Japanese Journal of Cancer and Chemotherapy最新文献_第4页

[A Case of Hyperammonemia Induced by 5‒FU in a Patient with Advanced Rectal Cancer]. [5-FU致晚期直肠癌高氨血症1例]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-02-01

Akira Ishii, Shinobu Tomochika, Yasuhiro Fujiwara, Hironori Tanaka, Mitsuo Nishiyama, Hiroto Matsui, Yoshitaro Shindo, Yukio Tokumitsu, Yusaku Watanabe, Noriko Maeda, Michihisa Iida, Hidenori Takahashi, Tatsuya Ioka, Hiroaki Nagano

{"title":"[A Case of Hyperammonemia Induced by 5‒FU in a Patient with Advanced Rectal Cancer].","authors":"Akira Ishii, Shinobu Tomochika, Yasuhiro Fujiwara, Hironori Tanaka, Mitsuo Nishiyama, Hiroto Matsui, Yoshitaro Shindo, Yukio Tokumitsu, Yusaku Watanabe, Noriko Maeda, Michihisa Iida, Hidenori Takahashi, Tatsuya Ioka, Hiroaki Nagano","doi":"","DOIUrl":"","url":null,"abstract":"A 74‒year‒old male was diagnosed with advanced rectal cancer with bowel obstruction, and abscess formation. After sigmoid colostomy, FOLFOXIRI plus bevacizumab as preoperative chemotherapy was initiated. On day 3, during continuous administration of 5‒fluorouracil(5‒FU), the patient developed impaired consciousness accompanied by convulsive seizures and conjugate deviation. Electroencephalography(EEG)revealed no epileptic discharges, and imaging studies revealed no abnormality. A blood test showed a high ammonia level of 367μmol/L. In the absence of prior liver disease, the cause was suspected to be due to high‒dose 5‒FU. Administration of lactulose was started. The ammonia level normalized and the consciousness recovered quickly by the following day. It was thought that chemotherapy would be difficult to continue, and 1 month later, robot‒assisted low anterior resection and ileostomy were performed. The patient was discharged home without complication on postoperative day 13. We report this case of advanced rectal cancer in which administration of high‒dose 5‒FU caused hyperammonemia accompanied by impaired consciousness, with a literature review.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 2","pages":"123-125"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Role of Anti‒Angiogenic Therapy in Tumor Immune Microenvironment]. [抗血管生成治疗在肿瘤免疫微环境中的作用]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-02-01

Minoru Kobayashi, Satoru Miura

引用次数: 0

Identification of Thoracic Duct Injury Site via Inguinal Subcutaneous Injection of ICG in Esophagectomy-A Case Report. 食管切除术中腹股沟皮下注射ICG识别胸导管损伤部位1例。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-02-01

Nobuaki Nakae, Tomonori Nakanoko, Manabu Yasuda, Takahiro Arai, Tomohide Kawashita, Kazuki Nishino, Mizuki Ninomiya

引用次数: 0

[A Case of High‒Grade Appendiceal Mucinous Neoplasm Undergoing Ileocecal Resection]. 高级别阑尾黏液性肿瘤行回盲切除1例。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-02-01

Soichiro Ogawa, Yoshiaki Kuriu, Yuji Fujita, Shun Ito, Ryo Takeda, Yoshihisa Matsumoto, Tomoki Konishi, Hisataka Matsuo, Shuhei Komatsu, Hisashi Ikoma, Kazuma Okamoto, Shusuke Sato, Yuko Sano, Yoji Urata, Eigo Otsuji

引用次数: 0

[Mitochondria in Cancer and Immunity]. [线粒体在癌症和免疫中的作用]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-02-01

