[Enhancing CAR-T/CAR-NK Cells through by Cytokine Signaling].

Q4 Medicine
Yuki Kagoya
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引用次数: 0

Abstract

Chimeric antigen receptor(CAR)T-cell therapy has already been in the clinic due to its marked efficacy against several hematologic cancers. However, a significant number of patients relapse after a transient response, and the applicable diseases are still limited. Cytokine signaling is one of the most promising targets to enhance the therapeutic efficacy of CAR-T cells. At the same time, several cytokines are closely associated with toxicity, as exemplified by cytokine release syndrome. Here I will present representative findings on cytokines that have been shown to modulate CAR-T cell functions. I will also present our recent studies on how to simultaneously address efficacy and safety issues in CAR-T cell therapy. We will also briefly discuss CAR-NK cells, in which cytokines play an essential role.

通过细胞因子信号传导增强CAR-T/CAR-NK细胞。
嵌合抗原受体(CAR) t细胞疗法由于其对几种血液病的显著疗效已经进入临床。然而,相当一部分患者在短暂反应后复发,适用的疾病仍然有限。细胞因子信号是增强CAR-T细胞治疗效果最有希望的靶点之一。同时,一些细胞因子与毒性密切相关,如细胞因子释放综合征。在这里,我将介绍已被证明调节CAR-T细胞功能的细胞因子的代表性发现。我还将介绍我们最近关于如何同时解决CAR-T细胞治疗的有效性和安全性问题的研究。我们还将简要讨论CAR-NK细胞,其中细胞因子起着至关重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
0.20
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0.00%
发文量
337
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