from canonical Th1. In this paper, we will discuss the properties of the novel Th1-like CD4+ T-cell cluster discovered by the authors, and the prediction performance of anti-tumor T-cell immunity.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 5","pages":"377-382"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pancreaticoduodenectomy with Pancreaticogastric Anastomosis for Jehovah's Witness Patients].

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Kenjiro Kitasato, Taku Akahoshi, Ippei Murata, Masanori Ikota, Rama Adikrisna, Tomoyuki Ohta, Sho Mineta, Yoshihiko Tsuruta

{"title":"[Pancreaticoduodenectomy with Pancreaticogastric Anastomosis for Jehovah's Witness Patients].","authors":"Kenjiro Kitasato, Taku Akahoshi, Ippei Murata, Masanori Ikota, Rama Adikrisna, Tomoyuki Ohta, Sho Mineta, Yoshihiko Tsuruta","doi":"","DOIUrl":"","url":null,"abstract":"Background: Jehovah's Witnesses followers may have limited treatment options because they do not accept blood transfusion therapy for religious reasons. In addition, pancreatoduodenectomy is known to carry a high risk of intra-abdominal bleeding due to postoperative pancreatic fistula. Our hospital has a policy of providing surgical treatment to Jehovah's Witnesses whenever possible, and we perform pancreaticoduodenectomy with pancreaticogastric anastomosis in the belief that it is less likely to cause fatal complications in the short term.Subject: Four pancreaticoduodenectomies were performed on Jehovah's Witness believers between November 2017 and May 2024. The diseases were IPMC, ampullary carcinoma, cholangiocarcinoma, and duodenal carcinoma in one case each. All patients underwent reconstruction with gastro-pancreatic anastomosis.Results: All patients completed the treatment without blood transfusion. Operation time: 514 minutes, blood loss: 290 mL. Postoperative hospital stay was 40 days. Intra-abdominal abscess was observed in one patient, but there were no hemorrhagic complications and no in-hospital death.Conclusion: Pancreaticoduodenectomy with pancreaticogastric anastomosis for Jehovah's Witnesses patient at our hospital was considered acceptable.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 4","pages":"351-353"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Gastric Cancer with Mediastinal Lymph Node Recurrence Four Years after Surgery Despite Pathologically Complete Response to Preoperative Chemotherapy]. [1例胃癌纵隔淋巴结术后4年复发，术前化疗病理完全缓解]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Shigeyoshi Higashi, Haruna Furukawa, Tomohiro Takahashi, Shogo Yanagi, Yoko Oga, Nobuo Takiguchi, Yoshitoshi Ichikawa, Ryo Tsunashima, Yoshiaki Omura, Masakazu Miyake, Masaki Kashiwazaki, Masahiro Tanemura

{"title":"[A Case of Gastric Cancer with Mediastinal Lymph Node Recurrence Four Years after Surgery Despite Pathologically Complete Response to Preoperative Chemotherapy].","authors":"Shigeyoshi Higashi, Haruna Furukawa, Tomohiro Takahashi, Shogo Yanagi, Yoko Oga, Nobuo Takiguchi, Yoshitoshi Ichikawa, Ryo Tsunashima, Yoshiaki Omura, Masakazu Miyake, Masaki Kashiwazaki, Masahiro Tanemura","doi":"","DOIUrl":"","url":null,"abstract":"A 71-year-old man was diagnosed with advanced gastric cancer of the upper body of the stomach by esophagogastroduodenoscopy. CT scan showed enlarged left supraclavicular fossa and mediastinal lymph nodes. U, type 4, cT4aN2M1 (LYM), Stage ⅣB was diagnosed and chemotherapy(SOX)was administered. After chemotherapy, the distant lymph nodes shrank and PET-CT scan showed no distant lymph node involvement. ycT1bN0M0, Stage Ⅰ was diagnosed. Laparoscopic total gastrectomy D2 dissection was performed as conversion surgery. Pathological findings were ypT0N0(0/34)M0 and histological response Grade 3. As postoperative adjuvant chemotherapy, S-1 was administered for about 1 year. The left supraclavicular fossa and mediastinal lymph nodes remained reduced and patients were followed up while imaging studies were performed. Four years post-operatively, the patient was diagnosed with recurrence due to elevated tumor markers and rapid enlargement of supraclavicular fossa and mediastinal lymph nodes. We experienced a case in which the patient had a pathological complete response but recurred 4 years after surgery.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 4","pages":"320-322"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Benefits of Laparoscopic Gastrectomy for Elderly Patients: Masato Mitsuda]. 腹腔镜胃切除术对老年患者的益处：Masato Mitsuda。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Daiki Matsubara, Daiki Matsubara, Mizuki Tamai, Fumiaki Ochi, Tomoya Hatakeyama, Tatsuya Kumano, Yoshiki Itokawa