Takahiro Taki, Teruya Morinaga, Yosuke Togashi

{"title":"[Mitochondria in Cancer and Immunity].","authors":"Takahiro Taki, Teruya Morinaga, Yosuke Togashi","doi":"","DOIUrl":"","url":null,"abstract":"Mitochondria are multifunctional organelles responsible not only for ATP production via oxidative phosphorylation but also for a wide range of cellular activities, including biosynthesis, redox regulation, signal transduction, and the control of apoptosis. In both cancer and immune cells, mitochondrial function plays various roles that extend beyond mere energy production. While cancer cells are known for the Warburg effect‒an enhanced glycolysis even in the presence of oxygen-they also actively utilize mitochondrial metabolism to fuel tumor progression. Furthermore, mutations in mitochondrial DNA(mtDNA) and alterations in nuclear genes encoding mitochondrial proteins contribute to tumorigenesis through various mechanisms, such as epigenetic modifications and the evasion of apoptosis. In immune cells, such as T cells and macrophages, mitochondrial metabolism is crucial for their differentiation and functional regulation. Key processes such as T cell activation, memory formation, and exhaustion, as well as macrophage functional polarization and inflammatory responses, are tightly linked to mitochondrial functional states. Recently, intercellular mitochondrial transfer within the tumor microenvironment has emerged as a significant phenomenon. Cancer cells can acquire mitochondria from surrounding cells to enhance their metabolic capacity and therapeutic resistance. Conversely, the transfer of mitochondria from cancer cells to T cells has been shown to suppress antitumor immune responses through metabolic dysfunction and homoplasmic replacement of T cell mtDNA. Based on these findings, therapeutic strategies targeting mitochondria are under investigation. These include inhibiting mitochondrial metabolism in cancer cells, boosting mitochondrial metabolism in T cells, and blocking intercellular mitochondrial transfer. Although preclinical studies have yielded promising results, further research is necessary to establish effective clinical therapies that can precisely modulate the complex metabolic interplay between cancer and immune cells.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 2","pages":"73-79"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case Report of Cecal Cancer with Port Site Recurrence and Right Inguinal Lymph Node Metastasis after Laparoscopic Ileo‒Cecal Resection]. [腹腔镜回盲肠切除术后盲肠癌Port部位复发及右侧腹股沟淋巴结转移1例报告]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-02-01

Keita Saito, Shiori Hatamoto, Shuta Hattori, Ryoma Yagi, Takahiro Sawatsubashi, Ryo Tanaka, Takashi Ishikawa, Hideki Nakatsuka, Kouei Nihei, Takashi Kato, Yoichi Ajioka

{"title":"[A Case Report of Cecal Cancer with Port Site Recurrence and Right Inguinal Lymph Node Metastasis after Laparoscopic Ileo‒Cecal Resection].","authors":"Keita Saito, Shiori Hatamoto, Shuta Hattori, Ryoma Yagi, Takahiro Sawatsubashi, Ryo Tanaka, Takashi Ishikawa, Hideki Nakatsuka, Kouei Nihei, Takashi Kato, Yoichi Ajioka","doi":"","DOIUrl":"","url":null,"abstract":"A 74‒year‒old man was diagnosed with cecal cancer and performed ileo‒cecal resection with D3 lymphadenectomy. The postoperative pathological diagnosis was pT3N0M0, pStage Ⅱa. He was followed up without postoperative adjuvant chemotherapy. One year after the surgery, he developed pain in the port area of the right‒lower abdomen, and CT showed a mass with contrast enhancement at the port site. In addition, a lymph node mass was observed in the right inguinal region. Because of severe pain at the port site, an excisional biopsy of the abdominal wall was performed for both diagnostic and therapeutic purposes. The pathological diagnosis confirmed metastasis of cecal cancer. An excisional biopsy of a lymph node in the right inguinal region was performed, and pathological diagnosis was a metastasis of cecal cancer. Two years have passed without postoperative chemotherapy, and he remains alive without recurrence. The metastasis was thought to have metastasized lymphatically to the inguinal region from the port site recurrence. We report on the port site recurrence and lymphatic metastasis from the metastatic lesion.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 2","pages":"129-131"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Survey of the Effect of Adding Aprepitant at the First Treatment of Regimens Containing Carboplatin on Antiemetic Efficacy]. [含卡铂方案首次加用阿瑞吡坦对止吐效果的影响调查]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-02-01

