[Pathological Complete Response to Chemotherapy in Four Cases of Pancreatic Cancer].

Abstract

While recent advances in chemotherapy for pancreatic cancer have improved treatment outcomes, pathological complete responses(pCR)remain rare. Here, we present four cases of pancreatic cancer in which a pCR was achieved following chemotherapy. Three cases were classified as borderline resectable and one was resectable. Two patients received gemcitabine+nab-paclitaxel, 1 received mFOLFIRINOX, and one received gemcitabine+S-1 therapy. Histopathological examination after resection revealed only fibrosis and scarring. No tumor cells were found in any of these cases, leading to diagnoses of pCR. Two of the 4 patients survived without recurrence for a long time. The other 2 patients experienced recurrence, one of whom died 8 months after surgery.