{"title":"[Benefits of Laparoscopic Gastrectomy for Elderly Patients: Masato Mitsuda].","authors":"Daiki Matsubara, Daiki Matsubara, Mizuki Tamai, Fumiaki Ochi, Tomoya Hatakeyama, Tatsuya Kumano, Yoshiki Itokawa","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To evaluate the outcomes of laparoscopic gastrectomy for gastric cancer in elderly patients.Methods: We evaluated the short-term outcomes of open and laparoscopic gastrectomy procedures performed in 89 patients with gastric cancer(≥80 years: n=13, <80 years: n=76)between September 2013 and March 2023.Results: There were no significant differences in patient background, surgical technique, surgical approach, pathology, or short-term outcomes. Preoperative nutritional status(PNI and GNRI)was significantly lower in the elderly group. Laparoscopic surgery was associated with a longer operative time, lower blood loss, and shorter postoperative hospital stay than open surgery. There was no difference in the rates of CD Grade 3+ complications between open and laparoscopic surgery in patients aged <80 years, while laparoscopic surgery was associated with significantly lower complication rates in patients aged ≥80 years. Considering that patients in the open surgery group were more likely to have advanced cancer, we performed a risk factor analysis for CD Grade 3+ complications in patients >80 years of age, and demonstrated that the surgical approach and operative time were significantly associated with the risk of complications.Conclusion: The results suggest that laparoscopic surgery may reduce complication rates in elderly patients.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 4","pages":"369-371"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Pancreaticoduodenectomy for a Patient with Ampullary Cancer Combined with Intracystic Papillary Neoplasm]. 【壶腹癌合并囊内乳头状瘤行胰十二指肠切除术1例】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Koji Hayashi, Yoshiteru Katsura, Narumi Sawamura, Risa Kawamoto, Yo Akazawa, Ryuta Ueda, Masahiro Koh, Akio Hara, Hiroshi Takeyama, Natsumi Tanaka, Naomi Urano, Shu Okamura, Chikara Ebisui, Hideoki Yokouchi, Masahiko Yano

引用次数: 0

[A Case of Advanced Gastric Cancer with Cervical Lymph Node Metastasis Responding to SOX+Nivolumab and Treated with Conversion Surgery]. [1例晚期胃癌伴颈部淋巴结转移对SOX+尼武单抗有效并行转换手术治疗]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Kohki Ishimaru, Yusuke Akamaru, Kentaro Nishida, Hiromichi Miyagaki, Soichiro Mori, Masatoshi Nomura, Yukihiro Yoshikawa, Koki Tamai, Daisuke Takiuchi, Takuya Hamakawa, Mitsuyoshi Tei, Masanori Tsujie

引用次数: 0

[A Case of Anal Canal Squamous Cell Carcinoma with Extensive Rectal Stricture after Chemoradiotherapy]. 放化疗后肛管鳞状细胞癌伴广泛直肠狭窄1例。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Akinobu Kondo, Shota Suzuki, Satoshi Tomeoku, Tomomi Tanigawa, Ken Ichikawa, Yoshihiro Okuda, Michio Kohno, Minoru Tanaka

引用次数: 0

[A Case of Complete Cured by Multidisciplinary Treatment for Repeated Recurrent of Primary Peritoneal Cancer]. 多学科综合治疗原发性腹膜癌反复复发1例。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-04-01

Yoshimi Hirohashi, Kazuya Uchikawa, Chieko Hotta, Hirofumi Sato, Hiroshi Kubo, Masako Asai, Yusuke Kawashima, Tomonori Shimonishi, Yoshito Akagi

{"title":"[A Case of Complete Cured by Multidisciplinary Treatment for Repeated Recurrent of Primary Peritoneal Cancer].","authors":"Yoshimi Hirohashi, Kazuya Uchikawa, Chieko Hotta, Hirofumi Sato, Hiroshi Kubo, Masako Asai, Yusuke Kawashima, Tomonori Shimonishi, Yoshito Akagi","doi":"","DOIUrl":"","url":null,"abstract":"A 56-year-old female received the low anterior resection for RS rectal cancer(T4aN1M0)in June 2010. In February 2011, abdominal CT showed paraaortic lymph node swelling, we resected it, because of lymphatic metastasis from rectal cancer suspected. The resected specimen showed the histological feature similar with ovarian cancer rather than rectal cancer. But uterus and adnexa were not unremarkable on gynecologic examination. She received FOLFOX therapy. In December 2012, abdominal CT revealed a growing mass lesion at posterior to the rectosigmoidal anastomosis. We suspected local recurrence of rectal cancer, chemoradiotherapy(S-1+39 Gy)was administrated, a recurrent lesion was reduced and was followed up. In September 2014, abdominal CT showed the local recurrent lesion enlarged, then we started FOLFIRI+cetuximab. However, tumor progressed with no effect of chemotherapy. In May 2015, we performed the low anterior resection with excision of the local recurrent lesion. Histopathological evaluation of the resected specimen revealed a serous adenocarcinoma, like an origin of ovarium on immunohistochemical examination, highly suspected primary peritoneal cancer. Systemic chemotherapy with 4 courses of carboplatin and docetaxel(DC)therapy was administrated as adjuvant chemotherapy. In December 2016, CA125 level increased, PET-CT showed FDG accumulation in the local recurrent lesion, so we started DC therapy again. The recurrent lesion was disappeared rapidly, followed by 9 courses. She is still alive without recurrence 7 years after DC therapy.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"52 4","pages":"345-347"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0