Sari Shikibu, Koki Hashimoto, Wataru Toya, Hisanori Shimizu, Ryoko Sakai, Manabu Akazawa, Hiroyuki Kanao, Masakazu Yamaguchi

引用次数: 0

[Strategic Combination Approaches in Cancer Immunotherapy]. 肿瘤免疫治疗的策略组合方法。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-02-01

Yuya Nishii, Yasushi Goto

引用次数: 0

[A Case of Liver Metastatic Recurrence of Transverse Colon Cancer Responding to Capecitabine+Bevacizumab Therapy]. [1例横断面结肠癌肝转移复发对卡培他滨+贝伐单抗治疗的响应]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-02-01

Hana Kawahata, Hajime Yokomizo, Sachiyo Okayama, Shunsuke Iwamoto, Shinichi Asaka, Takebumi Usui, Shunichi Shiozawa

{"title":"[A Case of Liver Metastatic Recurrence of Transverse Colon Cancer Responding to Capecitabine+Bevacizumab Therapy].","authors":"Hana Kawahata, Hajime Yokomizo, Sachiyo Okayama, Shunsuke Iwamoto, Shinichi Asaka, Takebumi Usui, Shunichi Shiozawa","doi":"","DOIUrl":"","url":null,"abstract":"The patient was a 78‒year‒old woman. A liver tumor was detected on abdominal computed tomography(CT)performed for follow‒up after breast cancer surgery. Further examination revealed transverse colon cancer and liver metastases; therefore, transverse colon resection with D3 lymph node dissection and resection of the central 2 segments of the liver were performed. Four months later, liver recurrence was found on CT, which was diagnosed as unresectable, and chemotherapy was planned. Chemotherapy with capecitabine+oxaliplatin+bevacizumab was initiated. The capecitabine and oxaliplatin dosages were reduced due to adverse events. The CT scan showed PR; therefore, maintenance therapy with capecitabine+bevacizumab was initiated. The recurrent tumor continued to gradually shrink, and only a cystic lesion was observed on CT. CT performed 4 years and 1 month after the initiation of chemotherapy showed that the cystic lesion had almost disappeared from the liver. We believe that the factor contributing to the long‒term response in this case was the appropriate dose reduction and cessation of chemotherapy.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 2","pages":"121-122"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Robot-Assisted Thoracoscopic Extended Thymectomy for Thymoma Associated with Generalized Myasthenia Gravis]. 【机器人辅助胸腔镜下胸腺瘤扩展切除术合并广泛性重症肌无力一例】。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2026-01-01

Tomoyuki Yamaguchi, Serina Akai, Nozomi Uozumi, Koji Yasuda, Hiroshi Shintani

{"title":"[A Case of Robot-Assisted Thoracoscopic Extended Thymectomy for Thymoma Associated with Generalized Myasthenia Gravis].","authors":"Tomoyuki Yamaguchi, Serina Akai, Nozomi Uozumi, Koji Yasuda, Hiroshi Shintani","doi":"","DOIUrl":"","url":null,"abstract":"A 53-year-old male patient presented with dyspnea and was admitted with the diagnosis of bacterial pneumonia.His respiratory condition did not improve despite the resolution of fever with antibiotic therapy, and he was eventually diagnosed with thymoma associated with myasthenia gravis.The patient underwent robot-assisted thoracoscopic extended thymectomy under general anesthesia.The anterior mediastinal tissue was resected en bloc using 5 ports and the port-hopping function of the robotic system.The operation time was 264 min, and the blood loss was 55 g.Histopathologic examination led to the definitive diagnosis of type B2 thymoma.Postoperatively, muscle strength improved, oral intake resumed after extubation, and the patient was transferred to rehabilitation on day 35.Achieving adequate dissection without approaching from both the right and left sides is generally challenging in resecting mediastinal tissue via thoracoscopic extended thymectomy.The subxiphoid approach may pose similar limitations.However, in the present case, the use of the port-hopping function during robot-assisted surgery allowed scope insertion from various positions, enabling excellent visualization.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"53 1","pages":"60-62"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0